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Volumn 76, Issue 4, 2008, Pages 361-367

Molecular mechanism of manganese exposure-induced dopaminergic toxicity

Author keywords

Apoptosis; Dopamine; Manganese; Neurotoxicity; Oxidative stress; Transcription factor

Indexed keywords

7 NITROINDAZOLE; ALPHA TOCOPHEROL; DOPAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LACTATE DEHYDROGENASE; MANGANESE; REACTIVE OXYGEN METABOLITE; SN 50;

EID: 43849113143     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2008.03.004     Document Type: Article
Times cited : (73)

References (53)
  • 1
    • 0030878073 scopus 로고    scopus 로고
    • Oxidative DNA damage in the Parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra
    • Alam A.I., Jenner A., Daniel S.E., Lees A.J., Cairns N., Marsden C.D., Jenner P., and Halliwell B. Oxidative DNA damage in the Parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J. Neurochem. 69 (1997) 1196-1203
    • (1997) J. Neurochem. , vol.69 , pp. 1196-1203
    • Alam, A.I.1    Jenner, A.2    Daniel, S.E.3    Lees, A.J.4    Cairns, N.5    Marsden, C.D.6    Jenner, P.7    Halliwell, B.8
  • 2
    • 0035425503 scopus 로고    scopus 로고
    • Nitric oxide synthases: structure, function and inhibition
    • Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem. J. 357 (2001) 593-615
    • (2001) Biochem. J. , vol.357 , pp. 593-615
    • Alderton, W.K.1    Cooper, C.E.2    Knowles, R.G.3
  • 3
    • 0033911123 scopus 로고    scopus 로고
    • Manganese: brain transport and emerging research needs
    • Aschner M. Manganese: brain transport and emerging research needs. Environ. Health Perspect. 108 (2000) 429-432
    • (2000) Environ. Health Perspect. , vol.108 , pp. 429-432
    • Aschner, M.1
  • 4
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal M.F. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38 (1995) 357-366
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 5
    • 0027226219 scopus 로고
    • Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination
    • Brewer G.J., Torricelli J.R., Evege E.K., and Price P.J. Optimized survival of hippocampal neurons in B27-supplemented neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35 (1993) 567-576
    • (1993) J. Neurosci. Res. , vol.35 , pp. 567-576
    • Brewer, G.J.1    Torricelli, J.R.2    Evege, E.K.3    Price, P.J.4
  • 6
    • 0027447043 scopus 로고
    • Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism
    • Brouillet E.T., Shinova I., McGarvey U., Hochberg F., and Beal M.F. Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism. Exp. Neurol. 120 (1993) 89-94
    • (1993) Exp. Neurol. , vol.120 , pp. 89-94
    • Brouillet, E.T.1    Shinova, I.2    McGarvey, U.3    Hochberg, F.4    Beal, M.F.5
  • 7
    • 0042847323 scopus 로고    scopus 로고
    • Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric oxide synthase activation and cytotoxicity
    • Chen J., Wersinger C., and Sidhu A. Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastoma cells induces nitric oxide synthase activation and cytotoxicity. J. Biol. Chem. 278 (2003) 28089-28100
    • (2003) J. Biol. Chem. , vol.278 , pp. 28089-28100
    • Chen, J.1    Wersinger, C.2    Sidhu, A.3
  • 8
    • 0035116226 scopus 로고    scopus 로고
    • Dopaminergic cell death induced by MPP (+), oxidant and specific neurotoxicants shares the common molecular mechanism
    • Chun H.S., Gibson G.E., DeGiorgio L.A., Zhang H., Kidd V.J., and Son J.H. Dopaminergic cell death induced by MPP (+), oxidant and specific neurotoxicants shares the common molecular mechanism. J. Neurochem. 76 (2001) 1010-1021
    • (2001) J. Neurochem. , vol.76 , pp. 1010-1021
    • Chun, H.S.1    Gibson, G.E.2    DeGiorgio, L.A.3    Zhang, H.4    Kidd, V.J.5    Son, J.H.6
  • 9
    • 0034006478 scopus 로고    scopus 로고
    • Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo
    • Dehmer T., Lindenau J., Haid S., Dichgans J., and Schulz J.B. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J. Neurochem. 74 (2000) 2213-2216
    • (2000) J. Neurochem. , vol.74 , pp. 2213-2216
    • Dehmer, T.1    Lindenau, J.2    Haid, S.3    Dichgans, J.4    Schulz, J.B.5
  • 10
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with IKBα induction and block of NF-κB and iNOS activation
    • Dehmer T., Heneka M.T., Sastre M., Dichgans J., and Schulz J.B. Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with IKBα induction and block of NF-κB and iNOS activation. J. Neurochem. 88 (2004) 494-501
    • (2004) J. Neurochem. , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 12
    • 0038039186 scopus 로고    scopus 로고
    • Cyanide enhancement of dopamine-induced apoptosis in mesencephalon cells involves mitochondrial dysfunction and oxidative stress
    • Douglas C.J., Prabhakaran K., Li L., Gunasekar P.G., Shou Y., Borowitz J.L., and Isom G.E. Cyanide enhancement of dopamine-induced apoptosis in mesencephalon cells involves mitochondrial dysfunction and oxidative stress. Neurotoxicology 24 (2003) 333-342
    • (2003) Neurotoxicology , vol.24 , pp. 333-342
    • Douglas, C.J.1    Prabhakaran, K.2    Li, L.3    Gunasekar, P.G.4    Shou, Y.5    Borowitz, J.L.6    Isom, G.E.7
  • 13
    • 0040368216 scopus 로고    scopus 로고
    • Prospects for new restorative and neuroprotective treatments in Parkinson's disease
    • Dunnett S., and Bjorklund A. Prospects for new restorative and neuroprotective treatments in Parkinson's disease. Nature 399 (1999) A32-A39
    • (1999) Nature , vol.399
    • Dunnett, S.1    Bjorklund, A.2
  • 15
    • 0024578572 scopus 로고
    • Manganese catalysis of dopamine oxidation
    • Florence T.M., and Stauber J.L. Manganese catalysis of dopamine oxidation. Sci. Total Environ. 78 (1989) 233-240
    • (1989) Sci. Total Environ. , vol.78 , pp. 233-240
    • Florence, T.M.1    Stauber, J.L.2
  • 16
    • 0033002854 scopus 로고    scopus 로고
    • Manganese and calcium transport in mitochondria: implication for manganese toxicity
    • Gavin C.E., Gunter K.K., and Gunter T.E. Manganese and calcium transport in mitochondria: implication for manganese toxicity. Neurotoxicology 20 (1999) 445-454
    • (1999) Neurotoxicology , vol.20 , pp. 445-454
    • Gavin, C.E.1    Gunter, K.K.2    Gunter, T.E.3
  • 17
    • 0001228390 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh S., and Karim M. Missing pieces in the NF-κB puzzle. Cell 109 (2002) 881-896
    • (2002) Cell , vol.109 , pp. 881-896
    • Ghosh, S.1    Karim, M.2
  • 18
    • 0034485450 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase inhibitor has a neuroprotective effect in a rat model of brain injury
    • Gorlach C., Hortobagyi T., Hortobagyi S., and Benyo Z. Neuronal nitric oxide synthase inhibitor has a neuroprotective effect in a rat model of brain injury. Restor. Neurol. Neurosci. 17 (2000) 71-76
    • (2000) Restor. Neurol. Neurosci. , vol.17 , pp. 71-76
    • Gorlach, C.1    Hortobagyi, T.2    Hortobagyi, S.3    Benyo, Z.4
  • 19
    • 0028868773 scopus 로고
    • Monitoring intracellular nitric oxide formation by dichlorofluorescein in neuronal cells
    • Gunasekar P.G., Kanthasamy A.G., Borowitz J.L., and Isom G.E. Monitoring intracellular nitric oxide formation by dichlorofluorescein in neuronal cells. J. Neurosci. Methods 61 (1995) 15-21
    • (1995) J. Neurosci. Methods , vol.61 , pp. 15-21
    • Gunasekar, P.G.1    Kanthasamy, A.G.2    Borowitz, J.L.3    Isom, G.E.4
  • 20
    • 0035158938 scopus 로고    scopus 로고
    • Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells
    • Gunasekar P.G., Li L., Prabhakaran K., Ebyl V., Borowitz J.L., and Isom G.E. Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells. Toxicol. Sci. 64 (2001) 83-89
    • (2001) Toxicol. Sci. , vol.64 , pp. 83-89
    • Gunasekar, P.G.1    Li, L.2    Prabhakaran, K.3    Ebyl, V.4    Borowitz, J.L.5    Isom, G.E.6
  • 21
    • 43849084933 scopus 로고    scopus 로고
    • Dopamine modulation enhances manganese toxicity involving oxidative stress and inducible nitric oxide synthase: a key mechanism for cell death [abstract]
    • Gunasekar P.G., Prabhakaran K., and Ghosh D. Dopamine modulation enhances manganese toxicity involving oxidative stress and inducible nitric oxide synthase: a key mechanism for cell death [abstract]. Soc. Neurosci. 42 (2003) 91
    • (2003) Soc. Neurosci. , vol.42 , pp. 91
    • Gunasekar, P.G.1    Prabhakaran, K.2    Ghosh, D.3
  • 22
    • 0029933450 scopus 로고    scopus 로고
    • Role of oxidative stress in the neurotoxic effects of intrastriatal dopamine injections
    • Hastings T.G., Lewis D.A., and Zigmond M.J. Role of oxidative stress in the neurotoxic effects of intrastriatal dopamine injections. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 1056-1061
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1056-1061
    • Hastings, T.G.1    Lewis, D.A.2    Zigmond, M.J.3
  • 25
    • 0028003788 scopus 로고
    • Using psychological tests for the early detection of neurotoxic effects of low level manganese exposure
    • Iregren A. Using psychological tests for the early detection of neurotoxic effects of low level manganese exposure. Neurotoxicology 15 (1994) 671-677
    • (1994) Neurotoxicology , vol.15 , pp. 671-677
    • Iregren, A.1
  • 26
    • 0033002711 scopus 로고    scopus 로고
    • Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests
    • Iregren A. Manganese neurotoxicity in industrial exposures: proof of effects, critical exposure level, and sensitive tests. Neurotoxicology 20 (1999) 315-323
    • (1999) Neurotoxicology , vol.20 , pp. 315-323
    • Iregren, A.1
  • 27
    • 0028059308 scopus 로고
    • Oxidative damage in neurodegenerative disease
    • Jenner P. Oxidative damage in neurodegenerative disease. Lancet 344 (1994) 796-798
    • (1994) Lancet , vol.344 , pp. 796-798
    • Jenner, P.1
  • 28
    • 0037656051 scopus 로고    scopus 로고
    • Manganese: a high-octane disputes
    • Kaiser J. Manganese: a high-octane disputes. Science 300 (2003) 926-928
    • (2003) Science , vol.300 , pp. 926-928
    • Kaiser, J.1
  • 29
    • 0345104211 scopus 로고    scopus 로고
    • Molecular cloning and characterization of rat inducible nitric oxide synthase (iNOS) gene
    • Keinanen R., Vartianen N., and Koistinaho J. Molecular cloning and characterization of rat inducible nitric oxide synthase (iNOS) gene. Gene (Amst.) 234 (1999) 297-305
    • (1999) Gene (Amst.) , vol.234 , pp. 297-305
    • Keinanen, R.1    Vartianen, N.2    Koistinaho, J.3
  • 30
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 31
    • 0142090757 scopus 로고    scopus 로고
    • Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats
    • Lau Y.S., Petroske E., Meredith G.E., and Wang J.Q. Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats. Neuropharmacology 45 (2003) 986-994
    • (2003) Neuropharmacology , vol.45 , pp. 986-994
    • Lau, Y.S.1    Petroske, E.2    Meredith, G.E.3    Wang, J.Q.4
  • 32
    • 0034001229 scopus 로고    scopus 로고
    • Manganese intoxication
    • Lee J. Manganese intoxication. Arch. Neurol. 57 (2000) 597-599
    • (2000) Arch. Neurol. , vol.57 , pp. 597-599
    • Lee, J.1
  • 34
    • 0023737423 scopus 로고
    • Selective vulnerability of glutathione metabolism and cellular defense mechanism in rat striatum to Mn
    • Liccione J.J., and Maines M.D. Selective vulnerability of glutathione metabolism and cellular defense mechanism in rat striatum to Mn. J. Pharmacol. Exp. Ther. 247 (1988) 156-161
    • (1988) J. Pharmacol. Exp. Ther. , vol.247 , pp. 156-161
    • Liccione, J.J.1    Maines, M.D.2
  • 35
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron and dioxygen-their mutual interactions and possible implications in the development of Parkinson's disease
    • Linert W., Herlinger E., Jameson R.F., Kienzl E., Jellinger K., and Youdim M.B.H. Dopamine, 6-hydroxydopamine, iron and dioxygen-their mutual interactions and possible implications in the development of Parkinson's disease. Biochim. Biophys. Acta 1316 (1996) 160-168
    • (1996) Biochim. Biophys. Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3    Kienzl, E.4    Jellinger, K.5    Youdim, M.B.H.6
  • 37
    • 0031589730 scopus 로고    scopus 로고
    • Metabolic inhibition enhances selective toxicity of L-DOPA towards mesencephalic dopamine neurons in vitro
    • Nakao N., Nakai K., and Itakura T. Metabolic inhibition enhances selective toxicity of L-DOPA towards mesencephalic dopamine neurons in vitro. Brain Res. 777 (1997) 202-209
    • (1997) Brain Res. , vol.777 , pp. 202-209
    • Nakao, N.1    Nakai, K.2    Itakura, T.3
  • 38
    • 0035793684 scopus 로고    scopus 로고
    • NF-κB activation and IκBα dynamism involved in iNOS and chemokine induction in astroglial cells
    • Nomura Y. NF-κB activation and IκBα dynamism involved in iNOS and chemokine induction in astroglial cells. Life Sci. 68 (2001) 1695-1701
    • (2001) Life Sci. , vol.68 , pp. 1695-1701
    • Nomura, Y.1
  • 39
    • 0027344487 scopus 로고
    • Degeneration of dopaminergic neurons and free radicals. Possible participation of levodopa
    • Ogawa N., Edamastu R., Mizukawa K., Asanura M., Kohno M., and Mosi A. Degeneration of dopaminergic neurons and free radicals. Possible participation of levodopa. Adv. Neurol. 60 (1993) 242-256
    • (1993) Adv. Neurol. , vol.60 , pp. 242-256
    • Ogawa, N.1    Edamastu, R.2    Mizukawa, K.3    Asanura, M.4    Kohno, M.5    Mosi, A.6
  • 40
    • 0033002368 scopus 로고    scopus 로고
    • Manganese neurotoxicity: a review of clinical features, imaging and pathology
    • Pal K.P., Samii A., and Calne D.B. Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology 20 (1999) 227-238
    • (1999) Neurotoxicology , vol.20 , pp. 227-238
    • Pal, K.P.1    Samii, A.2    Calne, D.B.3
  • 42
    • 0031723859 scopus 로고    scopus 로고
    • Role of endogenous glutathione in the oxidation of dopamine
    • Rabinovich A.D., and Hastings T.G. Role of endogenous glutathione in the oxidation of dopamine. J. Neurochem. 71 (1998) 2071-2078
    • (1998) J. Neurochem. , vol.71 , pp. 2071-2078
    • Rabinovich, A.D.1    Hastings, T.G.2
  • 43
    • 0031840980 scopus 로고    scopus 로고
    • Role of transcription factors in inflammatory lung diseases
    • Rahman I., and MacNee W. Role of transcription factors in inflammatory lung diseases. Thorax 53 (1998) 601-612
    • (1998) Thorax , vol.53 , pp. 601-612
    • Rahman, I.1    MacNee, W.2
  • 44
    • 0037114383 scopus 로고    scopus 로고
    • Early activation of transcription factor, NF-κB following low-level Manganese exposure
    • Ramesh G.T., Ghosh D., and Gunasekar P.G. Early activation of transcription factor, NF-κB following low-level Manganese exposure. Toxcol. Lett. 136 (2002) 151-158
    • (2002) Toxcol. Lett. , vol.136 , pp. 151-158
    • Ramesh, G.T.1    Ghosh, D.2    Gunasekar, P.G.3
  • 45
    • 0031828219 scopus 로고    scopus 로고
    • Iron and manganese-catalyzed autoxidation of dopamine in the presence of l-cysteine: possible insights into iron and manganese-mediated dopaminergic neurotoxicity
    • Shen X.M., and Dryhurst G. Iron and manganese-catalyzed autoxidation of dopamine in the presence of l-cysteine: possible insights into iron and manganese-mediated dopaminergic neurotoxicity. Chem. Res. Toxicol. 11 (1998) 824-837
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 824-837
    • Shen, X.M.1    Dryhurst, G.2
  • 46
    • 0032585055 scopus 로고    scopus 로고
    • Enhancement of cytotoxicity and clastogenicity of L-DOPA and dopamine by manganese and copper
    • Snyder R.D., and Friedman M.B. Enhancement of cytotoxicity and clastogenicity of L-DOPA and dopamine by manganese and copper. Mutat. Res. 405 (1998) 1-8
    • (1998) Mutat. Res. , vol.405 , pp. 1-8
    • Snyder, R.D.1    Friedman, M.B.2
  • 47
    • 0027235477 scopus 로고
    • Free radical and lipid peroxidation in manganese-induced neuronal injury
    • Sun A.Y., Yang W.L., and Kim H.D. Free radical and lipid peroxidation in manganese-induced neuronal injury. Ann. NY Acad. Sci. 679 (1993) 358-363
    • (1993) Ann. NY Acad. Sci. , vol.679 , pp. 358-363
    • Sun, A.Y.1    Yang, W.L.2    Kim, H.D.3
  • 48
    • 43849089969 scopus 로고    scopus 로고
    • USCENTCOM Enhanced Particulate Matter Surveillance Sampling Protocol, U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), through October 1, 2006.
    • USCENTCOM Enhanced Particulate Matter Surveillance Sampling Protocol, U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM), through October 1, 2006.
  • 49
    • 0000191753 scopus 로고
    • Lactate dehydrogenase
    • Bergemeyer H. (Ed), Verlag Chemie, Weinheim
    • Vassault S.A. Lactate dehydrogenase. In: Bergemeyer H. (Ed). Methods of Enzyme Analysis vol. 13 (1983), Verlag Chemie, Weinheim 118-133
    • (1983) Methods of Enzyme Analysis , vol.13 , pp. 118-133
    • Vassault, S.A.1
  • 50
    • 0032171420 scopus 로고    scopus 로고
    • Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide
    • Wink D.A., and Mitchell J.B. Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radic. Biol. Med. 25 (1998) 434-456
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 434-456
    • Wink, D.A.1    Mitchell, J.B.2
  • 51
    • 0028097287 scopus 로고
    • Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity
    • Xia Q.W., Cho H., Kashiwabara Y., Baum M., Weidner J.R., Elliston K., Mumford R., and Nathan C. Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity. J. Biol. Chem. 269 (1994) 28500-28505
    • (1994) J. Biol. Chem. , vol.269 , pp. 28500-28505
    • Xia, Q.W.1    Cho, H.2    Kashiwabara, Y.3    Baum, M.4    Weidner, J.R.5    Elliston, K.6    Mumford, R.7    Nathan, C.8
  • 52
    • 0029550090 scopus 로고
    • Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockers
    • Zeevalk G.D., Derr-Yellin E., and Nicklas W.J. Relative vulnerability of dopamine and GABA neurons in mesencephalic culture to inhibition of succinate dehydrogenase by malonate and 3-nitropropionic acid and protection by NMDA receptor blockers. J. Pharmacol. Exp. Ther. 275 (1995) 1124-1130
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 1124-1130
    • Zeevalk, G.D.1    Derr-Yellin, E.2    Nicklas, W.J.3
  • 53
    • 0026784401 scopus 로고
    • Neurochemical response to 6-hydroxy-dopamine and L-DOPA therapy: implications in Parkinson's disease
    • Zigmond M.J., Hastings T.G., and Abercromie E.D. Neurochemical response to 6-hydroxy-dopamine and L-DOPA therapy: implications in Parkinson's disease. Ann. NY Acad. Sci. 648 (1992) 71-86
    • (1992) Ann. NY Acad. Sci. , vol.648 , pp. 71-86
    • Zigmond, M.J.1    Hastings, T.G.2    Abercromie, E.D.3


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