Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio

Journal of Experimental Biology

Volumn 201, Issue 1, 1998, Pages 115-120

  Orgad, Sara ^a   Nelson, Hannah ^a   Segal, Daniel ^a   Nelson, Nathan ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Bacterial resistance; Drosophila melanogaster; Metal ions; Taste behavior; Transporters

Indexed keywords

CALCIUM CHLORIDE; CARRIER PROTEIN; CHLORIDE; DIVALENT CATION; DROSOPHILA PROTEIN; FERROUS CHLORIDE; FERROUS ION; MAGNESIUM CHLORIDE; MALVOLIO PROTEIN, DROSOPHILA; MANGANESE CHLORIDE; MANGANESE DERIVATIVE; MEMBRANE PROTEIN; METAL; ZINC CHLORIDE; ZINC DERIVATIVE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DROSOPHILA MELANOGASTER; DRUG EFFECT; GENETICS; ION TRANSPORT; MUTATION; TASTE;

ANIMALS; BEHAVIOR, ANIMAL; CALCIUM CHLORIDE; CARRIER PROTEINS; CATIONS, DIVALENT; CHLORIDES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FERROUS COMPOUNDS; ION PUMPS; MAGNESIUM CHLORIDE; MANGANESE COMPOUNDS; MEMBRANE PROTEINS; METALS; MUTATION; TASTE; ZINC COMPOUNDS;

ANIMALIA; BACTERIA (MICROORGANISMS); DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER; SACCHAROMYCES CEREVISIAE;

EID: 0031933728     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. 2+ from brain tissue during activity. Nature 308, 734-736.
2. BERG, J. M. AND SHI, Y. (1996). The galvanization of biology: a growing appreciation for the roles of zinc. Science 271, 1081-1085.
3. CELLIER, M., PRIVE, G., BELOUCHI, A., KWAN, T., RODRIGUES, V., CHIA, W. AND GROS, P. (1995). Nramp defines a family of membrane proteins. Proc. natn. Acad. Sci. U.S.A. 92, 10089-10093.
4. CHAN, J., XING, Y., MAGLIOZZO, R. S. AND BLOOM, B. R. (1992). Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. exp. Med. 175, 1111-1122.
5. COOPER, J. B., MCINTYRE, K., BADASSO, M. O., WOOD, S. P., ZHANG, Y., GARBE, T. R. AND YOUNG, D. (1995). X-ray structure analysis of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis at 2.0 Angstroms resolution reveals novel dimer-dimer interactions. J. molec. Biol. 246, 531-544.
6. FALK, R. AND ATIDIA, J. (1975). Mutation affecting taste perception in Drosophila melanogaster. Nature 254, 325-326.
7. FEDER, J. N., GNIRKE, A., THOMAS, W., TSUCHIHASHI, Z., RUDDY, D. A., BASAVA, A., DORMISHIAN, F., DOMINGO, R., JR, ELLIS, M. C., FULLAN, A., HINTON, L. M., JONES, N. L., KIMMEL, B. E., KRONMAL, G. S., LAUER, P., LEE, V. K., LOEB, D. B., MAPA, F. A., MCCLELLAND, E., MEYER, N. C., MINTIER, G. A., MOELLER, N., MOORE, T., MORIKANG, E., PRASS, C. E., QUINTANA, L., STARNES, S. M., SCHATZMAN, R. C., BRUNKE, K. J., DRAYNA, D. T., RISCH, N. J., BACON, B. R. AND WOLFF, R. K. (1996). A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 13, 399-408.
8. FRIDOVICH, I. (1995). Superoxide radical and superoxide dismutases. A. Rev. Biochem. 64, 97-112.
9. GOVONI, G., VIDAL, S., CELLIER, M., LEPAGE, P., MALO, D. AND GROS, P. (1995). Genomic structure, promoter sequence and induction of expression of the mouse Nramp1 gene in macrophages. Genomics 27, 9-19.
10. GUNSHIN, H., MACKENZIE, B., BERGER, U. V., GUNSHIN, Y., ROMERO, M. F., BORON, W. F., NUSSBERGER, S., GOLLAN, J. L. AND HEDIGER, M. A. (1997). Cloning and characterization of mammalian proton-coupled metal-ion transporter. Nature 388, 482-488.
11. HOWELL, G. A., WELCH, M. G. AND FREDERICKSON, C. J. (1984). Stimulation-induced uptake and release of zinc in hippocampal slices. Nature 308, 736-738.
12. INAMDAR, M., VIJAYRAGHAVAN, K. AND RODRIGUES, V. (1993). The Drosophila homolog of the human transcription factor TEF-1, scalloped, is essential for normal taste behavior. J. Neurogenet. 9, 123-139.
13. ISONO, K. AND KIKUCHI, T. (1973). Autosomal recessive mutation in sugar response of Drosophila. Nature 248, 243-244.
14. KOH, J.-Y., SUH, S. W., GWAG, B. J., HE, Y. Y., HSU, C. Y. AND CHOI, D. W. (1996). The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016.
15. LAH, M. S., DIXON, M. M., PATTRIDGE, K. A., STALLINGS, W. C., FEE, J. A. AND LUDWIG, M. L. (1995). Structure-function in Escherichia coli iron superoxide dismutase: comparisons with the manganese enzyme from Thermus thermophilus. Biochemistry 34, 1646-1660.
16. LIU, X. F. AND CULOTTA, V. C. (1994). The rquirement for yeast superoxide dismutase is bypassed through mutation in BSD2, a novel metal homeostasis gene. Molec. cell. Biol. 14, 7037-7045.
17. LIU, X. F., SUPEK, F., NELSON, N. AND CULOTTA, V. C. (1997). The control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene. J. biol. Chem. 272, 11763-11769.
18. PALMITER, R. D., COLE, T. B., QUAIFE, C. J. AND FINDLEY, S. D. (1996). ZnT-3, a putative transporter of zinc into synaptic vesicles. Proc. natn. Acad. Sci. U.S.A. 93, 14934-14939.
19. PETERS, S., KOH, J. AND CHOI, D. W. (1987). Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 236, 589-593.
20. RICHFIELD, E. K. (1993). Zinc modulation of drug binding, cocaine affinity states and dopamine uptake on the dopamine uptake complex. Molec. Pharmac. 43, 100-108.
21. RODRIGUES, V., CHEAH, P. Y., RAY, K. AND CHIA, W. (1995). malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour. EMBO J. 14, 3007-3020.
22. SEGUELA, P., HAGHIGHI, A., SOGHOMONIAN, J. J. AND COOPER, E. (1996). A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. J. Neurosci. 16, 448-155.
23. SHUTO, M., OGITA, K., MINAMI, T., MAEDA, H. AND YONEDA, Y. (1997). Inhibition of [3H]MK-801 binding by ferrous (II) but not ferric (III) ions in a manner different from that by sodium nitroprusside (II) in rat brain synaptic membranes. J. Neurochem. 69, 744-752.
24. SUPEK, F., SUPEKOVA, L., NELSON, H. AND NELSON, N. (1996). A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. natn. Acad. Sci. U.S.A. 93, 5105-5110.
25. SUPEK, F., SUPEKOVA, L., NELSON, H. AND NELSON, N. (1997). Function of metal-ion homeostasis in the cell division cycle, mitochondrial protein processing, sensitivity to mycobacterial infection and brain functions. J. exp. Biol. 200, 321-330.
26. TANIMURA, T., ISONO, K., TAKAMURA, T. AND SHIMADA, I. (1982). Genetic dimorphism in the taste sensitivity to trehalose in Drosophila melanogaster. J. comp. Physiol. A 147, 265.
27. TOMPKINS, L., CARDOSA, M. J., WHITE, F. V. AND SANDERS, T. G. (1979). Isolation and analysis of chemosensory behavior mutants in Drosophila melanogaster. Proc. natn. Acad. Sci. U.S.A. 76, 884-887.
28. VIDAL, S., BELOUCHI, A. M., CELLIER, M., BEATTY, B. AND GROS, P. (1995a). Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm. Genome 6, 224-230.
29. VIDAL, S., TREMBLAY, M. L., GOVONI, G., GAUTHIER, S., SEBASTIANI, G., MALO, D., SKAMENE, E., OLIVIER, M., JOTHY, S. AND GROS, P. (1995b). The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. exp. Med. 182, 655-666.
30. VIDAL, S. M., MALO, D., VOGAN, K., SKAMENE, E. AND GROS, P. (1993). Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73, 469-485.
31. VIJAYRAGHAVAN, K., KAUR, J., PARANJAPE, J. AND RODRIGUES, V. (1992). The east gene of Drosophila melanogaster is expressed in the developing embryonic nervous system and is required for normal olfactory and gustatory responses of the adult. Dev. Biol. 154, 23-36.
32. 2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 328, 640-643.