메뉴 건너뛰기




Volumn 18, Issue 3, 2010, Pages 235-245

Mitochondria: The secret chamber of therapeutic targets for age-associated degenerative diseases

Author keywords

Degenerative disease; Mitochondria; Mitochondrial medicine; Therapeutic

Indexed keywords

3 HYDROXYBUTYRIC ACID; ALCOHOL DEHYDROGENASE; ALPHA TOCOPHEROL; ARGININE; ASCORBIC ACID; CARNITINE; CREATINE; CYCLOSPORIN A; CYSTAMINE; DICHLOROACETIC ACID; DIMETHYLGLYCINE; DNA DIRECTED DNA POLYMERASE GAMMA; HUNTINGTIN; IDEBENONE; MENADIONE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOCHONDRIAL TRANSCRIPTION FACTOR B; MULTIVITAMIN; NICOTINAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; RIBOFLAVIN; SUCCINIC ACID; THIAMINE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR NRF2; UBIDECARENONE; UBIQUINONE; UNINDEXED DRUG;

EID: 77957372038     PISSN: 19769148     EISSN: None     Source Type: Journal    
DOI: 10.4062/biomolther.2010.18.3.235     Document Type: Review
Times cited : (12)

References (63)
  • 1
    • 76749110211 scopus 로고    scopus 로고
    • Mitochondrial dysfunction enhances the migration of vascular smooth muscle cells via suppression of Akt phosphorylation
    • Ahn, S. Y., Choi, Y. S., Koo, H. J., Jeong, J. H., Park, W. H., Kim, M., Piao, Y. and Pak, Y. K. (2010). Mitochondrial dysfunction enhances the migration of vascular smooth muscle cells via suppression of Akt phosphorylation. Biochim. Biophys. Acta. 1800, 275-281.
    • (2010) Biochim. Biophys. Acta. , vol.1800 , pp. 275-281
    • Ahn, S.Y.1    Choi, Y.S.2    Koo, H.J.3    Jeong, J.H.4    Park, W.H.5    Kim, M.6    Piao, Y.7    Pak, Y.K.8
  • 2
    • 0033972463 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
    • Barja, G. and Herrero, A. (2000). Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB. J. 14, 312-318.
    • (2000) FASEB. J. , vol.14 , pp. 312-318
    • Barja, G.1    Herrero, A.2
  • 3
    • 0034194090 scopus 로고    scopus 로고
    • The changing face of mitochondrial research
    • Capaldi, R. A. (2000). The changing face of mitochondrial research. Trends Biochem. Sci. 25, 212-214.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 212-214
    • Capaldi, R.A.1
  • 4
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: Dynamic organelles in disease, aging, and development
    • Chan, D. C. (2006a). Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241-1252.
    • (2006) Cell , vol.125 , pp. 1241-1252
    • Chan, D.C.1
  • 5
    • 33750445482 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in mammals
    • Chan, D. C. (2006b). Mitochondrial fusion and fission in mammals. Annu. Rev. Cell Dev. Biol. 22, 79-99.
    • (2006) Annu. Rev. Cell Dev. Biol. , vol.22 , pp. 79-99
    • Chan, D.C.1
  • 6
    • 77951096150 scopus 로고    scopus 로고
    • Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases
    • Chen, H. and Chan, D. C. (2009). Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-176.
    • (2009) Hum. Mol. Genet. , vol.18
    • Chen, H.1    Chan, D.C.2
  • 7
    • 64249133725 scopus 로고    scopus 로고
    • S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
    • Cho, D. H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z. and Lipton, S. A. (2009). S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science 324, 102-105.
    • (2009) Science , vol.324 , pp. 102-105
    • Cho, D.H.1    Nakamura, T.2    Fang, J.3    Cieplak, P.4    Godzik, A.5    Gu, Z.6    Lipton, S.A.7
  • 8
    • 33646122451 scopus 로고    scopus 로고
    • Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) on mitochondrial transcription factor A (TFAM) promoter
    • Choi, Y. S., Hong, J. M., Lim, S., Ko, K. S. and Pak, Y. K. (2006). Impaired coactivator activity of the Gly482 variant of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) on mitochondrial transcription factor A (TFAM) promoter. Biochem. Biophys. Res. Commun. 344, 708-712.
    • (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 708-712
    • Choi, Y.S.1    Hong, J.M.2    Lim, S.3    Ko, K.S.4    Pak, Y.K.5
  • 9
    • 2342562963 scopus 로고    scopus 로고
    • Regulation of mitochondrial transcription factor A expression by high glucose
    • Choi, Y. S., Lee, K. U. and Pak, Y. K. (2004). Regulation of mitochondrial transcription factor A expression by high glucose. Ann. N Y Acad. Sci. 1011, 69-77.
    • (2004) Ann. N Y Acad. Sci. , vol.1011 , pp. 69-77
    • Choi, Y.S.1    Lee, K.U.2    Pak, Y.K.3
  • 10
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi, G. A., Shibata, D., Soong, N. W. and Arnheim, N. (1992). A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. U S A 89, 7370-7374.
    • (1992) Proc. Natl. Acad. Sci. U S A , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 12
    • 34548627532 scopus 로고    scopus 로고
    • DNA replication and transcription in mammalian mitochondria
    • Falkenberg, M., Larsson, N. G. and Gustafsson, C. M. (2007). DNA replication and transcription in mammalian mitochondria. Annu. Rev. Biochem. 76, 679-699.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 679-699
    • Falkenberg, M.1    Larsson, N.G.2    Gustafsson, C.M.3
  • 13
    • 77953508445 scopus 로고    scopus 로고
    • Mitochondria as a target in treatment
    • Frantz, M. C. and Wipf, P. (2010). Mitochondria as a target in treatment. Environ. Mol. Mutagen. 51, 462-475.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 462-475
    • Frantz, M.C.1    Wipf, P.2
  • 14
    • 77953799916 scopus 로고    scopus 로고
    • Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes
    • Fujitani, Y., Ueno, T. and Watada, H. (2010). Autophagy in health and disease. 4. The role of pancreatic beta-cell autophagy in health and diabetes. Am. J. Physiol. Cell Physiol. 299, C1-6.
    • (2010) Am. J. Physiol. Cell Physiol. , vol.299
    • Fujitani, Y.1    Ueno, T.2    Watada, H.3
  • 15
    • 10644229290 scopus 로고    scopus 로고
    • The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells
    • Gaspari, M., Falkenberg, M., Larsson, N. G. and Gustafsson, C. M. (2004). The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells. EMBO. J. 23, 4606-4614.
    • (2004) EMBO. J. , vol.23 , pp. 4606-4614
    • Gaspari, M.1    Falkenberg, M.2    Larsson, N.G.3    Gustafsson, C.M.4
  • 16
    • 34250204271 scopus 로고    scopus 로고
    • The machines that divide and fuse mitochondria
    • Hoppins, S., Lackner, L. and Nunnari, J. (2007). The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 76, 751-780.
    • (2007) Annu. Rev. Biochem. , vol.76 , pp. 751-780
    • Hoppins, S.1    Lackner, L.2    Nunnari, J.3
  • 17
    • 41949114990 scopus 로고    scopus 로고
    • Role of mitochondrial dysfunction in insulin resistance
    • Kim, J. A., Wei, Y. and Sowers, J. R. (2008). Role of mitochondrial dysfunction in insulin resistance. Circ. Res. 102, 401-414.
    • (2008) Circ. Res. , vol.102 , pp. 401-414
    • Kim, J.A.1    Wei, Y.2    Sowers, J.R.3
  • 20
    • 33750464884 scopus 로고    scopus 로고
    • Cell biology: Power games
    • Lane, N. (2006a). Cell biology: power games. Nature 443, 901-903.
    • (2006) Nature , vol.443 , pp. 901-903
    • Lane, N.1
  • 21
    • 33645460107 scopus 로고    scopus 로고
    • Mitochondrial disease: Powerhouse of disease
    • Lane, N. (2006b). Mitochondrial disease: powerhouse of disease. Nature 440, 600-602.
    • (2006) Nature , vol.440 , pp. 600-602
    • Lane, N.1
  • 22
    • 77953627194 scopus 로고    scopus 로고
    • Somatic mitochondrial DNA mutations in mammalian aging
    • Larsson, N. G. (2010). Somatic mitochondrial DNA mutations in mammalian aging. Annu. Rev. Biochem. 79, 683-706.
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 683-706
    • Larsson, N.G.1
  • 23
    • 0035202150 scopus 로고    scopus 로고
    • Animal models for respiratory chain disease
    • Larsson, N. G. and Rustin, P. (2001). Animal models for respiratory chain disease. Trends Mol. Med. 7, 578-581.
    • (2001) Trends Mol. Med. , vol.7 , pp. 578-581
    • Larsson, N.G.1    Rustin, P.2
  • 25
    • 0037069375 scopus 로고    scopus 로고
    • Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
    • Lee, C. K., Allison, D. B., Brand, J., Weindruch, R. and Prolla, T. A. (2002). Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc. Natl. Acad. Sci. U S A 99, 14988-14993.
    • (2002) Proc. Natl. Acad. Sci. U S A , vol.99 , pp. 14988-14993
    • Lee, C.K.1    Allison, D.B.2    Brand, J.3    Weindruch, R.4    Prolla, T.A.5
  • 26
    • 22044448247 scopus 로고    scopus 로고
    • Mitochondria-based model for fetal origin of adult disease and insulin resistance
    • Lee, H. K., Park, K. S., Cho, Y. M., Lee, Y. Y. and Pak, Y. K. (2005). Mitochondria-based model for fetal origin of adult disease and insulin resistance. Ann. N Y Acad. Sci. 1042, 1-18.
    • (2005) Ann. N Y Acad. Sci. , vol.1042 , pp. 1-18
    • Lee, H.K.1    Park, K.S.2    Cho, Y.M.3    Lee, Y.Y.4    Pak, Y.K.5
  • 27
    • 0032429843 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus
    • Lee, H. K., Song, J. H., Shin, C. S., Park, D. J., Park, K. S., Lee, K. U. and Koh, C. S. (1998). Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res. Clin. Pract. 42, 161-167.
    • (1998) Diabetes Res. Clin. Pract. , vol.42 , pp. 161-167
    • Lee, H.K.1    Song, J.H.2    Shin, C.S.3    Park, D.J.4    Park, K.S.5    Lee, K.U.6    Koh, C.S.7
  • 28
    • 71549121668 scopus 로고    scopus 로고
    • The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?
    • Lee, J., Boo, J. H. and Ryu, H. (2009). The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start? Adv. Drug Deliv. Rev. 61, 1316-1323.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1316-1323
    • Lee, J.1    Boo, J.H.2    Ryu, H.3
  • 30
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1alpha: A key regulator of energy metabolism
    • Liang, H. and Ward, W. F. (2006). PGC-1alpha: a key regulator of energy metabolism. Adv. Physiol. Educ. 30, 145-151.
    • (2006) Adv. Physiol. Educ. , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 31
    • 65249107688 scopus 로고    scopus 로고
    • Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance
    • Lim, S., Ahn, S. Y., Song, I. C., Chung, M. H., Jang, H. C., Park, K. S., Lee, K. U., Pak, Y. K. and Lee, H. K. (2009). Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One 4, e5186.
    • (2009) PLoS One , vol.4
    • Lim, S.1    Ahn, S.Y.2    Song, I.C.3    Chung, M.H.4    Jang, H.C.5    Park, K.S.6    Lee, K.U.7    Pak, Y.K.8    Lee, H.K.9
  • 32
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin, M. T. and Beal, M. F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 34
    • 75149115122 scopus 로고    scopus 로고
    • Control of mitochondrial transport and localization in neurons
    • MacAskill, A. F. and Kittler, J. T. (2010). Control of mitochondrial transport and localization in neurons. Trends Cell Biol. 20, 102-112.
    • (2010) Trends Cell Biol. , vol.20 , pp. 102-112
    • MacAskill, A.F.1    Kittler, J.T.2
  • 35
    • 33947512416 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in atherosclerosis
    • Madamanchi, N. R. and Runge, M. S. (2007). Mitochondrial dysfunction in atherosclerosis. Circ. Res. 100, 460-473.
    • (2007) Circ. Res. , vol.100 , pp. 460-473
    • Madamanchi, N.R.1    Runge, M.S.2
  • 36
    • 3042695377 scopus 로고    scopus 로고
    • Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells
    • Matsushima, Y., Garesse, R. and Kaguni, L. S. (2004). Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells. J. Biol. Chem. 279, 26900-26905.
    • (2004) J. Biol. Chem. , vol.279 , pp. 26900-26905
    • Matsushima, Y.1    Garesse, R.2    Kaguni, L.S.3
  • 37
    • 58149302896 scopus 로고    scopus 로고
    • Parkin mitochondria in the autophagosome
    • McBride, H. M. (2008). Parkin mitochondria in the autophagosome. J. Cell. Biol. 183, 757-759.
    • (2008) J. Cell. Biol. , vol.183 , pp. 757-759
    • McBride, H.M.1
  • 38
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G. and Attardi, G. (1999). Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286, 774-779.
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 40
    • 58149314211 scopus 로고    scopus 로고
    • Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
    • Narendra, D., Tanaka, A., Suen, D. F. and Youle, R. J. (2008). Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J. Cell Biol. 183, 795-803.
    • (2008) J. Cell Biol. , vol.183 , pp. 795-803
    • Narendra, D.1    Tanaka, A.2    Suen, D.F.3    Youle, R.J.4
  • 41
    • 27544466847 scopus 로고    scopus 로고
    • Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes
    • Okamoto, K. and Shaw, J. M. (2005). Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. Annu. Rev. Genet. 39, 503-536.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 503-536
    • Okamoto, K.1    Shaw, J.M.2
  • 44
    • 0344500890 scopus 로고    scopus 로고
    • Peripheral blood mitochondrial DNA content correlates with lipid oxidation rate during euglycemic clamps in healthy young men
    • Park, K. S., Song, J. H., Lee, K. U., Choi, C. S., Koh, J. J., Shin, C. S. and Lee, H. K. (1999). Peripheral blood mitochondrial DNA content correlates with lipid oxidation rate during euglycemic clamps in healthy young men. Diabetes Res. Clin. Pract. 46, 149-154.
    • (1999) Diabetes Res. Clin. Pract. , vol.46 , pp. 149-154
    • Park, K.S.1    Song, J.H.2    Lee, K.U.3    Choi, C.S.4    Koh, J.J.5    Shin, C.S.6    Lee, H.K.7
  • 49
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulinresistant offspring of patients with type 2 diabetes
    • Petersen, K. F., Dufour, S., Befroy, D., Garcia, R. and Shulman, G. I. (2004). Impaired mitochondrial activity in the insulinresistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350, 664-671.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 50
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M. and Spiegelman, B. M. (1998). A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 52
    • 33745410626 scopus 로고    scopus 로고
    • Mitochondrial disease
    • Schapira, A. H. (2006). Mitochondrial disease. Lancet. 368, 70-82.
    • (2006) Lancet. , vol.368 , pp. 70-82
    • Schapira, A.H.1
  • 53
    • 0033762782 scopus 로고    scopus 로고
    • Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
    • Silva, J. P., Kohler, M., Graff, C., Oldfors, A., Magnuson, M. A., Berggren, P. O. and Larsson, N. G. (2000). Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes. Nat. Genet. 26, 336-340.
    • (2000) Nat. Genet. , vol.26 , pp. 336-340
    • Silva, J.P.1    Kohler, M.2    Graff, C.3    Oldfors, A.4    Magnuson, M.A.5    Berggren, P.O.6    Larsson, N.G.7
  • 54
    • 0035344913 scopus 로고    scopus 로고
    • Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients
    • Song, J., Oh, J. Y., Sung, Y. A., Pak, Y. K., Park, K. S. and Lee, H. K. (2001). Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 24, 865-869.
    • (2001) Diabetes Care , vol.24 , pp. 865-869
    • Song, J.1    Oh, J.Y.2    Sung, Y.A.3    Pak, Y.K.4    Park, K.S.5    Lee, H.K.6
  • 59
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace, D. C. (2005). A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359-407.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 60
    • 77949882290 scopus 로고    scopus 로고
    • Mitochondrial energetics and therapeutics
    • Wallace, D. C., Fan, W. and Procaccio, V. (2010). Mitochondrial energetics and therapeutics. Annu. Rev. Pathol. 5, 297-348.
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 297-348
    • Wallace, D.C.1    Fan, W.2    Procaccio, V.3
  • 61
    • 58149091896 scopus 로고    scopus 로고
    • The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility
    • Wang, X. and Schwarz, T. L. (2009). The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Cell 136, 163-174.
    • (2009) Cell , vol.136 , pp. 163-174
    • Wang, X.1    Schwarz, T.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.