메뉴 건너뛰기




Volumn 26, Issue 4, 2010, Pages 353-363

The differential modulation on cytochrome P450 enzymes by garlic components

Author keywords

Anticancer; Chemoprotective; CYP450; Garlic; Xenobiotics

Indexed keywords

ANTICANCER; CHEMOPROTECTIVE; CYP450; GARLIC; XENOBIOTICS;

EID: 77957699362     PISSN: 87559129     EISSN: 15256103     Source Type: Journal    
DOI: 10.1080/87559129.2010.496023     Document Type: Article
Times cited : (10)

References (82)
  • 1
    • 0030029823 scopus 로고    scopus 로고
    • Therapeutic actions of garlic constituents
    • Agarwal, K.C. Therapeutic actions of garlic constituents. Med. Res. Rev. 1996, 16 (1), 111-124.
    • (1996) Med. Res. Rev , vol.16 , Issue.1 , pp. 111-124
    • Agarwal, K.C.1
  • 3
    • 0344839038 scopus 로고    scopus 로고
    • Garlic as an antioxidant: The good, the bad and the ugly
    • Banerjee, S.K.; Mukherjee, P.K.; Maulik, S.K. Garlic as an antioxidant: the good, the bad and the ugly. Phytother. Res. 2003, 17 (2), 97-106.
    • (2003) Phytother. Res , vol.17 , Issue.2 , pp. 97-106
    • Banerjee, S.K.1    Mukherjee, P.K.2    Maulik, S.K.3
  • 4
    • 33644835000 scopus 로고    scopus 로고
    • Clarifying he real bioactive constituents of garlic
    • Amagase, H. Clarifying he real bioactive constituents of garlic. Journal of Nutrition 2006, 136 (3), 716s-725s.
    • (2006) Journal of Nutrition , vol.136 , Issue.3
    • Amagase, H.1
  • 5
    • 33746329952 scopus 로고    scopus 로고
    • CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury
    • Cederbaum, A.I. CYP2E1-biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med. 2006, 73 (4), 657-672.
    • (2006) Mt Sinai J Med , vol.73 , Issue.4 , pp. 657-672
    • Cederbaum, A.I.1
  • 6
    • 10444229539 scopus 로고    scopus 로고
    • Role of cytochromes P450 in chemical toxicity and oxidative stress: Studies with CYP2E1
    • Gonzalez, F.J. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat. Res. 2005, 569 (1-2), 101-110.
    • (2005) Mutat. Res , vol.569 , Issue.2 , pp. 101-110
    • Gonzalez, F.J.1
  • 7
    • 36348995418 scopus 로고    scopus 로고
    • Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic
    • Chung, I.; Kwon, S.H.; Shim, S.T.; Kyung, K.H. Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. Journal of Food Science 2007, 72 (9), M437-M440.
    • (2007) Journal of Food Science , vol.72 , Issue.9
    • Chung, I.1    Kwon, S.H.2    Shim, S.T.3    Kyung, K.H.4
  • 8
    • 0035127376 scopus 로고    scopus 로고
    • Antioxidant health effects of aged garlic extract
    • Borek, C. Antioxidant health effects of aged garlic extract. J. Nutr. 2001, 131 (3s), 1010S-1015S.
    • (2001) J. Nutr , vol.131 , Issue.3 s
    • Borek, C.1
  • 9
    • 16244387163 scopus 로고    scopus 로고
    • Differential effects of organosulfur compounds from garlic oil on nitric oxide and prostaglandin E2 in stimulated macrophages
    • Chang, H.P.; Chen, Y.H. Differential effects of organosulfur compounds from garlic oil on nitric oxide and prostaglandin E2 in stimulated macrophages. Nutrition 2005, 21 (4), 530-536.
    • (2005) Nutrition , vol.21 , Issue.4 , pp. 530-536
    • Chang, H.P.1    Chen, Y.H.2
  • 10
    • 0020458459 scopus 로고
    • Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits
    • Koop, D.R.; Morgan, E.T.; Tarr, G.E.; Coon, M.J. Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J. Biol. Chem. 1982, 257 (14), 8472-8480.
    • (1982) J. Biol. Chem , vol.257 , Issue.14 , pp. 8472-8480
    • Koop, D.R.1    Morgan, E.T.2    Tarr, G.E.3    Coon, M.J.4
  • 11
    • 0026490252 scopus 로고
    • Purification and characterization of an acetone-inducible cytochrome P-450 from hamster liver microsomes
    • Puccini, P.; Menicagli, S.; Longo, V.; Santucci, A.; Gervasi, P.G. Purification and characterization of an acetone-inducible cytochrome P-450 from hamster liver microsomes. Biochem. J. 1992, 287 (Pt 3)(863-870).
    • (1992) Biochem. J , vol.287 , Issue.3 , pp. 863-870
    • Puccini, P.1    Menicagli, S.2    Longo, V.3    Santucci, A.4    Gervasi, P.G.5
  • 12
    • 0021795267 scopus 로고
    • Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid
    • Ryan, D.E.; Ramanathan, L.; Iida, S.; Thomas, P.E.; Haniu, M.; Shively, J.E.; Lieber, C.S.; Levin, W. Characterization of a major form of rat hepatic microsomal cytochrome P-450 induced by isoniazid. J. Biol. Chem. 1985, 260 (10), 6385-6393.
    • (1985) J. Biol. Chem , vol.260 , Issue.10 , pp. 6385-6393
    • Ryan, D.E.1    Ramanathan, L.2    Iida, S.3    Thomas, P.E.4    Haniu, M.5    Shively, J.E.6    Lieber, C.S.7    Levin, W.8
  • 13
    • 0023200612 scopus 로고
    • Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj
    • Wrighton, S.A.; Thomas, P.E.; Ryan, D.E.; Levin, W. Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch. Biochem. Biophys. 1987, 258 (1), 292-297.
    • (1987) Arch. Biochem. Biophys , vol.258 , Issue.1 , pp. 292-297
    • Wrighton, S.A.1    Thomas, P.E.2    Ryan, D.E.3    Levin, W.4
  • 14
    • 0026567713 scopus 로고
    • Oxidative and reductive metabolism by cytochrome P450 2E1
    • Koop, D.R. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 1992, 6 (2), 724-730.
    • (1992) FASEB J , vol.6 , Issue.2 , pp. 724-730
    • Koop, D.R.1
  • 15
    • 0026592561 scopus 로고
    • Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity
    • Yang, C.S.; Brady, J.F.; Hong, J.Y. Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. FASEB J. 1992, 6 (2), 737-744.
    • (1992) FASEB J , vol.6 , Issue.2 , pp. 737-744
    • Yang, C.S.1    Brady, J.F.2    Hong, J.Y.3
  • 16
    • 1642367217 scopus 로고    scopus 로고
    • The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride
    • Fukao, T.; Hosono, T.; Misawa, S.; Seki, T.; Ariga, T. The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. Food Chem. Toxicol. 2004, 42 (5), 743-749.
    • (2004) Food Chem. Toxicol , vol.42 , Issue.5 , pp. 743-749
    • Fukao, T.1    Hosono, T.2    Misawa, S.3    Seki, T.4    Ariga, T.5
  • 17
    • 0027304762 scopus 로고
    • Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics
    • Patten, C.J.; Thomas, P.E.; Guy, R.L.; Lee, M.; Gonzalez, F.J.; Guengerich, F.P.; Yang, C.S. Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics. Chem. Res. Toxicol. 1993, 6 (4), 511-518.
    • (1993) Chem. Res. Toxicol , vol.6 , Issue.4 , pp. 511-518
    • Patten, C.J.1    Thomas, P.E.2    Guy, R.L.3    Lee, M.4    Gonzalez, F.J.5    Guengerich, F.P.6    Yang, C.S.7
  • 20
    • 0030030355 scopus 로고    scopus 로고
    • Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice
    • Wang, E.J.; Li, Y.; Lin, M.; Chen, L.; Stein, A.P.; Reuhl, K.R.; Yang, C.S. Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice. Toxicol. Appl. Pharmacol. 1996, 136 (1), 146-154.
    • (1996) Toxicol. Appl. Pharmacol , vol.136 , Issue.1 , pp. 146-154
    • Wang, E.J.1    Li, Y.2    Lin, M.3    Chen, L.4    Stein, A.P.5    Reuhl, K.R.6    Yang, C.S.7
  • 21
    • 0030267208 scopus 로고    scopus 로고
    • Protective effects of diallyl sulfide on acetaminophen-induced toxicities
    • Hu, J.J.; Yoo, J.S.; Lin, M.; Wang, E.J.; Yang, C.S. Protective effects of diallyl sulfide on acetaminophen-induced toxicities. Food Chem. Toxicol. 1996, 34 (10), 963-969.
    • (1996) Food Chem. Toxicol , vol.34 , Issue.10 , pp. 963-969
    • Hu, J.J.1    Yoo, J.S.2    Lin, M.3    Wang, E.J.4    Yang, C.S.5
  • 22
    • 0030367945 scopus 로고    scopus 로고
    • Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice
    • Lin, M. C.; Wang, E. J.; Patten, C.; Lee, M. J.; Xiao, F.; Reuhl, K. R.; Yang, C. S. Protective effect of diallyl sulfone against acetaminophen-induced hepatotoxicity in mice. J. Biochem. Toxicol. 1996, 11 (1), 11-20.
    • (1996) J. Biochem. Toxicol , vol.11 , Issue.1 , pp. 11-20
    • Lin, M.C.1    Wang, E.J.2    Patten, C.3    Lee, M.J.4    Xiao, F.5    Reuhl, K.R.6    Yang, C.S.7
  • 23
    • 0031793267 scopus 로고    scopus 로고
    • Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice
    • Sumioka, I.; Matsura, T.; Kasuga, S.; Itakura, Y.; Yamada, K. Mechanisms of protection by S-allylmercaptocysteine against acetaminophen-induced liver injury in mice. Jpn. J. Pharmacol. 1998, 78 (2), 199-207.
    • (1998) Jpn. J. Pharmacol , vol.78 , Issue.2 , pp. 199-207
    • Sumioka, I.1    Matsura, T.2    Kasuga, S.3    Itakura, Y.4    Yamada, K.5
  • 24
    • 0035930888 scopus 로고    scopus 로고
    • Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice
    • Sumioka, I.; Matsura, T.; Yamada, K. Therapeutic effect of S-allylmercaptocysteine on acetaminophen-induced liver injury in mice. Eur. J. Pharmacol. 2001, 433 (2-3), 177-185.
    • (2001) Eur. J. Pharmacol , vol.433 , Issue.2-3 , pp. 177-185
    • Sumioka, I.1    Matsura, T.2    Yamada, K.3
  • 25
    • 0035861399 scopus 로고    scopus 로고
    • Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: Role of antioxidants
    • Sheweita, S.A.; El-Gabar, M.A.; Bastawy, M. Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants. Toxicology 2001, 169 (2), 83-92.
    • (2001) Toxicology , vol.169 , Issue.2 , pp. 83-92
    • Sheweita, S.A.1    El-Gabar, M.A.2    Bastawy, M.3
  • 26
    • 18844378181 scopus 로고    scopus 로고
    • Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus flavonoid as compared to vitamin E in CCl4 induced liver damage in rats
    • Augusti, K.T.; Anuradha Prabha, S.P.; Smitha, K.B.; Sudheesh, M.; George, A.; Joseph, M.C. contributor Nutraceutical effects of garlic oil, its nonpolar fraction and a Ficus flavonoid as compared to vitamin E in CCl4 induced liver damage in rats. Indian J. Exp. Biol. 2005, 43 (5), 437-444.
    • (2005) Indian J. Exp. Biol , vol.43 , Issue.5 , pp. 437-444
    • Augusti, K.T.1    Anuradha, P.S.P.2    Smitha, K.B.3    Sudheesh, M.4    George, A.5    Joseph, M.C.6
  • 27
    • 0022467358 scopus 로고
    • Garlic extract inhibits the enhanced peroxidation and production of lipids in carbon tetrachloride-induced liver injury
    • Kagawa, K.; Matsutaka, H.; Yamaguchi, Y.; Fukuhama, C. Garlic extract inhibits the enhanced peroxidation and production of lipids in carbon tetrachloride-induced liver injury. Jpn. J. Pharmacol. 1986, 42 (1), 19-26.
    • (1986) Jpn. J. Pharmacol , vol.42 , Issue.1 , pp. 19-26
    • Kagawa, K.1    Matsutaka, H.2    Yamaguchi, Y.3    Fukuhama, C.4
  • 29
    • 14844304367 scopus 로고    scopus 로고
    • Metabolism of alcohol
    • Lieber, C.S. Metabolism of alcohol. Clin. Liver Dis. 2005, 9 (1), 1-35.
    • (2005) Clin. Liver Dis , vol.9 , Issue.1 , pp. 1-35
    • Lieber, C.S.1
  • 30
    • 24644494404 scopus 로고    scopus 로고
    • Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1
    • Wu, D.; Cederbaum, A.I. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol. Appl. Pharmacol. 2005, 207 (2 Suppl), 70-76.
    • (2005) Toxicol. Appl. Pharmacol , vol.207 , Issue.2 SUPPL. , pp. 70-76
    • Wu, D.1    Cederbaum, A.I.2
  • 32
    • 34547145926 scopus 로고    scopus 로고
    • Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity
    • Ki, S.H.; Choi, J.H.; Kim, C.W.; Kim, S.G. Combined metadoxine and garlic oil treatment efficaciously abrogates alcoholic steatosis and CYP2E1 induction in rat liver with restoration of AMPK activity. Chem. Biol. Interact. 2007, 169 (2), 80-90.
    • (2007) Chem. Biol. Interact , vol.169 , Issue.2 , pp. 80-90
    • Ki, S.H.1    Choi, J.H.2    Kim, C.W.3    Kim, S.G.4
  • 33
  • 35
    • 53249091920 scopus 로고    scopus 로고
    • Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice
    • Zeng, T.; Zhang, C.L.; Zhu, Z.P.; Yu, L.H.; Zhao, X.L.; Xie, K.Q. Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice. Toxicology. 2008, 252 (1-3), 86-91.
    • (2008) Toxicology , vol.252 , Issue.3 , pp. 86-91
    • Zeng, T.1    Zhang, C.L.2    Zhu, Z.P.3    Yu, L.H.4    Zhao, X.L.5    Xie, K.Q.6
  • 36
    • 33750505407 scopus 로고    scopus 로고
    • CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation
    • Bardag-Gorce, F.; French, B.A.; Nan, L.; Song, H.; Nguyen, S.K.; Yong, H.; Dede, J.; French, S.W. CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation. Exp. Mol. Pathol. 2006, 81 (3), 191-201.
    • (2006) Exp. Mol. Pathol , vol.81 , Issue.3 , pp. 191-201
    • Bardag-Gorce, F.1    French, B.A.2    Nan, L.3    Song, H.4    Nguyen, S.K.5    Yong, H.6    Dede, J.7    French, S.W.8
  • 37
    • 23844456657 scopus 로고    scopus 로고
    • CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes
    • Liu, L. G.; Yan, H.; Yao, P.; Zhang, W.; Zou, L.J.; Song, F.F.; Li, K.; Sun, X.F. CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes. World. J. Gastroenterol. 2005, 11 (29), 4530-4535.
    • (2005) World. J. Gastroenterol , vol.11 , Issue.29 , pp. 4530-4535
    • Liu, L.G.1    Yan, H.2    Yao, P.3    Zhang, W.4    Zou, L.J.5    Song, F.F.6    Li, K.7    Sun, X.F.8
  • 38
    • 0038749577 scopus 로고    scopus 로고
    • Antioxidant nutrients and alcohol
    • McDonough, K.H. Antioxidant nutrients and alcohol. Toxicology 2003, 189 (1-2), 89-97.
    • (2003) Toxicology , vol.189 , Issue.2 , pp. 89-97
    • McDonough, K.H.1
  • 40
    • 0036890399 scopus 로고    scopus 로고
    • The cytochrome P450 superfamily: Biochemistry, evolution and drug metabolism in humans
    • Danielson, P.B. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr. Drug Metab. 2002, 3 (6), 561-597.
    • (2002) Curr. Drug Metab , vol.3 , Issue.6 , pp. 561-597
    • Danielson, P.B.1
  • 41
    • 0027186187 scopus 로고
    • Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic
    • Pan, J.; Hong, J.Y.; Ma, B.L.; Ning, S.M.; Paranawithana, S.R.; Yang, C.S. Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic. Arch. Biochem. Biophys. 1993, 302 (2), 337-342.
    • (1993) Arch. Biochem. Biophys , vol.302 , Issue.2 , pp. 337-342
    • Pan, J.1    Hong, J.Y.2    Ma, B.L.3    Ning, S.M.4    Paranawithana, S.R.5    Yang, C.S.6
  • 42
    • 0035024221 scopus 로고    scopus 로고
    • Dietary fat and garlic oil independently regulate hepatic cytochrome p(450) 2B1 and the placental form of glutathione S-transferase expression in rats
    • Chen, H.W.; Yang, J.J.; Tsai, C.W.; Wu, J.J.; Sheen, L.Y.; Ou, C.C.; Lii, C.K. Dietary fat and garlic oil independently regulate hepatic cytochrome p(450) 2B1 and the placental form of glutathione S-transferase expression in rats. J. Nutr. 2001, 131 (5), 1438-1443.
    • (2001) J. Nutr , vol.131 , Issue.5 , pp. 1438-1443
    • Chen, H.W.1    Yang, J.J.2    Tsai, C.W.3    Wu, J.J.4    Sheen, L.Y.5    Ou, C.C.6    Lii, C.K.7
  • 43
    • 0037116438 scopus 로고    scopus 로고
    • Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats
    • Wu, C.C.; Sheen, L.Y.; Chen, H.W.; Kuo, W.W.; Tsai, S.J.; Lii, C.K. Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. J. Agric. Food Chem. 2002, 50 (2), 378-383.
    • (2002) J. Agric. Food Chem , vol.50 , Issue.2 , pp. 378-383
    • Wu, C.C.1    Sheen, L.Y.2    Chen, H.W.3    Kuo, W.W.4    Tsai, S.J.5    Lii, C.K.6
  • 44
    • 33746559210 scopus 로고    scopus 로고
    • Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs
    • Lii, C.K.; Tsai, C.W.; Wu, C.C. Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs. J. Agric. Food Chem. 2006, 54 (14), 5191-5196.
    • (2006) J. Agric. Food Chem , vol.54 , Issue.14 , pp. 5191-5196
    • Lii, C.K.1    Tsai, C.W.2    Wu, C.C.3
  • 46
    • 0028324459 scopus 로고
    • Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: Opportunities and limitations
    • Yang, C.S.; Smith, T.J.; Hong, J.Y. Cytochrome P-450 enzymes as targets for chemoprevention against chemical carcinogenesis and toxicity: opportunities and limitations. Cancer Res. 1994, 54 (7 Suppl.), 1982s-1986s.
    • (1994) Cancer Res , vol.54 , Issue.7 SUPPL.
    • Yang, C.S.1    Smith, T.J.2    Hong, J.Y.3
  • 47
    • 0030693162 scopus 로고    scopus 로고
    • Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides
    • Siess, M.H.; Le Bon, A.M.; Canivenc-Lavier, M.C.; Suschetet, M. Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides. Cancer Lett. 1997, 120 (2), 195-201.
    • (1997) Cancer Lett , vol.120 , Issue.2 , pp. 195-201
    • Siess, M.H.1    Le Bon, A.M.2    Canivenc-Lavier, M.C.3    Suschetet, M.4
  • 48
    • 0034599106 scopus 로고    scopus 로고
    • Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation
    • Guyonnet, D.; Belloir, C.; Suschetet, M.; Siess, M.H.; Le Bon, A.M. Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation. Mutat Res. 2000, 466 (1), 17-26.
    • (2000) Mutat Res , vol.466 , Issue.1 , pp. 17-26
    • Guyonnet, D.1    Belloir, C.2    Suschetet, M.3    Siess, M.H.4    Le Bon, A.M.5
  • 49
    • 25144464000 scopus 로고    scopus 로고
    • Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic
    • Davenport, D.M.; Wargovich, M.J. Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. Food Chem. Toxicol. 2005, 43 (12), 1753-1762.
    • (2005) Food Chem. Toxicol , vol.43 , Issue.12 , pp. 1753-1762
    • Davenport, D.M.1    Wargovich, M.J.2
  • 51
    • 0043128560 scopus 로고    scopus 로고
    • Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers
    • Markowitz, J.S.; Devane, C.L.; Chavin, K.D.; Taylor, R.M.; Ruan, Y.; Donovan, J.L. Effects of garlic (Allium sativum L.) supplementation on cytochrome P450 2D6 and 3A4 activity in healthy volunteers. Clin. Pharmacol. Ther. 2003, 74 (2), 170-177.
    • (2003) Clin. Pharmacol. Ther , vol.74 , Issue.2 , pp. 170-177
    • Markowitz, J.S.1    Devane, C.L.2    Chavin, K.D.3    Taylor, R.M.4    Ruan, Y.5    Donovan, J.L.6
  • 52
    • 33644841936 scopus 로고    scopus 로고
    • In vitro interactions of water-soluble garlic components with human cytochromes p450
    • Greenblatt, D.J.; Leigh-Pemberton, R.A.; von Moltke, L.L. In vitro interactions of water-soluble garlic components with human cytochromes p450. J. Nutr. 2006, 136 (3 Suppl.), 806S-809S.
    • (2006) J. Nutr , vol.136 , Issue.3 SUPPL.
    • Greenblatt, D.J.1    Leigh-Pemberton, R.A.2    von Moltke, L.L.3
  • 54
    • 0025895757 scopus 로고
    • Reactions and significance of cytochrome P-450 enzymes
    • Guengerich, F.P. Reactions and significance of cytochrome P-450 enzymes. J. Biol. Chem. 1991, 266 (16), 10019-10022.
    • (1991) J. Biol. Chem , vol.266 , Issue.16 , pp. 10019-10022
    • Guengerich, F.P.1
  • 55
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich, F.P.; Shimada, T. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol. 1991, 4 (4), 391-407.
    • (1991) Chem. Res. Toxicol , vol.4 , Issue.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 56
    • 46149095280 scopus 로고    scopus 로고
    • CYP450 pharmacogenetics for personalizing cancer therapy
    • van Schaik, R.H. CYP450 pharmacogenetics for personalizing cancer therapy. Drug Resist. Update 2008, 11 (3), 77-98.
    • (2008) Drug Resist. Update , vol.11 , Issue.3 , pp. 77-98
    • van Schaik, R.H.1
  • 58
    • 0030926119 scopus 로고    scopus 로고
    • Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in the rat
    • Huber, W.W.; McDaniel, L.P.; Kaderlik, K.R.; Teitel, C.H.; Lang, N.P.; Kadlubar, F.F. Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in the rat. Mutat. Res. 1997, 376 (1-2), 115-122.
    • (1997) Mutat. Res , vol.376 , Issue.2 , pp. 115-122
    • Huber, W.W.1    McDaniel, L.P.2    Kaderlik, K.R.3    Teitel, C.H.4    Lang, N.P.5    Kadlubar, F.F.6
  • 59
    • 0032782686 scopus 로고    scopus 로고
    • Chemoprevention of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine-induced mammary carcinogenesis in rats
    • Mori, H.; Sugie, S.; Rahman, W.; Suzui, N. Chemoprevention of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine-induced mammary carcinogenesis in rats. Cancer Lett. 1999, 143 (2), 195-198.
    • (1999) Cancer Lett , vol.143 , Issue.2 , pp. 195-198
    • Mori, H.1    Sugie, S.2    Rahman, W.3    Suzui, N.4
  • 61
    • 0022039421 scopus 로고
    • The chemistry of garlic and onions
    • Block, E. The chemistry of garlic and onions. Sci. Am. 1985, 252 (3), 114-119.
    • (1985) Sci. Am , vol.252 , Issue.3 , pp. 114-119
    • Block, E.1
  • 62
    • 0015162717 scopus 로고
    • Plants used against cancer
    • Hartwell, J.L. Plants used against cancer. A survey. Lloydia 1971, 34 (4), 386-425.
    • (1971) A Survey. Lloydia , vol.34 , Issue.4 , pp. 386-425
    • Hartwell, J.L.1
  • 63
    • 0035089498 scopus 로고    scopus 로고
    • Garlic and cancer: A critical review of the epidemiologic literature
    • Fleischauer, A.T.; Arab, L. Garlic and cancer: a critical review of the epidemiologic literature. J. Nutr. 2001, 131 (3s), 1032S-1040S.
    • (2001) J. Nutr , vol.131 , Issue.3 s
    • Fleischauer, A.T.1    Arab, L.2
  • 64
    • 0023815321 scopus 로고
    • Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
    • Brady, J.F.; Li, D.C.; Ishizaki, H.; Yang, C.S. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities. Cancer Res. 1988, 48 (21), 5937-5940.
    • (1988) Cancer Res , vol.48 , Issue.21 , pp. 5937-5940
    • Brady, J.F.1    Li, D.C.2    Ishizaki, H.3    Yang, C.S.4
  • 65
    • 33644848167 scopus 로고    scopus 로고
    • Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats
    • Katsuki, T.; Hirata, K.; Ishikawa, H.; Matsuura, N.; Sumi, S.; Itoh, H. Aged garlic extract has chemopreventative effects on 1,2-dimethylhydrazine-induced colon tumors in rats. J Nutr. 2006, 136 (3 Suppl.), 847S-851S.
    • (2006) J Nutr , vol.136 , Issue.3 SUPPL.
    • Katsuki, T.1    Hirata, K.2    Ishikawa, H.3    Matsuura, N.4    Sumi, S.5    Itoh, H.6
  • 66
    • 0026658213 scopus 로고
    • Anticarcinogenic action of diallyl sulfide in hamster buccal pouch and forestomach
    • Nagabhushan, M.; Line, D.; Polverini, P.J.; Solt, D.B. Anticarcinogenic action of diallyl sulfide in hamster buccal pouch and forestomach. Cancer Lett. 1992, 66 (3), 207-216.
    • (1992) Cancer Lett , vol.66 , Issue.3 , pp. 207-216
    • Nagabhushan, M.1    Line, D.2    Polverini, P.J.3    Solt, D.B.4
  • 67
    • 0030869443 scopus 로고    scopus 로고
    • Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyreneinduced cancer in mice
    • Srivastava, S.K.; Hu, X.; Xia, H.; Zaren, H.A.; Chatterjee, M.L.; Agarwal, R.; Singh, S.V. Mechanism of differential efficacy of garlic organosulfides in preventing benzo(a)pyreneinduced cancer in mice. Cancer Lett. 1997, 118 (1), 61-67.
    • (1997) Cancer Lett , vol.118 , Issue.1 , pp. 61-67
    • Srivastava, S.K.1    Hu, X.2    Xia, H.3    Zaren, H.A.4    Chatterjee, M.L.5    Agarwal, R.6    Singh, S.V.7
  • 68
    • 0037248249 scopus 로고    scopus 로고
    • S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis
    • Sundaresan, S.; Subramanian, P. S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis. Pol. J. Pharmacol. 2003, 55 (1), 37-42.
    • (2003) Pol. J. Pharmacol , vol.55 , Issue.1 , pp. 37-42
    • Sundaresan, S.1    Subramanian, P.2
  • 69
    • 33644843543 scopus 로고    scopus 로고
    • Preclinical perspectives on garlic and cancer
    • Milner, J.A. Preclinical perspectives on garlic and cancer. J. Nutr. 2006, 136 (3 Suppl), 827S-831S.
    • (2006) J. Nutr , vol.136 , Issue.3 SUPPL.
    • Milner, J.A.1
  • 70
    • 0037301861 scopus 로고    scopus 로고
    • Garlic [Allium sativum]: A review of its potential use as an anti-cancer agent
    • Thomson, M.; Ali, M. Garlic [Allium sativum]: a review of its potential use as an anti-cancer agent. Curr. Cancer Drug Targets 2003, 3 (1), 67-81.
    • (2003) Curr. Cancer Drug Targets , vol.3 , Issue.1 , pp. 67-81
    • Thomson, M.1    Ali, M.2
  • 71
    • 0034921254 scopus 로고    scopus 로고
    • Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis
    • Milner, J.A. Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis. Adv. Exp. Med. Biol. 2001, 492, 69-81.
    • (2001) Adv. Exp. Med. Biol , vol.492 , pp. 69-81
    • Milner, J.A.1
  • 72
    • 43549097841 scopus 로고    scopus 로고
    • Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise?
    • Nagini, S. Cancer chemoprevention by garlic and its organosulfur compounds-panacea or promise? Anticancer Agents Med. Chem. 2008, 8 (3), 313-321
    • (2008) Anticancer Agents Med. Chem , vol.8 , Issue.3 , pp. 313-321
    • Nagini, S.1
  • 73
    • 0032838660 scopus 로고    scopus 로고
    • Low doses of diallyl disulfide, a compound derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat
    • Munday, R.; Munday, C.M. Low doses of diallyl disulfide, a compound derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat. Nutr. Cancer. 1999, 34 (1), 42-48.
    • (1999) Nutr. Cancer , vol.34 , Issue.1 , pp. 42-48
    • Munday, R.1    Munday, C.M.2
  • 74
    • 0024781837 scopus 로고
    • Mechanisms of induction of enzymes that protect against chemical carcinogenesis
    • Talalay, P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. Adv Enzyme Regul. 1989, 28, 237-250.
    • (1989) Adv Enzyme Regul , vol.28 , pp. 237-250
    • Talalay, P.1
  • 75
    • 19544363787 scopus 로고    scopus 로고
    • Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis
    • Bhuvaneswari, V.; Abraham, S.K.; Nagini, S. Combinatorial antigenotoxic and anticarcinogenic effects of tomato and garlic through modulation of xenobiotic-metabolizing enzymes during hamster buccal pouch carcinogenesis. Nutrition 2005, 21 (6), 726-731.
    • (2005) Nutrition , vol.21 , Issue.6 , pp. 726-731
    • Bhuvaneswari, V.1    Abraham, S.K.2    Nagini, S.3
  • 76
    • 0034251950 scopus 로고    scopus 로고
    • The alcohol-inducible form of cytochrome P450 (CYP 2E1): Role in toxicology and regulation of expression
    • Novak, R.F.; Woodcroft, K.J. The alcohol-inducible form of cytochrome P450 (CYP 2E1): role in toxicology and regulation of expression. Arch. Pharm. Res. 2000, 23 (4), 267-282.
    • (2000) Arch. Pharm. Res , vol.23 , Issue.4 , pp. 267-282
    • Novak, R.F.1    Woodcroft, K.J.2
  • 77
    • 0030992920 scopus 로고    scopus 로고
    • Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats
    • Jin, L.; Baillie, T.A. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats. Chem. Res. Toxicol. 1997, 10 (3), 318-327.
    • (1997) Chem. Res. Toxicol , vol.10 , Issue.3 , pp. 318-327
    • Jin, L.1    Baillie, T.A.2
  • 78
    • 0033736512 scopus 로고    scopus 로고
    • Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs
    • Forkert, P.G.; Premdas, P.D.; Bowers, R.J. Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs. Am. J. Respir. Cell Mol. Biol. 2000, 23 (5), 687-695.
    • (2000) Am. J. Respir. Cell Mol. Biol , vol.23 , Issue.5 , pp. 687-695
    • Forkert, P.G.1    Premdas, P.D.2    Bowers, R.J.3
  • 79
    • 0034089655 scopus 로고    scopus 로고
    • Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone
    • Premdas, P.D.; Bowers, R.J.; Forkert, P.G. Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone. J Pharmacol. Exp. Ther. 2000, 293 (3), 1112-1120.
    • (2000) J Pharmacol. Exp. Ther , vol.293 , Issue.3 , pp. 1112-1120
    • Premdas, P.D.1    Bowers, R.J.2    Forkert, P.G.3
  • 80
    • 0031588947 scopus 로고    scopus 로고
    • Molecular modelling of CYP2E1 enzymes from rat, mouse and man: An explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity
    • Lewis, D.F.; Bird, M.G.; Parke, D.V. Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity. Toxicology 1997, 118 (2-3), 93-113.
    • (1997) Toxicology , vol.118 , Issue.2-3 , pp. 93-113
    • Lewis, D.F.1    Bird, M.G.2    Parke, D.V.3
  • 81
    • 0026667521 scopus 로고
    • Metabolism of garlic constituents in the isolated perfused rat liver
    • Egen-Schwind, C.; Eckard, R.; Kemper, F.H. Metabolism of garlic constituents in the isolated perfused rat liver. Planta Med. 1992, 58 (4), 301-305.
    • (1992) Planta Med , vol.58 , Issue.4 , pp. 301-305
    • Egen-Schwind, C.1    Eckard, R.2    Kemper, F.H.3
  • 82
    • 0028824504 scopus 로고
    • Effects of garlic oil on rat hepatic P4502E1 expression
    • Kwak, M.K.; Kim, S.G.; Kim, N.D. Effects of garlic oil on rat hepatic P4502E1 expression. Xenobiotica 1995, 25 (10), 1021-1029.
    • (1995) Xenobiotica , vol.25 , Issue.10 , pp. 1021-1029
    • Kwak, M.K.1    Kim, S.G.2    Kim, N.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.