Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [γ2(R43Q)] found in human epilepsy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 23, 2002, Pages 15170-15175

  Bowser, David N ^a   Wagner, David A ^a   Czajkowski, Cynthia ^a   Cromer, Brett A ^a   Parker, Michael W ^a   Wallace, Robyn H ^a   Harkin, Louise A ^a   Mulley, John C ^a   Marini, Carla ^a   Berkovic, Samuel F ^a   Williams, David A ^a   Jones, Mathew V ^a   Petrou, Steven ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Rapid agonist application; Two electrode voltage clamp; Xenopus oocytes

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ARGININE; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; FLUNITRAZEPAM; GLUTAMINE; IMIDAZOPYRIDINE DERIVATIVE; RECEPTOR SUBUNIT; ZOLPIDEM;

ABSENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BENIGN CHILDHOOD EPILEPSY; CONTROLLED STUDY; FEBRILE CONVULSION; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS; THALAMOCORTICAL TRACT; VOLTAGE CLAMP; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; ANTI-ANXIETY AGENTS; CELL LINE; DIAZEPAM; EPILEPSY; FLUNITRAZEPAM; GAMMA-AMINOBUTYRIC ACID; HUMANS; KINETICS; MEMBRANE POTENTIALS; MUTAGENESIS, SITE-DIRECTED; NEURONS; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PYRIDINES; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SYNAPSES; SYNAPTIC TRANSMISSION; TRANSFECTION; XENOPUS;

ANIMALIA; XENOPUS LAEVIS;

EID: 0037069440     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.212320199     Document Type: Article

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