Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue

Nature Cell Biology

Volumn 9, Issue 4, 2007, Pages 422-427

  Ravid, Tommer ^a   Hochstrasser, Mark ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; LYSINE; MEMBRANE PROTEIN; POLYUBIQUITIN; PROTEASOME; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

ARTICLE; AUTOREGULATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME LOCALIZATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN STRUCTURE; PROTEIN TARGETING; QUALITY CONTROL; UBIQUITINATION; YEAST;

AMINO ACIDS; CATALYTIC DOMAIN; CYSTEINE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GREEN FLUORESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; PLASMIDS; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; YEASTS;

EID: 33947539481     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1558     Document Type: Article

References (30)

1. Wickner, S., Maurizi, M. R. & Gottesman, S. Posttranslational quality control: Folding, refolding, and degrading proteins. Science 286, 1888-1893 (1999).
2. Meusser, B., Hirsch, C., Jarosch, E. & Sommer, T. ERAD: The long road to destruction. Nature Cell Biol 7, 766-772 (2005).
3. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genetics 30, 405-439 (1996).
4. Pickart, C. M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533 (2001).
5. Biederer, T., Volkwein, C. & Sommer, T. Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278, 1806-1809 (1997).
6. Gardner, R. G., Shearer, A. G. & Hampton, R. Y. In vivo action of the HRD ubiquitin ligase complex: Mechanisms of endoplasmic reticulum quality control and sterol regulation. Mol. Cell Biol. 21, 4276-4291 (2001).
7. Biederer, T., Volkwein, C. & Sommer, T. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J. 15, 2069-2076 (1996).
8. Laney, J. D., Mobley, E. F. & Hochstrasser, M. The short-lived Matα2 transcriptional repressor is protected from degradation in vivo by interactions with its corepressors Tup1 and Ssn6. Mol. Cell Biol. 26, 371-380 (2006).
9. Friedlander, R., Jarosch, E., Urban, J., Volkwein, C. & Sommer, T. A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nature Cell Biol. 2, 379-384 (2000).
10. Johnson, E. S., Ma, P. C. M., Ota, I. M. & Varshavsky, A. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270, 17442-17456 (1995).
11. Xie, Y. & Varshavsky, A. UFD4 lacking the proteasome-binding region catalyses ubiquitination but is impaired in proteolysis. Nature Cell Biol. 4, 1003-1007 (2002).
12. Walter, J., Urban, J., Volkwein, C. & Sommer, T. Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p. EMBO J. 20, 3124-3131 (2001).
13. Rape, M. & Kirschner, M. W. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432, 588-595 (2004).
14. Yamanaka, A. et al. Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome. Mol. Biol. Cell 11, 2821-2831 (2000).
15. Machida, Y. J. et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol. Cell 23, 589-596 (2006).
16. Wu, P. Y. et al. A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J. 22, 5241-5250 (2003).
17. Cook, W. J., Martin, P. D., Edwards, B. F., Yamazaki, R. K. & Chau, V. Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Biochem 36, 1621-1627 (1997).
18. Swanson, R., Locher, M. & Hochstrasser, M. A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matα2 repressor degradation. Genes Dev. 15, 2660-2674 (2001).
19. Ciechanover, A. & Ben-Saadon, R. N-terminal ubiquitination: More protein substrates join in. Trends Cell Biol. 14, 103-106 (2004).
20. Coulombe, P., Rodier, G., Bonnell, E., Thibault, P. & Meloche, S. N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome. Mol. Cell Biol. 24, 6140-6150 (2004).
21. Hodgins, R. R. W., Ellison, K. S. & Ellison, M. J. Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency. J. Biol. Chem. 267, 8807-8812 (1992).
22. Hodgins, R., Gwozd, C., Arnason, T., Cummings, M. & Ellison, M. J. The tail of a ubiquitin-conjugating enzyme redirects multi-ubiquitin chain synthesis from the lysine 48-linked configuration to a novel nonlysine-linked form. J. Biol. Chem. 271, 28766-28771 (1996).
23. Lin, Y., Hwang, W. C. & Basavappa, R. Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. J. Biol. Chem. 277, 21913-21921 (2002).
24. Cadwell, K. & Coscoy, L. Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase. Science 309, 127-130 (2005).
25. Haldeman, M. T., Xia, G., Kasperek, E. M. & Pickart, C. M. Structure and function of ubiquitin conjugating enzyme E2-25K: The tail is a core-dependent activity element. Biochem. 36, 10526-10537 (1997).
26. Hochstrasser, M. Lingering mysteries of ubiquitin-chain assembly. Cell 124, 27-34 (2006).
27. Chen, P., Johnson, P., Sommer, T., Jentsch, S. & Hochstrasser, M. Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MATα2 repressor. Cell 74, 357-369 (1993).
28. Ravid, T., Kreft, S. G. & Hochstrasser, M. Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways. EMBO J. 25, 533-543 (2006).
29. Varelas, X., Ptak, C. & Ellison, M. J. Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity. Mol. Cell Biol. 23, 5388-5400 (2003).
30. Deng, M. & Hochstrasser, M. Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 443, 827-831 (2006).