Improved specific productivity in cephalexin synthesis by immobilized PGA in silica magnetic micro-particles

Biotechnology and Bioengineering

Volumn 107, Issue 5, 2010, Pages 753-762

  Bernardino, Susana M S A ^a,b   Fernandes, Pedro ^b   Fonseca, Luís P ^b  

^a POLYTECHNIC INSTITUTE OF LEIRIA   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

Author keywords

lactam antibiotics; Cephalexin; Enzyme immobilization; Kinetically controlled synthesis; Penicillin G acylase; Sol gel

Indexed keywords

ACYL DONORS; AQUEOUS MEDIA; AQUEOUS MEDIUM; CEPHALEXIN; CONTROLLED SYNTHESIS; HAZARDOUS REAGENTS; IMMOBILIZED BIOCATALYSTS; KINETICALLY CONTROLLED SYNTHESIS; MICRO-PARTICLES; PENICILLIN G ACYLASE; PHARMACEUTICAL INDUSTRY; SPECIFIC PRODUCTIVITY;

ANTIBIOTICS; DRUG PRODUCTS PLANTS; ENZYMES; GELS; MAGNETIC PROPERTIES; PRODUCTIVITY; SILICA; SOL-GEL PROCESS; SOL-GELS; SOLS; SUBSTRATES;

ENZYME IMMOBILIZATION;

CEFALEXIN; NUCLEOPHILE; PENICILLIN G; SILICA GEL;

AQUEOUS SOLUTION; ARTICLE; BIOCATALYST; DRUG HALF LIFE; DRUG SPECIFICITY; DRUG SYNTHESIS; MEMBRANE MICROPARTICLE; PH; TEMPERATURE;

ANTI-BACTERIAL AGENTS; BIOTECHNOLOGY; CEPHALEXIN; ENZYMES, IMMOBILIZED; HALF-LIFE; HYDROGEN-ION CONCENTRATION; MAGNETICS; MICROSPHERES; PENICILLIN AMIDASE; SILICON DIOXIDE; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 77958574445     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22867     Document Type: Article

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