Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 6 49-6, 2004, Pages

  Clarke, Lane L ^a,b   Gawenis, Lara R ^a,b   Bradford, Emily M ^a   Judd, Louise M ^c   Boyle, Kathryn T ^a   Simpson, Janet E ^a,b   Shull, Gary E ^c   Tanabe, Hiroki ^d   Ouellette, Andre J ^d   Franklin, Craig L ^b   Walker, Nancy M ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cryptdins; Defensin; Inflammation; Innate immunity; Intestinal infection

Indexed keywords

ALPHA DEFENSIN; CELL PROTEIN; CRYPTDIN; LAXATIVE; LYSOZYME; MESSENGER RNA; UNCLASSIFIED DRUG; PEPTIDE FRAGMENT; PROTEIN PRECURSOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; CELL GRANULE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYSTIC FIBROSIS; DISSOLUTION; DOWN REGULATION; ELECTRON MICROSCOPY; HOST RESISTANCE; IMMUNE DEFICIENCY; INFECTION RESISTANCE; INTESTINE CRYPT; INTESTINE INFECTION; INTESTINE OBSTRUCTION; MOUSE; MUCUS; NONHUMAN; NORTHERN BLOTTING; PANETH CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SALMONELLA TYPHIMURIUM; WILD TYPE; AEROBIC BACTERIUM; ANIMAL; BACTERIAL COUNT; BACTERIAL INFECTION; BACTERIUM; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MOUSE; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; INTESTINE; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MICROVILLUS; ULTRASTRUCTURE;

ANIMALS; BACTERIA; BACTERIA, AEROBIC; BACTERIAL INFECTIONS; COLONY COUNT, MICROBIAL; CYTOPLASMIC GRANULES; DOWN-REGULATION; INTESTINES; MICE; MICE, INBRED CFTR; MICROSCOPY, ELECTRON; MICROVILLI; MURAMIDASE; PANETH CELLS; PEPTIDE FRAGMENTS; PROTEIN PRECURSORS; RNA, MESSENGER; SALMONELLA TYPHIMURIUM;

EID: 2642541851     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00393.2003     Document Type: Article

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