Synthetic chemerin-derived peptides suppress inflammation through ChemR23

Journal of Experimental Medicine

Volumn 205, Issue 4, 2008, Pages 767-775

  Cash, Jenna L ^a   Hart, Rosie ^a   Russ, Andreas ^b   Dixon, John P C ^c   Colledge, William H ^c   Doran, Joanne ^c   Hendrick, Alan G ^c   Carlton, Mark B L ^c   Greaves, David R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Takeda Cambridge   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CHEMERIN 11; CHEMERIN 13; CHEMERIN 15; CHEMERIN 19; CHEMERIN 6; CHEMERIN 8; CHEMERIN DERIVATIVE; G PROTEIN COUPLED RECEPTOR; PROTEIN CHEMR23; PROTEIN M20; PROTEIN N19; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG MECHANISM; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES; CHEMOTACTIC FACTORS; CHEMOTAXIS; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NEUTRALIZATION TESTS; PEPTIDES; PERITONITIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, G-PROTEIN-COUPLED; ZYMOSAN;

EID: 42249083372     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071601     Document Type: Article

References (24)

1. Taylor, P.R., L. Martinez-Pomares, M. Stacey, H.H. Lin, G.D. Brown, and S. Gordon. 2005. Macrophage receptors and immune recognition. Annu. Rev. Immunol. 23:901-944.
2. Han, J., and R.J. Ulevitch. 2005. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6:1198-1205.
3. Wittamer, V., J.D. Franssen, M. Vulcano, J.F. Mirjolet, E. Le Poul, I. Migeotte, S. Brezillon, R. Tyldesley, C. Blanpain, M. Detheux, et al. 2003. Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids. J. Exp. Med. 198:977-985.
4. Meder, W., M. Wendland, A. Busmann, C. Kutzleb, N. Spodsberg, H. John, R. Richter, D. Schleuder, M. Meyer, and W.G. Forssmann. 2003. Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23. FEBS Lett. 555:495-499.
5. Zabel, B.A., S.J. Allen, P. Kulig, J.A. Allen, J. Cichy, T.M. Handel, and E.C. Butcher. 2005. Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J. Biol. Chem. 280:34661-34666.
6. Wittamer, V., B. Bondue, A. Guillabert, G. Vassart, M. Parmentier, and D. Communi. 2005. Neutrophil-mediated maturation of chemerin: a link between innate and adaptive immunity. J. Immunol. 175:487-493.
7. Samson, M., A.L. Edinger, P. Stordeur, J. Rucker, V. Verhasselt, M. Sharron, C. Govaerts, C. Mollereau, G. Vassart, R.W. Doms, and M. Parmentier. 1998. ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 28:1689-1700.
8. Zabel, B.A., T. Ohyama, L. Zuniga, J.Y. Kim, B. Johnston, S.J. Allen, D.G. Guido, T.M. Handel, and E.C. Butcher. 2006. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp. Hematol. 34:1106-1114.
9. Zabel, B.A., L. Zuniga, T. Ohyama, S.J. Allen, J. Cichy, T.M. Handel, and E.C. Butcher. 2006. Chemoattractants, extracellular proteases, and the integrated host defense response. Exp. Hematol. 34:1021-1032.
10. Barnea, G., W. Strapps, G. Herrada, Y. Berman, J. Ong, B. Kloss, R. Axel, and K.J. Lee. 2008. From the cover: the genetic design of signaling cascades to record receptor activation. Proc. Natl. Acad. Sci. USA. 105:64-69.
11. Arita, M., F. Bianchini, J. Aliberti, A. Sher, N. Chiang, S. Hong, R. Yang, N.A. Petasis, and C.N. Serhan. 2005. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J. Exp. Med. 201:713-722.
12. Arita, M., T. Ohira, Y.P. Sun, S. Elangovan, N. Chiang, and C.N. Serhan. 2007. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J. Immunol. 178:3912-3917.
13. Arita, M., M. Yoshida, S. Hong, E. Tjonahen, J.N. Glickman, N.A. Petasis, R.S. Blumberg, and C.N. Serhan. 2005. Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc. Natl. Acad. Sci. USA. 102:7671-7676.
14. Wittamer, V., F. Gregoire, P. Robberecht, G. Vassart, D. Communi, and M. Parmentier. 2004. The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J. Biol. Chem. 279:9956-9962.
15. Lawrence, T., D.A. Willoughby, and D.W. Gilroy. 2002. Anti-inflammatory lipid mediators and insights into the resolution of inflammation. Nat. Rev. Immunol. 2:787-795.
16. Getting, S.J., R.J. Flower, and M. Perretti. 1997. Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1. Br. J. Pharmacol. 120:1075-1082.
17. Damazo, A.S., S. Yona, R.J. Flower, M. Perretti, and S.M. Oliani. 2006. Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J. Immunol. 176:4410-4418.
18. Henderson, R.B., J.A.R. Hobbs, M. Mathies, and N. Hogg. 2003. Rapid recruitment of inflammatory monocytes is independent of neutrophil migration. Blood. 102:328-335.
19. Taylor, P.R., D.M. Reid, S.E. Heinsbroek, G.D. Brown, S. Gordon, and S.Y. Wong. 2005. Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo. Eur. J. Immunol. 35:2163-2174.
20. Movat, H.Z., and M.I. Cybulsky. 1987. Neutrophil emigration and microvascular injury. Role of chemotaxins, endotoxin, interleukin-1 and tumor necrosis factor alpha. Pathol. Immunopathol. Res. 6:153-176.
21. Movat, H.Z., M.I. Cybulsky, I.G. Colditz, M.K. Chan, and C.A. Dinarello. 1987. Acute inflammation in gram-negative infection: endotoxin, interleukin 1, tumor necrosis factor, and neutrophils. Fed. Proc. 46:97-104.
22. Choi, J.-H., E. Brummer, Y.J. Kang, P.P. Jones, and D.A. Stevens. 2006. Inhibitor [kappa]B and nuclear factor [kappa]B in granulocytemacrophage colony-stimulating factor antagonism of dexamethasone suppression of the macrophage response to Aspergillus fumigatus conidia. J. Infect. Dis. 193:1023-1028.
23. Schwab, J.M., N. Chiang, M. Arita, and C.N. Serhan. 2007. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 447:869.
24. Livak, K.J., and T.D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402-408