Penicillin acylase-catalyzed synthesis of β-lactam antibiotics in water-methanol mixtures: Effect of cosolvent content and chemical nature of substrate on reaction rates and yields

Journal of Molecular Catalysis B: Enzymatic

Volumn 1, Issue 3-6, 1996, Pages 201-211

  Kim, Min Gon ^a   Lee, Sun Bok ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Ampicillin; Penicillin acylase; Penicillin G; Pivampicillin; Solvent effects on apparent pK values; Solvent effects on reaction rates and yields; Water cosolvent mixtures; Lactam antibiotic synthesis

Indexed keywords

ANTIBIOTICS; CATALYSIS; CATALYST ACTIVITY; ENZYME KINETICS; ENZYMES; ESTERS; MATHEMATICAL MODELS; METHANOL; ORGANIC SOLVENTS; SOLUBILITY; THERMODYNAMICS; WATER;

COSOLVENT CONTENT; LACTAM ANTIBIOTICS; PENICILLIN ACYLASE; PHENYLACETIC ACID; WATER COSOLVENT MIXTURES;

BIOSYNTHESIS;

EID: 0030568603     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/1381-1177(96)00007-0     Document Type: Article

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