An in vivo and in vitro comparison of CYP induction in rat liver and intestine using slices and quantitative RT-PCR

Chemico-Biological Interactions

Volumn 151, Issue 1, 2004, Pages 1-11

  Martignoni, Marcella ^a   De Kanter, Ruben ^a   Grossi, Pietro ^a   Mahnke, Axel ^a   Saturno, Grazia ^a   Monshouwer, Mario ^a  

^a Preclinical Development   (Italy)

Author keywords

Colon; CYP induction; Duodenum; Ileum; In vitro; Intestinal slices; Liver slices; Methods; Rat

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 3A1; DEXAMETHASONE; MESSENGER RNA; PHENOBARBITAL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; INCUBATION TIME; INTESTINE; LIVER SLICE; MALE; NONHUMAN; PROTEIN INDUCTION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; BETA-NAPHTHOFLAVONE; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; DNA PRIMERS; ENZYME INDUCTION; INTESTINES; LIVER; MALE; PHENOBARBITAL; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 10644287790     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2004.10.002     Document Type: Article

References (32)

1. D.A. Smith Induction and drug development Eur. J. Pharmacol. 11 2000 185 189
2. D.E. Amacher, S.J. Schomaker, and J.E. Burkhardt The relationship among microsomal enzyme induction, liver weight and histological change in rat toxicology studies Food Chem. Toxicol. 36 1998 831 839
3. P. Grasso, and R.H. Hinton Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver Mutat. Res. 248 1991 271 290
4. J. Pan, Q. Xiang, A.B. Renwick, R.J. Price, S.E. Ball, J. Kao, J.A. Scatina, and B.G. Lake Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices Xenobiotica 32 2002 739 747
5. M.S. Gokhale, T.E. Bunton, J. Zurlo, and J.D. Yager Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices Xenobiotica 27 1997 341 355
6. R.G. Bars, A.M. Mitchell, C.R. Wolf, and C.R. Elcombe Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry Biochem. J. 262 1989 151 158
7. V.E. Kostrubsky, V. Ramachandran, R. Venkataramanan, K. Dorko, J.E. Esplen, S. Zhang, J.F. Sinclair, S.A. Wrighton, and S.C. Strom The use of human hepatocyte cultures to study the induction of cytochrome P-450 Drug Metab. Dispos. 27 1999 887 894
8. J.T. Moore, and S.A. Kliewer Use of the nuclear receptor PXR to predict drug interactions Toxicology 153 2000 1 10
9. L. Vignati, A. Bogni, P. Grossi, and M. Monshouwer A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction Toxicology 199 2004 23 33
10. A.T. Drahushuk, B.P. McGarrigle, B.P. Slezak, J.J. Stegeman, and J.R. Olson Time- and concentration-dependent induction of CYP1A1 and CYP1A2 in precision-cut rat liver slices incubated in dynamic organ culture in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin Toxicol. Appl. Pharmacol. 155 1999 127 138
11. U.D. Kuhn, F.K. Splinter, M. Rost, and D. Muller Induction of cytochrome P4501A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin Exp. Toxicol. Pathol. 50 1998 491 496
12. L.S. Kaminsky, and Q.Y. Zhang The small intestine as a xenobiotic-metabolizing organ Drug Metab. Dispos. 31 2003 1520 1525
13. M.M. Doherty, and W.N. Charman The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism? Clin. Pharmacokinet. 41 2002 235 253
14. R. de Kanter, A. Tuin, E. van de Kerkhof, M. Martignoni, A.L. Draaisma, M.H. de Jager, I.A.M. de Graaf, D.K.F. Meijer, G.M.M. Groothuis, A new technique to prepare precision-cut slices from small intestine and colon, J. Pharmacol. Toxicol. Methods, in press.
15. A.E. Vickers, M. Zollinger, R. Dannecker, R. Tynes, F. Heitz, and V. Fischer In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions Drug Metab. Dispos. 29 2001 1269 1276
16. A.E.M. Vickers, R.L. Fisher, K. Brendel, J. Guertler, R. Dannecker, B. Keller, and V. Fischer Sites of biotransformation for the cyclosporin derivative SDZ IMM 125 using human liver and kidney slices and intestine. Comparison with rat liver slices and cyclosporin A metabolism Drug Metab. Dispos. 23 1995 327 333
17. A.E. Vickers, V. Fischer, S. Connors, R.L. Fisher, J.P. Baldeck, G. Maurer, and K. Brendel Cyclosporin A metabolism in human liver, kidney, and intestine slices. Comparison to rat and dog slices and human cell lines Drug Metab. Dispos. 20 1992 802 809
18. M.A. Malfatti, M.S. Connors, R.J. Mauthe, and J.S. Felton The capability of rat colon tissue slices to metabolize the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Cancer Res. 56 1996 2550 2555
19. M. Martignoni, M. Monshouwer, R. de Kanter, D. Pezzetta, A. Moscone, and P. Grossi Phase I and phase II metabolic activities are retained in liver slices from mouse, rat, dog, monkey and human after cryopreservation Toxic. In Vitro 18 2004 121 128
20. B.G. Lake, J.A. Beamand, A.C. Japenga, A. Renwick, S. Davies, and R.J. Price Induction of cytochrome P-450-dependent enzyme activities in cultured rat liver slices Food Chem. Toxicol. 31 1993 377 386
21. R.Z. Turncliff, P.J. Meier, and K.L. Brouwer Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes Drug Metab. Dispos. 32 2004 834 839
22. M. Niemi, J.T. Backman, M.F. Fromm, P.J. Neuvonen, and K.T. Kivisto Pharmacokinetic interactions with rifampicin: clinical relevance Clin. Pharmacokinet. 42 2003 819 850
23. J.T. Backman, K.T. Kivisto, K.T. Olkkola, and P.J. Neuvonen The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin Eur. J. Clin. Pharmacol. 54 1998 53 58
24. Y. Kato, K. Haraguchi, S. Yumoto, T. Yamazaki, Y. Nagano, N. Koga, Y. Masuda, and R. Kimura Metabolite of 2,2′,4′,5-tetrabromobiphenyl, 3-methylsulphonyl-2,2′,4′,5-tetrabromobiphenyl, a potent inducer of CYP2B1/2 in rat Xenobiotica 32 2002 289 303
25. M.T. Donato, M.J. Gomez-Lechon, and J.V. Castell A microassay for measuring cytochrome P450IA1 and P450IIB1 activities in intact human and rat hepatocytes cultured on 96-well plates Anal. Biochem. 213 1993 29 33
26. P.G. Traber, W.M. McDonnell, W. Wang, and R. Florence Expression and regulation of cytochrome P-450I genes (CYP1A1 and CYP1A2) in the rat alimentary tract Biochim. Biophys. Acta 1171 1992 167 175
27. C. Meredith, M.P. Scott, A.B. Renwick, R.J. Price, and B.G. Lake Studies on the induction of rat hepatic CYP1A, CYP2B, CYP3A and CYP4A subfamily form mRNAs in vivo and in vitro using precision-cut rat liver slices Xenobiotica 33 2003 511 527
28. T. Matsubara, H.J. Kim, M. Miyata, M. Shimada, K. Nagata, and Y. Yamazoe Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat J. Pharmacol. Exp. Ther. 309 2004 1282 1290
29. Q. Mei, K. Richards, K. Strong-Basalyga, S.E. Fauty, A. Taylor, M. Yamazaki, T. Prueksaritanont, J.H. Lin, and J. Hochman Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P4503A1/2 J. Pharm. Sci. 93 2004 2488 2496
30. Q.-Y. Zhang, J. Wikoff, D. Dunbar, M. Fasco, and L. Kaminsky Regulation of cytochrome P4501A1 expression in rat small intestine Drug Metab. Dispos. 25 1997 21 26
31. M.P. Lopez-Garcia Endogenous nitric oxide is responsible for the early loss of P450 in cultured rat hepatocytes FEBS Lett. 438 1998 145 149
32. D. Muller, P. Steinmetzer, K. Pissowotzki, and R. Glockner Induction of cytochrome P4502B1-mRNA and pentoxyresorufin O-depentylation after exposure of precision-cut rat liver slices to phenobarbital Toxicology 144 2000 93 97