Microfluidic biochip for the perifusion of precision-cut rat liver slices for metabolism and toxicology studies

Biotechnology and Bioengineering

Volumn 105, Issue 1, 2010, Pages 184-194

  Van Midwoud, Paul M ^a   Groothuis, Geny M M ^a   Merema, Marjolijn T ^a   Verpoorte, Elisabeth ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

7 ethoxycoumarin; Metabolism; Micro fluidics; Perifusion culture; Rat liver slices

Indexed keywords

7-ETHOXYCOUMARIN; ADME-TOX; CHEMICAL ENTITY; DETECTION SENSITIVITY; DRUG CANDIDATES; DRUG DEVELOPMENT; DRUG METABOLISMS; EARLY DETECTION; FLOW CONDITION; IN-VITRO; IN-VIVO; LIVER SLICES; METABOLIC RATES; MICRO DEVICES; MICRO FLUIDIC BIOCHIPS; MICRO-CHAMBERS; PHASE I; PHASE II; POLYDIMETHYLSILOXANE PDMS; PRECISION CUT; RAT LIVERS; WASTE PRODUCTS; WELL PLATES;

ELECTRIC CONDUCTIVITY MEASUREMENT; LIVER; MICROFLUIDICS; OXYGEN; PORTABLE EQUIPMENT; PUMPS; SILICONES; TOXICITY;

METABOLISM;

7 ETHOXYCOUMARIN; DIMETICONE; GLUCURONIDE; LACTATE DEHYDROGENASE; SULFATE; UMBELLIFERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHIP; GAS DIFFUSION; IN VITRO STUDY; INCUBATION TIME; LIVER SLICE; MALE; METABOLIC RATE; METABOLITE; MICROFLUIDIC ANALYSIS; NONHUMAN; RAT;

ANIMALS; CELL SURVIVAL; COUMARINS; HYDROGEN-ION CONCENTRATION; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICROFLUIDICS; MOLECULAR STRUCTURE; RATS; RATS, WISTAR; TISSUE CULTURE TECHNIQUES; TOXICOLOGY;

RATTUS;

EID: 73949083886     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22516     Document Type: Article

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