Inflammation, a link between obesity and cardiovascular disease

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Nakayama, Tomohiro ^a   Wang, Zhaoxia ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AMYLOID A PROTEIN; APELIN; C REACTIVE PROTEIN; CHEMERIN; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OMENTIN; RESISTIN; RETINOIC ACID RECEPTOR; RETINOL BINDING PROTEIN 4; SECRETORY PROTEIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VASPIN; SERUM AMYLOID A;

ATHEROSCLEROSIS; BODY FAT DISTRIBUTION; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; GENDER; HUMAN; INFLAMMATION; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVIEW; ANIMAL; ARTICLE; IMMUNOLOGY; METABOLISM;

ADIPONECTIN; ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; INFLAMMATION; LEPTIN; OBESITY; RESISTIN; SERUM AMYLOID A PROTEIN;

EID: 77956869772     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/535918     Document Type: Review

References (215)

1. Sowers J. R., Obesity as a cardiovascular risk factor The American Journal of Medicine 2003 115 8 37 41
2. The World Health Report 2002, Reducing Risks, Promoting Healthy Life 2002 Geneva, Switzerland World Health Organization
3. Aoi N., Soma M., Nakayama T., Rahmutula D., Kosuge K., Izumi Y., Matsumoto K., Variable number of tandem repeat of the 5′ -flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension Hypertension Research 2004 27 10 711 716
4. Kosuge K., Soma M., Nakayama T., Aoi N., Sato M., Haketa A., Uwabo J., Izumi Y., Matsumoto K., Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese Endocrine 2008 34 13 87 95
5. Strohacker K., McFarlin B. K., Influence of obesity, physical inactivity, and weight cycling on chronic inflammation Frontiers in Bioscience 2010 2 98 104
6. Williams K. J., Tabas I., The response-to-retention hypothesis of atherogenesis reinforced Current Opinion in Lipidology 1998 9 5 471 474
7. Williams K. J., Tabas I., Lipoprotein retention- and clues for atheroma regression Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 8 1536 1540
8. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman J. M., Positional cloning of the mouse obese gene and its human homologue Nature 1994 372 6505 425 432
9. Attie A. D., Scherer P. E., Adipocyte metabolism and obesity Journal of Lipid Research 2009 50 supplement S395 S399
10. DeClercq V., Taylor C., Zahradka P., Adipose tissue: the link between obesity and cardiovascular disease Cardiovascular Hematological Disorders Drug Targets 2008 8 3 228 237
11. Fattah C., Farah N., Barry S., O'Connor N., Stuart B., Turner M. J., The measurement of maternal adiposity Journal of Obstetrics and Gynaecology 2009 29 8 686 689
12. Sweeting H. N., Measurement and definitions of obesity in childhood and adolescence: a field guide for the uninitiated Nutrition Journal 2007 6, article 32
13. Zamboni M., Turcato E., Armellini F., Kahn H. S., Zivelonghi A., Santana H., Bergamo-Andreis I.A., Bosello O., Sagittal abdominal diameter as a practical predictor of visceral fat International Journal of Obesity 1998 22 7 655 660
14. Kahn H. S., Choosing an index for abdominal obesity: an opportunity for epidemiologic clarification Journal of Clinical Epidemiology 1993 46 5 491 494
15. Rajala M. W., Scherer P. E., Minireview: the adipocyteat the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 2003 144 9 3765 3773
16. Rodrguez A., Cataln V., Gmez-Ambrosi J., Frhbeck G., Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Current Pharmaceutical Design 2007 13 21 2169 2175
17. Bjorntorp P., The regulation of adipose tissue distribution in humans International Journal of Obesity 1996 20 4 291 302
18. Stevens J., Katz E. G., Huxley R. R., Associations between gender, age and waist circumference European Journal of Clinical Nutrition 2010 64 1 6 15
19. Geer E. B., Shen W., Gender differences in insulin resistance, body composition, and energy balance Gender Medicine 2009 6 1 60 75
20. Canoy D., Distribution of body fat and risk of coronary heart disease in men and women Current Opinion in Cardiology 2008 23 6 591 598
21. Samad F., Yamamoto K., Pandey M., Loskutoff D. J., Elevated expression of transforming growth factor- in adipose tissue from obese mice Molecular Medicine 1997 3 1 37 48
22. Fried S. K., Bunkin D. A., Greenberg A. S., Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid The Journal of Clinical Endocrinology Metabolism 1998 83 3 847 850
23. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W. Jr., Obesity is associated with macrophage accumulation in adipose tissue The Journal of Clinical Investigation 2003 112 12 1796 1808
24. Cinti S., Mitchell G., Barbatelli G., Murano I., Ceresi E., Faloia E., Wang S., Fortier M., Greenberg A. S., Obin M. S., Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Journal of Lipid Research 2005 46 11 2347 2355
25. hman M. K., Shen Y., Obimba C. I., Wright A. P., Warnock M., Lawrence D. A., Eitzman D. T., Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice Circulation 2008 117 6 798 805
26. Tarakiolu M., Erbaci A. B., Usalan C., Deveci R., Kocaba R., Acute effect of hemodialysis on serum levels of the proinflammatory cytokines Mediators of Inflammation 2003 12 1 15 19
27. Johnston T. P., Li Y., Jamal A. S., Stechschulte D. J., Dileepan K. N., Poloxamer 407-induced atherosclerosis in mice appears to be due to lipid derangements and not due to its direct effects on endothelial cells and macrophages Mediators of Inflammation 2003 12 3 147 155
28. Karlsson C., Lindell K., Ottosson M., Sjstrm L., Carlsson B., Carlsson L. M. S., Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II The Journal of Clinical Endocrinology Metabolism 1998 83 11 3925 3929
29. Frhbeck G., The adipose tissue as a source of vasoactive factors Current Medicinal Chemistry: Cardiovascular and Hematological Agents 2004 2 3 197 208
30. Wee C. C., Mukamal K. J., Huang A., Davis R. B., McCarthy E. P., Mittleman M. A., Obesity and C-reactive protein levels among white, black, and hispanic US adults Obesity 2008 16 4 875 880
31. Keaney J. F. Jr., Larson M. G., Vasan R. S., Wilson P. W. F., Lipinska I., Corey D., Massaro J. M., Sutherland P., Vita J. A., Benjamin E. J., Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 3 434 439
32. Ryo M., Nakamura T., Kihara S., Kumada M., Shibazaki S., Takahashi M., Nagai M., Matsuzawa Y., Funahashi T., Adiponectin as a biomarker of the metabolic syndrome Circulation Journal 2004 68 11 975 981
33. Yudkin J. S., Kumari M., Humphries S. E., Mohamed-Ali V., Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000 148 2 209 214
34. Hayaishi-Okano R., Yamasaki Y., Katakami N., Ohtoshi K., Gorogawa S.-I., Kuroda A., Matsuhisa M., Kosugi K., Nishikawa N., Kajimoto Y., Hori M., Elevated C-reactive protein associates with early-stage carotid atherosclerosis in young subjects with type 1 diabetes Diabetes Care 2002 25 8 1432 1438
35. Sigurdardottir V., Fagerberg B., Hulthe J., Preclinical atherosclerosis and inflammation in 61-year-old men with newly diagnosed diabetes and established diabetes Diabetes Care 2004 27 4 880 884
36. Saremi A., Anderson R. J., Luo P., Moritz T. E., Schwenke D. C., Allison M., Reaven P. D., Association between IL-6 and the extent of coronary atherosclerosis in the veterans affairs diabetes trial (VADT) Atherosclerosis 2009 203 2 610 614
37. Katakami N., Kaneto H., Matsuhisa M., Miyatsuka T., Sakamoto K., Kawamori D., Yoshiuchi K., Nakamura Y., Kato K., Yamamoto K., Kosugi K., Hori M., Yamasaki Y., Association of soluble CD40 ligand with carotid atherosclerosis in Japanese type 1 diabetic patients Diabetologia 2006 49 7 1670 1676
38. Reilly M. P., Iqbal N., Schutta M., Wolfe M. L., Scally M., Localio A. R., Rader D. J., Kimmel S. E., Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes The Journal of Clinical Endocrinology Metabolism 2004 89 8 3872 3878
39. Pepys M. B., Hirschfield G. M., C-reactive protein: a critical update The Journal of Clinical Investigation 2003 111 12 1805 1812
40. van der Zee P. M., Bir E., Trouw L. A., Ko Y., de Winter R. J., Hack C. E., Sturk A., Nieuwland R., C-reactive protein in myocardial infarction binds to circulating microparticles but is not associated with complement activation Clinical Immunology 2010 135 3 490 495
41. Kaptoge S., Angelantonio E. D., Lowe G., C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis The Lancet 2010 375 9709 132 140
42. Momiyama Y., Ohmori R., Fayad Z. A., Kihara T., Tanaka N., Kato R., Taniguchi H., Nagata M., Nakamura H., Ohsuzu F., Associations between plasma C-reactive protein levels and the severities of coronary and aortic atherosclerosis Journal of Atherosclerosis and Thrombosis 2010 17 5 460 467
43. Ouchi N., Kihara S., Funahashi T., Nakamura T., Nishida M., Kumada M., Okamoto Y., Ohashi K., Nagaretani H., Kishida K., Nishizawa H., Maeda N., Kobayashi H., Hiraoka H., Matsuzawa Y., Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue Circulation 2003 107 5 671 674
44. Esposito K., Pontillo A., Di Palo C., Giugliano G., Masella M., Marfella R., Giugliano D., Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial Journal of the American Medical Association 2003 289 14 1799 1804
45. Esposito K., Marfella R., Ciotola M., Di Palo C., Giugliano F., Giugliano G., D'Armiento M., D'Andrea F., Giugliano D., Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial Journal of the American Medical Association 2004 292 12 1440 1446
46. Okita K., Nishijima H., Murakami T., Nagai T., Morita N., Yonezawa K., Iizuka K., Kawaguchi H., Kitabatake A., Can exercise training with weight loss lower serum C-reactive protein levels? Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 10 1868 1873
47. Donges C. E., Duffield R., Drinkwater E. J., Effects of resistance or aerobic exercise training on interleukin-6, C-reactive protein, and body composition Medicine and Science in Sports and Exercise 2010 42 2 304 313
48. Mann J. J., Payne J. R., Shah T., Pennell D. J., Humphries S. E., Montgomery H. E., C-reactive protein gene variant and the human left ventricular growth response to exercise: data from the LARGE heart study Journal of Cardiovascular Pharmacology 2010 55 1 26 29
49. Malle E., de Beer F. C., Human serum amyloid A (SAA) protein: a prominent acute-phase reactant for clinical practice European Journal of Clinical Investigation 1996 26 6 427 435
50. Gabay C., Kushner I., Acute-phase proteins and other systemic responses to inflammation The New England Journal of Medicine 1999 340 6 448 454
51. Yamada T., Inflammatory markers; C-reactive protein (CRP) and serum amyloid A (SAA) Rinsho Byori 2005 53 6 558 561
52. Poitou C., Viguerie N., Cancello R., De Matteis R., Cinti S., Stich V., Coussieu C., Gauthier E., Courtine M., Zucker J. D., Barsh G. S., Saris W., Bruneval P., Basdevant A., Langin D., Clment K., Serum amyloid A: production by human white adipocyte and regulation by obesity and nutrition Diabetologia 2005 48 3 519 528
53. Kisilevsky R., Tam S.-P., Acute phase serum amyloid A, cholesterol metabolism, and cardiovascular disease Pediatric Pathology Molecular Medicine 2002 21 3 291 305
54. Libby P., Ridker P. M., Novel inflammatory markers of coronary risk: theory versus practice Circulation 1999 100 11 1148 1150
55. Zhao Y., He X., Shi X., Huang C., Liu J., Zhou S., Heng C.-K., Association between serum amyloid A and obesity: a meta-analysis and systematic review Inflammation Research 2010 59 5 323 334
56. Danesh J., Muir J., Wong Y.-K., Ward M., Gallimore J. R., Pepys M. B., Risk factors for coronary heart disease and acute-phase proteins. A population-based study European Heart Journal 1999 20 13 954 959
57. Jylhv J., Haarala A., Eklund C., Pertovaara M., Khnen M., Hutri-Khnen N., Levula M., Lehtimki T., Huupponen R., Jula A., Juonala M., Viikari J., Raitakari O., Hurme M., Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study Journal of Internal Medicine 2009 266 3 286 295
58. Gmez-Ambrosi J., Azcona C., Patio-Garca A., Frhbeck G., Serum amyloid A concentration is increased in obese children and adolescents Journal of Pediatrics 2008 153 1 71 75
59. Kotani K., Satoh N., Kato Y., Araki R., Koyama K., Okajima T., Tanabe M., Oishi M., Yamakage H., Yamada K., Hattori M., Shimatsu A., A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome Atherosclerosis 2009 204 2 526 531
60. Johnson B. D., Kip K. E., Marroquin O. C., Ridker P. M., Kelsey S. F., Shaw L. J., Pepine C. J., Sharaf B., Bairey Merz C. N., Sopko G., Olson M. B., Reis S. E., Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Circulation 2004 109 6 726 732
61. Kosuge M., Ebina T., Ishikawa T., Hibi K., Tsukahara K., Okuda J., Iwahashi N., Ozaki H., Yano H., Kusama I., Nakati T., Umemura S., Kimura K., Serum amyloid A is a better predictor of clinical outcomes than C-reactive protein in non-ST-segment elevation acute coronary syndromes Circulation Journal 2007 71 2 186 190
62. Ridker P. M., Hennekens C. H., Buring J. E., Rifai N., C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women The New England Journal of Medicine 2000 342 12 836 843 (Pubitemid 30165206)
63. Hatanaka E., Monteagudo P. T., Marrocos M. S. M., Campa A., Interaction between serum amyloid A and leukocytesa possible role in the progression of vascular complications in diabetes Immunology Letters 2007 108 2 160 166
64. Yang R. Z., Lee M. J., Hu H., Pollin T. I., Ryan A. S., Nicklas B. J., Snitker S., Horenstein R. B., Hull K., Goldberg N. H., Goldberg A. P., Shuldiner A. R., Fried S. K., Gong D. W., Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications PLoS Medicine 2006 3 6, article e287
65. Wilson P. G., Thompson J. C., Webb N. R., de Beer F. C., King V. L., Tannock L. R., Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner American Journal of Pathology 2008 173 6 1902 1910
66. Song C., Shen Y., Yamen E., Hsu K., Yan W., Witting P. K., Geczy C. L., Freedman S. B., Serum amyloid A may potentiate prothrombotic and proinflammatory events in acute coronary syndromes Atherosclerosis 2009 202 2 596 604
67. Poitou C., Divoux A., Faty A., Tordjman J., Hugol D., Aissat A., Keophiphath M., Henegar C., Commans S., Clment K., Role of serum amyloid A in adipocyte-macrophage cross talk and adipocyte cholesterol efflux The Journal of Clinical Endocrinology Metabolism 2009 94 5 1810 1817
68. Brea D., Sobrino T., Blanco M., Fraga M., Agulla J., Rodrguez-Yez M., Rodrguez-Gonzlez R., Prez de la Ossa N., Leira R., Forteza J., Dvalos A., Castillo J., Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation Atherosclerosis 2009 205 2 561 567
69. Uurtuya S., Kotani K., Koibuchi H., Taniguchi N., Yamada T., Serum amyloid A protein and carotid intima-media thickness in healthy young subjects Journal of Atherosclerosis and Thrombosis 2009 16 3 299 300
70. Carty C. L., Heagerty P., Heckbert S. R., Enquobahrie D. A., Jarvik G. P., Davis S., Tracy R. P., Reiner A. P., Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1 and TNF genes in the Cardiovascular Health Study Journal of Atherosclerosis and Thrombosis 2009 16 4 419 430
71. O'Brien K. D., Chait A., Serum amyloid A: the other inflammatory protein Current Atherosclerosis Reports 2006 8 1 62 68
72. Ley S. H., Harris S. B., Connelly P. W., Mamakeesick M., Gittelsohn J., Hegele R. A., Retnakaran R., Zinman B., Hanley A. J. G., Adipokines and incident type 2 diabetes in an aboriginal Canadian population: the Sandy Lake Health and Diabetes Project Diabetes Care 2008 31 7 1410 1415
73. Samaras K., Botelho N. K., Chisholm D. J., Lord R. V., Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes Obesity 2010 18 5 884 889
74. Ye X. Y., Xue Y. M., Sha J. P., Li C. Z., Zhen Z. J., Serum amyloid A attenuates cellular insulin sensitivity by increasing JNK activity in 3T3-L1 adipocytes Journal of Endocrinological Investigation 2009 32 7 568 575
75. Halaas J. L., Gajiwala K. S., Maffei M., Cohen S. L., Chait B. T., Rabinowitz D., Lallone R. L., Burley S. K., Friedman J. M., Weight-reducing effects of the plasma protein encoded by the obese gene Science 1995 269 5223 543 546
76. Badman M. K., Flier J. S., The adipocyte as an active participant in energy balance and metabolism Gastroenterology 2007 132 6 2103 2115
77. Guo K., McMinn J. E., Ludwig T., Yu Y.-H., Yang G., Chen L., Loh D., Li C., Chua S. Jr., Zhang Y., Disruption of peripheral leptin signaling in mice results in hyperleptinemia without associated metabolic abnormalities Endocrinology 2007 148 8 3987 3997
78. Pelleymounter M. A., Cullen M. J., Baker M. B., Hecht R., Winters D., Boone T., Collins F., Effects of the obese gene product on body weight regulation in ob/ob mice Science 1995 269 5223 540 543
79. Farooqi I. S., Matarese G., Lord G. M., Keogh J. M., Lawrence E., Agwu C., Sanna V., Jebb S. A., Perna F., Fontana S., Lechler R. I., Depaoli A. M., O'Rahilly S., Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency The Journal of Clinical Investigation 2002 110 8 1093 1103
80. Oral E. A., Simha V., Ruiz E., Andewelt A., Premkumar A., Snell P., Wagner A. J., DePaoli A. M., Reitman M. L., Taylor S. I., Gorden P., Garg A., Leptin-replacement therapy for lipodystrophy The New England Journal of Medicine 2002 346 8 570 578
81. Luo J. D., Zhang G. S., Chen M. S., Leptin and cardiovascular diseases Timely Topic in Medicine, Cardiovascular Diseases 2005 9 E34
82. Schwartz M. W., Woods S. C., Porte D. Jr., Seeley R. J., Baskin D. G., Central nervous system control of food intake Nature 2000 404 6778 661 671
83. Flier J. S., Obesity wars: molecular progress confronts an expanding epidemic Cell 2004 116 2 337 350
84. Buettner C., Muse E. D., Cheng A., Chen L., Scherer T., Pocai A., Su K., Cheng B., Li X., Harvey-White J., Schwartz G. J., Kunos G., Rossetti L., Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms Nature Medicine 2008 14 6 667 675
85. Blher S., Mantzoros C. S., Leptin in humans: lessons from translational research American Journal of Clinical Nutrition 2009 89 3 991S 997S
86. Ozcan L., Ergin A. S., Lu A., Chung J., Sarkar S., Nie D., Myers M. G. Jr., Ozcan U., Endoplasmic reticulum stress plays a central role in development of leptin resistance Cell Metabolism 2009 9 1 35 51
87. Rosenbaum M., Sy M., Pavlovich K., Leibel R. L., Hirsch J., Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli The Journal of Clinical Investigation 2008 118 7 2583 2591
88. Farooqi I. S., Bullmore E., Keogh J., Gillard J., O'Rahilly S., Fletcher P. C., Leptin regulates striatal regions and human eating behavior Science 2007 317 5843 1355
89. Ahima R. S., Revisiting leptin's role in obesity and weight loss The Journal of Clinical Investigation 2008 118 7 2380 2383
90. Sweeney G., Cardiovascular effects of leptin Nature Reviews Cardiology 2010 7 1 22 29
91. Brennan A. M., Li T. Y., Kelesidis I., Gavrila A., Hu F. B., Mantzoros C. S., Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study Diabetologia 2007 50 6 1178 1185
92. Welsh P., Murray H. M., Buckley B. M., De Craen A. J. M., Ford I., Jukema J. W., Macfarlane P. W., Packard C. J., Stott D. J., Westendorp R. G. J., Shepherd J., Sattar N., Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population Diabetes Care 2009 32 2 308 310
93. Karakas M., Zierer A., Herder C., Baumert J., Meisinger C., Koenig W., Thorand B., Leptin, adiponectin, their ratio and risk of coronary heart disease: results from the MONICA/KORA Augsburg Study 19842002 Atherosclerosis 2010 209 1 220 225
94. Singh P., Peterson T. E., Barber K. R., Kuniyoshi F. S., Jensen A., Hoffmann M., Shamsuzzaman A. S.M., Somers V. K., Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells Biochemical and Biophysical Research Communications 2010 392 1 47 52
95. Hongo S., Watanabe T., Arita S., Kanome T., Kageyama H., Shioda S., Miyazaki A., Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages American Journal of Physiology 2009 297 2 E474 E482
96. Vecchione C., Maffei A., Colella S., Aretini A., Poulet R., Frati G., Gentile M. T., Fratta L., Trimarco V., Trimarco B., Lembo G., Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway Diabetes 2002 51 1 168 173
97. Rodrguez A., Fortuo A., Gmez-Ambrosi J., Zalba G., Dez J., Frhbeck G., The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism Endocrinology 2007 148 1 324 331
98. Bigalke B., Stellos K., Geisler T., Seizer P., Mozes V., Gawaz M., High plasma levels of adipocytokines are associated with platelet activation in patients with coronary artery disease Platelets 2010 21 1 11 19
99. Fisher A. A., Goh S. L., Srikusalankul W., Southcott E. N., Davis M. W., Serum leptin levels in older patients with hip fractureimpact on peri-operative myocardial injury The American Heart Hospital Journal 2009 7 1 9 16
100. Mcgaffin K. R., Zou B., McTiernan C. F., O'Donnell C. P., Leptin attenuates cardiac apoptosis after chronic ischaemic injury Cardiovascular Research 2009 83 2 313 324
101. Schober A., Weber C., Editorial: leptin and EPCs in arterial injury: yes, we can! Circulation Research 2008 103 5 447 449
102. Hasty A. H., Shimano H., Osuga J.-I., Namatame I., Takahashi A., Yahagi N., Perrey S., Iizuka Y., Tamura Y., Amemiya-Kudo M., Yoshikawa T., Okazaki H., Ohashi K., Harada K., Matsuzaka T., Sone H., Gotoda T., Nagai R., Ishibashi S., Yamada N., Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor The Journal of Biological Chemistry 2001 276 40 37402 37408
103. Wallace A. M., McMahon A. D., Packard C. J., Kelly A., Shepherd J., Gaw A., Sattar N., Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS) Circulation 2001 104 25 3052 3056
104. Matsuzawa Y., Funahashi T., Kihara S., Shimomura I., Adiponectin and metabolic syndrome Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 1 29 33
105. Bobbert T., Rochlitz H., Wegewitz U., Akpulat S., Mai K., Weickert M. O., Mhlig M., Pfeiffer A. F. H., Spranger J., Changes of adiponectin oligomer composition by moderate weight reduction Diabetes 2005 54 9 2712 2719
106. Capeau J., The story of adiponectin and its receptors AdipoR1 and R2: to follow Journal of Hepatology 2007 47 5 736 738
107. Yamauchi T., Nio Y., Maki T., Kobayashi M., Takazawa T., Iwabu M., Okada-Iwabu M., Kawamoto S., Kubota N., Kubota T., Ito Y., Kamon J., Tsuchida A., Kumagai K., Kozono H., Hada Y., Ogata H., Tokuyama K., Tsunoda M., Ide T., Murakami K., Awazawa M., Takamoto I., Froguel P., Hara K., Tobe K., Nagai R., Ueki K., Kadowaki T., Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions Nature Medicine 2007 13 3 332 339
108. Hansen T., Ahlstrm H., Sderberg S., Hulthe J., Wikstrm J., Lind L., Johansson L., Visceral adipose tissue, adiponectin levels and insulin resistance are related to atherosclerosis as assessed by whole-body magnetic resonance angiography in an elderly population Atherosclerosis 2009 205 1 163 167
109. Tilg H., Hotamisligil G. S., Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance Gastroenterology 2006 131 3 934 945
110. Stofkova A., Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity Endocrine Regulations 2009 43 4 157 168
111. Bauche I. B., El Mkadem S. A., Pottier A.-M., Senou M., Many M.-C., Rezsohazy R., Penicaud L., Maeda N., Funahashi T., Brichard S. M., Overexpression of adiponectin targeted to adipose tissue in transgenic mice: impaired adipocyte differentiation Endocrinology 2007 148 4 1539 1549
112. Otabe S., Yuan X., Fukutani T., Wada N., Hashinaga T., Nakayama H., Hirota N., Kojima M., Yamada K., Overexpression of human adiponectin in transgenic mice results in suppression of fat accumulation and prevention of premature death by high-calorie diet American Journal of Physiology 2007 293 1 E210 E218
113. Qiao L., Zou C., van der Westhuyzen D. R., Shao J., Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism Diabetes 2008 57 7 1824 1833
114. Deng G., Long Y., Yu Y.-R., Li M.-R., Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway International Journal of Obesity 2010 34 1 165 171
115. Ran J., Xiong X., Liu W., Guo S., Li Q., Zhang R., Lao G., Increased plasma adiponectin closely associates with vascular endothelial dysfunction in type 2 diabetic patients with diabetic nephropathy Diabetes Research and Clinical Practice 2010 88 2 177 183
116. Pea A. S., Belobrajdic D. P., Wiltshire E., Gent R., Hirte C., Couper J., Adiponectin relates to smooth muscle function and folate in obese children International Journal of Pediatric Obesity 2010 5 2 185 191
117. Ohashi K., Parker J. L., Ouchi N., Higuchi A., Vita J. A., Gokce N., Pedersen A. A., Kalthoff C., Tullin S., Sams A., Summer R., Walsh K., Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype The Journal of Biological Chemistry 2010 285 9 6153 6160
118. Ouchi N., Walsh K., Adiponectin as an anti-inflammatory factor Clinica Chimica Acta 2007 380 1-2 24 30
119. Beauloye V., Zech F., Mong H. T. T., Clapuyt P., Maes M., Brichard S. M., Determinants of early atherosclerosis in obese children and adolescents The Journal of Clinical Endocrinology Metabolism 2007 92 8 3025 3032
120. Sattar N., Wannamethee G., Sarwar N., Tchernova J., Cherry L., Wallace A. M., Danesh J., Whincup P. H., Adiponectin and coronary heart disease: a prospective study and meta-analysis Circulation 2006 114 7 623 629
121. Ouedraogo R., Gong Y., Berzins B., Wu X., Mahadev K., Hough K., Chan L., Goldstein B. J., Scalia R., Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo The Journal of Clinical Investigation 2007 117 6 1718 1726
122. Maahs D. M., Ogden L. G., Kinney G. L., Wadwa P., Snell-Bergeon J. K., Dabelea D., Hokanson J. E., Ehrlich J., Eckel R. H., Rewers M., Low plasma adiponectin levels predict progression of coronary artery calcification Circulation 2005 111 6 747 753
123. Fargnoli J. L., Sun Q., Olenczuk D., Qi L., Zhu Y., Hu F. B., Mantzoros C. S., Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function European Journal of Endocrinology 2010 162 2 281 288
124. Calabro P., Chang D. W., Willerson J. T., Yeh E. T. H., Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation Journal of the American College of Cardiology 2005 46 6 1112 1113
125. Steppan C. M., Bailey S. T., Bhat S., Brown E. J., Banerjee R. R., Wright C. M., Patel H. R., Ahima R. S., Lazar M. A., The hormone resistin links obesity to diabetes Nature 2001 409 6818 307 312
126. Kunnari A. M., Savolainen E.-R., Ukkola O. H., Kesniemi Y. A., Jokela M. A., The expression of human resistin in different leucocyte lineages is modulated by LPS and TNF Regulatory Peptides 2009 157 13 57 63
127. Manduteanu I., Pirvulescu M., Gan A. M., Stan D., Simion V., Dragomir E., Calin M., Manea A., Simionescu M., Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells Biochemical and Biophysical Research Communications 2010 391 3 1443 1448
128. Yang R.-Z., Huang Q., Xu A., McLenithan J. C., Eison J. A., Shuldiner A. R., Alkan S., Gong D.-W., Comparative studies of resistin expression and phylogenomics in human and mouse Biochemical and Biophysical Research Communications 2003 310 3 927 935
129. Verma S., Li S.-H., Wang C.-H., Fedak P. W. M., Li R.-K., Weisel R. D., Mickle D. A. G., Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction Circulation 2003 108 6 736 740
130. Calabro P., Samudio I., Willerson J. T., Yeh E. T. H., Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways Circulation 2004 110 21 3335 3340
131. Banerjee R. R., Rangwala S. M., Shapiro J. S., Rich A. S., Rhoades B., Qi Y., Wang J., Rajala M. W., Pocai A., Scherer P. E., Steppan C. M., Ahima R. S., Obici S., Rossetti L., Lazar M. A., Regulation of fasted blood glucose by resistin Science 2004 303 5661 1195 1198
132. McTernan C. L., McTernan P. G., Harte A. L., Levick P. L., Barnett A. H., Kumar S., Resistin, central obesity, and type 2 diabetes Lancet 2002 359 9300 46 47
133. Li M., Fisette A., Zhao X.-Y., Deng J.-Y., Mi J., Cianflone K., Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents International Journal of Obesity 2009 33 4 424 439
134. Haseeb A., Iliyas M., Chakrabarti S., Farooqui A. A., Naik S. R., Ghosh S., Suragani M., Ehtesham N. Z., Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population Journal of Biosciences 2009 34 3 405 414
135. Asano H., Izawa H., Nagata K., Nakatochi M., Kobayashi M., Hirashiki A., Shintani S., Nishizawa T., Tanimura D., Naruse K., Matsubara T., Murohara T., Yokota M., Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population Diabetologia 2010 53 2 234 246
136. Lee J. H., Bullen J. W. Jr., Stoyneva V. L., Mantzoros C. S., Circulating resistin in lean, obese, and insulin-resistant mouse models: lack of association with insulinemia and glycemia American Journal of Physiology 2005 288 3 E625 E632
137. Valsamakis G., McTernan P. G., Chetty R., Al Daghri N., Field A., Hanif W., Barnett A. H., Kumar S., Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines Metabolism: Clinical and Experimental 2004 53 4 430 434
138. Vendrell J., Broch M., Vilarrasa N., Molina A., Gmez J. M., Gutirrez C., Simn I., Soler J., Richart C., Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity Obesity Research 2004 12 6 962 971
139. Samal B., Sun Y., Stearns G., Xie C., Suggs S., McNiece I., Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor Molecular and Cellular Biology 1994 14 2 1431 1437
140. Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., Matsuki Y., Murakami M., Ichisaka T., Murakami H., Watanabe E., Takagi T., Akiyoshi M., Ohtsubo T., Kihara S., Yamashita S., Makishima M., Funahashi T., Yamanaka S., Hiramatsu R., Matsuzawa Y., Shimomura I., Visfatin: a protein secreted by visceral fat that mimics the effects of insulin Science 2005 307 5708 426 430 (Pubitemid 40139988)
141. Revollo J. R., Krner A., Mills K. F., Satoh A., Wang T., Garten A., Dasgupta B., Sasaki Y., Wolberger C., Townsend R. R., Milbrandt J., Kiess W., Imai S.-I., Nampt/PBEF/visfatin regulates insulin secretion in cells as a systemic NAD biosynthetic enzyme Cell Metabolism 2007 6 5 363 375
142. Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., Matsuki Y., Murakami M., Ichisaka T., Murakami H., Watanabe E., Takagi T., Akiyoshi M., Ohtsubo T., Kihara S., Yamashita S., Makishima M., Funahashi T., Yamanaka S., Hiramatsu R., Matsuzawa Y., Shimomura I., Retraction Science 2007 318 5850 565
143. Jia S. H., Li Y., Parodo J., Kapus A., Fan L., Holstein O. D., Marshall J. C., Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in
144. Moschen A. R., Kaser A., Enrich B., Mosheimer B., Theurl M., Niederegger H., Tilg H., Visfatin, an adipocytokine with proinflammatory and immunomodulating properties Journal of Immunology 2007 178 3 1748 1758
145. Kralisch S., Klein J., Lossner U., Bluher M., Paschke R., Stumvoll M., Fasshauer M., Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes Journal of Endocrinology 2005 185 3 R1 R8
146. Choi K. C., Ryu O. H., Lee K. W., Kim H. Y., Seo J. A., Kim S. G., Kim N. H., Choi D. S., Baik S. H., Choi K. M., Effect of PPAR- and- agonist on the expression of visfatin, adiponectin, and TNF- in visceral fat of OLETF rats Biochemical and Biophysical Research Communications 2005 336 3 747 753
147. Hallschmid M., Randeva H., Tan B. K., Kern W., Lehnert H., Relationship between cerebrospinal fluid visfatin (PBEF/Nampt) levels and adiposity in humans Diabetes 2009 58 3 637 640
148. Rasouli N., Kern P. A., Adipocytokines and the metabolic complications of obesity The Journal of Clinical Endocrinology Metabolism 2008 93 11, supplement 1 s64 s73
149. Laudes M., Oberhauser F., Schulte D. M., Freude S., Bilkovski R., Mauer J., Rappl G., Abken H., Hahn M., Schulz O., Krone W., Visfatin/PBEF/Nampt and resistin expressions in circulating blood monocytes are differentially related to obesity and type 2 diabetes in humans Hormone and Metabolic Research 2010 42 4 268 273
150. Imai S.-I., Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases Current Pharmaceutical Design 2009 15 1 20 28
151. Varma V., Yao-Borengasser A., Rasouli N., Bodles A. M., Phanavanh B., Lee M.-J., Starks T., Kern L. M., Spencer H. J. III, McGehee R. E. Jr., Fried S. K., Kern P. A., Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation The Journal of Clinical Endocrinology Metabolism 2007 92 2 666 672
152. Berndt J., Klting N., Kralisch S., Kovacs P., Fasshauer M., Schn M. R., Stumvoll M., Blher M., Plasma visfatin concentrations and fat depot-specific mRNA expression in humans Diabetes 2005 54 10 2911 2916
153. Liu S. W., Qiao S. B., Yuan J. S., Liu D. Q., Association of plasma visfatin levels with inflammation, atherosclerosis and acute coronary syndromes (ACS) in humans Clinical Endocrinology 2009 71 2 202 207
154. Davutoglu M., Ozkaya M., Guler E., Garipardic M., Gursoy H., Karabiber H., Kilinc M., Plasma visfatin concentrations in childhood obesity: relationships to insulin resistance and anthropometric indices Swiss Medical Weekly 2009 139 1-2 22 27
155. Liang Y., Xu X. M., Wang H. S., Wang P. W., Correlation between the expression of gastrocolic omentum visfatin mRNA and gestational diabetes mellitus Zhonghua Fu Chan Ke Za Zhi 2008 43 11 824 827
156. Blakemore A. I. F., Meyre D., Delplanque J., Vatin V., Lecoeur C., Marre M., Tichet J., Balkau B., Froguel P., Walley A. J., A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity Obesity 2009 17 8 1549 1553
157. Cataln V., Gmez-Ambrosi J., Rodrguez A., Association of increased Visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. Nutrition, Metabolism and Cardiovascular Diseases. In press
158. Stofkova A., Resistin and visfatin: regulators of insulin sensitivity, inflammation and immunity Endocrine Regulations 2010 44 1 25 36
159. Dahl T. B., Yndestad A., Skjelland M., ie E., Dahl A., Michelsen A., Dams J. K., Tunheim S. H., Ueland T., Smith C., Bendz B., Tonstad S., Gullestad L., Frland S. S., Krohg-Srensen K., Russell D., Aukrust P., Halvorsen B., Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization Circulation 2007 115 8 972 980
160. Takebayashi K., Suetsugu M., Wakabayashi S., Aso Y., Inukai T., Association between plasma visfatin and vascular endothelial function in patients with type 2 diabetes mellitus Metabolism: Clinical and Experimental 2007 56 4 451 458
161. Garten A., Petzold S., Krner A., Imai S.-I., Kiess W., Nampt: linking NAD biology, metabolism and cancer Trends in Endocrinology and Metabolism 2009 20 3 130 138
162. Chan T.-F., Chen Y.-L., Lee C.-H., Chou F.-H., Wu L.-C., Jong S.-B., Tsai E.-M., Decreased plasma visfatin concentrations in women with gestational diabetes mellitus Journal of the Society for Gynecologic Investigation 2006 13 5 364 367
163. Chen M.-P., Chung F.-M., Chang D.-M., Tsai J.C.-R., Huang H.-F., Shin S.-J., Lee Y.-J., Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus The Journal of Clinical Endocrinology Metabolism 2006 91 1 295 299
164. Haider D. G., Pleiner J., Francesconi M., Wiesinger G. F., Mller M., Wolzt M., Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes The Journal of Clinical Endocrinology Metabolism 2006 91 11 4702 4704
165. Roh S.-G., Song S.-H., Choi K.-C., Katoh K., Wittamer V., Parmentier M., Sasaki S.-I., Chemerina new adipokine that modulates adipogenesis via its own receptor Biochemical and Biophysical Research Communications 2007 362 4 1013 1018
166. Wittamer V., Bondue B., Guillabert A., Vassart G., Parmentier M., Communi D., Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity Journal of Immunology 2005 175 1 487 493
167. Parolini S., Santoro A., Marcenaro E., Luini W., Massardi L., Facchetti F., Communi D., Parmentier M., Majorana A., Sironi M., Tabellini G., Moretta A., Sozzani S., The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues Blood 2007 109 9 3625 3632
168. Lehrke M., Becker A., Greif M., Stark R., Laubender R. P., Von Ziegler F., Lebherz C., Tittus J., Reiser M., Becker C., Gke B., Leber A. W., Parhofer K. G., Broedl U. C., Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis European Journal of Endocrinology 2009 161 2 339 344
169. Wang L. Y., Wei L., Yu H. Y., Zhang Y., Jia W. P., Relationship of serum Chemerin to obesity and type 2 diabetes mellitus Zhonghua Yi Xue Za Zhi 2009 89 4 235 238
170. Stejskal D., Karpisek M., Hanulova Z., Svestak M., Chemerin is an independent marker of the metabolic syndrome in a Caucasian populationa pilot study Biomedical Papers of the Medical Faculty of the University Palack, Olomouc, Czechoslovakia 2008 152 2 217 221
171. Du X.-Y., Zabel B. A., Myles T., Allen S. J., Handel T. M., Lee P. P., Butcher E. C., Leung L. L., Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets The Journal of Biological Chemistry 2009 284 2 751 758
172. Goralski K. B., McCarthy T. C., Hanniman E. A., Zabel B. A., Butcher E. C., Parlee S. D., Muruganandan S., Sinal C. J., Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism The Journal of Biological Chemistry 2007 282 38 28175 28188
173. Albanesi C., Scarponi C., Pallotta S., Daniele R., Bosisio D., Madonna S., Fortugno P., Gonzalvo-Feo S., Franssen J.-D., Parmentier M., De Pit O., Girolomoni G., Sozzani S., Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment The Journal of Experimental Medicine 2009 206 1 249 258
174. Wittamer V., Franssen J.-D., Vulcano M., Mirjolet J.-F., Le Poul E., Migeotte I., Brzillon S., Tyldesley R., Blanpain C., Detheux M., Mantovani A., Sozzani S., Vassart G., Parmentier M., Communi D., Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids The Journal of Experimental Medicine 2003 198 7 977 985
175. John H., Hierer J., Haas O., Forssmann W.-G., Quantification of angiotensin-converting-enzyme-mediated degradation of human chemerin 145154 in plasma by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry Analytical Biochemistry 2007 362 1 117 125
176. Guillabert A., Wittamer V., Bondue B., Godot V., Imbault V., Parmentier M., Communi D., Role of neutrophil proteinase 3 and mast cell chymase in chemerin proteolytic regulation Journal of Leukocyte Biology 2008 84 6 1530 1539
177. Cash J. L., Hart R., Russ A., Dixon J. P. C., Colledge W. H., Doran J., Hendrick A. G., Carlton M. B. L., Greaves D. R., Synthetic chemerin-derived peptides suppress inflammation through ChemR23 The Journal of Experimental Medicine 2008 205 4 767 775
178. Takahashi M., Takahashi Y., Takahashi K., Zolotaryov F. N., Hong K. S., Kitazawa R., Iida K., Okimura Y., Kaji H., Kitazawa S., Kasuga M., Chihara K., Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes FEBS Letters 2008 582 5 573 578
179. Bozaoglu K., Bolton K., McMillan J., Zimmet P., Jowett J., Collier G., Walder K., Segal D., Chemerin is a novel adipokine associated with obesity and metabolic syndrome Endocrinology 2007 148 10 4687 4694
180. Fontana L., Eagon J. C., Trujillo M. E., Scherer P. E., Klein S., Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 2007 56 4 1010 1013
181. Komiya T., Tanigawa Y., Hirohashi S., Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice Biochemical and Biophysical Research Communications 1998 251 3 759 762
182. Yang R.-Z., Lee M.-J., Hu H., Pray J., Wu H.-B., Hansen B. C., Shuldiner A. R., Fried S. K., McLenithan J. C., Gong D.-W., Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action American Journal of Physiology 2006 290 6 E1253 E1261
183. Schffler A., Neumeier M., Herfarth H., Frst A., Schlmerich J., Bchler C., Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue Biochimica et Biophysica Acta 2005 1732 13 96 102
184. Pan H.-Y., Guo L., Li Q., Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes Diabetes Research and Clinical Practice 2010 88 1 29 33
185. de Souza Batista C. M., Yang R.-Z., Lee M.-J., Glynn N. M., Yu D.-Z., Pray J., Ndubuizu K., Patil S., Schwartz A., Kligman M., Fried S. K., Gong D.-W., Shuldiner A. R., Pollin T. I., McLenithan J. C., Omentin plasma levels and gene expression are decreased in obesity Diabetes 2007 56 6 1655 1661
186. Tan B. K., Adya R., Farhatullah S., Lewandowski K. C., O'Hare P., Lehnert H., Randeva H. S., Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome ex vivo in vivo regulation of omentin-1 by insulin and glucose Diabetes 2008 57 4 801 808
187. Lee D. K., George S. R., O'Dowd B. F., Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity Trends in Pharmacological Sciences 2006 27 4 190 194
188. Iwanaga Y., Kihara Y., Takenaka H., Kita T., Down-regulation of cardiac apelin system in hypertrophied and failing hearts: possible role of angiotensin II-angiotensin type 1 receptor system Journal of Molecular and Cellular Cardiology 2006 41 5 798 806
189. Ronkainen V.-P., Ronkainen J. J., Hnninen S. L., Leskinen H., Ruas J. L., Pereira T., Poellinger L., Vuolteenaho O., Tavi P., Hypoxia inducible factor regulates the cardiac expression and secretion of apelin The FASEB Journal 2007 21 8 1821 1830
190. Atluri P., Morine K. J., Liao G. P., Panlilio C. M., Berry M. F., Hsu V. M., Hiesinger W., Cohen J. E., Woo Y. J., Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression Cellular Molecular Biology Letters 2007 12 1 127 138
191. Zhang J., Ren C. X., Qi Y. F., Lou L. X., Chen L., Zhang L. K., Wang X., Tang C., Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats Life Sciences 2006 79 12 1153 1159
192. Higuchi K., Masaki T., Gotoh K., Chiba S., Katsuragi I., Tanaka K., Kakuma T., Yoshimatsu H., Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice Endocrinology 2007 148 6 2690 2697
193. Zhang Z., Yu B., Tao G.-Z., Apelin protects against cardiomyocyte apoptosis induced by glucose deprivation Chinese Medical Journal 2009 122 19 2360 2365
194. Telejko B., Kuzmicki M., Wawrusiewicz-Kurylonek N., Szamatowicz J., Nikolajuk A., Zonenberg A., Zwierz-Gugala D., Jelski W., LaudaDski P., Wilczynski J., Kretowski A., Gorska M., Plasma apelin levels and apelin/APJ mRNA expression in patients with gestational diabetes mellitus Diabetes Research and Clinical Practice 2010 87 2 176 183
195. Ellinor P. T., Low A. F., MacRae C. A., Reduced apelin levels in lone atrial fibrillation European Heart Journal 2006 27 2 222 226
196. Chong K. S., Gardner R. S., Morton J. J., Ashley E. A., McDonagh T. A., Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure European Journal of Heart Failure 2006 8 4 355 360
197. Francia P., Salvati A., Balla C., De Paolis P., Pagannone E., Borro M., Gentile G., Simmaco M., De Biase L., Volpe M., Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin European Journal of Heart Failure 2007 9 3 306 309
198. Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y. S., Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity Proceedings of the National Academy of Sciences of the United States of America 2005 102 30 10610 10615
199. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., Natori T., Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long-Evans Tokushima Fatty (OLETF) strain Diabetes 1992 41 11 1422 1428
200. Klting N., Berndt J., Kralisch S., Kovacs P., Fasshauer M., Schn M. R., Stumvoll M., Blher M., Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes Biochemical and Biophysical Research Communications 2006 339 1 430 436
201. Cho J.-K., Han T.-K., Kang H.-S., Combined effects of body mass index and cardio/respiratory fitness on serum vaspin concentrations in Korean young men European Journal of Applied Physiology 2010 108 2 347 353
202. Youn B.-S., Klting N., Kratzsch J., Lee N., Park J. W., Song E.-S., Ruschke K., Oberbach A., Fasshauer M., Stumvoll M., Blher M., Serum vaspin concentrations in human obesity and type 2 diabetes Diabetes 2008 57 2 372 377
203. Ye Y., Hou X.-H., Pan X.-P., Lu J.-X., Jia W.-P., Serum vaspin level in relation to postprandial plasma glucose concentration in subjects with diabetes Chinese Medical Journal 2009 122 21 2530 2533
204. Yang Q., Graham T. E., Mody N., Preitner F., Peroni O. D., Zabolotny J. M., Kotani K., Quadro L., Kahn B. B., Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 2005 436 7049 356 362
205. Mody N., Graham T. E., Tsuji Y., Yang Q., Kahn B. B., Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice American Journal of Physiology 2008 294 4 E785 E793
206. Munkhtulga L., Nagashima S., Nakayama K., Utsumi N., Yanagisawa Y., Gotoh T., Omi T., Kumada M., Zolzaya K., Lkhagvasuren T., Kagawa Y., Fujiwara H., Hosoya Y., Hyodo M., Horie H., Kojima M., Ishibashi S., Iwamoto S., Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI Obesity 2010 18 5 1006 1014
207. Suh J.-B., Kim S.-M., Cho G.-J., Choi K.-M., Han J.-H., Taek Geun H., Elevated serum retinol-binding protein 4 is associated with insulin resistance in older women Metabolism: Clinical and Experimental 2010 59 1 118 122
208. An C., Wang H., Liu X., Li Y., Su Y., Gao X., Jiang W., Serum retinol-binding protein 4 is elevated and positively associated with insulin resistance in postmenopausal women Endocrine Journal 2009 56 8 987 996
209. Klein K., Bancher-Todesca D., Leipold H., Retinol-binding protein 4 in patients with gestational diabetes mellitus Journal of Women's Health 2010 19 3 517 521
210. Gao S., Li M., Wang Z., Zhang X. J., Li H. H., Zhang K., Wu C. Y., Serum levels of retinol-binding protein-4 and its association with metabolic syndrome in first-degree relatives of type 2 diabetes mellitus Zhonghua Yi Xue Za Zhi 2009 89 30 2129 2133
211. Lin C.-C., Lai M.-M., Li T.-C., Li C.-I., Liu C.-S., Chen C.-C., Wu M.-T., Relationship between serum retinol-binding protein 4 and visfatin and the metabolic syndrome Diabetes Research and Clinical Practice 2009 85 1 24 29
212. Santoro N., Perrone L., Cirillo G., Brienza C., Grandone A., Cresta N., Miraglia Del Giudice E., Variations of retinol binding protein 4 levels are not associated with changes in insulin resistance during puberty Journal of Endocrinological Investigation 2009 32 5 411 414
213. Al-Daghri N. M., Al-Attas O. S., Alokail M., Draz H. M., Bamakhramah A., Sabico S., Retinol binding protein-4 is associated with TNF- and not insulin resistance in subjects with type 2 diabetes mellitus and coronary heart disease Disease Markers 2009 26 3 135 140
214. Bobbert P., Weithuser A., Andres J., Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathy European Journal of Heart Failure 2009 11 12 1163 1168
215. Sasaki M., Otani T., Kawakami M., Ishikawa S.-E., Elevation of plasma retinol-binding protein 4 and reduction of plasma adiponectin in subjects with cerebral infarction Metabolism: Clinical and Experimental 2010 59 4 527 532