Blocking GABA(A) receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat

Psychopharmacology

Volumn 139, Issue 1-2, 1998, Pages 108-116

  Nowak, K L ^a   McBride, W J ^a   Lumeng, L ^b   Li, T K ^b   Murphy, J M ^c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Ethanol intake; GABA; Microinjection; Picrotoxin; Ventral tegmental area

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; PICROTOXIN; SACCHARIN;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEMALE; FOOD INTAKE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; VENTRAL TEGMENTUM;

ALCOHOL DRINKING; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA AGONISTS; GABA ANTAGONISTS; MUSCIMOL; PICROTOXIN; RATS; RECEPTORS, GABA-A; VENTRAL TEGMENTAL AREA;

EID: 0031697721     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050695     Document Type: Article

References (49)

1. Arnt J, Scheel-Kruger J (1979) GABA in the ventral tegmental urea: differential regional effects on locomotion, aggression and food intake after microinjections of GABA agonists and antagonists. Life Sci 25:1351-1360
2. Boismare F, Daoust M, Moore N, Saligaut C, Ljuintre JP, Chretien P. Duriach JA (1984) A homotaurine derivative reduces the voluntary intake of ethanol by rats: are cerebral GABA receptors involved? Pharmacol Biochem Behav 21:787-789
3. A agonist, on voluntary ethanol intake in laboratory rats. Pharmacol Biochem Behav 43:1121-1127
4. Boyle AE, Segal R, Smith BR, Amit Z (1993) Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats. Pharmacol Biochem Behav 46:179-182
5. Brodie MS, Shefner SA, Dunwiddie TV (1990) Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro. Brain Res 508:65-69
6. Cooper SJ, Bowyer DM, van der Hoek G (1989) Effects of the imidazobenzodiazepine Ro 15-4513 on saccharin choice and acceptance, and on food intake, in the rat. Brain Res 494: 172-176
7. Daoust M, Saligaut C, Lhuintre JP, Moore N, Flipo JL, Boismare F (1987) GABA transmission, but not benzodiazepine receptor stimulation, modulates ethanol intake by rats. Alcohol 4:469-472
8. 2 dopaminergic mechanisms. Psychopharmacology 130:85-90
9. Fadda F, Argiolas A, Melis MR, DeMontism G, Gessa GL (1983) Suppression of voluntary ethanol consumption in rats by gamma-butyrolactone. Life Sci 32:1471-1477
10. Fibiger HC, Phillips AG (1986) Reward, motivation, cognition: psychobiology of mesotelencephalic dopamine systems. In: Mountcastle VB, Bloom FE, Geiger SR (eds) Handbook of physiology: vol 4. The nervous system. American Physiological Society, Bethesda, Md., pp 647-675
11. Fibiger HC, Phillips AG (1987) On the role of catecholamine neurotransmitters in brain reward systems: implications for the neurobiology of affect. In: Oreland L, Engel J (eds) Brain reward systems and abuse. Raven Press, New York, pp 61-74
12. Harris RA, Brodie MS, Dunwiddie TV (1992) Possible substrates of ethanol reinforcement: GABA and dopamine. Ann NY Acad Sci 654:62-69
13. Hodge CW, Haraguchi M, Erickson H, Samson HH (1993) Ventral tegmental microinjections of quinpirole decrease ethanol and sucrose-reinforced responding. Alcohol Clin Exp Res 17:370-375
14. Hodge CW, Samson HH, Tolliver GA, Haraguchi M (1994) Effects of intraaccumbens injections of dopamine agonists and antagonists on sucrose and sucrose-ethanol reinforced responding. Pharmacol Biochem Behav 48:141-150
15. A agonist muscimol on self-administration of ethanol and sucrose. Pharmacol Biochem Behav 53:971-977
16. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283:151-159
17. A receptor blockade in the anterior ventral tegmental area increases extracellular levels of dopamine in the nucleus accumbens of rats. J Neurochem 69:137-143
18. A antagonists directly into the ventral tegmental area and adjacent regions. Behav Neurosci 111:369-380
19. Imperato A, Di Chiara G (1986) Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Pharmacol Exp Ther 239:221-229
20. Jankowska E, Kostowski W (1995) The effect of tropisteron injected into the nucleus accumbens septi on ethanol consumption in rats. Alcohol 12:195-198
21. Johnson SW, North RA (1992) Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J Physiol 450: 455-468
22. Kalivas PW, Churchill L, Klitenick MA (1993) The circuitry mediating the translation of motivational stimuli into adaptive motor responses. In: Kalivas PW. Barnes CD (eds) Limbic motor circuits and neuropsychiatry. CRC Press, London, pp 237-287
23. Katner SN, McBride WJ, Lumeng L, Li T-K, Murphy JM (1997) Alcohol intake of P rats is regulated by muscarinic receptors in the pedunculopontine nucleus and VTA. Pharmacol Biochem Behav 58:497-504
24. Keppel G (1982) Design and analysis: a researcher's handbook. 2nd edn. Prentice-Hall, New Jersey
25. Koob GF, Bloom FE (1988) Cellular and molecular mechanisms of drug dependence. Science 242:715-723
26. Le Moal M, Simon H (1991) Mesocorticolimbic dopaminergic network: functional and regulatory roles. Physiol Rev 71:155-234
27. McBride WJ, Murphy JM, Lumeng L, Li T-K (1988) Effects of RO 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacol Biochem Behav 30: 1045-1050
28. McKinzie DL, Eha R, Murphy JM, McBride WJ, Lumeng L, Li T-K (1996) Effects of taste aversion training on the acquisition of alcohol drinking in adolescent P and HAD rat lines. Alcohol Clin Exp Res 20: 682-687
29. Mogenson GJ, Wu M, Marchands SK (1979) Locomotor activity initiated by microinfusions of picrotoxin into the ventral tegmental area. Brain Res 161:311-319
30. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd edn. Academic Press, Orlando, Fla.
31. Phillips AG, Coury A, Fiorino D, LePiane FG, Brown E, Fibiger HC (1992) Self-stimulation of the ventral tegmental area enhances dopamine release in the nucleus accumbens: a microdialysis study. Ann NY Acad Sci 654:199-206
32. Rassnick S, D'Amico E, Riley E, Koob GF (1993) GABA antagonists and benzodiazepine partial inverse agonists reduce motivated responding for ethanol. Alcohol Clin Exp Res 7:124-130
33. Russell RN, McBride WJ, Lumeng L, Li T-K, Murphy JM (1996) Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. Alcohol 13:515-519
34. Samson HH, Tolliver GA, Pfeffer AO, Sadeghi KC (1987) Oral ethanol reinforcement and the effect of the partial inverse benzodiazepine agonist RO 15-4513. Pharmacol Biochem Behav 33:601-608
35. Samson HH, Tolliver GA, Haraguchi M, Hodge CW (1992) Alcohol self-administration: role of mesolimbic dopamine. Ann NY Acad Sci 654:224-253
36. Samson HH, Hodge CW, Tolliver GA, Haraguchi M (1993) Effect of dopamine agonists and antagonists on ethanol reinforced behavior: the involvement of the nucleus accumbens. Brain Res Bull 30:133-141
37. Smith BR, Robidoux J, Amit Z (1992) GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats. Alcohol Alcohol 27:227-231
38. Stewart RB, McBride WJ, Lumeng L, Li T-K, Murphy JM (1991) Chronic alcohol consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion produced by ethanol injections. Psychopharmacology 105:530-534
39. Stinus L, Herman JP, Le Moal M (1982) GABAergic mechanisms within the ventral tegmental area: involvement of dopaminergic (A 10) and non-dopaminergic neurons. Psychopharmacology 77:186-192
40. Suaud-Chagny MF, Chergui K, Chouvet G, Gonon F (1992) Relationship between dopamine release in the rat nucleus accumbens and the discharge activity of dopaminergic neurons during local in vivo application of amino acids in the ventral tegmental area. Neuroscience 49:63-72
41. Van Bockstaele EJ, Pickel VM (1995) GABA-containing neurons in the ventral tegmental area project to the nucleus accumbens in rat brain. Brain Res 682:215-221
42. Walaas I, Fonnum F (1980) Biochemical evidence for gamma-aminobutyrate containing fibers from the nucleus accumbens to the substantia nigra and ventral tegmental area in the rat. Neuroscience 5:63-72
43. Wegelius K, Halonen T, Korpi ER (1993) Gamma-vinyl GABA decreases voluntary alcohol consumption in alcohol-preferring AA rats. Pharmacol Toxicol 73:150-152
44. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258
45. Westerink BHC, Kwint H-F, de Vries JB (1996) Neuropharmacology of mesolimbic dopamine neurons: dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain. J Neurosci 16:2605-2611
46. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492
47. Wise RA, Rompre PP (1989) Brain dopamine and reward. Annu Rev Psychol 40:191-225
48. Yim CY, Mogenson GJ (1980) Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergie neurons in the ventral tegmental area to stimulation of the nucleus accumbens. Brain Res 199:466-472
49. Yoshimoto K, McBride WJ, Lumeng L, Li T-K (1991) Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9:17-22