Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster

Journal of Clinical Investigation

Volumn 107, Issue 6, 2001, Pages 685-693

  Ma, Enbo ^a   Gu, Xiang Qun ^a   Wu, Xiaohui ^b   Xu, Tian ^b   Haddad, Gabriel G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; CALCIUM; CHLORIDE; GENE PRODUCT; OXYGEN; PROTEIN DADAR; PROTEIN HYPNOS 2; SODIUM; UNCLASSIFIED DRUG;

ADAPTATION; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC SCREENING; HEART INFARCTION; HUMAN; HYPOXIA; NERVE CELL DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STRESS;

DROSOPHILA MELANOGASTER;

EID: 0035100188     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11625     Document Type: Article

References (32)

1. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death
2. Purification and characterization of a novel stress protein, the 150-kDa oxygen-regulated protein (ORP150), from cultured rat astrocytes and its expression in ischemic mouse brain
3. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
4. Targeting gene expression to hypoxic tumor cells
5. Notch signaling
6. Tracing the roots of ion channels
7. Extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
8. Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster
9. 2 deprivation: An anoxia-regulated novel gene in Drosophila melanogaster
10. 2 deprivation in Drosophila melanogaster
11. Voltage-gated currents and firing properties of embryonic Drosophila neurons grown in a chemically defined medium
12. Drosophila neurons respond differently to hypoxia and cyanide than rat neurons
13. A standardized nomenclature for adenosine deaminases that act on RNA
14. A mammalian RNA editing enzyme
15. RED2, a brain-specific member of the RNA-specific adenosine deaminase family
16. Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3
17. Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases
18. RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation
19. The mle(napts) RNA helicase mutation in Drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing
20. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity
21. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
22. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
23. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
24. Regulation of serotonin-2C receptor G-protein coupling by RNA editing
25. + channels with altered functional properties
26. RNA editing in the Drosophila DMCA1A calcium-channel alpha 1 subunit transcript
27. Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications
28. Genetic studies of membrane excitability in Drosophia: Lethal interaction between two temperature-sensitive paralytic mutations
29. A Drosophila calcium a1 subunit gene maps to a genetic locus associated with behavioral and visual defects
30. Ion channels and exchangers that mediate ischemic neuronal injury
31. Role of glutamate receptors and voltage-dependent calcium and sodium channels in the extracellular glutamate/aspartare accumulation and subsequent neuronal injury induced by oxygen/glucose deprivation in cultured hippocampal neurons
32. + channels