Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 5, 2007, Pages 2120-2126

  Bakavoli, M ^a   Nikpour, M ^a   Rahimizadeh, M ^a   Saberi, M R ^b   Sadeghian, H ^a  

^a FERDOWSI UNIVERSITY OF MASHHAD   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

15 Lipoxygenase; 5 Bromo 2,4 dichloro 6 methylpyrimidine; Docking; Molecular modeling; Pyrimido 4,5 b 1,4 benzothiazine; QSAR

Indexed keywords

2 (4 ETHYLPIPERAZIN 1 YL)4 METHYLPYRIMIDO[4,5 B][1,4]BENZOTHIAZINE; 4 METHYL 2 (4 METHYLPIPERAZIN 1 YL)PYRIMIDO[4,5 B][1,4]BENZOTHIAZINE; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE INHIBITOR; BENZOTHIAZINE DERIVATIVE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; IC 50; INFRARED SPECTROSCOPY; MOLECULAR INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ARACHIDONATE 15-LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROPHOTOMETRY, INFRARED; THIAZINES;

EID: 33846616354     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.12.022     Document Type: Article

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