ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32606-32615

  Chu, Kwan Yi ^a   Lin, Yalin ^a   Hendel, Alon ^a   Kulpa, Jerzy E ^a   Brownsey, Roger W ^a   Johnson, James D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; APOPTOSIS; ATP-CITRATE LYASE; BETA CELL; CASPASE-3; CCAAT/ENHANCER-BINDING PROTEINS; CELLULAR LIPID; ENDOPLASMIC RETICULUM STRESS; ER STRESS; EXTRACELLULAR; FREE FATTY ACID; HUMAN ISLETS; IN-VITRO; INDUCED APOPTOSIS; KEY ENZYMES; MIN6 CELLS; NON-ADDITIVE; OVER-EXPRESSION; PANCREATIC BETA CELLS; PROGRAMMED CELL DEATHS; PROTEIN LEVEL; SIMILAR DEGREE; TYPE-2 DIABETES;

ENZYME ACTIVITY; FATTY ACIDS; LIPIDS; METABOLISM; PHOSPHORYLATION; PROTEINS;

CELL DEATH;

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE CITRATE LYASE; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PALMITIC ACID; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; GENE SILENCING; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; INSULIN RELEASE; INTRACELLULAR SIGNALING; LIPID DIET; LONG TERM EXPOSURE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION KINETICS;

ANIMALS; APOPTOSIS; ATP CITRATE (PRO-S)-LYASE; CELL LINE; COENZYME A; DIABETES MELLITUS, TYPE 2; DIETARY FATS; ENDOPLASMIC RETICULUM; HUMANS; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; OXIDATION-REDUCTION; PALMITATES; RECOMBINANT FUSION PROTEINS; THAPSIGARGIN;

MUS;

EID: 77957795415     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.157172     Document Type: Article

References (57)

1. Bell, G. I., and Polonsky, K. S. (2001) Nature 414, 788-791
2. Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., and Butler, P. C. (2003) Diabetes 52, 102-110
3. Kahn, S. E. (2001) J. Clin. Endocrinol. Metab. 86, 4047-4058
4. Prentki, M., Joly, E., El-Assaad, W., and Roduit, R. (2002) Diabetes 51, Suppl. 3, S405-S413
5. Golay, A., Zech, L., Shi, M. Z., Chiou, Y. A., Reaven, G. M., and Chen, Y. D. (1987) J. Clin. Endocrinol. Metab. 65, 512-518
6. Jeffrey, K. D., Alejandro, E. U., Luciani, D. S., Kalynyak, T. B., Hu, X., Li, H., Lin, Y., Townsend, R. R., Polonsky, K. S., and Johnson, J. D. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 8452-8457
7. Unger, R. H. (1995) Diabetes 44, 863-870
8. Boden, G., and Shulman, G. I. (2002) Eur. J. Clin. Invest. 32, Suppl. 3, 14-23
9. Zhou, Y. P., and Grill, V. E. (1994) J. Clin. Invest. 93, 870-876
10. Fraze, E., Donner, C. C., Swislocki, A. L., Chiou, Y. A., Chen, Y. D., and Reaven, G. M. (1985) J. Clin. Endocrinol. Metab. 61, 807-811
11. Lee, Y., Hirose, H., Zhou, Y. T., Esser, V., McGarry, J. D., and Unger, R. H. (1997) Diabetes 46, 408-413
12. Knowles, S. E., Jarrett, I. G., Filsell, O. H., and Ballard, F. J. (1974) Biochem. J. 142, 401-411
13. Beigneux, A. P., Kosinski, C., Gavino, B., Horton, J. D., Skarnes, W. C., and Young, S. G. (2004) J. Biol. Chem. 279, 9557-9564
14. MacDonald, M. J., Smith, A. D., 3rd, Hasan, N. M., Sabat, G., and Fahien, L. A. (2007) J. Biol. Chem. 282, 30596-30606
15. MacDonald, M. J., Longacre, M. J., Langberg, E. C., Tibell, A., Kendrick, M. A., Fukao, T., and Ostenson, C. G. (2009) Diabetologia 52, 1087-1091
16. Guay, C., Madiraju, S. R., Aumais, A., Joly, E., and Prentki, M. (2007) J. Biol. Chem. 282, 35657-35665
17. Joseph, J. W., Odegaard, M. L., Ronnebaum, S. M., Burgess, S. C., Muehlbauer, J., Sherry, A. D., and Newgard, C. B. (2007) J. Biol. Chem. 282, 31592-31600
18. Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., and Thompson, C. B. (2005) Oncogene 24, 6314-6322
19. Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., and Thompson, C. B. (2005) Cancer Cell 8, 311-321
20. Migita, T., Narita, T., Nomura, K., Miyagi, E., Inazuka, F., Matsuura, M., Ushijima, M., Mashima, T., Seimiya, H., Satoh, Y., Okumura, S., Nakagawa, K., and Ishikawa, Y. (2008) Cancer Res. 68, 8547-8554
21. Potapova, I. A., El-Maghrabi, M. R., Doronin, S. V., and Benjamin, W. B. (2000) Biochemistry 39, 1169-1179
22. Berwick, D. C., Hers, I., Heesom, K. J., Moule, S. K., and Tavare, J. M. (2002) J. Biol. Chem. 277, 33895-33900
23. Hughes, K., Ramakrishna, S., Benjamin, W. B., and Woodgett, J. R. (1992) Biochem. J. 288, 309-314
24. Houston, B., and Nimmo, H. G. (1985) Biochim. Biophys. Acta 844, 233-239
25. Linn, T. C., and Srere, P. A. (1979) J. Biol. Chem. 254, 1691-1698
26. Gwiazda, K. S., Yang, T. L., Lin, Y., and Johnson, J. D. (2009) Am. J. Physiol. Endocrinol. Metab. 296, E690-E701
27. Cistola, D. P., and Small, D. M. (1991) J. Clin. Invest. 87, 1431-1441
28. Deleted in proof
29. Lacy, P. E., and Kostianovsky, M. (1967) Diabetes 16, 35-39
30. Dror, V., Nguyen, V., Walia, P., Kalynyak, T. B., Hill, J. A., and Johnson, J. D. (2007) Diabetologia 50, 2504-2515
31. Alejandro, E. U., and Johnson, J. D. (2008) J. Biol. Chem. 283, 2407-2417
32. King, M. T., Reiss, P. D., and Cornell, N. W. (1988) Methods Enzymol. 166, 70-79
33. Ally, A., and Park, G. (1992) J. Chromatogr. 575, 19-27
34. Roche, E., Farfari, S., Witters, L. A., Assimacopoulos-Jeannet, F., Thumelin, S., Brun, T., Corkey, B. E., Saha, A. K., and Prentki, M. (1998) Diabetes 47, 1086-1094
35. Pearce, N. J., Yates, J. W., Berkhout, T. A., Jackson, B., Tew, D., Boyd, H., Camilleri, P., Sweeney, P., Gribble, A. D., Shaw, A., and Groot, P. H. (1998) Biochem. J. 334, 113-119
36. Maedler, K., Spinas, G. A., Dyntar, D., Moritz, W., Kaiser, N., and Donath, M. Y. (2001) Diabetes 50, 69-76
37. Atkinson, L. L., Kelly, S. E., Russell, J. C., Bar-Tana, J., and Lopaschuk, G. D. (2002) Diabetes 51, 1548-1555
38. Luciani, D. S., Gwiazda, K. S., Yang, T. L., Kalynyak, T. B., Bychkivska, Y., Frey, M. H., Jeffrey, K. D., Sampaio, A. V., Underhill, T. M., and Johnson, J. D. (2009) Diabetes 58, 422-432
39. Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., and Thompson, C. B. (2009) Science 324, 1076-1080
40. Gribble, A. D., Ife, R. J., Shaw, A., McNair, D., Novelli, C. E., Bakewell, S., Shah, V. P., Dolle, R. E., Groot, P. H., Pearce, N., Yates, J., Tew, D., Boyd, H., Ashman, S., Eggleston, D. S., Haltiwanger, R. C., and Okafo, G. (1998) J. Med. Chem. 41, 3582-3595
41. Suzuki, M., and Okuda, H. (1981) J. Nutr. Sci. Vitaminol. 27, 595-598
42. Berkhout, T. A., Havekes, L. M., Pearce, N. J., and Groot, P. H. (1990) Biochem. J. 272, 181-186
43. Kutlu, B., Cardozo, A. K., Darville, M. I., Kruhøffer, M., Magnusson, N., Ørntoft, T., and Eizirik, D. L. (2003) Diabetes 52, 2701-2719
44. Knowles, L. M., Yang, C., Osterman, A., and Smith, J. W. (2008) J. Biol. Chem. 283, 31378-31384
45. Cunha, D. A., Hekerman, P., Ladrière, L., Bazarra-Castro, A., Ortis, F., Wakeham, M. C., Moore, F., Rasschaert, J., Cardozo, A. K., Bellomo, E., Overbergh, L., Mathieu, C., Lupi, R., Hai, T., Herchuelz, A., Marchetti, P., Rutter, G. A., Eizirik, D. L., and Cnop, M. (2008) J. Cell Sci. 121, 2308-2318
46. Pirot, P., Ortis, F., Cnop, M., Ma, Y., Hendershot, L. M., Eizirik, D. L., and Cardozo, A. K. (2007) Diabetes 56, 1069-1077
47. Eitel, K., Staiger, H., Rieger, J., Mischak, H., Brandhorst, H., Brendel, M. D., Bretzel, R. G., Häring, H. U., and Kellerer, M. (2003) Diabetes 52, 991-997
48. Johnson, J. D., Han, Z., Otani, K., Ye, H., Zhang, Y., Wu, H., Horikawa, Y., Misler, S., Bell, G. I., and Polonsky, K. S. (2004) J. Biol. Chem. 279, 24794-24802
49. Kharroubi, I., Ladrière, L., Cardozo, A. K., Dogusan, Z., Cnop, M., and Eizirik, D. L. (2004) Endocrinology 145, 5087-5096
50. Lai, E., Bikopoulos, G., Wheeler, M. B., Rozakis-Adcock, M., and Volchuk, A. (2008) Am. J. Physiol. Endocrinol. Metab. 294, E540-E550
51. Lupi, R., Dotta, F., Marselli, L., Del Guerra, S., Masini, M., Santangelo, C., Patané, G., Boggi, U., Piro, S., Anello, M., Bergamini, E., Mosca, F., Di Mario, U., Del Prato, S., and Marchetti, P. (2002) Diabetes 51, 1437-1442
52. Martinez, S. C., Tanabe, K., Cras-Méneur, C., Abumrad, N. A., Bernal- Mizrachi, E., and Permutt, M. A. (2008) Diabetes 57, 846-859
53. Sargsyan, E., Ortsäter, H., Thorn, K., and Bergsten, P. (2008) J. Endocrinol. 199, 41-50
54. Fujimoto, K., Hanson, P. T., Tran, H., Ford, E. L., Han, Z., Johnson, J. D., Schmidt, R. E., Green, K. G., Wice, B. M., and Polonsky, K. S. (2009) J. Biol. Chem. 284, 27664-27673
55. Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Komiya, K., Azuma, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., and Watada, H. (2008) Cell Metab. 8, 325-332
56. Wang, Q., Jiang, L., Wang, J., Li, S., Yu, Y., You, J., Zeng, R., Gao, X., Rui, L., Li, W., and Liu, Y. (2009) Hepatology 49, 1166-1175
57. Flamez, D., Berger, V., Kruhøffer, M., Orntoft, T., Pipeleers, D., and Schuit, F. C. (2002) Diabetes 51, 2018-2024