Synthesis and biological evaluation of analogues of a novel inhibitor of β-amyloid secretion

Journal of Medicinal Chemistry

Volumn 53, Issue 14, 2010, Pages 5302-5319

  Chakrabarti, Enakshi ^a   Ghosh, Subrata ^b   Sadhukhan, Sushabhan ^b   Sayre, Lawrence ^b   Tochtrop, Gregory P ^b   Smith, Jonathan D ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DICHLORO N [2 (3 METHYLBENZYLSULFANYL)ETHYL]BENZAMIDE; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NERVE CELL CULTURE; NONHUMAN; SENILE PLAQUE; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BENZAMIDES; CELL LINE; CELL MEMBRANE PERMEABILITY; CEREBRAL CORTEX; HUMANS; INJECTIONS, INTRAVENOUS; MICE; MICE, TRANSGENIC; NEURONS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 77954729177     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100308g     Document Type: Article

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