Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance

Diabetes

Volumn 55, Issue 5, 2006, Pages 1421-1429

  Kwan, Edwin P ^a   Xie, Li ^a   Sheu, Laura ^a   Nolan, Christopher J ^b   Prentki, Marc ^b   Betz, Andrea ^c   Brose, Nils ^c   Gaisano, Herbert Y ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cm, membrane capacitance; DAG, diacylglycerol; GSIS, glucose stimulated insulin secretion; IPGTT, intraperitoneal glucose tolerance test; KRBH, Krebs Ringer bicarbonate buffer containing 10 mmol l HEPES; PKC, protein kinase C

Indexed keywords

AMINO ACID RECEPTOR; DIACYLGLYCEROL; GLUCOSE; INSULIN; MUNC18 PROTEIN; MUTANT PROTEIN; PHORBOL ESTER; PROTEIN MUNC13 1; SNARE PROTEIN; SYNTAXIN 1A; UNCLASSIFIED DRUG; NERVE PROTEIN; UNC13A PROTEIN, MOUSE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXOCYTOSIS; GENE MUTATION; GENE OVEREXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HETEROZYGOSITY; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN ISOLATION; ANIMAL; BRAIN; CROSS BREEDING; GENETICS; GLUCOSE INTOLERANCE; MOUSE; MOUSE MUTANT; PANCREAS ISLET; PATCH CLAMP; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SECRETION;

ANIMALS; BRAIN; CROSSES, GENETIC; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; POLYMERASE CHAIN REACTION;

EID: 33745291822     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db05-1263     Document Type: Article

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