Comparison of five incubation systems for rat liver slices using functional and viability parameters

Journal of Pharmacological and Toxicological Methods

Volumn 38, Issue 2, 1997, Pages 59-69

  Olinga, Peter ^a   Groen, Kees ^b   Hof, Ingrid H ^a   De Kanter, Ruben ^c   Koster, Henk J ^c   Leeman, Winfried R ^d   Rutten, Alphons A J J L ^d,e   Van Twillert, Klaas ^b   Groothuis, Geny M M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c Solvay Pharmaceuticals Inc   (Netherlands)

^d TNO   (Netherlands)

^e ntervet International bv   (Netherlands)

Author keywords

Drug metabolism; Incubation system; Rat liver slices; Vaibility

Indexed keywords

LIDOCAINE; PHENAZONE; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG METABOLISM; INCUBATION TIME; LIVER MICROSOME METABOLISM; LIVER SLICE; MALE; NONHUMAN; PRESERVATION; RAT;

ANIMALS; ENERGY METABOLISM; L-LACTATE DEHYDROGENASE; LIVER; MALE; ORGAN CULTURE TECHNIQUES; POTASSIUM; RATS; RATS, WISTAR; XENOBIOTICS;

ANIMALIA;

EID: 0030656215     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(97)00060-9     Document Type: Article

References (30)

1. Atkinson DE (1968) The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 7:4030-4.
2. Berridge MV and Tan AS (1993) Characterization of the Cellular Reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular Localization, Substrate Dependence, and Involvement of Mitochondrial Electron Transport in MTT Reduction. Arch Biochem Biophys 303:474-482.
3. Berry MN and Friend DS (1969) High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 43:506-20.
4. Campbell AK and Hales CN (1971) Maintenance of viable cells in an organ culture of mature rat liver. Exp Cell Res 68:33-42.
5. de Kanter R and Koster HJ (1995) Cryopreservation of rat and monkey liver slices. ATLA 23:653-665.
6. Dogterom P (1993) Development of a simple incubation system for metabolism studies with precision-cut liver slices. Drug Metab Dispos 21:699-704.
7. Fisher R, Nau H, Gandolfi AJ, Putnam CW and Brendel K (1991) Valproic acid hepatotoxicity in human liver slices. Drug Chem Toxicol 14:375-94.
8. Fisher RL, Shaughnessy RP, Jenkins PM, Austin ML, Roth GL, Gandolfi AJ and Brendel K (1995) Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: optimazation of tissue slice culture, part 1. Toxicol Methods 5:99-113.
9. Goethals F, Deboyser D, Lefebvre V, de Coster I and Roberfroid M (1990) Adult rat liver slices as a model for studying the hepatotoxicity of vincaalkaloids. Toxic in Vitro 4:435-8.
10. Groen K, Breimer DD and van Bezooijen CFA (1992) Metabolism of simultaneously administered antipyrine and theophylline in male BN/BiRij rats before and after induction with 3-methylcholanthrene. Drug Metab Dispos 20:502-6.
11. Hart A, Mattheyse J and Balinsky JB (1983) An organ culture of postnatal rat liver slices. In vitro 19:841-852.
12. Imaoka S, Enomoto K, Oda Y, Asada A, Fujimori M, Shimada T, Fujita S, Guengerich FP and Funae Y (1990) Lidocaine metabolism by human cytochrome P450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P450s. J Pharmacol Exp Ther 255:1385-91.
13. Krumdieck CL, dos Santos JE and Ho KJ (1980) A new instrument for the rapid preparation of tissue slices. Anal Biochem 104:118-123.
14. Leeman W, van de Gevel I and Rutten A (1995) Cytotoxicity of menadione and aflatoxin B1 in rat liver slices using netwell inserts as a new culture system. Toxic in Vitro 9:291-298.
15. Monshouwer M, Witkamp RF, Nijmeijer SM, Van Amsterdam JG and Van Miert ASJPAM (1996) Suppression of cytochrome P450-and UDP glucuronosyl transferase dependent enzyme activities by pro-inflammatory citokines and possible rol of nitric oxide in primary cultures of pig hepatocytes. Toxicol Appl Pharmacol 137: 237-244.
16. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immun Meth 65:55-63.
17. Olinga P, Merema MT, Hof IH, Visser J, Meijer DKF and Groothuis GMM (Submitted) Fast analysis of ATP, ADP, AMP and adenosine with gradient ion-pair reversed-phase liquid chromatography as viability test for hepatocytes.
18. Olinga P, Merema MT, Meijer DKF, Slooff MJH and Groothuis GMM (1993) Human liver slices express the same lidocaine biotransformation rate as isolated human hepatocytes. ATLA 21:466-468.
19. Paine AJ (1991) The maintenance of cytochrome P450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P450 system. Chem Biol Interact 74:1-31.
20. Palette C, Dubor F, Rovei V and Advenier C (1993) Determination of antipyrine sulphoconjugates in isolated cultured rat hepatocytes. Xenobiotica 23:181-91.
21. Parrish AR, Gandolfi AJ and Brendel K (1995) Precision cut liver slices: applications in pharmacology and toxicology. Life Sci 57: 1887-1901.
22. (SFBC) SFdBC (1982) Ann Biol Clin 40:160-164.
23. Skett P (1994) Problems in using isolated and cultured hepatocytes for xenobiotic metabolism/metabolism-based toxicity testing-solutions? Toxic in Vitro 3:491-504.
24. Smith P, Gandolfi A, Krumdieck C, Putnam C, Zukowski C, Davis W and Brendel K (1985) Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sci 36:1367-1375.
25. Tanaka A, Uyama S, Tanaka K, Katayama T, Yamamoto N, Yamaoka Y and Ozawa K (1992) The role of enhanced mitochondrial phosphorylation in rat liver transplantation. J Surg Res 52:59-64.
26. Utesch D, Diener B, Molitor E, Oesch F and Platt KL (1992) Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes. Biochem Pharmacol 44:309-15.
27. van 't Klooster GAE, Blaauboer BJ, Noordhoek J and van Miert ASJPAM (1993) Cytochrome P450 induction and metabolism of alkoxyresofurins, ethylmorphine and testosterone in cultured hepatocytes from goats, sheep and cattle. Biochem Pharmacol 46:1781-1790.
28. van der Graaff M, Vermeulen NP, Joeres RP and Breimer DD (1984) Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt. Pharmacology 29:99-109.
29. Warburg O (1923) Versuche an überlebendem Carcinomgewebe. Biochem Z 142:317-333.
30. Wortelboer HM, de Kruif CA, van Iersel AA, Falke HE, Noordhoek J and Blaauboer BJ (1990) The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers. Biochem Pharmacol 40:2525-34.