Assessing energetic contributions to binding from a disordered region in a protein-protein interaction

Biochemistry

Volumn 49, Issue 43, 2010, Pages 9256-9268

  Cho, Sangwoo ^a   Swaminathan, Chittoor P ^a   Bonsor, Daniel A ^b   Kerzic, Melissa C ^a   Guan, Rongjin ^a,e   Yang, Jianying ^a,f   Kieke, Michele C ^c,g   Andersen, Peter S ^d   Kranz, David M ^c   Mariuzza, Roy A ^a   Sundberg, Eric J ^b  

^a UNIVERSITY OF MARYLAND   (United States)

^b BOSTON BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d Symphogen AS   (Denmark)

^e RUTGERS UNIVERSITY   (United States)

^f MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^g Kinesiology and Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY MATURATION; BEFORE AND AFTER; BINDING AFFINITIES; COMPLEX FORMATIONS; CONFORMATIONAL FLEXIBILITY; DIRECTED EVOLUTION; DISORDERED PROTEINS; DISORDERED REGIONS; EXPERIMENTAL METHODS; FUNCTIONAL PROTEINS; HEAT CAPACITIES; HEAT CAPACITY CHANGE; ISOTHERMAL TITRATION CALORIMETRY; MODEL PROTEINS; MODEL SYSTEM; PROTEIN BINDING PARTNERS; PROTEIN COMPLEXES; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL TRANSITIONS; SURFACE AREA; TRAINING SETS; X-RAY STRUCTURE;

BINDING ENERGY; BIOCHEMISTRY; COMPLEXATION; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; ORDER DISORDER TRANSITIONS; SPECIFIC HEAT;

PROTEINS;

T LYMPHOCYTE RECEPTOR BETA CHAIN;

ARTICLE; BINDING AFFINITY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ANIMALS; CALORIMETRY; DIRECTED MOLECULAR EVOLUTION; MICE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; THERMODYNAMICS;

EID: 78049270023     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1008968     Document Type: Article

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