T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways

Journal of Allergy and Clinical Immunology

Volumn 119, Issue 3, 2007, Pages 662-670

  Fujiwara, Michio ^a   Hirose, Koichi ^a   Kagami, Shin ichiro ^b   Takatori, Hiroaki ^a   Wakashin, Hidefumi ^a   Tamachi, Tomohiro ^a   Watanabe, Norihiko ^a   Saito, Yasushi ^a   Iwamoto, Itsuo ^c   Nakajima, Hiroshi ^b  

^a Clinical Cell Biology

^b CHIBA UNIVERSITY   (Japan)

^c ASAHI GENERAL HOSPITAL   (Japan)

Author keywords

Allergic inflammation; Eosinophils; T bet; TH17 cells; TH2 cells

Indexed keywords

ANTIGEN; CD4 ANTIGEN; INTERLEUKIN 17; STAT6 PROTEIN; TRANSCRIPTION FACTOR T BET;

ADOPTIVE TRANSFER; ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EOSINOPHIL; EOSINOPHILIA; HELPER CELL; MOUSE; NEUTROPHIL; NEUTROPHILIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY TRACT INFLAMMATION; TH17 CELL; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; ASTHMA; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; EOSINOPHILS; INTERLEUKIN-13; INTERLEUKIN-17; LUNG; MICE; MICE, MUTANT STRAINS; NEUTROPHILS; STAT6 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; TH2 CELLS; TRACHEA;

EID: 33847331537     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.12.643     Document Type: Article

References (32)

1. Larche M., Robinson D.S., and Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 111 (2003) 450-463
2. Cohn L., Elias J.A., and Chupp G.L. Asthma: mechanisms of disease persistence and progression. Annu Rev Immunol 22 (2004) 789-815
3. Holgate S.T., and Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 368 (2006) 780-793
4. + T cells. J Exp Med 177 (1993) 573-576
5. Coyle A.J., Tsuyuki S., Bertrand C., Huang S., Aguet M., Alkan S.S., et al. Mice lacking the IFN-γ receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 156 (1996) 2680-2685
6. Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
7. Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., and Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295 (2002) 338-342
8. Finotto S., Neurath M.F., Glickman J.N., Qin S., Lehr H.A., Green F.H., et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295 (2002) 336-338
9. Raby B.A., Hwang E.S., Van Steen K., Tantisira K., Peng S., Litonjua A., et al. T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med 173 (2006) 64-70
10. Takeda K., Tanaka T., Shi W., Matsumoto M., Minami M., Kashiwamura S., et al. Essential role of STAT6 in IL-4 signalling. Nature 380 (1996) 627-630
11. + T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. Am Rev Respir Dis 146 (1992) 374-377
12. Kagami S., Nakajima H., Kumano K., Suzuki K., Suto A., Imada K., et al. Both STAT5a and STAT5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. Blood 95 (2000) 1370-1377
13. Seto Y., Nakajima H., Suto A., Shimoda K., Saito Y., Nakayama K.I., et al. Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol 170 (2003) 1077-1083
14. McDevitt A.L., Deming M.S., Rosenberg H.F., and Dyer K.D. Gene structure and enzymatic activity of mouse eosinophil-associated ribonuclease 2. Gene 267 (2001) 23-30
15. Larson K.A., Olson E.V., Madden B.J., Gleich G.L., Lee N.A., and Lee J.J. Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A 93 (1996) 12370-12375
16. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol 2 (2002) 933-944
17. Sullivan B.M., Juedes A., Szabo S.J., von Herrath M., and Glimcher L.H. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A 100 (2003) 15818-15823
18. Liu N., Ohnishi N., Ni L., Akira S., and Bacon K.B. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat Immunol 4 (2003) 687-693
19. Lugo-Villarino G., Maldonado-Lopez R., Possemato R., Penaranda C., and Glimcher L.H. T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A 100 (2003) 7749-7754
20. Moseley T.A., Haudenschild D.R., Rose L., and Reddi A.H. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev 14 (2003) 155-174
21. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 6 (2006) 329-333
22. + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
23. Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141
24. Mathur A.N., Chang H.C., Zisoulis D.G., Kapur R., Belladonna M.L., Kansas G.S., et al. T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood 108 (2006) 1595-1601
25. Wills-Karp M. IL-12/IL-13 axis in allergic asthma. J Allergy Clin Immunol 107 (2001) 9-18
26. + T cells. Nat Immunol 3 (2002) 549-557
27. Finotto S., Hausding M., Doganci A., Maxeiner J.H., Lehr H.A., Luft C., et al. Asthmatic changes in mice lacking T-bet are mediated by IL-13. Int Immunol 17 (2005) 993-1007
28. Reiner S.L., and Locksley R.M. The regulation of immunity to Leishmania major. Annu Rev Immunol 13 (1995) 151-177
29. Nakajima H., Nakao A., Kumano K., Yamamoto H., and Iwamoto I. Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol 122 (2000) s20-s24
30. Ulloa L., Doody J., and Massague J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 397 (1999) 710-713
31. Davoine Q., Nutku E., Taha R., Page N., Olivenstein R., Elias J., et al. IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108 (2001) 430-438
32. Chakir J., Shannon J., Molet S., Fukakusa M., Elias J., Laviolette M., et al. Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 111 (2003) 1293-1298