Conserved noncoding sequences are selectively constrained and not mutation cold spots

Nature Genetics

Volumn 38, Issue 2, 2006, Pages 223-227

  Drake, Jared A ^a,b   Bird, Christine ^c   Nemesh, James ^a,b   Thomas, Daryl J ^d   Newton Cheh, Christopher ^b,e,f   Reymond, Alexandre ^g   Excoffier, Laurent ^h   Attar, Homa ^g   Antonarakis, Stylianos E ^g   Dermitzakis, Emmanouil T ^c   Hirschhorn, Joel N ^a,b,i  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d University of California   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f FRAMINGHAM HEART STUDY   (United States)

^g UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^h UNIVERSITY OF BERN   (Switzerland)

ⁱ HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; COMPARATIVE STUDY; EVOLUTION; GENE FREQUENCY; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; INSTRUMENTATION; INTRON; MISSENSE MUTATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

CONSERVED SEQUENCE; GENE FREQUENCY; HUMANS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION GROUPS; SELECTION (GENETICS);

MAMMALIA;

EID: 31744448843     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1710     Document Type: Article

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