Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways

Neurobiology of Disease

Volumn 40, Issue 1, 2010, Pages 82-92

  Saini, Nidhi ^a   Oelhafen, Sandra ^a   Hua, Haiqing ^a   Georgiev, Oleg ^a   Schaffner, Walter ^a   Büeler, Hansruedi ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Drosophila; Metal chelators; Oxidative stress; Parkin; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; COPPER IMPORTER B; COPPER PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; MUTANT PROTEIN; PARAQUAT; PARKIN; ROTENONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHELATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DROSOPHILA; EYE EXAMINATION; GENE OVEREXPRESSION; LIFE EXTENSION; LONGEVITY; MORBIDITY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; LONGEVITY; MUTATION; NEURONS; PARKINSON DISEASE; UBIQUITIN-PROTEIN LIGASES;

EID: 77955594704     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.05.011     Document Type: Article

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