miRNA genes and the brain: Implications for psychiatric disordersa

Human Mutation

Volumn 31, Issue 11, 2010, Pages 1195-1204

  Forero, Diego A ^a,b,c,d   Van Der Ven, Karlijn ^a,b   Callaerts, Patrick ^a,c   Del Favero, Jurgen ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d CENTRO DE INVESTIGACIONES   (Colombia)

Author keywords

Brain disorders; MicroRNAs; Noncoding RNA; Psychiatric diseases; Schizophrenia

Indexed keywords

MICRORNA; UNTRANSLATED RNA;

ANXIETY DISORDER; BRAIN DISEASE; CENTRAL NERVOUS SYSTEM; GENE EXPRESSION; GENETIC VARIABILITY; HUMAN; M MODE ECHOCARDIOGRAPHY; MENTAL DISEASE; MOLECULAR GENETICS; MOOD DISORDER; NERVE CELL PLASTICITY; PRIORITY JOURNAL; RETT SYNDROME; REVIEW; RISK FACTOR; RNA PROCESSING; SCHIZOPHRENIA; SUBSTANCE ABUSE;

ANIMALS; BRAIN; DOWN-REGULATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MENTAL DISORDERS; MICRORNAS; MOLECULAR BIOLOGY; NEURONAL PLASTICITY; RISK FACTORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, UNTRANSLATED; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 78049438573     PISSN: 10597794     EISSN: 10981004     Source Type: Journal    
DOI: 10.1002/humu.21344     Document Type: Review

References (111)

1. Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Sestan N, State M. 2005. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science 310:317-320.
2. Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS. 2008. Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics 9:153-161.
3. Adams BD, Furneaux H, White BA. 2007. The micro-ribonucleic acid (miRNA) miR-206 targets the human estrogen receptor-alpha (ERalpha) and represses ERalpha messenger RNA and protein expression in breast cancer cell lines. Mol Endocrinol 21:1132-1147.
4. Alaerts M, Del-Favero J. 2009. Searching genetic risk factors for schizophrenia and bipolar disorder: learn from the past and back to the future. Hum Mutat 30:1139-1152.
5. Ashraf S, Mcloon A, Sclarsic S, Kunes S. 2006. Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 124:191-205.
6. Bak M, Silahtaroglu A, Moller M, Christensen M, Rath MF, Skryabin B, Tommerup N, Kauppinen S. 2008. MicroRNA expression in the adult mouse central nervous system. RNA 14:432-444.
7. Bartel DP. 2009. MicroRNAs: target recognition and regulatory functions. Cell 136:215-233.
8. Beveridge NJ, Gardiner E, Carroll AP, Tooney PA, Cairns MJ. 2009. Schizophrenia is associated with an increase in cortical microRNA biogenesis. Mol Psychiatry [Epub ahead of print].
9. Beveridge NJ, Tooney PA, Carroll AP, Gardiner E, Bowden N, Scott RJ, Tran N, Dedova I, Cairns MJ. 2008. Dysregulation of miRNA 181b in the temporal cortex in schizophrenia. Hum Mol Genet 17:1156-1168.
10. Bodmer W, Bonilla C. 2008. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 40:695-701.
11. Bond AM, Vangompel MJ, Sametsky EA, Clark MF, Savage JC, Disterhoft JF, Kohtz JD. 2009. Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry. Nat Neurosci 12:1020-1027.
12. Burmeister M, McInnis MG, Zollner S. 2008. Psychiatric genetics: progress amid controversy. Nat Rev Genet 9:527-540.
13. Burmistrova OA, Goltsov AY, Abramova LI, Kaleda VG, Orlova VA, Rogaev EI. 2007. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry(Mosc) 72:578-582.
14. Cai X, Hagedorn CH, Cullen BR. 2004. Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10:1957-1966.
15. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan BM, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Ninwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y. 2005. The transcriptional landscape of the mammalian genome. Science 309:1559-1563.
16. Carter CJ. 2006. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res 86:1-14.
17. Chandrasekar V, Dreyer JL. 2009. microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced plasticity. Mol Cell Neurosci 42L:350-362.
18. Chen H, Wang N, Burmeister M, McInnis MG. 2009. MicroRNA expression changes in lymphoblastoid cell lines in response to lithium treatment. Int J Neuropsychopharmacol 2:1-7.
19. Chen W, Jensen L, Gecz J, Fryns JP, Moraine C, de Brouwer A, Chelly J, Moser B, Ropers H, Kuss A. 2007. Mutation screening of brain-expressed X-chromosomal miRNA genes in 464 patients with nonsyndromic X-linked mental retardation. Eur J Hum Genet 15:375-378.
20. Chendrimada T, Finn K, Ji X, Baillat D, Gregory R, Liebhaber S, Pasquinelli A, Shiekhattar R. 2007. MicroRNA silencing through RISC recruitment of eIF6. Nature 447:823-828.
21. Cheng HY, Papp JW, Varlamova O, Dziema H, Russell B, Curfman JP, Nakazawa T, Shimizu K, Okamura H, Impey S, Obrietan K. 2007. microRNA modulation of circadian-clock period and entrainment. Neuron 54:813-829.
22. Choi KH, Elashoff M, Higgs BW, Song J, Kim S, Sabunciyan S, Diglisic S, Yolken RH, Knable MB, Torrey EF, Webster MJ. 2008. Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. BMC Psychiatry 8:87.
23. Conner TS, Jensen KP, Tennen H, Furneaux HM, Kranzler HR, Covault J. 2010. Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. Am J Med Genet B Neuropsychiatr Genet 153B:67-78.
24. Davis CJ, Bohnet SG, Meyerson JM, Krueger JM. 2007. Sleep loss changes microRNA levels in the brain: a possible mechanism for state-dependent translational regulation. Neurosci Lett 422:68-73.
25. Davis TH, Cuellar TL, Koch SM, Barker AJ, Harfe BD, McManus MT, Ullian EM. 2008. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci 28:4322-4330.
26. Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. 2004. Processing of primary microRNAs by the Microprocessor complex. Nature 432:231-235.
27. Diederichs S, Haber DA. 2007. Dual role for argonautes in MicroRNA processing and posttranscriptional regulation of MicroRNA expression. Cell 131:1097-1108.
28. Drake J, Bird C, Nemesh J, Thomas D, Newton-Cheh C, Reymond A, Excoffier L, Attar H, Antonarakis S, Dermitzakis E, Hirschhorn J. 2005. Conserved noncoding sequences are selectively constrained and not mutation cold spots. Nat Genet 38:223-227.
29. D'Sa C, Duman RS. 2002. Antidepressants and neuroplasticity. Bipolar Disord 4:183-194.
30. Duan R, Pak C, Jin P. 2007. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet 16:1124-1131.
31. Elashoff M, Higgs BW, Yolken RH, Knable MB, Weis S, Webster MJ, Barci BM, Torrey EF. 2007. Meta-analysis of 12 genomic studies in bipolar disorder. J Mol Neurosci 31:221-243.
32. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P. 2005. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313-1323.
33. Feng J, Sun G, Yan J, Noltner K, Li W, Buzin CH, Longmate J, Heston LL, Rossi J, Sommer SS. 2009. Evidence for X-chromosomal schizophrenia associated with microRNA alterations. PLoS ONE 4:e6121.
34. Filipowicz W, Bhattacharyya SN, Sonenberg N. 2008. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9:102-114.
35. Fiore R, Siegel G, Schratt G. 2008. MicroRNA function in neuronal development, plasticity and disease. Biochim Biophys Acta 1779:471-478.
36. Forero DA, Casadesus G, Perry G, Arboleda H. 2006. Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med 10:796-805.
37. Forstemann K, Horwich MD, Wee L, Tomari Y, Zamore PD. 2007. Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by Dicer-1. Cell 130:287-297.
38. Giraldez AJ, Cinalli RM, Glasner ME, Enright AJ, Thomson JM, Baskerville S, Hammond SM, Bartel DP, Schier AF. 2005. MicroRNAs regulate brain morphogenesis in zebrafish. Science 308:833-838.
39. Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. 2005. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 123:631-640.
40. Gregory RI, Yan KP, Amuthan G, Chendrimada T, Doratotaj B, Cooch N, Shiekhattar R. 2004. The Microprocessor complex mediates the genesis of microRNAs. Nature 432:235-240.
41. Griffiths-Jones S, Saini HK, van DS, Enright AJ. 2008. miRBase: tools for microRNA genomics. Nucleic Acids Res 36:D154-D158.
42. Hansen T, Olsen L, Lindow M, Jakobsen KD, Ullum H, Jonsson E, Andreassen OA, Djurovic S, Melle I, Agartz I, Hall HÃ, Timm S, Wang AG, Werge T. 2007. Brain expressed microRNAs implicated in schizophrenia etiology. PLoS ONE 2:e873.
43. He X, Zhang Q, Liu Y, Pan X. 2007. Cloning and identification of novel MicroRNAs from rat hippocampus. Acta Biochim Biophys Sin 39:708-714.
44. Higgs BW, Elashoff M, Richman S, Barci B. 2006. An online database for brain disease research. BMC Genomics 7:70.
45. Huang W, Li MD. 2009. Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504. Biol Psychiatry 65:702-705.
46. Hunsberger JG, Austin DR, Chen G, Manji HK. 2009. MicroRNAs in mental health: from biological underpinnings to potential therapies. Neuromolecular Med 11:173-182.
47. Jensen KP, Covault J, Conner TS, Tennen H, Kranzler HR, Furneaux HM. 2009. A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. Mol Psychiatry 14:381-389.
48. Jin P, Zarnescu DC, Ceman S, Nakamoto M, Mowrey J, Jongens TA, Nelson DL, Moses K, Warren ST. 2004. Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci 7:113-117.
49. Kapranov P, Willingham AT, Gingeras TR. 2007. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet 8:413-423.
50. Karginov F, Conaco C, Xuan Z, Schmidt B, Parker J, Mandel G, Hannon G. 2007. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci USA 104:19291-19296.
51. Karr J, Vagin V, Chen K, Ganesan S, Olenkina O, Gvozdev V, Featherstone DE. 2009. Regulation of glutamate receptor subunit availability by microRNAs. J Cell Biol 185:685-697.
52. Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engstrom PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C. 2005. Antisense transcription in the mammalian transcriptome. Science 309:1564-1566.
53. Kendler KS. 2006. Reflections on the relationship between psychiatric genetics and psychiatric nosology. Am J Psychiatry 163:1138-1146.
54. Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G. 2004. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci USA 101:360-365.
55. Klein M, Lioy D, Ma L, Impey S, Mandel G, Goodman R. 2007. Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA. Nat Neurosci 10:1513-1514.
56. Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, Wahlestedt C. 2009. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc Natl Acad Sci USA 106:3507-3512.
57. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. 2001. Identification of novel genes coding for small expressed RNAs. Science 294:853-858.
58. Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH, Kim VN. 2004. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 23:4051-4060.
59. Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Roser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schafer H, Walitza S, Reif A, Stephan DA, Jacob C. 2008. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 115:1573-1585.
60. Liang Y, Ridzon D, Wong L, Chen C. 2007. Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8:166.
61. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. 2009. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373:234-239.
62. Lin SL, Chang SJ, Ying SY. 2006. First in vivo evidence of microRNA-induced fragile X mental retardation syndrome. Mol Psychiatry 11:616-617.
63. Liu J, Carmell MA, Rivas FV, Marsden CG, Thomson JM, Song JJ, Hammond SM, Joshua-Tor L, Hannon GJ. 2004. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305:1437-1441.
64. Liu X, Park JK, Jiang F, Liu Y, McKearin D, Liu Q. 2007. Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. RNA 13:2324-2329.
65. Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U. 2004. Nuclear export of microRNA precursors. Science 303:95-98.
66. Ma D, Salyakina D, Jaworski JM, Konidari I, Whitehead PL, Andersen AN, Hoffman JD, Slifer SH, Hedges DJ, Cukier HN, Griswold AJ, McCauley JL, Beecham GW, Wright HH, Abramson RK, Martin ER, Hussman JP, Gilbert JR, Cuccaro ML, Haines JL, Pericak-Vance MA. 2009. A genome-wide association study of autism reveals a common novel risk locus at 5p14.1. Ann Hum Genet 73:263-273.
67. Macrae I, Ma E, Zhou M, Robinson C, Doudna J. 2008. In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci USA 105:512-517.
68. McQueen MB, Devlin B, Faraone SV, Nimgaonkar VL, Sklar P, Smoller JW, Abou JR, Albus M, Bacanu SA, Baron M, Barrett TB, Berrettini W, Blacker D, Byerley W, Cichon S, Coryell W, Craddock N, Daly MJ, DePaulo JR, Edenberg HJ, Foroud T, Gill M, Gilliam TC, Hamshere M, Jones I, Jones L, Juo SH, Kelsoe JR, Lambert D, Lange C, Lerer B, Liu J, Maier W, Mackinnon JD, McInnis MG, McMahon FJ, Murphy DL, Nothen MM, Nurnberger JI, Pato CN, Pato MT, Potash JB, Propping P, Pulver AE, Rice JP, Rietschel M, Scheftner W, Schumacher J, Segurado R, Van SK, Xie W, Zandi PP, Laird NM. 2005. Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet 77:582-595.
69. Meerson A, Cacheaux L, Goosens KA, Sapolsky RM, Soreq H, Kaufer D. 2009. Changes in brain MicroRNAs contribute to cholinergic stress reactions. J Mol Neurosci 40:47-55.
70. Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S. 2008. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 65:1006-1014.
71. Mercer TR, Dinger ME, Sunkin SM, Mehler MF, Mattick JS. 2008. Specific expression of long noncoding RNAs in the mouse brain. Proc Natl Acad Sci USA 105:716-721.
72. Mercer TR, Qureshi IA, Gokhan S, Dinger ME, Li G, Mattick JS, Mehler MF. 2010. Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation. BMC Neurosci 11:14.
73. Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR. 2004. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol 5:R68.
74. Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ, Luo S, Zhang L, van Velkinburgh JC, Farmer AD, Lewis S, Beavis WD, Schilkey FD, Virk SM, Black CF, Myers MK, Mader LC, Langley RJ, Utsey JP, Kim RW, Roberts RC, Khalsa SK, Garcia M, Ambriz-Griffith V, Harlan R, Czika W, Martin S, Wolfinger RD, Perrone-Bizzozero NI, Schroth GP, Kingsmore SF. 2008. Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum. PLoS One 3:e3625.
75. Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, Antoniades A, Domenici E, Perry J, Rothen S, Vandeleur CL, Mooser V, Waeber G, Vollenweider P, Preisig M, Lucae S, Muller-Myhsok B, Holsboer F, Middleton LT, Roses AD. 2010. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Mol Psychiatry 15:589-601.
76. Muinos-Gimeno M, Guidi M, Kagerbauer B, Martin-Santos R, Navines R, Alonso P, Menchon JM, Gratacos M, Estivill X, Espinosa-Parrilla Y. 2009. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum Mutat 30:1062-1071.
77. Muinos-Gimeno M, Montfort M, Bayes M, Estivill X, Espinosa-Parrilla Y. 2010. Design and evaluation of a panel of single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease. Eur J Hum Genet 18:218-226.
78. Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV. 2008. Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B:1337-1344.
79. Ng MY, Levinson DF, Faraone SV, Suarez BK, DeLisi LE, Arinami T, Riley B, Paunio T, Pulver AE, Irmansyah, Holmans PA, Escamilla M, Wildenauer DB, Williams NM, Laurent C, Mowry BJ, Brzustowicz LM, Maziade M, Sklar P, Garver DL, Abecasis GR, Lerer B, Fallin MD, Gurling HM, Gejman PV, Lindholm E, Moises HW, Byerley W, Wijsman EM, Forabosco P, Tsuang MT, Hwu HG, Okazaki Y, Kendler KS, Wormley B, Fanous A, Walsh D, O'Neill FA, Peltonen L, Nestadt G, Lasseter VK, Liang KY, Papadimitriou GM, Dikeos DG, Schwab SG, Owen MJ, O'Donovan MC, Norton N, Hare E, Raventos H, Nicolini H, Albus M, Maier W, Nimgaonkar VL, Terenius L, Mallet J, Jay M, Godard S, Nertney D, Alexander M, Crowe RR, Silverman JM, Bassett AS, Roy MA, Merette C, Pato CN, Pato MT, Roos JL, Kohn Y, Amann-Zalcenstein D, Kalsi G, McQuillin A, Curtis D, Brynjolfson J, Sigmundsson T, Petursson H, Sanders AR, Duan J, Jazin E, Myles-Worsley M, Karayiorgou M, Lewis CM. 2009. Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 14:774-785.
80. Olsen L, Klausen M, Helboe L, Nielsen FC, Werge T. 2009. MicroRNAs show mutually exclusive expression patterns in the brain of adult male rats. PLoS One 4:e7225.
81. Pasquinelli AE, Reinhart BJ, Slack FJ, Martindale MQ, Kuroda MI, Maller BR, Hayward DC, Ball EE, Degnan B, Muller P, Spring J, Srinivasan A, Fishman MC, Finnerty J, Corbo J, Levine M, Leahy P, Davidson E, Ruvkun GB. 2000. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408:86-89.
82. Perkins D, Jeffries C, Jarskog F, Thomson M, Woods K, Newman M, Parker J, Jin J, Hammond S. 2007. miRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder. Genome Biol 8:R27.
83. Perkins DO, Jeffries C, Sullivan P. 2005. Expanding the "central dogma": the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia. Mol Psychiatry 10:69-78.
84. Pillai R, Bhattacharyya S, Artus C, Zoller T, Cougot N, Basyuk E, Bertrand E, Filipowicz W. 2005. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 309:1573-1576.
85. Place RF, Li LC, Pookot D, Noonan EJ, Dahiya R. 2008. MicroRNA-373 induces expression of genes with complementary promoter sequences. Proc Natl Acad Sci USA 105:1608-1613.
86. Quach H, Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quintana-Murci L. 2009. Signatures of purifying and local positive selection in human miRNAs. Am J Hum Genet 84:316-327.
87. Ramocki MB, Zoghbi HY. 2008. Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. Nature 455:912-918.
88. Rigoutsos I, Huynh T, Miranda K, Tsirigos A, McHardy A, Platt D. 2006. Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes. Proc Natl Acad Sci USA 103:6605-6610.
89. Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S. 2006. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Mol Psychiatry 11:965-978.
90. Saini HK, Griffiths-Jones S, Enright AJ. 2007. Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci USA 104:17719-17724.
91. Saunders M, Liang H, Li WH. 2007. Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci USA 104:3300-3305.
92. Schloesser RJ, Huang J, Klein PS, Manji HK. 2008. Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology 33:110-133.
93. Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D, Thompson RC, Francks C, Meng F, Antoniades A, Southwick AM, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Day R, Matthews K, McGuffin P, Strauss JS, Kennedy JL, Middleton L, Roses AD, Watson SJ, Vincent JB, Myers RM, Farmer AE, Akil H, Burns DK, Boehnke M. 2009. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA 106:7501-7506.
94. Sone M, Hayashi T, Tarui H, Agata K, Takeichi M, Nakagawa S. 2007. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci 120:2498-2506.
95. Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. 2008. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet 40:751-760.
96. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Borglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Bottcher Y, Olesen J, Breuer R, Moller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Rethelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Group, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de FR, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Lim YJ, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jonsson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St CD, Goldstein DB, Stefansson K, Collier DA, Kahn RS, Linszen DH, van OJ, Wiersma D, Bruggeman R, Cahn W, de HL, Krabbendam L, Myin-Germeys I. 2009. Common variants conferring risk of schizophrenia. Nature 460:744-747.
97. Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nothen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van DR, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW. 2009. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 14:359-375.
98. Talebizadeh Z, Butler MG, Theodoro MF. 2008. Feasibility and relevance of examining lymphoblastoid cell lines to study role of microRNAs in autism. Autism Res 1:240-250.
99. Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. 2008. MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455:1124-1128.
100. Uchida S, Nishida A, Hara K, Kamemoto T, Suetsugi M, Fujimoto M, Watanuki T, Wakabayashi Y, Otsuki K, McEwen BS, Watanabe Y. 2008. Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. Eur J Neurosci 27:2250-2261.
101. Vo N, Klein M, Varlamova O, Keller D, Yamamoto T, Goodman R, Impey S. 2005. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci USA 102:16426-16431.
102. Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, Sakurai T, Rappaport E, Lajonchere CM, Munson J, Estes A, Korvatska O, Piven J, Sonnenblick LI, Alvarez Retuerto AI, Herman EI, Dong H, Hutman T, Sigman M, Ozonoff S, Klin A, Owley T, Sweeney JA, Brune CW, Cantor RM, Bernier R, Gilbert JR, Cuccaro ML, McMahon WM, Miller J, State MW, Wassink TH, Coon H, Levy SE, Schultz RT, Nurnberger JI, Haines JL, Sutcliffe JS, Cook EH, Minshew NJ, Buxbaum JD, Dawson G, Grant SF, Geschwind DH, Pericak-Vance MA, Schellenberg GD, Hakonarson H. 2009. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature 459:528-533.
103. Wayman GA, Davare M, Ando H, Fortin D, Varlamova O, Cheng HY, Marks D, Obrietan K, Soderling TR, Goodman RH, Impey S. 2008. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc Natl Acad Sci USA 105:9093-9098.
104. Wheeler G, Ntounia-Fousara S, Granda B, Rathjen T, Dalmay T. 2006. Identification of new central nervous system specific mouse microRNAs. FEBS Lett 580:2195-2200.
105. Xu K, Bogert BA, Li W, Su K, Lee A, Gao FB. 2004. The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1. Curr Biol 14:1025-1034.
106. Zhang C. 2008. MicroRNomics: a newly emerging approach for disease biology. Physiol Genomics 33:139-147.
107. Zhang J, Liu Q, Zhang W, Li J, Li Z, Tang Z, Li Y, Han C, Hall SH, Zhang Y. 2010. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides. Acta Biochim Biophys Sin (Shanghai) 42:145-153.
108. Zhang L, Wang T, Wright AF, Suri M, Schwartz CE, Stevenson RE, Valle D. 2006. A microdeletion in Xp11.3 accounts for co-segregation of retinitis pigmentosa and mental retardation in a large kindred. Am J Med Genet A 140:349-357.
109. Zhao JJ, Hua YJ, Sun DG, Meng XX, Xiao HS, Ma X. 2006. Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray. Childs Nerv Syst 22:1419-1425.
110. Zhou R, Yuan P, Wang Y, Hunsberger JG, Elkahloun A, Wei Y, Damschroder-Williams P, Du J, Chen G, Manji HK. 2009. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology 34:1395-1405.
111. Zhu Y, Kalbfleisch T, Brennan MD, Li Y. 2009. A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene. Schizophr Res 109:86-89.