A forward genetic screen in Drosophila implicates insulin signaling in age-related locomotor impairment

Experimental Gerontology

Volumn 44, Issue 8, 2009, Pages 532-540

  Jones, Melanie A ^a   Gargano, Julia Warner ^b   Rhodenizer, Devin ^a   Martin, Ian ^a   Bhandari, Poonam ^a   Grotewiel, Mike ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Aging; Behavior; Functional senescence; Genetics; Oxidative stress

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ACTIN; DECAPENTAPLEGIC PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HELIX LOOP HELIX PROTEIN; INSULIN; PARAQUAT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; T BOX TRANSCRIPTION FACTOR; WNT PROTEIN;

AGING; ALLELE; ANIMAL CELL; ARTICLE; COMORBIDITY; CONTROLLED STUDY; DEPRESSION; DROSOPHILA; ENZYME ACTIVE SITE; FALLING; FEMALE; GENE DISRUPTION; GENE INSERTION; GENETIC SCREENING; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SIGNAL TRANSDUCTION; STRAIN IDENTIFICATION;

AGING; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 67650587299     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.05.007     Document Type: Article

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