Synthesis and evaluation of analogues of the partial agonist 6- (propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6- PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3- carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABA(A) receptors

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2537-2552

  Cox, Eric D ^a   Diaz Arauzo, Hernando ^a   Huang, Qi ^a   Reddy, Mundla S ^a   Ma, Chunrong ^a   Harris, Brad ^c   McKernan, Ruth ^b   Skolnick, Phil ^c   Cook, James M ^a  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 6 (PROPYLOXY) 4 (METHOXYMETHYL) BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; 6 BENZYLOXY 4 METHOXYMETHYL BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE RECEPTOR; BETA CARBOLINE DERIVATIVE; DIAZEPAM; DRUG CARRIER; FLUNITRAZEPAM; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BINDING, COMPETITIVE; CARBOLINES; CELL LINE; CEREBRAL CORTEX; DRUG DESIGN; GABA AGONISTS; HUMANS; MALE; MICE; MUSCLE RELAXATION; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032474846     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970460b     Document Type: Article

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