Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7548-7564

  Yin, Wenyuan ^a   Majumder, Samarpan ^b   Clayton, Terry ^a   Petrou, Steven ^c   Vanlinn, Michael L ^a   Namjoshi, Ojas A ^a   Ma, Chunrong ^a   Cromer, Brett A ^c   Roth, Bryan L ^b   Platt, Donna M ^d   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alcohol antagonist; Benzodiazepine; Beta carboline; GABA receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5 ISOPROPOXY 4 METHYL BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; BETA CARBOLINE DERIVATIVE; FLUMAZENIL; SUCROSE;

ALCOHOL ABUSE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RAT; RECEPTOR AFFINITY; SONOGASHIRA REACTION; STILLE REACTION; STRUCTURE ACTIVITY RELATION;

ALCOHOLISM; ANIMALS; BENZODIAZEPINES; BINDING SITES; CARBOLINES; CELL LINE; COMPUTER SIMULATION; GABA-A RECEPTOR ANTAGONISTS; HUMANS; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS; RODENTIA;

EID: 77957976870     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.049     Document Type: Article

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