GABA(A)-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats

Brain Research

Volumn 794, Issue 1, 1998, Pages 103-118

  June, Harry L ^a   Cason, Charity R ^a   Cheatham, Greg ^a   Lui, Ruiyan ^b   Gan, Tong ^b   Cook, James M ^b  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Benzodiazepine inverse agonist; EtOH sedation; GABA(A) subunit; GABA(A) BDZ receptor; Locomotor activity; Striatum; Xenopus oocyte

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AZIDE; BENZODIAZEPINE DERIVATIVE; FLUMAZENIL; GABAERGIC RECEPTOR AFFECTING AGENT; HYPNOTIC SEDATIVE AGENT; PYRIDAZINE DERIVATIVE; RY 008;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEUS ACCUMBENS; OOCYTE; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; RAT; SEDATION; XENOPUS; ALCOHOL INTOXICATION; ANALYSIS OF VARIANCE; ANIMAL; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ALCOHOLIC INTOXICATION; ANALYSIS OF VARIANCE; ANIMALS; AZIDES; BENZODIAZEPINES; CORPUS STRIATUM; ETHANOL; FLUMAZENIL; GABA AGENTS; HYPNOTICS AND SEDATIVES; MALE; OOCYTES; PYRIDAZINES; RATS; RATS, WISTAR; RECEPTORS, GABA-A; XENOPUS;

EID: 0032565441     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00222-4     Document Type: Article

References (65)

1. A receptor α3 and α4 subunits mRNAs in the rat brain, Mol. Brain Res. 12 (1992) 293-314.
2. K. Beaumont, W. Chilton, H.I. Yamamura, S.J. Enna, Muscimol binding in rat brain: association with synaptic GABA receptors, Brain Res. 148 (1978) 153-162.
3. H.C. Becker, Effects of the imidazobenzodiazepine RO15-4513 on the stimulant and depressant actions of ethanol on spontaneous locomotor activity, Life Sci. 43 (1988) 643-650.
4. J.J. Bourguignon, F. Schlewer, A. Melikian, D. Chantreaux, J.C. Molimard, M. Heaulme, J.P. Chambon, K. Biziere, C.G. Wermuth, Aminopyridazines: derivatives of SR 95103 structure activity relationships, Pharmacologist 27 (1985) 518.
5. A receptor distribution, Eur. J. Pharmacol. 148 (1988) 283-288.
6. R.L. Brunner, J. Altman, Locomotor deficits in adult rats with moderate to massive retardation of cerebellar development during infancy, Behav. Biol. 9 (1973) 169-188.
7. M.S. Dar, Selective antagonism of acute ethanol-induced motor disturbances by centrally administered RO15-4513 in mice, Pharmacol. Biochem. Behav. 42 (1992) 473-479.
8. L.J. Draski, R.A. Deitrich, Initial effects of ethanol on the central nervous system, in: R.A. Deitrich, V.G. Erwin (Eds.), Pharmacological Effects of Ethanol on the Nervous System, Vol. 14, CRC Press, Boca Raton, FL, 1996, pp. 277-244.
9. B.C. Dudek, T.J. Phillips, Genotype-dependent effects of GABAergic agents on sedative properties of ethanol, Psychopharmacology (Berlin) 98 (1989) 518-523.
10. S.J. Enna, E.W. Karbon, GABA receptors: an overview, in: R.W. Olsen, J.C. Venter (Eds.), Benzodiazepine/GABA Receptors and Chloride Channels: Structural and Functional Properties, Alan R. Liss, New York, 1986, pp. 41-56.
11. 3H]-THIP to rat brain synaptic membranes, J. Neurochem. 38 (1982) 1123-1129.
12. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits, J. Comp. Neurol. 359 (1995) 154-194.
13. G.D. Frye, G.R. Breese, An evaluation of the locomotor stimulating action of ethanol in rats and mice, Psychopharmacology (Berlin) 75 (1981) 372-379.
14. C.R. Gardner, A review of recently-developed ligands for neuronal benzodiazepine receptors and their pharmacological activities, Prog. Neuropsychopharmacol. Biol. Psychiatry 16 (1992) 755-781.
15. C.R. Goodlett, J.D. Thomas, J.R. West, Long-term deficits in cerebellar growth and rotarod performance of rats following binge-like alcohol exposure during the neonatal brain growth spurt, Neurotoxicol. Teratol. 13 (1991) 69-74.
16. A receptors, Neuropharmacology 35 (1996) 1307-1314.
17. C.M. Harris, H. Lal, Central nervous system effects of RO15-4513, Drug Dev. Res. 13 (1988) 187-203.
18. A receptors expressed in mammalian cells and Xenopus oocytes, Alcohol. Clin. Exp. Res. 21 (1997) 444-451.
19. A receptor site, Brain Res. 384 (1986) 224-231.
20. A receptor antagonist activity to rat brain, Neuropharmacology 25 (1986) 1279-1283.
21. A antagonist to rat brain membranes, J. Neurochem. 48 (1987) 1677-1686.
22. A receptors with α5 subunits, Poster presented at the 35th Annual Meeting of the American College of Neuropharmacology, Caribe Hilton, San Juan, Puerto Rico, December, 1996.
23. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats, Eur. J. Pharmacol. 283 (1995) 151-159.
24. Y. Ito, T. Koshiba, M. Doi, S. Asami, H. Fukuda, Y. Murakoshi, Characterization of antagonistic activity and binding properties of SR 95531, a pyridazinyl-GABA derivative, in rat brain and cultured cerebellar neuronal cells, Synapse 10 (1992) 326-333.
25. H.C. Jackson, D.J. Nutt, Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice, Eur. J. Pharmacol. 221 (1992) 199-203.
26. H.C. Jackson, D.J. Nutt, Inverse agonists and alcohol, in: M. Sarter, D.J. Nutt, R.G. Lister (Eds.), Benzodiazepine Receptor Inverse Agonists, Wiley-Liss, New York, 1995, pp. 113-138.
27. H.L. June, L.T. Johnson, M.J. Lewis, RO15-4513 attenuates depression of open-field horizontal activity by ethanol in rats, Alcohol 6 (1989) 335-337.
28. H.L. June, S.E. Duemler, T.L. Greene, J.A. Williams, M. Lin, S.L. Devaraju, S.H.A. Chen, M.J. Lewis, J.M. Murphy, Effects of benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol, J. Pharmacol. Exp. Ther. 274 (1995) 1105-1112.
29. H.L. June, B.H. Hwang, J.M. Murphy, GABAergic transmission in the meso-accumbens is involved in alcohol reinforcement, Alcohol Alcohol. 32 (1997) 337, Abstract No. SY115.
30. H.L. June, L. Torres, C.R. Cason, B.H. Hwang, M.R. Braun, J.M. Murphy, RO19-4603 antagonizes EtOH motivated behaviors: neuropharmacological studies, Brain Res. 784 (1998) 256-275.
31. H.L. June, D. Zuccarelli, L. Torres, K.S. Craig, J. DeLong, C.R. Cason, J.M. Murphy, High affinity benzodiazepine antagonists reduce responding maintained by EtOH presentation in ethanol-preferring (p) rats, J. Pharmacol. Exp. Ther. 284 (1998) 1006-1014.
32. G.F. Koob, Drug abuse: anatomy, pharmacology and function of reward pathways, Trends Pharmacol. Sci. 13 (1992) 177-184.
33. A receptors in the actions of alcohol and in alcoholism: recent advances, Alcohol Alcohol. 29 (1994) 115-129.
34. A receptor, Nature 361 (1993) 356-359.
35. S. Liljequist, J. Engel, Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes, Psychopharmacology (Berlin) 78 (1982) 71-75.
36. R.G. Lister, The benzodiazepine receptor inverse agonists FG 7142 and RO15-4513 both reverse some of the behavioral effects of ethanol in a holeboard test, Life Sci. 41 (1987) 1481-1489.
37. R.G. Lister, Behavioral interactions between ethanol and imidazodiazepines with high affinities for benzodiazepine receptors, Life Sci. 42 (1988) 1385-1393.
38. R.G. Lister, D.J. Nutt, RO15-4513 and its interaction with ethanol, Adv. Alcohol Subst. Abuse 7 (1988) 119-123.
39. R.G. Lister, D.J. Nutt, Alcohol antagonists-the continuing quest, Alcohol. Clin. Exp. Res. 12 (1988) 566-569.
40. R.G. Lister, M.J. Durcan, Antagonism of the intoxicating effects of ethanol by the potent benzodiazepine receptor ligand RO19-4603, Brain Res. 482 (1989) 141-144.
41. R.G. Lister, D.J. Greenblatt, D.R. Abernethy, S.E. File, Pharmacokinetic studies on RO15-1788, a benzodiazepine receptor ligand, in the brain of the rat, Brain Res. 290 (1984) 183-186.
42. R. Liu, Part I. An enatiospecific synthesis of 5-methoxy-(d)trytophan and related indole amino acids which serve as building blocks required for the synthesis of alkaloids and peptides. Part II. Synthesis and pharmacological properties of novel imidazobenzodiazepines: high affinity, selectivity probes for α5 containing GABA receptors, Doctoral dissertation, University of Wisconsin, at Milwaukee, Microfilms International, 1996.
43. A benzodiazepine receptor subtype, Med. Chem. Res. 5 (1995) 700-709.
44. A receptors, J. Med. Chem. 39 (1996) 1928-1934.
45. J.W. Mandema, M.T. Kuck, M. Danhopf, In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy, J. Pharmacol. Exp. Ther. 261 (1992) 56-61.
46. A. Martz, R.A. Deitrich, R.A. Harris, Behavioral evidence for the involvement of gamma-aminobutyric acid in the actions of ethanol, Eur. J. Pharmacol. 89 (1983) 53-62.
47. 3H]SR 95531: microscopic analysis of binding in the rat brain and allosteric modulation by several benzodiazepine and barbiturate receptor ligands, Synapse 2 (1988) 163-173.
48. Z. Meng, M.S. Dar, Intrastriatal RO15-4513 functionally antagonizes ethanol-induced motor incoordination and striatal adenosinergic modulation of ethanol-induced motor incoordination in rats, J. Pharmacol. Exp. Ther. 271 (1994) 524-534.
49. A receptor/chloride channel complex, in: R.A. Deitrich, V.G. Erwin (Eds.), Vol. 4, Pharmacological Effects of Ethanol on the Nervous System, CRC Press, Boca Raton, FL, 1996, pp. 51-67.
50. A receptor function and gene expression in the central nervous system, in: R.J. Bradley, R.A. Harris (Eds.), International Review of Neurobiology, Vol. 38, Academic Press, San Diego, 1995.
51. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Orlando, FL, 1986.
52. L.A. Pohorecky, Biphasic action of ethanol, Biobehav. Rev. 1 (1977) 231-240.
53. 3H] muscimol for GABA receptor studies, Nature 273 (1978) 392-394.
54. P.D. Suzdak, J.R. Glowa, J.N. Crawley, R.D. Schwartz, P. Skolnick, S.M. Paul, A selective imidazobenzodiazepine antagonist of ethanol in the rat, Science 234 (1986) 1243-1247.
55. P.D. Suzdak, S.M. Paul, J.N. Crawley, Effects of RO15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat, J. Pharmacol. Exp. Ther. 245 (1988) 880-886.
56. M.K. Ticku, M. Mhatre, A.K. Mehta, Modulation of GABAergic transmission by ethanol, in: G. Biggio, A. Concas, E. Costa (Eds.), GABAergic Synaptic Transmission: Molecular, Pharmacological, and Clinical Aspects. Advances in Biochemical Psychopharmacology, Vol. 47, Raven Press, New York, 1992.
57. H. Wachtel, N.E. Anden, Motor activity of rats following intracerebral injections of drugs influencing GABA mechanisms, Naunyn-Schmiedeberg's Arch. Pharmacol. 302 (1978) 133-139.
58. K.A. Wafford, P.J. Whiting, J.A. Kemp, Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant γ-aminiobutyric acid A receptor subtypes, Mol. Pharmacol. 43 (1993) 240-244.
59. A antagonists, Trends Pharmacol. Sci. 11 (1986) 421-424.
60. A receptor subtypes, in: R.J. Bradley, R.A. Harris (Eds.), International Review of Neurobiology, Vol. 38, Academic Press, San Diego, 1995.
61. A receptor subunit mRNAs in the rat brain: I. Telencephalon, diencephalon, mesencephalon, J. Neurosci. 12 (1992) 1040-1062.
62. 3H]tert-butyl-8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a] [1,4]benzodiazepine-3-carboxylate (ZG-63), Eur. J. Pharmacol 247 (1993) 57-63.
63. A receptor α4 subunit: identification of a unique diazepam-insensitive binding site, Eur. J. Pharmacol. 291 (1995) 319-325.
64. A receptors, J. Med. Chem. 38 (1995) 1679-1688.
65. W. Zhang, K.F. Koehler, P. Zhang, J.M. Cook, Development of a comprehensive pharmacophore model for the benzodiazepine receptor, Drug Design Discovery 12 (1995) 193-248.