Studies of molecular pharmacophore/receptor models for GABA(A)/benzodiazepine receptor subtypes: Binding affinities of substituted β-carbolines at recombinant αxβ3γ2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis

Drug Design and Discovery

Volumn 16, Issue 1, 1999, Pages 55-76

  Huang, Qi ^a   Cox, Eric D ^a   Gan, Tong ^a   Ma, Chunrong ^a   Bennett, Dennis W ^a   McKernan, Ruth M ^b   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

carbolines; Benzodiazepine receptor; Computer modeling; Pharmacophore; Quantitative structure activity relationships (QSAR); Subtypes

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; BETA CARBOLINE DERIVATIVE; RECEPTOR SUBTYPE; RECOMBINANT RECEPTOR; UNINDEXED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; LIPOPHILICITY; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; CARBOLINES; COMPUTER SIMULATION; LIGANDS; MOLECULAR STRUCTURE; PROTEIN BINDING; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032873036     PISSN: 10559612     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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