Anxiety over GABAA receptor structure relieved by AChBP

Trends in Biochemical Sciences

Volumn 27, Issue 6, 2002, Pages 280-287

  Cromer, Brett A ^a   Morton, Craig J ^a   Parker, Michael W ^a  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE; BENZODIAZEPINE; BINDING PROTEIN;

ALLOSTERISM; BINDING SITE; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; BENZODIAZEPINES; CARRIER PROTEINS; ION CHANNELS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RECEPTORS, GABA-A;

EID: 0036607862     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(02)02092-3     Document Type: Review

References (48)

1. Quaternary structure of the acetylcholine receptor
2. Quaternary structure of the native GABA(A) receptor determined by electron microscopic image analysis
3. Ultrastructure of the 5-hydroxytryptamine3 receptor
4. A channel subtypes
5. GABAC receptors: Relatively simple transmitter-gated ion channels?
6. C receptors: A comparison of native versus recombinant receptors
7. A receptors
8. Identification of a [H-3]muscimol photoaffinity substrate in the bovine γ-aminobutyric acid(A) receptor α subunit
9. A receptors
10. Nicotinic acetylcholine receptor at 4.6 Å resolution: Transverse tunnels in the channel wall
11. Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptor
12. Structure of a glutamate-receptor ligand-binding core in complex with kainate
13. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities
14. Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor
15. A glia-derived acetylcholine-binding protein that modulates synaptic transmission
16. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors
17. Nicotinic receptors in wonderland
18. Neurobiology. Snails, synapses and smokers
19. Neurotransmitter-gated ion channels as unconventional allosteric protein
20. Nicotinic receptors at the amino acid level
21. A-receptor subtypes really occur in the brain?
22. How quickly can GABA(A) receptors open?
23. A receptor channels
24. Receptor needs 2 homologous domains of the β-subunit for activation by GABA but not by pentobarbital
25. Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation
26. 2 Y97 and L99 line the GABA binding site: Insights into mechanisms of agonist and antagonist actions
27. Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye
28. From ab initio quantum mechanics to molecular neurobiology: A cation-π binding site in the nicotinic receptor
29. Cation-π interactions in structural biology
30. A receptor α5 subunit are crucial for receptor function
31. A receptor: Evidence for a β-strand
32. A receptor α 1, subunit is essential for GABA binding and chloride ion current gating
33. Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist
34. A single amino acid of the human γ-aminobutyric acid type A receptor γ2 subunit determines benzodiazepine efficacy
35. 3H]Flunitrazepam is histidine 102 of the α subunit
36. A receptors is essential for benzodiazepine agonist binding
37. A receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the α subunit and predicts orientation of these within the benzodiazepine pharmacophore
38. A receptors: Relative orientation of ligands and amino acid side chains
39. A receptors
40. Identification of benzodiazepine binding site residues in the γ2 subunit of the gamma-aminobutyric acid(A) receptor
41. A receptor: Structural rearrangements detected during channel gating
42. Acetylcholine receptor channel imaged in the open state
43. Identification of transduction elements for benzodiazepine modulation of the GABA(A) receptor: Three residues are required for allosteric coupling
44. Benzodiazepines induce a conformational change in the region of the γ-aminobutyric acid type A receptor α1-subunit M3 membrane-spanning segment
45. Mutant GABA(A) receptor γ2-subunit in childhood absence epilepsy and febrile seizures
46. A single histidine residue is essential for zinc inhibition of GABA rho1 receptors
47. Site-directed mutagenesis of N-linked glycosylation sites on the γ-aminobutyric acid type A receptor α 1 subunit
48. MOLSCRIPT: A program to produce both detailed and schematic plots of proteins