Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

Journal of Neurochemistry

Volumn 77, Issue 2, 2001, Pages 519-529

  Paris, Irmgard ^a   Dagnino Subiabre, Alexies ^a   Marcelain, Katherine ^a   Bennett, Lori B ^a   Caviedes, Pablo ^a,b   Caviedes, Raúl ^d   Azar, Claudio Olea ^c   Segura Aguilar, Juan ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b SANSUM DIABETES RESEARCH INSTITUTE   (United States)

^c Laboratory of Neurosciences   (Chile)

^d NONE

Author keywords

Aminochrome; Copper; Dopamine; DT diaphorase; Free radicals; Quinones

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; AMINOCHROME; CATALASE; CHROMIUM DERIVATIVE; COPPER; COPPER SULFATE; COPPER ZINC SUPEROXIDE DISMUTASE; DICOUMAROL; DOPAMINE RECEPTOR; GLUTATHIONE PEROXIDASE; MESSENGER RNA; NOMIFENSINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; COPPER METABOLISM; DRUG OXIDATION; DRUG POTENTIATION; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME REGULATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SPIN TRAPPING;

ANIMALS; CATALASE; CELL LINE; COPPER SULFATE; DICUMAROL; DOPAMINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INDUCTION; GLUTATHIONE PEROXIDASE; INDOLEQUINONES; INDOLES; ION TRANSPORT; METALLOTHIONEIN; NAD(P)H DEHYDROGENASE (QUINONE); NEURONS; NOMIFENSINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARKINSON DISEASE; RATS; RNA, MESSENGER; SUBSTANTIA NIGRA; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0035052491     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00243.x     Document Type: Article

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