Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: The significance of backbone interactions

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 8, 2010, Pages 2976-2985

  Tal Gan, Yftah ^a   Freeman, Noam S ^a   Klein, Shoshana ^a   Levitzki, Alexander ^a   Gilon, Chaim ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

N Methylation; Peptidomimetics; Peptoid; PKB Akt; Solid phase peptide synthesis

Indexed keywords

PEPTIDOMIMETIC AGENT; PROTEIN KINASE B INHIBITOR; PTR 6154; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; OLIGOPEPTIDES; PEPTOIDS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77950517649     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.02.031     Document Type: Article

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