Defensins and innate host defence of the gastrointestinal tract

Gut

Volumn 45, Issue 6, 1999, Pages 911-915

  Bevins, C I ^a   Martin Porter, E ^b   Ganz, T ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEFENSIN; PEPTIDE;

BACTERIAL OVERGROWTH; BACTERICIDAL ACTIVITY; GASTROINTESTINAL TRACT; HOST RESISTANCE; INTESTINE MUCOSA; NECROTIZING ENTEROCOLITIS; PANETH CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW;

EID: 0032732928     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.45.6.911     Document Type: Review

References (73)

1. Zasloff M. Antibiotics peptides as mediators of innate immunity. Curr Opin Immunol 1992;4:3-7.
2. Boman HG. Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 1995;13:61-92.
3. Martin E, Ganz T, Lehrer RI. Defensins and other endogenous peptide antibiotics of vertebrates. J Leuk Biol 1995;58:128-36.
4. Hancock REW, Falla T, Brown M. Cationic bactericidal peptides. Adv Microb Physiol 1995;37:135-75.
5. Lehrer RI, Bevins CL, Ganz T. Defensins and other antimicrobial peptides. In: Ogra PL, Mestecky J, Lamm ME, Strober WM, Bienstock J, eds. Mucosal Immunology, 2nd Ed. New York: Academic Press, 1998:89-99.
6. Epple P, Apel K, Bohlmann H. Overexpression of an endogenous thionin enhances resistance of Arabidopsis against Fusarium oxysporum. Plant Cell 1997;9:509-20.
7. Fritig B, Heitz T, Legrand M. Antimicrobial proteins in induced plant defense. Curr Opin Immunol 1998;10:16-22.
8. Ohshima M, Mitsuhura I, Okamoto M, et al. Enhanced resistance to bacterial diseases of transgenic tobacco plants overexpressing sarcotoxin 1A, a bactericidal peptide of insect. J Biochem (Tokyo) 1999;125:431-5.
9. Lemaitre B, Nicolas E, Michaur L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996;86:973-83.
10. Selsted ME, Harwig SS. Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide. J Biol Chem 1989;264:4003-7.
11. Tang Y-Q, Selsted ME. Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J Biol Chem 1993;268:66-19-53.
12. Zimmermann GR, Legault P, Selsted ME, et al. Solution structure of bovine neutrophil beta-defensin-12: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry 1995;34:13663-71.
13. Sparkes RS, Kronenberg M, Heinzmann C, et al. Assignment of defensin gene(s) to human chromosome 8p23. Genomics 1989;5:240-4.
14. Harder J, Siebert R, Zhang Y, et al. Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23-1. Genomics 1997;46:472-5.
15. Liu L, Zhao C, Heng HH, et al. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 1997;43:316-20.
16. Ouellette AJ, Pravtcheva D, Ruddle FH, et al. Localization of the eryptdin locus on mouse chromosome 8. Genomics 1989;5:233-9.
17. Huttner KM, Kozak CA, Bevins CL. The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett 1997;413:45-9.
18. Morrison GM, Davidson DJ, Kilanowski FM, et al. Mouse beta defensin-1 is a functional homolog of human beta defensin-1. Mamm Genome 1998;9:453-7.
19. Bals R, Goldman MJ, Wilson JM. Mouse beta-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract. Infect Immun 1998;66:1225-32.
20. Jia HP, Mills JN, Barahmand-pour F, et al. Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. Infect Immun 1999;67:4827-33.
21. Selsted ME, Brown DM, DeLange RJ, et al. Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages. J Biol Chem 1983;258:14485-9.
22. Selsted ME, Harwig SS, Ganz T, et al. Primary structures of three human neutrophil defensins. J Clin Invest 1985;76:1436-9.
23. Ganz T, Selsted ME, Szklarek D, et al. Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 1985;76:1427-35.
24. Selsted ME, Miller SI, Henschen AH, et al. Enteric defensins: antibiotic peptide components of intestine host defense. J Cell Biol 1992;118:929-36.
25. Harwig SS, Eisenhauer PB, Chen NP, et al. Cryptdins: endogenous antibiotic peptides of small intestinal Paneth cells. Adv Exp Med Biol 1995;371A:251-5.
26. Quayle AJ, Porter EM, Nussbaum AA, et al. Gene expression, immunolocalization and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 1998;152:1247-58.
27. Diamond G, Zasloff M, Eck H, et al. Tracheal antimicrobial peptide, a novel cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Sci USA 1991;88:3952-6.
28. Diamond G, Bevins CL. β-defensins: endogenous antibiotics of the innate host defense response. Clin Immunol Immunopathol 1998;88:221-5.
29. Schonwetter BS, Stolzenberg ED, Zasloff MA. Epithelial antibiotics induced at sites of inflammation. Science 1995;267:1645-8.
30. Krisanaprakornkit S, Weinberg A, Perez CN, et al. Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998;66:4222-8.
31. Tarver AP, Clark DP, Diamond G, et al. Enteric β-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial expression associated with Cryprospiridium parvum expression. Infect Immun 1998;66:1045-56.
32. Shi J, Zhang G, Wu H, et al. Porcine epithelial beta-defensin 1 is expressed in the dorsal tongue at antimicrobial concentrations. Infect Immun 1999;67:3121-7.
33. Bensch KW, Raida M, Mägert H-J, et al. hBD-1: a novel β-defensin from human plasma. FEBS Lett 1995;368:331-5.
34. Zhao C, Wang I, Lehrer RI. Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 1996;396:319-22.
35. Harder J, Barrels J, Christophers E, et al. A peptide antibiotic from human skin. Nature 1997;387:861.
36. Valore EV, Park CH, Quayle AJ, et al. Human β-defensin-1: An antimicrobial peptide of urogenital tissues. J Clin Ivest 1998;101:1633-42.
37. Selsted ME, Tang Y-Q, Morris WL, et al. Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem 1993;268:6641-8.
38. Ouellette AJ, Greco RM, James M, et al. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J Cell Biol 1989;108:1687-95.
39. Jones DE, Bevins CL, Paneth cells of the human small intestine express an antimicrobial peptide gene. J Biol Chem 1992;267:23216-25.
40. Jones DE, Bevins CL. Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel. FEBS Lett 1993;315:187-92.
41. Ouellette AJ, Hsieh MM, Nosek MT, et al. Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun 1994;62:5040-7.
42. Mallow EB, Harris A, Salzman N, et al. Human enteric defensins: gene structure and developmental expression. J Biol Chem 1996;271:4038-45.
43. Darmoul D, Ouellette AJ. Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine. Am J Physiol 1996;271:G68-74.
44. Ouellette AJ, Miller SI, Henschen AH, et al. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett 1992;304:146-8.
45. Eisenhauer PB, Harwig SSSI, Lehrer RI. Cryptdins: antimicrobial defensins of the murine small intestine. Infect Immun 1992;60:3556-65.
46. Porter E, Liu L, Oren A, et al. Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun 1997;65:2389-95.
47. Porter E, van Dam E, Valore E, et al. Broad spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun 1997;65:2396-401.
48. Peeters T, Vantrappen G. The Paneth cell: a source of intestinal lysozyme. Gut 1975;16:553-8.
49. Harwig SSL, Tan L, Qu X-D, et al. Bactericidal properties of murine intestinal phospholipase A2. J Clin Invest 1995;95:603-10.
50. Qu XD, Lloyd KC, Walsh JH, et al. Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells. Infect Immun 1996;64:5161-5.
51. Satoh Y. Atropine inhibits the degranulation of Paneth cells in ex-germ-free mice. Cell Tissue Res 1988;253:397-402.
52. Albedi FM, Lorenzetti E, Contini M, et al. Immature Paneth cells in intestinal metaplasia of gastric mucosa. Appl Pathol 1984;2:43-8.
53. Symonds DA. Paneth cell metaplasia in diseases of the colon and rectum. Arch Pathol 1974;97:343-7.
54. Bry L, Falk P, Huttner K, et al. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci USA 1994;91:10335-9.
55. Stappenbeck TS, Wong MH, Saam JR, et al. Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium. Curr Opin Cell Biol 1998;10:702-9.
56. Ganz T. Biosynthesis of defensins and other antimicrobial peptides. Ciba Foundation Symposium 1994;186:62-76.
57. Bateman A, Singh A, Shustik C, et al. The isolation and identification of multiple forms of the neutrophil granule peptides from human leukemic cells. J Biol Chem 1991;266:7524-30.
58. Harwig SSL, Park ASK, Lehrer RI. Characterization of defensin precursors in mature human neutrophils. Blood 1992;79:1532-7.
59. Valore EV, Ganz T. Posttranslational processing of defensins in immature human myeloid cells. Blood 1992;79:1538-44.
60. Liu L, Ganz T. The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting. Blood 1995;85:1095-103.
61. Valore EV, Martin E, Harwig SS, et al. Intramolecular inhibition of human defensin HNP-1 by its propiece. J Clin Invest 1996;97:1624-9.
62. Porter EM, Poles MA, Lee JS, et al. Isolation of human intestinal defensins from ileal neobladder urine. FEBS Lett 1998;434:272-6.
63. Aley SB, Zimmerman M, Hetsko M, et al. Killing of Giardia lambia by cryptdins and cationic neutrophil peptides. Infect Immun 1994;62:5397-403.
64. Singh A, Bateman A, Zhu QZ, et al. Structure of a novel human granulocyte peptide with anti-ACTH activity. Biochem Biophys Res Commun 1988;155:524-9.
65. MacLeod RJ, Hamilton JR, Bateman A, et al. Corticostatic peptides cause nifedipine-sensitive volume reduction in jejunal villus enterocytes. Proc Natl Acad Sci USA 1991;88:552-6.
66. Chertov O, Michiel DF, Xu L, et al. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem 1996;271:2935-40.
67. Higazi AA, Lavi E, Bdeir K, et al. Defensin stimulates the binding of lipoprotein (a) to human vascular endothelial and smooth muscle cells. Blood 1997;89:4290-8.
68. Lencer WI, Cheung G, Strohmeier GR, et al. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci USA 1997;94:8585-9.
69. Lillard JW Jr, Boyaka PN, Chertov O, et al. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proc Natl Acad Sci USA 1999;96:651-6.
70. Garabedian EM, Roberts LJJ, McNevin MS, et al. Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem 1997;272:23729-40.
71. Kliegman RM, Fanaroff AA. Necrotizing enterocolitis. N Engl. J Med 1984;310:1093-103.
72. Ballance WA, Dahms BB, Shenker N, et al. Pathology of neonatal necrotizing enterocolitis: a ten year experience. J Pediatr 1990;117;S6-13.
73. Salzman NH, Polin RA, Harris MC, et al. Enteric defensin expression in necrotizing enterocolitis. Pediatr Res 1998;44:20-6.