Evaluation of CYP1A1 and CYP2B1/2 m-RNA induction in rat liver slices using the NanoString® Technology: A novel tool for drug discovery lead optimization

Drug Metabolism Letters

Volumn 3, Issue 3, 2009, Pages 171-175

  Palamanda, Jairam R ^a   Kumari, Pramila ^a   Murgolo, Nicholas ^a   Benbow, Larry ^a   Lin, Xinjie ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Automation; CYP1A1; CYP2B1 2; Cytochrome P450; HTP or high throughput; Induction; Liver slices; NanoString ; Real time PCR

Indexed keywords

BETA NAPHTHOFLAVONE; CARBAMAZEPINE; CHLORPROMAZINE; CLOTRIMAZOLE; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; DIAZEPAM; DOXYLAMINE; FLUTAMIDE; KETOCONAZOLE; LANSOPRAZOLE; LEFLUNOMIDE; NIMODIPINE; OLTIPRAZ; OMEPRAZOLE; OXAZEPAM; PHENOTHIAZINE; PHENYTOIN; RITONAVIR; RNA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RESEARCH; GENE EXPRESSION; INCUBATION TIME; INTERMETHOD COMPARISON; LABORATORY AUTOMATION; MALE; NANOTECHNOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; COMPUTATIONAL BIOLOGY; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; DRUG DISCOVERY; ENZYME INDUCTION; HIGH-THROUGHPUT SCREENING ASSAYS; LIVER; MALE; NANOTECHNOLOGY; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; STEROID HYDROXYLASES; TISSUE CULTURE TECHNIQUES;

RATTUS; RODENTIA;

EID: 70350704813     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231209789352094     Document Type: Article

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