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note
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We also were able to convert 3-methoxyphenylacetonitrile to the corresponding amidine in fair overall yield (36%) as an example utilising an aliphatic nitrile.
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16
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0142046861
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Ed. Patai S., Wiley, Ch.7
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85035177603
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Eldred C.D., Evans B., Hindley S., Judkins B.D., Kelly H.A., Kitchin J., Lumley P., Porter B., Ross B.C., Smith K.J., Taylor N.R. and Wheatcroft J.R., J. Med. Chem. 1994, 37, 3882.
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22
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85035175063
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note
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Portionwise addition of reagents minimises thermal decomposition of hydroxylamine which occurs with prolonged heating, resulting in higher yields.
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