Dopamine-dependent iron toxicity in cells derived from rat hypothalamus

Chemical Research in Toxicology

Volumn 18, Issue 3, 2005, Pages 415-419

  Paris, Irmgard ^a   Martinez Alvarado, Pedro ^a   Cárdenas, Sergio ^a   Perez Pastene, Carolina ^a   Graumann, Rebecca ^a   Fuentes, Patricio ^a   Olea Azar, Claudio ^b   Caviedes, Pablo ^a   Segura Aguilar, Juan ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; DICOUMAROL; DIHYDROLIPOAMIDE DEHYDROGENASE; DOPAMINE; FERRIC CHLORIDE; HYDROXYL RADICAL; IRON; NORADRENALIN TRANSPORTER; OXYGENASE; REBOXETINE;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HYPOTHALAMUS; IMMUNOFLUORESCENCE; IRON TRANSPORT; NEUROTOXICITY; NONHUMAN; OXIDATION; RAT; SPIN TRAPPING;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; CELL DEATH; CELL LINE; DICUMAROL; DOPAMINE; DOPAMINE BETA-HYDROXYLASE; FERRIC COMPOUNDS; FLUORESCENT ANTIBODY TECHNIQUE; HYPOTHALAMUS; INDOLEQUINONES; IRON; MICROSCOPY, CONFOCAL; MORPHOLINES; NAD(P)H DEHYDROGENASE (QUINONE); NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; RATS; RATS, INBRED F344; SYMPORTERS;

EID: 15344342576     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0497144     Document Type: Article

References (25)

1. Sofic, E., Riederer, P., Heinsen, H., Beckmann, H., Reynolds, G. P., Hebenstreit, G., and Youdim, M. B. (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J. Neural Transm. 74, 199-205.
2. Dexter, D. T., Wells, F. R., Lees, A. J., Agid, F., Agid, Y., Jenner, P., and Marsden, C. D. (1989) Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52, 1830-1836.
3. Berg, D., Roggendorf, W., Schroder, U., Klein, R., Tatschner, T., Benz, P., Tucha, O., Freier, M., Lange, K. W., Reiners, K., Gerlach, M., and Becker, G. (2002) Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury. Arch. Neurol. 59, 999-1005.
4. Gorell, J. M., Ordidge, R. J., Brown, G. G., Deniau, J. C., Buderer, N. M., and Helpern, J. A. (1995) Increased iron-related MRI contrast in the substantia nigra in Parkinson's disease. Neurology 45, 1138-1143.
5. Miyajima, H., Takahashi, Y., Serizawa, M., Kaneko, E., and Gitlin, J. D. (1996) Increased plasma lipid peroxidation in patients with aceruloplasminemia. Free Radical Biol. Med. 20, 757-760.
6. Morita, H., Ikeda, S., Yamamoto, K., Morita, S., Yoshida, K., Nomoto, S., Kato, M., and Yanagisawa, N. (1995) Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a Japanese family. Ann. Neurol. 37, 646-656.
7. Gerlach, M., Double, K. L., Ben-Shachar, D., Zecca, L., Youdim, M. B., and Riederer, P. (2003) Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease. Neurotox. Res. 5, 35-44.
8. Andersen, J. K. (2003) Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson's disease. Neurotox. Res. 5, 307-313.
9. Berg, D., Becker, G., Biederer, P., and Riess, O. (2002) Iron in neurodegenerative disorders. Neurotox. Res. 4, 637-653.
10. Linert, W., Herlinger, E., Jameson, R. F., Kienzl, E., Jellinger, K., and Youdim, M. B. (1996) Dopamine, 6-hydroxydopamine, iron, and dioxygen-Their mutual interactions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta 1316, 160-168.
11. Baez, S., Linderson, Y., and Segura-Aguilar, J. (1995) Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase. Biochem. Mol. Med. 54, 12-18.
12. Segura-Aguilar, J., Metodiewa, D., and Welch, C. J. (1998) Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects. Biochim. Biophys. Acta 1381, 1-6.
13. 3+ to produce a 6-hydroxydopamine like rotational behaviour. Neurotox. Res. 4, 127-131.
14. Arriagada, C., Paris, I., Sanchez de las Matas, M. J., Martinez-Alvarado, P., Cardenas, S., Castaneda, P., Graumann, R., Perez-Pastene, C., Olea-Azar, C., Couve, E., Herrero, M. T., Caviedes, P., and Segura-Aguilar, J. (2004) On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: Mitochondria damage, necrosis, and hydroxyl radical formation. Neurobiol. Dis. 16, 468-477.
15. Diaz-Veliz, G., Mora, S., Gomez, P., Dossi, M. T., Montiel, J., Arriagada, C., Aboitiz, F., and Segura-Aguilar, J. (2004) Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicoumarol, a DT-diaphorase inhibitor. Pharmacol. Biochem. Behav. 77, 245-251.
16. Paris, I., Dagnino-Subiabre, A., Marcelain, K., Bennett, L. B., Caviedes, P., Caviedes, R., Olea-Azar, C., and Segura-Aguilar, J. (2001) Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J. Neurochem. 77, 519-529.
17. Segura-Aguilar, J., Metodiewa, D., and Baez, S. (2001) The possible role of one electron reduction of aminochrome in the neurodegenerative processes of the dopaminergic systems. Neurotox. Res. 3, 157-166.
18. Graumann, R., Paris, I., Martinez-Alvarado, P., Rumanque, P., Perez-Pastene, C., Cardenas, S. P., Marin, P., Diaz-Grez, F., Caviedes, R., Caviedes, P., and Segura-Aguilar, J. (2002) Oxidation of dopamine to aminochrome as a mechanism for neurodegeneration of dopaminergic systems in Parkinson's disease. Possible neuroprotective role of DT-diaphorase. Pol. J. Pharmacol. 54, 573-579.
19. 3+ induce neurotoxicity of dopamine: Prevention of quinone derived oxygen toxicity by DT-diaphorase and superoxid dismutase. Chem.-Biol. Interact. 72, 309-324.
20. Hurtado-Guzman, C., Martinez-Alvarado, P., Dagnino-Subiabre, A., Paris, I., Caviedes, Caviedes, R., Cassels, B. K., and Segura-Aguilar, J. (2002) Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture. Neurotox. Res. 4, 161-163.
21. Prota, G. (2000) Melanins, melanogenesis and melanocytes: Looking at their functional significance from the chemist's viewpoint. Pigm. Cell Res. 13, 283-293.
22. Roubert, C., Sagne, C., Kapsimali, M., Vernier, P., Bourrat, F., and Giros, B. (2001) A Na(+)/Cl(-)-dependent transporter for catecholamines, identified as a norepinephrine transporter, is expressed in the brain of the teleost fish medaka (Oryzias latipes). Mol. Pharmacol. 60, 462-473.
23. Smythies, J., De Iuliis, A., Zanatta, L., and Galzigna, L. (2002) The biochemical basis of Parkinson's disease: The role of catecholamine o-quinones: a review-discussion. Neurotox. Res. 4, 77-81.
24. Sulzer, D., Bogulavsky, J., Larsen, K. E., Behr, G., Karatekin, E., Kleinman, M. H., Turro, N., Krantz, D., Edwards, R. H., Greene, L. A., and Zecca, L. (2000) Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc. Natl. Acad. Sci. U.S.A. 97, 11869-11874.
25. Aguilar Hernandez, R., Sanchez De Las Matas, M. J., Arriagada, C., Barcia, C., Caviedes, P., Herrero, M. T., and Segura-Aguilar J. (2003) MPP(+)-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity. Neurotox. Res. 5, 407-410.