N-terminal ubiquitination: More protein substrates join in

Trends in Cell Biology

Volumn 14, Issue 3, 2004, Pages 103-106

  Ciechanover, Aaron ^a   Ben Saadon, Ronen ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; PROTEIN; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CONJUGATION; HUMAN; MOLECULAR BIOLOGY; MOLECULAR EVOLUTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 1442323729     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcb.2004.01.004     Document Type: Short Survey

References (22)

1. Glickman M.H., Ciechanover A. The Ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol. Rev. 82:2002;373-428.
2. Pickart C.M. Mechanisms of ubiquitination. Annu. Rev. Biochem. 70:2001;503-533.
3. Hilt, W. and Wolf, D.H. eds (2000) Proteasomes: The World of Regulatory Proteolysis, Eurekah.com/Landes Bioscience Publishing Company, Texas.
4. Hicke L., Dunn R. Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu. Rev. Cell Dev. Biol. 19:2003;141-172.
5. Muratani M., Tansey W.P. How the ubiquitin-proteasome system controls transcription. Nat. Rev. Mol. Cell Biol. 4:2003;192-201.
6. Cdc4-bound substrate Sic1. Cell. 114:2003;611-622.
7. Scherer D.C., et al. Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl. Acad. Sci. U. S. A. 92:1995;11259-11263.
8. King R.W., et al. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol. Biol. Cell. 7:1996;1343-1357.
9. Hou D., et al. Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines. J. Biol. Chem. 269:1994;14244-14247.
10. Goldknopf I.L., Busch H. Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24. Proc. Natl. Acad. Sci. U. S. A. 74:1977;864-868.
11. Gronroos E., et al. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell. 10:2002;483-493.
12. Bloom J., et al. Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation. Cell. 115:2003;1-20.
13. Cip1 ubiquitination. Mol. Cell. 5:2000;403-410.
14. waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J. 22:2003;6365-6377.
15. Breitschopf K., et al. A novel site for ubiquitination: the N-terminal residue and not internal lysines of MyoD is essential for conjugation and degradation of the protein. EMBO J. 17:1998;5964-5973.
16. Reinstein E., et al. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene. 19:2000;5944-5950.
17. Aviel S., et al. Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway: targeting via ubiquitination of the N- terminal residue. J. Biol. Chem. 275:2000;23491-23499.
18. Ikeda M., et al. Lysine-independent ubiquitination of the Epstein-Barr virus LMP2A. Virology. 300:2002;153-159.
19. Fajerman I., et al. Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochem. Biophys. Res. Commun. 314:2004;505-512.
20. Varshavsky A. The N-end rule: functions, mysteries, uses. Proc. Natl. Acad. Sci. U. S. A. 93:1996;12142-12149.
21. Johnson E.S., et al. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270:1995;17442-17456.
22. Polevoda B., Sherman F. N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J. Mol. Biol. 325:2003;595-622.