Ferroportin and erythroid cells: An update

Advances in Hematology

Volumn 2010, Issue , 2010, Pages

  Sposi, Nadia Maria ^a   Cianetti, Luciano ^a   Gabbianelli, Marco ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN; HEPCIDIN; IRON; MESSENGER RNA;

BETA THALASSEMIA; CELL DIFFERENTIATION; ERYTHROID CELL; ERYTHROPOIESIS; GENE EXPRESSION; HEMATOPOIESIS; HOMEOSTASIS; HUMAN; IRON METABOLISM; IRON OVERLOAD; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATOR GENE; REVIEW;

EID: 77956795897     PISSN: 16879104     EISSN: 16879112     Source Type: Journal    
DOI: 10.1155/2010/404173     Document Type: Review

References (122)

1. Abboud S., Haile D. J., A novel mammalian iron-regulated protein involved in intracellular iron metabolism Journal of Biological Chemistry 2000 275 26 19906 19912
2. Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S. J., Moynihan J., Paw B. H., Drejer A., Barut B., Zapata A., Law T. C., Brugnara C., Lux S. E., Pinkus G. S., Pinkus J. L., Kingsley P. D., Palls J., Fleming M. D., Andrews N. C., Leonard I Z., Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 2000 403 6771 776 781
3. McKie A. T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T. J., Farzaneh F., Hediger M. A., Hentze M. W., Simpson R. J., A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Molecular Cell 2000 5 2 299 309
4. McKie A. T., Barlow D. J., The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1) Pflgers Archiv European Journal of Physiology 2004 447 5 801 806
5. Pietrangelo A., Non-HFE hemochromatosis Hepatology 2004 39 1 21 29
6. Mok H., Mendoza M., Prchal J. T., Balogh P., Schumacher A., Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice Development 2004 131 19 4871 4881
7. Zoller H., Koch R. O., Theurl I., Obrist P., Pietrangelo A., Montosi G., Haile D. J., Vogel W., Weiss G., Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload Gastroenterology 2001 120 6 1412 1419
8. Yang F., Wang X., Haile D. J., Piantadosi C. A., Ghio A. J., Iron increases expression of iron-export protein MTP1 in lung cells American Journal of Physiology 2002 283 5 L932 L939
9. Martini L. A., Tchack L., Wood R. J., Iron treatment downregulates DMT1 and IREG1 mRNA expression in Caco-2 cells Journal of Nutrition 2002 132 4 693 696
10. Schimanski L. M., Drakesmith H., Merryweather-Clarke A. T., Viprakasit V., Edwards J. P., Sweetland E., Bastin J. M., Cowley D., Chinthammitr Y., Robson K. J. H., Townsend A. R. M., In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations Blood 2005 105 10 4096 4102
11. Drakesmith H., Schimanski L. M., Ormerod E., Merryweather-Clarke A. T., Viprakasit V., Edwards J. P., Sweetland E., Bastin J. M., Cowley D., Chinthammitr Y., Robson K. J. H., Townsend A. R. M., Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin Blood 2005 106 3 1092 1097 (Pubitemid 41076459)
12. Gonalves A. S., Muzeau F., Blaybel R., Hetet G., Driss F., Delaby C., Canonne-Hergaux F., Beaumont C., Wild-type and mutant ferroportins do not form oligomers in transfected cells Biochemical Journal 2006 396 2 265 275
13. Liu X.-B., Yang F., Haile D. J., Functional consequences of ferroportin 1 mutations Blood Cells, Molecules, and Diseases 2005 35 1 33 46
14. De Domenico I., Ward D. M., Musci G., Kaplan J., Evidence for the multimeric structure of ferroportin Blood 2007 109 5 2205 2209
15. Schimanski L. M., Drakesmith H., Talbott C., Horne K., James J. R., Davis S. J., Sweetland E., Bastin J., Cowley D., Townsend A. R. M., Ferroportin: lack of evidence for multimers Blood Cells, Molecules, and Diseases 2008 40 3 360 369
16. Devalia V., Carter K., Walker A. P., Perkins S. J., Worwood M., May A., Dooley J. S., Autosomal dominant reticuloendothelial iron overload associated with a 3-base pair deletion in the ferroportin 1 gene (SLC11A3) Blood 2002 100 2 695 697
17. Pignatti E., Mascheroni L., Sabelli M., Barelli S., Biffo S., Pietrangelo A., Ferroportin is a monomer in vivo in mice Blood Cells, Molecules, and Diseases 2006 36 1 26 32
18. De Domenico I., Ward D. M., Nemeth E., Vaughn M. B., Musci G., Ganz T., Kaplan J., The molecular basis of ferroportin-linked hemochromatosis Proceedings of the National Academy of Sciences of the United States of America 2005 102 25 8955 8960
19. Rice A. E., Mendez M. J., Hokanson C. A., Rees D. C., Bjrkman P. J., Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter Journal of Molecular Biology 2009 386 3 717 732
20. Cairo G., Pietrangelo A., Iron regulatory proteins in pathobiology Biochemical Journal 2000 352 2 241 250
21. Lymboussaki A., Pignatti E., Montosi G., Garuti C., Haile D. J., Pietrangelo A., The role of the iron responsive element in the control of ferroportin1/IREG1/MTP1 gene expression Journal of Hepatology 2003 39 5 710 715
22. Liu X. B., Hill P., Haile D. J., Role of the ferroportin iron-responsive element in iron and nitric oxide dependent gene regulation Blood Cells, Molecules Diseases 2002 29 3 315 326
23. Brissot P., Troadec M.-B., Bardou-Jacquet E., Lan C. L., Jouanolle A.-M., Deugnier Y., Loral O., Current approach to hemochromatosis Blood Reviews 2008 22 4 195 210
24. Nemeth E., Tuttle M. S., Powelson J., Vaughn M. D., Donovan A., Ward D. M., Ganz T., Kaplan J., Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 2004 306 5704 2090 2093
25. Montosi G., Donovan A., Totaro A., Garuti C., Pignatti E., Cassanelli S., Trenor C. C., Gasparini P., Andrews N. C., Pietrangelo A., Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene Journal of Clinical Investigation 2001 108 4 619 623
26. Pietrangelo A., Hereditary hemochromatosisa new look at an old disease New England Journal of Medicine 2004 350 23 2383 2430
27. Pietrangelo A., Physiology of iron transport and the hemochromatosis gene American Journal of Physiology 2002 282 3 G403 G414
28. Testa U., Conti L., Sposi N. M., Varano B., Tritarelli E., Malorni W., Samoggia P., Rainaldi G., Peschle C., Belardelli F., Gessani S., IFN- selectively down-regulates transferrin receptor expression in human peripheral blood macrophages by a post-translational mechanism Journal of Immunology 1995 155 1 427 435
29. Karthikeyan G., Lewis L. K., Resnick M. A., The mitochondrial protein frataxin prevents nuclear damage Human Molecular Genetics 2002 11 11 1351 1362
30. Ponka P., Tissue-specific regulation of iron metabolism and heme synthesis: distinct control mechanisms in erythroid cells Blood 1997 89 1 1 25
31. Testa U., Pelosi E., Peschle C., The transferrin receptor Critical Reviews in Oncogenesis 1993 4 3 241 276
32. Testa U., Recent developments in the understanding of iron metabolism Hematology Journal 2002 3 2 63 89
33. Tsiftsoglou A. S., Vizirianakis I. S., Strouboulis J., Erythropoiesis: model systems, molecular regulators, and developmental programs IUBMB Life 2009 61 8 800 830
34. Weissman I. L., Stem cells: units of development, units of regeneration, and units in evolution Cell 2000 100 1 157 168
35. Orkin S. H., Zon L. I., Hematopoiesis: an evolving paradigm for stem cell biology Cell 2008 132 4 631 644
36. Palis J., Ontogeny of erythropoiesis Current Opinion in Hematology 2008 15 3 155 161
37. Koury M. J., Sawyer S. T., Brandt S. J., New insights into erythropoiesis Current Opinion in Hematology 2002 9 2 93 100
38. Ingley E., Tilbrook P. A., Klinken S. P., New insights into the regulation of erythroid cells IUBMB Life 2004 56 4 177 184
39. Stamatoyannopoulos G., Control of globin gene expression during development and erythroid differentiation Experimental Hematology 2005 33 3 259 271
40. Golde D. W., The stem cell Scientific American 1991 265 6 86 93
41. Metcalf D., The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells Nature 1989 339 6219 27 30
42. Orkin S. H., Development of the hematopoietic system Current Opinion in Genetics and Development 1996 6 5 597 602
43. Smith C., Hematopoietic stem cells and hematopoiesis Cancer Control 2003 10 1 9 16
44. Emerson S. G., Thomas S., Ferrara J. L., Greenstein J. L., Developmental regulation of erythropoiesis by hematopoietic growth factors: analysis on populations of BFU-E from bone marrow, peripheral blood, and fetal liver Blood 1989 74 1 49 55
45. Bernstein I. D., Andrews R. G., Zsebo K. M., Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+ lin- cells, and the generation of colony-forming cell progeny from CD34+ lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor Blood 1991 77 11 2316 2321
46. Lyman S. D., James L., Johnson L., Brasel K., De Vries P., Escobar S. S., Downey H., Splett R. R., Beckmann M. P., McKenna H. J., Cloning of the human homologue of the murine flt3 ligand: a growth factor early hematopoietic progenitor cells Blood 1994 83 10 2795 2801
47. Gabbianelli M., Pelosi E., Montesoro E., Valtieri M., Luchetti L., Samoggia P., Vitelli L., Barberi T., Testa U., Lyman S., Peschle C., Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors Blood 1995 86 5 1661 1670
48. Gabbianelli M., Sargiacomo M., Pelosi E., Testa U., Isacchi G., Peschle C., Pure human hematopoietic progenitors: permissive action of basic fibroblast growth factor Science 1990 249 4976 1561 1564
49. Berardi A. C., Wang A., Abraham J., Scadden D. T., Basic fibroblast growth factor mediates its effects on committed myeloid progenitors by direct action and has no effect on hematopoietic stem cells Blood 1995 86 6 2123 2129
50. Leary A. G., Ikebuchi K., Hirai Y., Wong G. G., Yang Y.-C., Clark S. C., Ogawa M., Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 Blood 1988 71 6 1759 1763
51. Metcalf D., Hematopoietic regulators: redundancy or subtlety? Blood 1993 82 12 3515 3523
52. Krantz S. B., Erythropoietin Blood 1991 77 3 419 434
53. Fried W., Erythropoietin Annual Review of Nutrition 1995 15 353 377
54. Demetri G. D., Griffin J. D., Granulocyte colony-stimulating factor and its receptor Blood 1991 78 11 2791 2808
55. Sherr C. J., Colony-stimulating factor-1 receptor Blood 1990 75 1 1 12
56. Kaushansky K., Lok S., Holly R. D., Broudy V. C., Lin N., Bailey M. C., Forstrom J. W., Buddle M. M., Oort P. J., Hagen F. S., Roth G. J., Papayannopoulou T., Foster D. C., Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature 1994 369 6481 568 571
57. Cianetti L., Segnalini P., Calzolari A., Morsilli O., Felicetti F., Ramoni C., Gabbianelli M., Testa U., Sposi N. M., Expression of alternative transcripts of ferroportin-1 during human erythroid differentiation Haematologica 2005 90 12 1595 1606
58. Frazer D. M., Wilkins S. J., Becker E. M., Vulpe C. D., Mckie A. T., Trinder D., Anderson G. J., Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats Gastroenterology 2002 123 3 835 844
59. Mok H., Jelinek J., Pai S., Cattanach B. M., Prchal J. T., Youssoufian H., Schumacher A., Disruption of ferroportin 1 regulation causes dynamic alterations in iron homeostasis and erythropoiesis in polycythaemia mice Development 2004 131 8 1859 1868
60. Zhang D.-L., Hughes R. M., Ollivierre-Wilson H., Ghosh M. C., Rouault T. A., A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression Cell Metabolism 2009 9 5 461 473
61. Chaston T., Chung B., Mascarenhas M., Marks J., Patel B., Srai S. K., Sharp P., Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells Gut 2008 57 3 374 382
62. Krause A., Neitz S., Mgert H.-J., Schulz A., Forssmann W.-G., Schulz-Knappe P., Adermann K., LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Letters 2000 480 2-3 147 150
63. Park C. H., Valore E. V., Waring A. J., Ganz T., Hepcidin, a urinary antimicrobial peptide synthesized in the liver Journal of Biological Chemistry 2001 276 11 7806 7810
64. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., Loral O., A new mouse liver specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload Journal of Biological Chemistry 2001 276 11 7811 7819
65. Ganz T., Nemeth E., Regulation of iron acquisition and iron distribution in mammals Biochimica et Biophysica Acta 2006 1763 7 690 699
66. Piperno A., Mariani R., Trombini P., Girelli D., Hepcidin modulation in human diseases: from research to clinic World Journal of Gastroenterology 2009 15 5 538 551
67. Lee P. L., Beutler E., Regulation of hepcidin and iron-overload disease Annual Review of Pathology 2009 4 489 515
68. Fleming R. E., Sly W. S., Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease Proceedings of the National Academy of Sciences of the United States of America 2001 98 15 8160 8162
69. Nicolas G., Chauvet C., Viatte L., Danan J. L., Bigard X., Devaux I., Beaumont C., Kahn A., Vaulont S., The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation Journal of Clinical Investigation 2002 110 7 1037 1044
70. Ganz T., Cellular iron: ferroportin is the only way out Cell Metabolism 2005 1 3 155 157
71. Andrews N. C., Forging a field: the golden age of iron biology Blood 2008 112 2 219 230
72. De Domenico I., McVey Ward D., Kaplan J., Regulation of iron acquisition and storage: consequences for iron-linked disorders Nature Reviews Molecular Cell Biology 2008 9 1 72 81
73. Dunn L. L., Rahmanto Y. S., Richardson D. R., Iron uptake and metabolism in the new millennium Trends in Cell Biology 2007 17 2 93 100
74. Dallalio G., Law E., Means R. T. Jr., Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations Blood 2006 107 7 2702 2704
75. Kattamis A., Papassotiriou I., Palaiologou D., Apostolakou F., Galani A., Ladis V., Sakellaropoulos N., Papanikolaou G., The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major Haematologica 2006 91 6 809 812
76. Pak M., Lopez M. A., Gabayan V., Ganz T., Rivera S., Suppression of hepcidin during anemia requires erythropoietic activity Blood 2006 108 12 3730 3735
77. Vokurka M., Krijt J., ulc K., Neas E., Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis Physiological Research 2006 55 6 667 674
78. Weatherall D. J., Clegg J. B., Weatherall D. J., Clegg J. B., The thalassemia syndromes The Thalassemia Syndromes 2001 4th Oxford, UK Blackwell Science 287 356
79. Weatherall D. J., Phenotype-genotype relationships in monogenic disease: lessons from the thalassaemias Nature Reviews Genetics 2001 2 4 245 255
80. Rund D., Rachmilewitz E., -thalassemia New England Journal of Medicine 2005 353 11 1135 1146
81. Gardenghi S., Marongiu M. F., Ramos P., Guy E., Breda L., Chadburn A., Liu Y., Amariglio N., Rechavi G., Rachmilewitz E. A., Breuer W., Cabantchik Z. I., Wrighting D. M., Andrews N. C., De Sousa M., Giardina P. J., Grady R. W., Rivella S., Ineffective erythropoiesis in -thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin Blood 2007 109 11 5027 5035
82. El Rassi F., Cappellini M. D., Inati A., Taher A., Beta-thalassemia intermedia: an overview Pediatric Annals 2008 37 5 322 328
83. Rivella S., Ineffective erythropoiesis and thalassemias Current Opinion in Hematology 2009 16 3 187 194
84. Weizer-Stern O., Adamsky K., Amariglio N., Levin C., Koren A., Breuer W., Rachmilewitz E., Breda L., Rivella S., Ioav Cabantchik Z., Rechavi G., Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera British Journal of Haematology 2006 135 1 129 138
85. Tanno T., Bhanu N. V., Oneal P. A., Goh S.-H., Staker P., Lee Y. T., Moroney J. W., Reed C. H., Luban N. L. C., Wang R.-H., Eling T. E., Childs R., Ganz T., Leitman S. F., Fucharoen S., Miller J. L., High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin Nature Medicine 2007 13 9 1096 1101
86. Bttner M., Laaff M., Schechinger B., Rappold G., Unsicker K., Suter-Crazzolara C., Characterization of the rat, mouse, and human genes of growth/differentiation factor-15/macrophage inhibiting cytokine-1 (GDF-15/MIC-1) Gene 1999 237 1 105 111
87. Wang R.-H., Li C., Xu X., Zheng Y., Xiao C., Zerfas P., Cooperman S., Eckhaus M., Rouault T., Mishra L., Deng C.-X., A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression Cell Metabolism 2005 2 6 399 409
88. Babitt J. L., Huang F. W., Wrighting D. M., Xia Y., Sidis Y., Samad T. A., Campagna J. A., Chung R. T., Schneyer A. L., Woolf C. J., Andrews N. C., Lin H. Y., Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression Nature Genetics 2006 38 5 531 539
89. Truksa J., Peng H., Lee P., Beutler E., Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6 Proceedings of the National Academy of Sciences of the United States of America 2006 103 27 10289 10293
90. Massagu J., TGF- signal transduction Annual Review of Biochemistry 1998 67 753 791
91. De Caestecker M., The transforming growth factor- superfamily of receptors Cytokine and Growth Factor Reviews 2004 15 1 1 11
92. Tamary H., Shalev H., Perez-Avraham G., Zoldan M., Levi I., Swinkels D. W., Tanno T., Miller J. L., Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I Blood 2008 112 13 5241 5244
93. Lakhal S., Talbot N. P., Crosby A., Stoepker C., Townsend A. R. M., Robbins P. A., Pugh C. W., Ratcliffe P. J., Mole D. R., Regulation of growth differentiation factor 15 expression by intracellular iron Blood 2009 113 7 1555 1563
94. Tanno T., Porayette P., Sripichai O., Noh S.-J., Byrnes C., Bhupatiraju A., Lee Y. T., Goodnough J. B., Harandi O., Ganz T., Paulson R. F., Miller J. L., Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells Blood 2009 114 1 181 186
95. Kanda J., Uchiyama T., Tomosugi N., Higuchi M., Uchiyama T., Kawabata H., Oncostatin M and leukemia inhibitory factor increase hepcidin expression in hepatoma cell lines International Journal of Hematology 2009 90 5 545 552
96. Chung B., Verdier F., Matak P., Deschemin J.-C., Mayeux P., Vaulont S., Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone FASEB Journal 2010 24 6 2093 2103
97. Tan J. S., Mohandas N., Conboy J. G., High frequency of alternative first exons in erythroid genes suggests a critical role in regulating gene function Blood 2006 107 6 2557 2561
98. Buratowski S., Transcription: gene expressionwhere to start? Science 2008 322 5909 1804 1805
99. Cairo G., Recalcati S., Iron-regulatory proteins: molecular biology and pathophysiological implications Expert Reviews in Molecular Medicine 2007 9 33 1 13
100. Canonne-Hergaux F., Donovan A., Delaby C., Wang H.-J., Gros P., Comparative studies of duodenal and macrophage ferroportin proteins American Journal of Physiology 2006 290 1 G156 G163
101. Delaby C., Pilard N., Puy H., Canonne-Hergaux F., Sequential regulation of ferroportin expression after erythrophagocytosis in murine macrophages: early mRNA induction by haem, followed by iron-dependent protein expression Biochemical Journal 2008 411 1 123 131
102. Lolascon A., De Falco L., Beaumont C., Molecular basis of inherited microcytic anemia due to defects in iron acquisitionor heme synthesis Haematologica 2009 94 3 395 408
103. Reichard J. F., Motz G. T., Puga A., Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1 Nucleic Acids Research 2007 35 21 7074 7086
104. Iwasaki K., MacKenzie E. L., Hailemariam K., Sakamoto K., Tsuji Y., Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of ref-1 during erythroid differentiation of K562 cells Molecular and Cellular Biology 2006 26 7 2845 2856
105. Tahara T., Sun J., Nakanishi K., Yamamoto M., Mori H., Saito T., Fujita H., Igarashi K., Taketani S., Heme positively regulates the expression of -globin at the locus control region via the transcriptional factor Bach1 in erythroid cells Journal of Biological Chemistry 2004 279 7 5480 5487
106. Fujita H., Yamamoto M., Yamagami T., Hayashi N., Bishop T. R., De Verneuil H., Yoshinaga T., Shibahara S., Morimoto R., Sassa S., Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells Biochimica et Biophysica Acta 1991 1090 3 311 316
107. Ogawa K., Sun J., Taketani S., Nakajima O., Nishitani C., Sassa S., Hayashi N., Yamamoto M., Shibahara S., Fujita H., Igarashi K., Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 EMBO Journal 2001 20 11 2835 2843
108. Alam J., Stewart D., Touchard C., Boinapally S., Choi A. M. K., Cook J. L., Nrf2, a Cap'n'Collar transcription factor, regulates induction of the heme oxygenase-1 gene Journal of Biological Chemistry 1999 274 37 26071 26078
109. Ishii T., Itoh K., Takahashi S., Sato H., Yanagawa T., Katoh Y., Bannai S., Yamamoto M., Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages Journal of Biological Chemistry 2000 275 21 16023 16029
110. Igarashi K., Hoshino H., Muto A., Suwabe N., Nishikawa S., Nakauchi H., Yamamoto M., Multivalent DNA binding complex generated by small Maf and Bach1 as a possible biochemical basis for -globin locus control region complex Journal of Biological Chemistry 1998 273 19 11783 11790
111. Marro S., Chiabrando D., Messana E., Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica. In press
112. Nemeth E., Iron regulation and erythropoiesis Current Opinion in Hematology 2008 15 3 169 175
113. Tsiftsoglou A. S., Tsamadou A. I., Papadopoulou L. C., Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects Pharmacology and Therapeutics 2006 111 2 327 345
114. Mabaera R., West R. J., Conine S. J., Macari E. R., Boyd C. D., Engman C. A., Lowrey C. H., A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger Experimental Hematology 2008 36 9 1057 1072
115. Kerenyi M. A., Grebien F., Gehart H., Schifrer M., Artaker M., Kovacic B., Beug H., Moriggl R., Mllner E. W., Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1 Blood 2008 112 9 3878 3888
116. Pinto J. P., Ribeiro S., Pontes H., Thowfeequ S., Tosh D., Carvalho F., Porto G., Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBP Blood 2008 111 12 5727 5733
117. De Domenico I., Lo E., Ward D. M., Kaplan J., Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2 Proceedings of the National Academy of Sciences of the United States of America 2009 106 10 3800 3805
118. Bank A., Regulation of human fetal hemoglobin: new players, new complexities Blood 2006 107 2 435 443
119. Gabbianelli M., Morsilli O., Massa A., Pasquini L., Cianciulli P., Testa U., Peschle C., Effective erythropoiesis and HbF reactivation induced by kit ligand in -thalassemia Blood 2008 111 1 421 429
120. Aerbajinai W., Zhu J., Gao Z., Chin K., Rodgers G. P., Thalidomide induces -globin gene expression through increased reactive oxygen species-mediated p38 MAPK signaling and histone H4 acetylation in adult erythropoiesis Blood 2007 110 8 2864 2871
121. Chen J.-J., Regulation of protein synthesis by the heme-regulated eIF2 kinase: relevance to anemias Blood 2007 109 7 2693 2699
122. Wek R. C., Jiang H.-Y., Anthony T. G., Coping with stress: EIF2 kinases and translational control Biochemical Society Transactions 2006 34 1 7 11