-
1
-
-
0019174693
-
Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes
-
Wilkinson K.D., et al. Ubiquitin is the ATP-dependent proteolysis factor I of rabbit reticulocytes. J. Biol. Chem. 1980, 255:7529-7532.
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 7529-7532
-
-
Wilkinson, K.D.1
-
2
-
-
70349441058
-
Ubiquitin-binding domains - from structures to functions
-
Dikic I., et al. Ubiquitin-binding domains - from structures to functions. Nat. Rev. Mol. Cell Biol. 2009, 10:659-671.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 659-671
-
-
Dikic, I.1
-
3
-
-
1442323729
-
N-terminal ubiquitination: more protein substrates join in
-
Ciechanover A., Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends Cell Biol. 2004, 14:103-106.
-
(2004)
Trends Cell Biol.
, vol.14
, pp. 103-106
-
-
Ciechanover, A.1
Ben-Saadon, R.2
-
4
-
-
34249042608
-
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
-
Wang X., et al. Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3. J. Cell Biol. 2007, 177:613-624.
-
(2007)
J. Cell Biol.
, vol.177
, pp. 613-624
-
-
Wang, X.1
-
5
-
-
21744433861
-
Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase
-
Cadwell K., Coscoy L. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Science 2005, 309:127-130.
-
(2005)
Science
, vol.309
, pp. 127-130
-
-
Cadwell, K.1
Coscoy, L.2
-
6
-
-
33947539481
-
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue
-
Ravid T., Hochstrasser M. Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat. Cell Biol. 2007, 9:422-427.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 422-427
-
-
Ravid, T.1
Hochstrasser, M.2
-
7
-
-
0041706156
-
A proteomics approach to understanding protein ubiquitination
-
Peng J., et al. A proteomics approach to understanding protein ubiquitination. Nat. Biotechnol. 2003, 21:921-926.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 921-926
-
-
Peng, J.1
-
8
-
-
33750219981
-
A ubiquitin ligase complex assembles linear polyubiquitin chains
-
Kirisako T., et al. A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006, 25:4877-4887.
-
(2006)
EMBO J.
, vol.25
, pp. 4877-4887
-
-
Kirisako, T.1
-
9
-
-
33645703441
-
A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking
-
Tagwerker C., et al. A tandem affinity tag for two-step purification under fully denaturing conditions: application in ubiquitin profiling and protein complex identification combined with in vivocross-linking. Mol. Cell Proteomics 2006, 5:737-748.
-
(2006)
Mol. Cell Proteomics
, vol.5
, pp. 737-748
-
-
Tagwerker, C.1
-
10
-
-
34547130325
-
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
-
Kim H.T., et al. Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J. Biol. Chem. 2007, 282:17375-17386.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17375-17386
-
-
Kim, H.T.1
-
11
-
-
71449095149
-
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
-
Kulathu Y., et al. Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain. Nat. Struct. Mol. Biol. 2009, 16:1328-1330.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 1328-1330
-
-
Kulathu, Y.1
-
12
-
-
33847056330
-
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH
-
Eddins M.J., et al. Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J. Mol. Biol. 2007, 367:204-211.
-
(2007)
J. Mol. Biol.
, vol.367
, pp. 204-211
-
-
Eddins, M.J.1
-
13
-
-
1342304089
-
Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling
-
Varadan R., et al. Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J. Biol. Chem. 2004, 279:7055-7063.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7055-7063
-
-
Varadan, R.1
-
14
-
-
67349231313
-
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains
-
Komander D., et al. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009, 10:466-473.
-
(2009)
EMBO Rep.
, vol.10
, pp. 466-473
-
-
Komander, D.1
-
15
-
-
73649116305
-
Exploring the Linkage Dependence of Polyubiquitin Conformations Using Molecular Modeling
-
Fushman D., Walker O. Exploring the Linkage Dependence of Polyubiquitin Conformations Using Molecular Modeling. J. Mol. Biol. 2010, 395:803-814.
-
(2010)
J. Mol. Biol.
, vol.395
, pp. 803-814
-
-
Fushman, D.1
Walker, O.2
-
16
-
-
20444391345
-
Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain
-
Varadan R., et al. Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain. Mol. Cell 2005, 18:687-698.
-
(2005)
Mol. Cell
, vol.18
, pp. 687-698
-
-
Varadan, R.1
-
17
-
-
33846548206
-
Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity
-
Huang D.T., et al. Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity. Nature 2007, 445:394-398.
-
(2007)
Nature
, vol.445
, pp. 394-398
-
-
Huang, D.T.1
-
18
-
-
28944435024
-
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34
-
Petroski M.D., Deshaies R.J. Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell 2005, 123:1107-1120.
-
(2005)
Cell
, vol.123
, pp. 1107-1120
-
-
Petroski, M.D.1
Deshaies, R.J.2
-
19
-
-
0033525582
-
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
-
Hofmann R.M., Pickart C.M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 1999, 96:645-653.
-
(1999)
Cell
, vol.96
, pp. 645-653
-
-
Hofmann, R.M.1
Pickart, C.M.2
-
20
-
-
33749506057
-
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation
-
Eddins M.J., et al. Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat. Struct. Mol. Biol. 2006, 13:915-920.
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 915-920
-
-
Eddins, M.J.1
-
22
-
-
29244447753
-
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis
-
Wang M., Pickart C.M. Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis. EMBO J. 2005, 24:4324-4333.
-
(2005)
EMBO J.
, vol.24
, pp. 4324-4333
-
-
Wang, M.1
Pickart, C.M.2
-
23
-
-
67649227630
-
Polyubiquitination by HECT E3s and the determinants of chain type specificity
-
Kim H.C., Huibregtse J.M. Polyubiquitination by HECT E3s and the determinants of chain type specificity. Mol. Cell Biol. 2009, 29:3307-3318.
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 3307-3318
-
-
Kim, H.C.1
Huibregtse, J.M.2
-
24
-
-
0037068455
-
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
-
Hoege C., et al. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002, 419:135-141.
-
(2002)
Nature
, vol.419
, pp. 135-141
-
-
Hoege, C.1
-
25
-
-
0034600851
-
Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
-
Ulrich H.D., Jentsch S. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J. 2000, 19:3388-3397.
-
(2000)
EMBO J.
, vol.19
, pp. 3388-3397
-
-
Ulrich, H.D.1
Jentsch, S.2
-
26
-
-
77954758752
-
The regulation of MDM2 by multisite phosphorylation-Opportunities for molecular-based intervention to target tumours?
-
Meek D.W., Hupp T.R. The regulation of MDM2 by multisite phosphorylation-Opportunities for molecular-based intervention to target tumours?. Semin. Cancer Biol. 2009.
-
(2009)
Semin. Cancer Biol.
-
-
Meek, D.W.1
Hupp, T.R.2
-
27
-
-
72449125109
-
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity
-
Cheng Q., et al. ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J. 2009, 28:3857-3867.
-
(2009)
EMBO J.
, vol.28
, pp. 3857-3867
-
-
Cheng, Q.1
-
28
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y., et al. Mdm2 promotes the rapid degradation of p53. Nature 1997, 387:296-299.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
-
29
-
-
71749107527
-
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
-
Dias S.S., et al. Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover. FEBS Lett. 2009, 583:3543-3548.
-
(2009)
FEBS Lett.
, vol.583
, pp. 3543-3548
-
-
Dias, S.S.1
-
30
-
-
33746648187
-
Critical role for Daxx in regulating Mdm2
-
Tang J., et al. Critical role for Daxx in regulating Mdm2. Nat. Cell Biol. 2006, 8:855-862.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 855-862
-
-
Tang, J.1
-
31
-
-
1842421376
-
A dynamic role of HAUSP in the p53-Mdm2 pathway
-
Li M., et al. A dynamic role of HAUSP in the p53-Mdm2 pathway. Mol. Cell 2004, 13:879-886.
-
(2004)
Mol. Cell
, vol.13
, pp. 879-886
-
-
Li, M.1
-
32
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang S., et al. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J. Biol. Chem. 2000, 275:8945-8951.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
-
33
-
-
46949093338
-
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
-
Song M.S., et al. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008, 27:1863-1874.
-
(2008)
EMBO J.
, vol.27
, pp. 1863-1874
-
-
Song, M.S.1
-
34
-
-
0034737438
-
Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding
-
Sakaguchi K., et al. Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding. J. Biol. Chem. 2000, 275:9278-9283.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9278-9283
-
-
Sakaguchi, K.1
-
35
-
-
70450227424
-
Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1
-
Lawrence C.L., et al. Stress-induced phosphorylation of S. pombe Atf1 abrogates its interaction with F box protein Fbh1. Curr. Biol. 2009, 19:1907-1911.
-
(2009)
Curr. Biol.
, vol.19
, pp. 1907-1911
-
-
Lawrence, C.L.1
-
36
-
-
68049084674
-
Breaking the chains: structure and function of the deubiquitinases
-
Komander D., et al. Breaking the chains: structure and function of the deubiquitinases. Nat. Rev. Mol. Cell Biol. 2009, 10:550-563.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 550-563
-
-
Komander, D.1
-
37
-
-
67649634849
-
Defining the human deubiquitinating enzyme interaction landscape
-
Sowa M.E., et al. Defining the human deubiquitinating enzyme interaction landscape. Cell 2009, 138:389-403.
-
(2009)
Cell
, vol.138
, pp. 389-403
-
-
Sowa, M.E.1
-
38
-
-
55549086868
-
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains
-
Winborn B.J., et al. The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J. Biol. Chem. 2008, 283:26436-26443.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26436-26443
-
-
Winborn, B.J.1
-
39
-
-
11844251985
-
A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions
-
Heyninck K., Beyaert R. A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions. Trends Biochem. Sci. 2005, 30:1-4.
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 1-4
-
-
Heyninck, K.1
Beyaert, R.2
-
40
-
-
33646034316
-
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea C.K., et al. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 2006, 22:245-257.
-
(2006)
Mol. Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
-
41
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
-
Wertz I.E., et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004, 430:694-699.
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
-
42
-
-
34249949779
-
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
-
Sobhian B., et al. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science 2007, 316:1198-1202.
-
(2007)
Science
, vol.316
, pp. 1198-1202
-
-
Sobhian, B.1
-
43
-
-
62549161305
-
Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80
-
Sims J.J., Cohen R.E. Linkage-specific avidity defines the lysine 63-linked polyubiquitin-binding preference of rap80. Mol. Cell 2009, 33:775-783.
-
(2009)
Mol. Cell
, vol.33
, pp. 775-783
-
-
Sims, J.J.1
Cohen, R.E.2
-
44
-
-
69149088033
-
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80
-
Sato Y., et al. Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO J. 2009, 28:2461-2468.
-
(2009)
EMBO J.
, vol.28
, pp. 2461-2468
-
-
Sato, Y.1
-
45
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
-
Rahighi S., et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009, 136:1098-1109.
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
-
46
-
-
61649103747
-
Structural basis for recognition of diubiquitins by NEMO
-
Lo Y.C., et al. Structural basis for recognition of diubiquitins by NEMO. Mol. Cell 2009, 33:602-615.
-
(2009)
Mol. Cell
, vol.33
, pp. 602-615
-
-
Lo, Y.C.1
-
47
-
-
70349995780
-
Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
-
Yoshikawa A., et al. Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin. FEBS Lett. 2009, 583:3317-3322.
-
(2009)
FEBS Lett.
, vol.583
, pp. 3317-3322
-
-
Yoshikawa, A.1
-
48
-
-
0034254546
-
Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes
-
Kawahara H., et al. Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. EMBO J. 2000, 19:4144-4153.
-
(2000)
EMBO J.
, vol.19
, pp. 4144-4153
-
-
Kawahara, H.1
-
49
-
-
17144417404
-
Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition
-
Wang Q., et al. Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition. J. Mol. Biol. 2005, 348:727-739.
-
(2005)
J. Mol. Biol.
, vol.348
, pp. 727-739
-
-
Wang, Q.1
-
50
-
-
68349135106
-
Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13
-
Zhang N., et al. Structure of the S5a:K48-linked diubiquitin complex and its interactions with Rpn13. Mol. Cell 2009, 35:280-290.
-
(2009)
Mol. Cell
, vol.35
, pp. 280-290
-
-
Zhang, N.1
-
51
-
-
34247349494
-
Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin
-
Kang Y., et al. Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. J. Mol. Biol. 2007, 369:168-176.
-
(2007)
J. Mol. Biol.
, vol.369
, pp. 168-176
-
-
Kang, Y.1
-
52
-
-
44349116590
-
Proteasome subunit Rpn13 is a novel ubiquitin receptor
-
Husnjak K., et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008, 453:481-488.
-
(2008)
Nature
, vol.453
, pp. 481-488
-
-
Husnjak, K.1
-
53
-
-
0038394715
-
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
-
Haglund K., et al. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 2003, 5:461-466.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 461-466
-
-
Haglund, K.1
-
54
-
-
33644852909
-
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain
-
Huang F., et al. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 2006, 21:737-748.
-
(2006)
Mol. Cell
, vol.21
, pp. 737-748
-
-
Huang, F.1
-
55
-
-
68249135262
-
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains
-
Sims J.J., et al. Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains. Nat. Struct. Mol. Biol. 2009, 16:883-889.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 883-889
-
-
Sims, J.J.1
-
56
-
-
69949093459
-
Direct activation of protein kinases by unanchored polyubiquitin chains
-
Xia Z.P., et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 2009, 461:114-119.
-
(2009)
Nature
, vol.461
, pp. 114-119
-
-
Xia, Z.P.1
-
57
-
-
65649115267
-
Recognition and processing of ubiquitin-protein conjugates by the proteasome
-
Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu. Rev. Biochem. 2009, 78:477-513.
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 477-513
-
-
Finley, D.1
-
58
-
-
44349094727
-
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
-
Schreiner P., et al. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature 2008, 453:548-552.
-
(2008)
Nature
, vol.453
, pp. 548-552
-
-
Schreiner, P.1
-
59
-
-
33749348820
-
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes
-
Hamazaki J., et al. A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J. 2006, 25:4524-4536.
-
(2006)
EMBO J.
, vol.25
, pp. 4524-4536
-
-
Hamazaki, J.1
-
60
-
-
33748188085
-
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
-
Yao T., et al. Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat. Cell Biol. 2006, 8:994-1002.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 994-1002
-
-
Yao, T.1
-
61
-
-
33845713194
-
HRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37
-
Qiu X.B., et al. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006, 25:5742-5753.
-
(2006)
EMBO J.
, vol.25
, pp. 5742-5753
-
-
Qiu, X.B.1
-
62
-
-
34548259958
-
P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
-
Pankiv S., et al. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 2007, 282:24131-24145.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24131-24145
-
-
Pankiv, S.1
-
63
-
-
60849099049
-
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
-
Kirkin V., et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol. Cell 2009, 33:505-516.
-
(2009)
Mol. Cell
, vol.33
, pp. 505-516
-
-
Kirkin, V.1
-
64
-
-
70350450808
-
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
-
Thurston T.L., et al. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 2009, 10:1215-1221.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 1215-1221
-
-
Thurston, T.L.1
-
65
-
-
0034010261
-
Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites
-
Drake M.T., et al. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. J. Biol. Chem. 2000, 275:6479-6489.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6479-6489
-
-
Drake, M.T.1
-
66
-
-
0037179662
-
Curvature of clathrin-coated pits driven by epsin
-
Ford M.G., et al. Curvature of clathrin-coated pits driven by epsin. Nature 2002, 419:361-366.
-
(2002)
Nature
, vol.419
, pp. 361-366
-
-
Ford, M.G.1
-
67
-
-
58549096725
-
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits
-
Kazazic M., et al. Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits. Traffic 2009, 10:235-245.
-
(2009)
Traffic
, vol.10
, pp. 235-245
-
-
Kazazic, M.1
-
68
-
-
36248991778
-
ESCRTing proteins in the endocytic pathway
-
Saksena S., et al. ESCRTing proteins in the endocytic pathway. Trends Biochem. Sci. 2007, 32:561-573.
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 561-573
-
-
Saksena, S.1
-
69
-
-
39149132089
-
ESCRT complexes and the biogenesis of multivesicular bodies
-
Hurley J.H. ESCRT complexes and the biogenesis of multivesicular bodies. Curr. Opin. Cell Biol. 2008, 20:4-11.
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 4-11
-
-
Hurley, J.H.1
-
70
-
-
33750532531
-
Molecular mechanisms of coupled monoubiquitination
-
Woelk T., et al. Molecular mechanisms of coupled monoubiquitination. Nat. Cell Biol. 2006, 8:1246-1254.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1246-1254
-
-
Woelk, T.1
-
71
-
-
33746594215
-
A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling
-
Fallon L., et al. A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat. Cell Biol. 2006, 8:834-842.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 834-842
-
-
Fallon, L.1
-
72
-
-
33645148675
-
Regulation of ubiquitin-binding proteins by monoubiquitination
-
Hoeller D., et al. Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 2006, 8:163-169.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 163-169
-
-
Hoeller, D.1
-
73
-
-
34247504273
-
Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway
-
Nikko E., Andre B. Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway. Traffic 2007, 8:566-581.
-
(2007)
Traffic
, vol.8
, pp. 566-581
-
-
Nikko, E.1
Andre, B.2
-
74
-
-
33745754789
-
A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes
-
Mizuno E., et al. A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes. Traffic 2006, 7:1017-1031.
-
(2006)
Traffic
, vol.7
, pp. 1017-1031
-
-
Mizuno, E.1
-
75
-
-
4344559454
-
An unstructured initiation site is required for efficient proteasome-mediated degradation
-
Prakash S., et al. An unstructured initiation site is required for efficient proteasome-mediated degradation. Nat. Struct. Mol. Biol. 2004, 11:830-837.
-
(2004)
Nat. Struct. Mol. Biol.
, vol.11
, pp. 830-837
-
-
Prakash, S.1
-
76
-
-
57749102552
-
Substrate selection by the proteasome during degradation of protein complexes
-
Prakash S., et al. Substrate selection by the proteasome during degradation of protein complexes. Nat. Chem. Biol. 2009, 5:29-36.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 29-36
-
-
Prakash, S.1
-
77
-
-
0026523562
-
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit
-
Henkel T., et al. Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit. Cell 1992, 68:1121-1133.
-
(1992)
Cell
, vol.68
, pp. 1121-1133
-
-
Henkel, T.1
-
78
-
-
0034745420
-
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
-
Xiao G., et al. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol. Cell 2001, 7:401-409.
-
(2001)
Mol. Cell
, vol.7
, pp. 401-409
-
-
Xiao, G.1
-
79
-
-
0027980321
-
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
-
Palombella V.J., et al. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell 1994, 78:773-785.
-
(1994)
Cell
, vol.78
, pp. 773-785
-
-
Palombella, V.J.1
-
80
-
-
0041856286
-
Stability of the Rel homology domain is critical for generation of NF-kappa B p50 subunit
-
Lin L., Kobayashi M. Stability of the Rel homology domain is critical for generation of NF-kappa B p50 subunit. J. Biol. Chem. 2003, 278:31479-31485.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31479-31485
-
-
Lin, L.1
Kobayashi, M.2
-
81
-
-
0035266072
-
ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal
-
Lee C., et al. ATP-dependent proteases degrade their substrates by processively unraveling them from the degradation signal. Mol. Cell 2001, 7:627-637.
-
(2001)
Mol. Cell
, vol.7
, pp. 627-637
-
-
Lee, C.1
-
82
-
-
0029924035
-
A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit
-
Lin L., Ghosh S. A glycine-rich region in NF-kappaB p105 functions as a processing signal for the generation of the p50 subunit. Mol. Cell Biol. 1996, 16:2248-2254.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 2248-2254
-
-
Lin, L.1
Ghosh, S.2
-
83
-
-
56949099243
-
Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing
-
Daskalogianni C., et al. Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing. J. Biol. Chem. 2008, 283:30090-30100.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 30090-30100
-
-
Daskalogianni, C.1
-
84
-
-
33646152750
-
Glycine-alanine repeats impair proper substrate unfolding by the proteasome
-
Hoyt M.A., et al. Glycine-alanine repeats impair proper substrate unfolding by the proteasome. EMBO J. 2006, 25:1720-1729.
-
(2006)
EMBO J.
, vol.25
, pp. 1720-1729
-
-
Hoyt, M.A.1
-
85
-
-
34547119036
-
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing
-
Kwun H.J., et al. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mimics Epstein-Barr virus EBNA1 immune evasion through central repeat domain effects on protein processing. J. Virol. 2007, 81:8225-8235.
-
(2007)
J. Virol.
, vol.81
, pp. 8225-8235
-
-
Kwun, H.J.1
-
86
-
-
33845223494
-
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage
-
Guo C., et al. Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol. Cell Biol. 2006, 26:8892-8900.
-
(2006)
Mol. Cell Biol.
, vol.26
, pp. 8892-8900
-
-
Guo, C.1
-
87
-
-
33847381960
-
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae
-
Parker J.L., et al. Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae. Nucleic Acids Res. 2007, 35:881-889.
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 881-889
-
-
Parker, J.L.1
-
88
-
-
44449138846
-
Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme
-
Zhuang Z., et al. Regulation of polymerase exchange between Poleta and Poldelta by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:5361-5366.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 5361-5366
-
-
Zhuang, Z.1
-
89
-
-
21044442126
-
UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex
-
Sugasawa K., et al. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 2005, 121:387-400.
-
(2005)
Cell
, vol.121
, pp. 387-400
-
-
Sugasawa, K.1
-
90
-
-
0035930582
-
UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation
-
Chen X., et al. UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. J. Biol. Chem. 2001, 276:48175-48182.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 48175-48182
-
-
Chen, X.1
-
91
-
-
57749198023
-
Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex
-
Scrima A., et al. Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell 2008, 135:1213-1223.
-
(2008)
Cell
, vol.135
, pp. 1213-1223
-
-
Scrima, A.1
-
92
-
-
17944361949
-
Sequential assembly of the nucleotide excision repair factors in vivo
-
Volker M., et al. Sequential assembly of the nucleotide excision repair factors in vivo. Mol. Cell 2001, 8:213-224.
-
(2001)
Mol. Cell
, vol.8
, pp. 213-224
-
-
Volker, M.1
-
93
-
-
33744781568
-
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage
-
Wang H., et al. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol. Cell 2006, 22:383-394.
-
(2006)
Mol. Cell
, vol.22
, pp. 383-394
-
-
Wang, H.1
-
94
-
-
35148894396
-
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
-
Ikura T., et al. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol. Cell Biol. 2007, 27:7028-7040.
-
(2007)
Mol. Cell Biol.
, vol.27
, pp. 7028-7040
-
-
Ikura, T.1
-
95
-
-
46149091721
-
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation
-
Fleming A.B., et al. H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation. Mol. Cell 2008, 31:57-66.
-
(2008)
Mol. Cell
, vol.31
, pp. 57-66
-
-
Fleming, A.B.1
-
96
-
-
0037019333
-
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
-
Sun Z.W., Allis C.D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 2002, 418:104-108.
-
(2002)
Nature
, vol.418
, pp. 104-108
-
-
Sun, Z.W.1
Allis, C.D.2
-
97
-
-
70349731733
-
Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability
-
Chandrasekharan M.B., et al. Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:16686-16691.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 16686-16691
-
-
Chandrasekharan, M.B.1
-
98
-
-
32944469894
-
Bortezomib: proteasome inhibition as an effective anticancer therapy
-
Richardson P.G., et al. Bortezomib: proteasome inhibition as an effective anticancer therapy. Annu. Rev. Med. 2006, 57:33-47.
-
(2006)
Annu. Rev. Med.
, vol.57
, pp. 33-47
-
-
Richardson, P.G.1
-
99
-
-
37649000950
-
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition
-
Nikiforov M.A., et al. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:19488-19493.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 19488-19493
-
-
Nikiforov, M.A.1
-
100
-
-
60549109872
-
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
-
Wang Q., et al. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:2200-2205.
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.106
, pp. 2200-2205
-
-
Wang, Q.1
|