Synthesis, in Vitro Affinity, and Efficacy of a Bis 8-Ethynyl-4H-imidazo[1,5a]-[1,4]benzodiazepine Analogue, the First Bivalent α5 Subtype Selective BzR/GABAA Antagonist

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5567-5570

  Li, Xiaoyan ^a   Cao, Hui ^a   Zhang, Chunchun ^a   Furtmueller, Roman ^b   Fuchs, Karoline ^b   Huck, Sigismund ^b   Sieghart, Werner ^b   Deschamps, Jeffrey ^c   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; BIS 8 ETHYNYL 4H IMIDAZO[1,5][1,4]BENZODIAZEPINE DERIVATIVE; DIAZEPAM; LIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; LIGAND BINDING; NONHUMAN; OOCYTE; RECEPTOR BINDING; SYNTHESIS; XENOPUS;

ANIMALS; BENZODIAZEPINONES; CELL LINE; CHLORIDE CHANNELS; CRYSTALLOGRAPHY, X-RAY; GABA ANTAGONISTS; HUMANS; IMIDAZOLES; LIGANDS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0347627160     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034164c     Document Type: Article

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