GABAA and Opioid Receptors of the Central Nucleus of the Amygdala Selectively Regulate Ethanol-Maintained Behaviors

Neuropsychopharmacology

Volumn 29, Issue 2, 2004, Pages 269-284

  Foster, Katrina L ^a   McKay, Peter F ^a   Seyoum, Regat ^a   Milbourne, Dana ^a   Yin, Wenyuan ^b   Sarma, P V S S ^b   Cook, James M ^b   June, Harry L ^a  

^a INDIANA UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Alcohol pharmacotherapy; Alcohol reinforcement; Benzodiazepine; GABAA receptor; Naltrexone; Opioid receptor alcohol preferring rats

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; ALCOHOL; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; NALTREXONE; OPIATE ANTAGONIST; OPIATE RECEPTOR; SUCROSE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG EFFECT; DRUG POTENTIATION; DRUG RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG TARGETING; EXPERIMENTAL TEST; INFUSION; INTERMETHOD COMPARISON; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; REGULATORY MECHANISM;

ALCOHOLISM; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ADDICTIVE; CARBOLINES; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; MALE; MICROINJECTIONS; NALTREXONE; NARCOTIC ANTAGONISTS; PUTAMEN; RATS; RATS, INBRED STRAINS; RECEPTORS, GABA-A; RECEPTORS, OPIOID; REINFORCEMENT (PSYCHOLOGY); SUCROSE; TIME FACTORS;

EID: 0842308151     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300306     Document Type: Article

References (79)

1. Alheid GF, Heimer L (1988). New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: the striatopallidal, amygdaloid, and corticopetal components of substantia innominata. Neuroscience 27: 1-39.
2. A receptor α3 and α4 subunits mRNAs in the rat brain. Mol Brain Res 12: 295-314.
3. Baldwin HA, Wall TL, Schuckit MA, Koob GF (1991). Differential effects of ethanol on punished responding in the P and NP rats. Alcoholism: Clin Exp Res 15: 700-704.
4. Bals-Kubic R, Ableitner A, Herz A, Shippenberg TS (1993). Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. J Pharmcol Exp Ther 264: 489-495.
5. Bowen CA, Grant KA (1998). Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination. Psychopharmacology (Berlin) 139: 86-94.
6. Carroll ME, Carmona G, May SA (1991). Modifying drug-reinforced behavior by altering the economic conditions of the drug and a non-drug reinforcer. J Exp Anal Behav 18: 361-376.
7. Carroll ME, Morgan AD, Lynch WJ, Campbell UC, Dess NK (2002). Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences. Psychopharmacology 161: 304-313.
8. A α1 subtype in mediating the sedative and anxiolytic properties of benzodiazepines. Alcoholism: Clin Exp Res 25, abstract 34).
9. Churchill L, Kalivas PW (1992). Dopamine depletion produces augmented behavioral responses to a mu-, but not a delta-opioid receptor agonist in the nucleus accumbens: lack of a role for receptor upregulation. Synapse 11: 47-57.
10. Cloninger CR (1987). Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410-416.
11. A receptors. J Med Chem 41: 2537-2552.
12. Cox ED, Hagen TJ, McKernan R, Cook JM (1995). BZ1 receptor specific ligands. Synthesis and biological properties of βCCt, a BZ1 receptor subtype specific antagonist. Med Chem Res 5: 710-718.
13. Cummings R, Garcia M, Mason D, Mc Kay PF, Foster KL, June HL (1999). Differential effects of unilateral versus bilateral micro-injections of nalmefene in the nucleus accumbens and ventral tegmental area in alcohol-preferring (P) rats. Alcoholism Clin Exp Res 22: 16A (Abstract #62).
14. A receptors in rat brain. Neuroscience 64: 1113-1128.
15. Freedman LJ, Cassell MD (1994). Distribution of dopamine fibers in the central division of the extended amygdala of the rat. Brain Res 633: 234-252.
16. A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359: 154-194.
17. Gonzales C, Chesselet MF (1991). Amygdalonigral pathway: an anterograde study in the rat with Phaseolus vulgaris leucoagglutinin (PHA-L). J Comp Neurol 297: 182-200.
18. Griebel G, Perrault G, Letang V, Granger P, Avenet P, Schoemaker H et al (1999). New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (ω) receptor subtypes. Psychopharmacology 146: 205-213.
19. A receptor α1 subtype in the ventral pallidum regulates EtOH-seeking behaviors. J Neurosci 22: 3766-3775.
20. Heyser CJ, Roberts AJ, Schulteis G, Koob GF (1999). Central administration of an opiate antagonist decreases oral ethanol self-administration in rats. Alcoholism: Clin Exp Res 23: 1468-1476.
21. Higgs S, Cooper SJ (1995). Benzodiazepine receptor inverse agonists and ingestive behaviors: the palatability hypothesis. In: Sarter M, Nutt DJ, Lister RG (eds). Benzodiazepine Receptor Inverse Agonists. Wiley-Liss: New York, pp 163-184.
22. Hodge CW, Chappelle AN, Samson HH (1995). GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcoholism: Clin Exp Res 19: 1486-1493.
23. Hodge CW, Cox AA (1998). The discriminative stimulus effects of ethanol are mediated by NMDA and GABA (A) receptors in specific limbic brain regions. Psychopharmacology (Berlin) 139: 95-107.
24. Honkaniemi J (1992). Colocalization of peptide-and tyrosine-hydroxylase- like immunoreactivities with Fos-immunoreactive neurons in the rat central amygdaloid nucleus after immobilization stress. Brain Res 598: 107-113.
25. Hwang BH, Lumeng L, Wu JY, Li TK (1990). Increased number of GABAergic terminals in the nucleus accumbens is associated with alcohol preference in rats. Alcoholism: Clin Exp Res 14: 503-507.
26. Hyytiä P, Kiiamnaa K (2001). Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats. Alcoholism: Clin Exp Res 25: 25-33.
27. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283: 151-159.
28. June HL (2002). Alcohol initiation procedures in rats: methods used in evaluating potential pharmacotherapeutic agents. In: Crawley J, Gerfen C, Mc Kay R, Rogawski M, Sibley D, Skolnick P (eds). Current Protocols in Neuroscience. John Wiley and Sons: New York, pp 9-23.
29. June HL, Grey C, Johnson TB, Williams L, Mc Kay P, Rock S et al (1998b). GABAergic substrates in the nucleus accumbens and dorsal hippocampus mediate responding maintained by EtOH presentation in alcohol-preferring (P) rats. Behav Pharmacol 9: S47.
30. June HL, Grey C, Warren-Reese C, Durr LF, Ricks-Cord A, Johnson A et al (1998c). The opioid receptor antagonist nalmefene reduces responding maintained by ethanol presentation: pre-clinical studies in ethanol-preferring and outbred Wistar rats. Alcoholism: Clin Exp Res 22: 2174-2185.
31. June HL, Grey C, Warren-Reese C, Ricks A, Cason CR (1998a). The effects of the novel benzodiazepine receptor inverse agonist Ru 34000 on ethanol-maintained responding. Eur J Pharmacol 350: 151-158.
32. A receptors containing α5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry. J Neurosci 21: 2166-2177.
33. A receptor α1 subtype in the ventral pallidum.
34. Kalivas PW (1993). Neurotransmitter regulation of dopamine neurons in the VTA. Brain Res Rev 18: 75-113.
35. Kalivas PW, Duffy P, Eberhardt H (1990). Modulation of A10 dopamine neurons by GABA agonists. J Pharmacol Exp Ther 253: 858-866.
36. Koob GF (1999). The role of the striatopallidal and extended amygdale systems in drug addiction. Ann NY Acad Sci 877: 445-460.
37. Koob GF, Le Moal M (1997). Drug Abuse: hedonic homeostatic dysregulation. Science 278: 52-58.
38. Koob GF, Roberts AJ, Schulteis G, Parsons LU, Heyser CJ, Hyyti P et al (1998a). Neurocircuitry targets in ethanol reward and dependence. Alcoholism: Clin Exp Res 22: 3-9.
39. Koob GF, Sanna PP, Bloom FE (1998b). Neuroscience of addiction. Neuron 21: 467-476.
40. Kosaka T, Kosaka K, Hataguchi Y, Nagatsu I, Wu JY, Ottersen OP et al (1987). Catecholaminergic neurons containing GABA-like and/or glutamic acid decarboxylase-like immunoreactivities in various brain regions of the rat. Exp Brain Res 66: 191-210.
41. Lankford MF, Myers RD (1994). Genetics of alcoholism: simultaneous presentation of a chocolate drink diminishes alcohol preference in high drinking HAD rats. Pharmacol Biochem Behav 49: 417-425.
42. Lewis MJ, June HL (1990). Neurobehavioral studies of ethanol reward and activation. Alcohol 7: 213-219.
43. Lüddens H, June HL, Cook JM, (In Preparation). βCCt produces agonist and antagonist effects in the in vivo HEK cells assay.
44. Lumeng L, Murphy JM, McBride WJ, Li T-K (1995). Genetic influences on alcohol preference in animals. In: Begleiter H (eds). The Genetics of Alcoholism. Oxford, New York. pp 165-201.
45. Mansour A, Fox CA, Akil H, Watson SJ (1995). Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 18: 22-29.
46. Mansour A, Khachaturian H, Lewis ME, Akil H, Watson SJ (1987). Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J Neurosc 7: 2445-2464.
47. McBride WJ (2002). Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. Pharmacol Biochem Behav 71: 509-515.
48. McBride WJ, Li TK (1998). Animals models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. Crit Rev Neurobiol 12: 339-369.
49. McBride WJ, Murphy JM, Lumeng L, Li TK (1988). Effects of Ro-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and non-preferring (NP) lines of rats. Pharmacol Biochem Behav 30: 104-150.
50. McDonald AJ (1982). Cytoarchitecture of the central amygdaloid nucleus of the rat. J Comp Neurol 208: 401-418.
51. A receptor α1 subtype. Nature 3: 587-592.
52. McKinzie DL, Eha R, Murphy JM, Mc Bride WJ, Lumeng L, Li TK (1996). Effects of taste aversion training on the acquisition of alcohol drinking in adolescent P and HAD lines. Alcoholism: Clin Exp Res 20: 682-687.
53. A receptors in the amygdala: role in feeding in fasted and satiated rats. Brain Res 586: 104.
54. Möeller C, Wiklund L, Wolfgang S, Thorsell A, Helilig M (1997). Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions. Brain Res 760: 94-101.
55. Morales M, Criado JR, Sanna PP, Henrikson SJ, Bloom FE (1998). Acute ethanol induces c-fos immunoreactivity in GABAergic neurons of the central nucleus of the amygdala. Brain Res 798: 333-336.
56. Murphy JM, Stewart RB, Bell RL, Badia-Elder NE, Carr LG, Mc Bride WJ et al (2002). Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low preference. Behav Genet 32: 363-388.
57. A receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat. Psychopharmacology 139: 108-116.
58. Oertel WH, Reithmuller G, Mugnaini E, Schmechel A, Weindl C, Gramsch C et al (1983). Opioid peptide-like immunoreactivity localized in GABAergic neurons of rat neostriatum and central amygdaloid nucleus. Life Sci 33: 73-76.
59. Paden CM, Krall S, Lynch WC (1987). Heterogeneous distribution and upregulation of mu, delta and kappa receptors in the amygdala. Brain Res 418: 349-355.
60. Paronis CA, Cox ED, Cook JM, Bergman J (2001). Different types of GABAA receptors may mediate the anticonflict and response rate-decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology (Berlin) 156: 461-468.
61. Paxinos G, Watson C (1998). The Rat Brain in Stereotaxic Coordinates. Academic Press: Sydney.
62. Petry NM, Heyman GM (1995). Behavioral economic analysis of concurrent ethanol/sucrose and sucrose reinforcement in the rat: effects of altering variable ratio requirements. J Exp Anal Behav 64: 331-359.
63. Pohorecky LA (1990). Interaction of ethanol and stress: research with experimental animals - an update. Alcohol Alcoholism 25: 263-276.
64. Porrino LJ, Williams-Hemby L, Whitlow C, Bowen C, Samson HH (1998). Metabolic mapping of the effects of oral alcohol self-administration in rats. Alcohol: Clin Exp Res 22: 176-182.
65. Rowlett JK, Tornatzky W, Cook JM, Ma C, Miczek KA (2001). Zolpidem, triazolam, and diazepam decrease vocalizations in mouse pups: differential antagonism by flumazenil and β-Carboline-3-carboxylate-t-butyl ester (β-CCt). J Pharmacol Exp Therap 297: 247-253.
66. Salimov RM, Mc Bride WJ, McKinzie DL, Lumeng L, Li TK (1996). Effects of ethanol consumption by adolescent alcohol-preferring P rats on subsequent behavioral performance in the cross-maze and slip funnel tests. Alcohol 13: 297-300.
67. A receptors in the rat amygdala. Pharmacol Biochem Behav 52: 701-706.
68. Sanger DJ, Benavides J, Perrault G, Morel E, Cohen C, Joly D et al (1994). Recent developments in the behavioral pharmacology of benzodiazepine (omega) receptors: evidence for the functional significance of receptor subtypes. Neurosci Biobehav Rev 18: 355-372.
69. 1 benzodiazepine receptor antagonist. Life Sci 35: 2227-2236.
70. Stewart RB, Gatto GJ, Lumeng L, Li TK, Murphy JM (1993). Comparison of alcohol-preferring P and nonpreferririg NP rats on tests of anxiety and for the anxiolytic effects of ethanol. Alcohol 10: 1-10.
71. Sun N, Cassell MD (1993). Intrinsic GABAergic neurons in the rat central extended amygdala. J Comp Neurol 330: 381-404.
72. Sun N, Yi H, Cassell MD (1994). Evidence for a GABAergic interface between cortical afferents and brainstem projection neurons in the rat central extended amygdala. J Comp Neurol 340: 43-64.
73. Turner JD, Bodewitz G, Thompson CL, Stephenson FA (1993). Immunohistochemical mapping of gamma-aminobutyric acid type-A receptor alpha subunits in rat central nervous system. In: Stephens DN (ed) Anxiolytic β-carbolines: From Molecular Biology to the Clinic. Springer-Verlag: New York, pp 29-49.
74. Veinante P, Stoeckel ME, Freund-Mercier MJ (1997). GABA and peptide-immunoreactivities colocalize in the rat central extended amygdala. Neuroreport 8: 2985-2989.
75. Weiss F, Lorang MT, Bloom FE, Koob GF (1993). Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetics and motivational determinants. J Pharmacol Exp Ther 267: 250-258.
76. Wilson MA (1992). Influences of gender, gonadectomy, and estrous cycle in GABA/BZ receptors and benzodiazepine responses in rats. Brain Res Bull 29: 165-172.
77. Wilson MA, Biscardi R (1992). Effects of gender and gonadectomy on responses to chronic benzodiazepine receptor agonist exposure in rats. Eur J Pharmacol 215: 99-107.
78. A receptor subunit mRNAs in the rat brain: telencephalon, diencephalon, mesencephalon. J Neurosci 12: 1040-1062.
79. A-α1 subtype. Paper Presented at the Committee on Problems of Drug Dependence 63rd Annual Meeting, Scottsdale, AZ, June 11-20.