Molecular dynamics simulations and elastic network analysis of protein kinase B (Akt/PKB) inactivation

Journal of Chemical Information and Modeling

Volumn 50, Issue 9, 2010, Pages 1602-1610

  Cheng, Shu ^a   Niv, Masha Y ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CELL SIGNALING; COMPLEX NETWORKS; LIGANDS; MOLECULAR DYNAMICS; PHOSPHORYLATION; PROTONATION; TRAJECTORIES;

COMPUTATIONAL STUDIES; CONFORMATIONAL CHANGE; CRYSTALLOGRAPHIC STRUCTURE; ELASTIC NETWORK MODELS; MOLECULAR DYNAMICS SIMULATIONS; NORMAL MODE ANALYSIS; NUMBER OF PRINCIPAL COMPONENTS; PROTEIN KINASE B (AKT/PKB);

ENZYMES;

ENZYME INHIBITOR; PROTEIN KINASE B;

ARTICLE; DRUG ANTAGONISM; ENZYME ACTIVE SITE; METABOLISM; MOLECULAR DYNAMICS; PHOSPHORYLATION; PRINCIPAL COMPONENT ANALYSIS; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MOLECULAR DYNAMICS SIMULATION; PHOSPHORYLATION; PRINCIPAL COMPONENT ANALYSIS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 77957241496     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci100076j     Document Type: Article

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