Epoxide formation from diallyl sulfone is associated with CYP2E1 inactivation in murine and human lungs

American Journal of Respiratory Cell and Molecular Biology

Volumn 23, Issue 5, 2000, Pages 687-695

  Forkert, P G ^a   Premdas, P D ^a   Bowers, R J ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MURINAE;

EID: 0033736512     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.23.5.4149     Document Type: Article

References (34)

1. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic
2. 1,1-Dichloroethylene-induced pulmonary injury
3. Reaction of glutathione with the electrophilic metabolites of 1,1,-dichloroethylene
4. CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: Formation of reactive intermediates and glutathione conjugates
5. Differential formation of 1,1,-dichloroethylene-metabolites in the lungs of adult and weanling male and female mice: Correlation with severities of bronchiolar cytotoxicity
6. 1,1-Dichloroethylene-induced Clara cell damage is associated with in situ formation of the reactive epoxide: Immunohistochemical detection of its glutathione conjugate
7. Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites
8. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats
9. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities
10. Expression of cytochrome P450 cDNAs in human B lymphoblastoid cells: Applications to toxicology and metabolite analysis
11. Radical chain cyclization of allylic compounds
12. Synthesis of epoxides using dimethyldioxirane: Trans-stilbene oxide
13. Monoclonal antibodies to ethanol-induced rat liver cytochrome P-450 that metabolizes aniline and nitrosamines
14. CYP2E1 is preferentially expressed in Clara cells of murine lung: Localization by in situ hybridization and immunohistochemical methods
15. Cytochrome P-450-dependent bioactivation of 1,1,-dichloroethylene to a reactive epoxide in human lung and liver microsomes
16. Protein measurement with the Foline phenol reagent
17. In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice
18. Metabolism of ethyl carbamate by pulmonary cytochrome P450 and carboxylesterase isozymes: Involvement of CYP2E1 and hydrolase A
19. Inactivation of cytochrome P-450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes by vinyl carbamate in murine pulmonary microsomes
20. Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice
21. Mapping the antigenic epitope for a monoclonal antibody against lysozyme
22. Mutagenic and alkylating activities of organophosphate impurities of commercial malathion
23. Use of p-(4-nitrobenzyl)pyridine as analytical reagent for ethylenimines and alkylating agents
24. Oxidation of trichloroethylene by liver microsomal cytochrome P-450: Evidence for chlorine migration in a transition state not involving trichloroethylene oxide
25. Acylation of protein lysines by trichloroethylene oxide
26. Effect of diallyl sulfide, a naturally occurring anti-carcinogen, on glutathione-dependent detoxification enzymes of female CD-1 mouse tissues
27. Protective effects of garlic and related organosulfur compounds on acetaminophen-induced hepatotoxicity in mice
28. Transcriptional activation of cytochrome P450 2B1/2 genes in rat liver by diallyl sulfide, a compound derived from garlic
29. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes
30. Regulation of cytochrome P450j, a high affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes
31. Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content
32. Suicidal destruction of cytochrome P-450 during oxidative drug metabolism
33. The allylisopropylacetamide and novonol heme adducts
34. Destruction of cytochrome P-450 by 2-isopropyl-4-pentenamide and methyl 2-isopropyl-4-pentenoate: Mass spectromeric characterization of prosthetic heme adducts and nonparticipation of epoxide metabolites