-
1
-
-
0025611180
-
Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma
-
1. AZZAWI M., BRADLEY B., JEFFERY P.K. et al. (1990) Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 142, 1407.
-
(1990)
Am Rev Respir Dis
, vol.142
, pp. 1407
-
-
Azzawi, M.1
Bradley, B.2
Jeffery, P.K.3
-
2
-
-
0030960802
-
Adoptive transfer of allergen-specific CD4+ T-cells induces airway inflammation and hyperresponsiveness in Brown-Norway rats
-
2. HACZKU A., MACARY P., HUANG T.-J. et al. (1997) Adoptive transfer of allergen-specific CD4+ T-cells induces airway inflammation and hyperresponsiveness in Brown-Norway rats. Immunology 91, 176.
-
(1997)
Immunology
, vol.91
, pp. 176
-
-
Haczku, A.1
Macary, P.2
Huang, T.-J.3
-
3
-
-
0029112518
-
Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T-cells in Brown-Norway rats
-
3. WATANABE A., MISHIMA H., RENZI P.M., XU L.-J., HAMID Q. & MARTIN J.G. (1995) Transfer of allergic airway responses with antigen-primed CD4+ but not CD8+ T-cells in Brown-Norway rats. J Clin Invest 96, 1303.
-
(1995)
J Clin Invest
, vol.96
, pp. 1303
-
-
Watanabe, A.1
Mishima, H.2
Renzi, P.M.3
Xu, L.-J.4
Hamid, Q.5
Martin, J.G.6
-
4
-
-
0031939693
-
Induction of pulmonary allergic responses by antigen-specific Th2 cells
-
4. LI X.-M., SCHOFIELD B.H., WANG Q.-F., KIM K.-H. & HUANG S.-K. ( 1998) Induction of pulmonary allergic responses by antigen-specific Th2 cells. J Immunol 160, 1378.
-
(1998)
J Immunol
, vol.160
, pp. 1378
-
-
Li, X.-M.1
Schofield, B.H.2
Wang, Q.-F.3
Kim, K.-H.4
Huang, S.-K.5
-
5
-
-
0025760379
-
Expression of mRNA for interleukins in mucosal bronchial biopsies from asthma
-
5. HAMID Q., AZZAWI M., YING S. et al. (1991) Expression of mRNA for interleukins in mucosal bronchial biopsies from asthma. J Clin Invest 87, 1541.
-
(1991)
J Clin Invest
, vol.87
, pp. 1541
-
-
Hamid, Q.1
Azzawi, M.2
Ying, S.3
-
6
-
-
0025108694
-
Regulation and deregulation of human IgE synthesis
-
6. ROMAGNIANI S. (1990) Regulation and deregulation of human IgE synthesis. Immunol Today 11, 316.
-
(1990)
Immunol Today
, vol.11
, pp. 316
-
-
Romagniani, S.1
-
7
-
-
0026643596
-
Interleukin-5, eosinophils and disease
-
7. SANDERSON C.J. (1992) Interleukin-5, eosinophils and disease. Blood 79, 3101.
-
(1992)
Blood
, vol.79
, pp. 3101
-
-
Sanderson, C.J.1
-
8
-
-
0030724369
-
Reduced interferon-γ but normal IL-4 and IL-5 release by peripheral blood mononuclear cells from Xhosa children with atopic asthma
-
8. NURSE B., HAUS M., PUTERMAN A.S., MEINBERG E.G. & POTTER P.C. (1997) Reduced interferon-γ but normal IL-4 and IL-5 release by peripheral blood mononuclear cells from Xhosa children with atopic asthma. J Allergy Clin Immunol 100, 662.
-
(1997)
J Allergy Clin Immunol
, vol.100
, pp. 662
-
-
Nurse, B.1
Haus, M.2
Puterman, A.S.3
Meinberg, E.G.4
Potter, P.C.5
-
9
-
-
0030586669
-
Nebulized IFN-γ inhibits the development of secondary allergic responses in mice
-
9. LACK G., BRADLEY K.L., HAMELMANN E. et al. (1996) Nebulized IFN-γ inhibits the development of secondary allergic responses in mice. J Immunol 157, 1432.
-
(1996)
J Immunol
, vol.157
, pp. 1432
-
-
Lack, G.1
Bradley, K.L.2
Hamelmann, E.3
-
10
-
-
0026507228
-
Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones
-
10. MAGGI E., PARRONCHI P., MANETTI R. et al. (1992) Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 148, 2142.
-
(1992)
J Immunol
, vol.148
, pp. 2142
-
-
Maggi, E.1
Parronchi, P.2
Manetti, R.3
-
11
-
-
0027321298
-
Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ
-
11. NOBLE A., STAYNOV D.Z. & KEMENY D.M. (1993) Generation of rat Th2-like cells in vitro is interleukin-4-dependent and inhibited by interferon-γ. Immunology 79, 562.
-
(1993)
Immunology
, vol.79
, pp. 562
-
-
Noble, A.1
Staynov, D.Z.2
Kemeny, D.M.3
-
13
-
-
0027486985
-
Acrosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea
-
13. NAKAJIMA H., IWAMOTO I. & YUSHIDA S. (1993) Acrosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. Am Rev Respir Dis 148, 1102.
-
(1993)
Am Rev Respir Dis
, vol.148
, pp. 1102
-
-
Nakajima, H.1
Iwamoto, I.2
Yushida, S.3
-
14
-
-
0031045582
-
The effect of anti-IL-4 monoclonal antibody, rapamycin and interferon-γ on airway hyperreactivity to acetylcholine in mice
-
14. NAGAI H., MAEDA Y. & TANAKA H. (1997) The effect of anti-IL-4 monoclonal antibody, rapamycin and interferon-γ on airway hyperreactivity to acetylcholine in mice. Clin Exp Allergy 27, 218.
-
(1997)
Clin Exp Allergy
, vol.27
, pp. 218
-
-
Nagai, H.1
Maeda, Y.2
Tanaka, H.3
-
15
-
-
0026316957
-
Characterisation of allergen-induced inflammation and bronchial hyperresponsiveness in sensitised Brown-Norway rats
-
15. ELWOOD W., LOTVALL J.O., BARNES P.J. & CHUNG K.F. (1991) Characterisation of allergen-induced inflammation and bronchial hyperresponsiveness in sensitised Brown-Norway rats. J Allergy Clin Immunol 88, 951.
-
(1991)
J Allergy Clin Immunol
, vol.88
, pp. 951
-
-
Elwood, W.1
Lotvall, J.O.2
Barnes, P.J.3
Chung, K.F.4
-
16
-
-
0029890890
-
Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitised Brown-Norway rats
-
16. HACZKU A., MACARY P., HADDAD E.-B. et al. (1996) Expression of Th-2 cytokines interleukin-4 and -5 and of Th-1 cytokine interferon-γ in ovalbumin-exposed sensitised Brown-Norway rats. Immunology 88, 247.
-
(1996)
Immunology
, vol.88
, pp. 247
-
-
Haczku, A.1
Macary, P.2
Haddad, E.-B.3
-
18
-
-
0022472884
-
The purification and characterization of rat gamma interferon by use of two monoclonal antibodies
-
18. VAN DER MEIDE P.H., DUBBELD M., VIJVERBERG K., KOS T. & SCHELLEKENS H. (1986) The purification and characterization of rat gamma interferon by use of two monoclonal antibodies. J Gen Virol 67, 1059.
-
(1986)
J Gen Virol
, vol.67
, pp. 1059
-
-
Van Der Meide, P.H.1
Dubbeld, M.2
Vijverberg, K.3
Kos, T.4
Schellekens, H.5
-
19
-
-
0029129165
-
T-cells subsets and activation in bronchial mucosa of sensitised Brown-Norway rats after single allergen exposure
-
19. HACZKU A., MOQBEL R., JACOBSON M., KAY A.B., BARNES P.J. & CHUNG K.F. (1995) T-cells subsets and activation in bronchial mucosa of sensitised Brown-Norway rats after single allergen exposure. Immunology 85, 591.
-
(1995)
Immunology
, vol.85
, pp. 591
-
-
Haczku, A.1
Moqbel, R.2
Jacobson, M.3
Kay, A.B.4
Barnes, P.J.5
Chung, K.F.6
-
20
-
-
0023277545
-
Single step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction
-
20. CHOMCZYNSKI P. & SACCHI N. (1987) Single step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction. Anal Biochem 162, 156.
-
(1987)
Anal Biochem
, vol.162
, pp. 156
-
-
Chomczynski, P.1
Sacchi, N.2
-
21
-
-
0033055079
-
+ T-cell depletion on bronchial hyperresponsiveness and inflammation in sensitised and allergen-exposed Brown-Norway rats
-
+ T-cell depletion on bronchial hyperresponsiveness and inflammation in sensitised and allergen-exposed Brown-Norway rats. Immunology 96, 416.
-
(1999)
Immunology
, vol.96
, pp. 416
-
-
Huang, T.-J.1
Macary, P.A.2
Kemeny, D.M.3
Chung, K.F.4
-
22
-
-
0032209767
-
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma
-
22. HOFSTRA C.L., VAN ARK I., HOFMAN G., NIJKAMP F.P., JARDIEU P.M. & VAN OOSTERHOUT A.J. (1998) Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. Am J Respir Cell Mol Biol 19, 826.
-
(1998)
Am J Respir Cell Mol Biol
, vol.19
, pp. 826
-
-
Hofstra, C.L.1
Van Ark, I.2
Hofman, G.3
Nijkamp, F.P.4
Jardieu, P.M.5
Van Oosterhout, A.J.6
-
23
-
-
0030587861
-
Mucosal IFN-γ gene transfer inhibits pulmonary allergic responses in mice
-
23. LI X.-M., CHOPRA R.K., CHOU T.-Y., SCHOFIELD B.H., WILLSKARP M. & HUANG S.-K. (1996) Mucosal IFN-γ gene transfer inhibits pulmonary allergic responses in mice. J Immunol 157, 3216.
-
(1996)
J Immunol
, vol.157
, pp. 3216
-
-
Li, X.-M.1
Chopra, R.K.2
Chou, T.-Y.3
Schofield, B.H.4
Karp, M.5
Huang, S.-K.6
-
24
-
-
0027409771
-
Interferon gamma inhibits interleukin 10 production by monocytes
-
24. CHOMARAT P., RISSOAN M.C., BANCHEREAU J. & MIOSSEC P. (1993) Interferon gamma inhibits interleukin 10 production by monocytes. J Exp Med 177, 523.
-
(1993)
J Exp Med
, vol.177
, pp. 523
-
-
Chomarat, P.1
Rissoan, M.C.2
Banchereau, J.3
Miossec, P.4
-
25
-
-
0028984136
-
+ T-cells into subpopulations with distinct cytokine profiles
-
+ T-cells into subpopulations with distinct cytokine profiles. J Immunol 155, 2928.
-
(1995)
J Immunol
, vol.155
, pp. 2928
-
-
Noble, A.1
Macary, P.A.2
Kemeny, D.M.3
-
27
-
-
0023032723
-
Antagonistic effects of γ interferon and steroids on tissue antigenicity
-
27. LESZCZYNSKI D., FERRY B., SCHELLEKENS H., VAN DER MEIDE P.H. & HAYRY P. (1986) Antagonistic effects of γ interferon and steroids on tissue antigenicity. J Exp Med 164, 1470.
-
(1986)
J Exp Med
, vol.164
, pp. 1470
-
-
Leszczynski, D.1
Ferry, B.2
Schellekens, H.3
Van Der Meide, P.H.4
Hayry, P.5
-
28
-
-
0024582382
-
Heterogeneous effects of IFN-γ in adjuvant arthritis
-
28. JACOB C.O., HOLOSHITZ J., VAN DER MEIDE P., STROBER S. & MCDEVITT H.O. (1989) Heterogeneous effects of IFN-γ in adjuvant arthritis. J Immunol 142, 1500.
-
(1989)
J Immunol
, vol.142
, pp. 1500
-
-
Jacob, C.O.1
Holoshitz, J.2
Van Der Meide, P.3
Strober, S.4
McDevitt, H.O.5
-
29
-
-
0031918920
-
+ T-cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice
-
+ T-cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice. Am J Respir Crit Care Med 157, 210.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 210
-
-
Hogan, S.P.1
Koskinen, A.2
Matthaei, K.I.3
Young, I.G.4
-
30
-
-
0030028768
-
Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and and lung damage in a mouse asthma model
-
30. FOSTER P.S., HOGAN S.P., RAMSAY A.J., MATTHAEI K.I. & YOUNG I.G. (1996) Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and and lung damage in a mouse asthma model. J Exp Med 183, 195.
-
(1996)
J Exp Med
, vol.183
, pp. 195
-
-
Foster, P.S.1
Hogan, S.P.2
Ramsay, A.J.3
Matthaei, K.I.4
Young, I.G.5
-
31
-
-
0030068235
-
Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
-
31. CORRY D.B., FOLKESSON H.G., WARNOCK M.L. et al. (1996) Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med 183, 109.
-
(1996)
J Exp Med
, vol.183
, pp. 109
-
-
Corry, D.B.1
Folkesson, H.G.2
Warnock, M.L.3
-
32
-
-
0026872537
-
Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell response in sensitized Brown-Norway rats
-
32. ELWOOD W., LOTVALL J.O., BARNES P.J. & CHUNG K.F. (1992) Effect of dexamethasone and cyclosporin A on allergen-induced airway hyperresponsiveness and inflammatory cell response in sensitized Brown-Norway rats. Am Rev Respir Dis 145, 1289.
-
(1992)
Am Rev Respir Dis
, vol.145
, pp. 1289
-
-
Elwood, W.1
Lotvall, J.O.2
Barnes, P.J.3
Chung, K.F.4
-
33
-
-
0028231944
-
Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised Brown-Norway rats
-
33. SUN J., ELWOOD W., HACZKU A., BARNES P.J., HELLEWELL P.G. & CHUNG K.F. (1994) Contribution of intercellular-adhesion molecule-1 in allergen-induced airway hyperresponsiveness and inflammation in sensitised Brown-Norway rats. Int Arch Allergy Immunol 104, 291.
-
(1994)
Int Arch Allergy Immunol
, vol.104
, pp. 291
-
-
Sun, J.1
Elwood, W.2
Haczku, A.3
Barnes, P.J.4
Hellewell, P.G.5
Chung, K.F.6
-
34
-
-
0030584820
-
Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T-cells to exhibit a Th2 cytokine profile
-
34. COYLE A.J., TSUYUKI S., BERTRAND C. et al. (1996) Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T-cells to exhibit a Th2 cytokine profile. J Immunol 156, 2680.
-
(1996)
J Immunol
, vol.156
, pp. 2680
-
-
Coyle, A.J.1
Tsuyuki, S.2
Bertrand, C.3
-
35
-
-
0021132094
-
Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure
-
35. O'BYRNE P.H., WALTERS E.H., GOLD B.D. et al. ( 1984) Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am Rev Respir Dis 130, 214.
-
(1984)
Am Rev Respir Dis
, vol.130
, pp. 214
-
-
O'Byrne, P.H.1
Walters, E.H.2
Gold, B.D.3
-
36
-
-
0022458202
-
The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airway reactivity in an animal model
-
36. MURPHY K.R., WILSON M.C., IRVIN C.G. et al. (1986) The requirement for polymorphonuclear leukocytes in the late asthmatic response and heightened airway reactivity in an animal model. Am Rev Respir Dis 134, 62.
-
(1986)
Am Rev Respir Dis
, vol.134
, pp. 62
-
-
Murphy, K.R.1
Wilson, M.C.2
Irvin, C.G.3
-
37
-
-
0032847226
-
Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsiveness
-
in press
-
37. HUANG T.-J., NEWTON R., HADDAD E.-B. & CHUNG K.F. (1999) Differential regulation of cytokine expression after allergen exposure of sensitized rats by cyclosporin A and corticosteroids: Relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol in press:.
-
(1999)
J Allergy Clin Immunol
-
-
Huang, T.-J.1
Newton, R.2
Haddad, E.-B.3
Chung, K.F.4
-
38
-
-
0031093680
-
Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration
-
38. HESSEL F.M., VAN OOSTERHOUT A.J., VAN ARK I. et al. (1997) Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration. Am J Respir Cell Mol Biol 16, 325.
-
(1997)
Am J Respir Cell Mol Biol
, vol.16
, pp. 325
-
-
Hessel, F.M.1
Van Oosterhout, A.J.2
Van Ark, I.3
-
39
-
-
0025783341
-
Organ specific cytokine therapy: Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-γ to the human lung
-
39. JAFFE H.A., BUHL R., MASTRANGELI A. et al. (1991) Organ specific cytokine therapy: local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-γ to the human lung. J Clin Invest 88, 397.
-
(1991)
J Clin Invest
, vol.88
, pp. 397
-
-
Jaffe, H.A.1
Buhl, R.2
Mastrangeli, A.3
-
40
-
-
0023093171
-
Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide
-
40. GIFFORD G.E. & LOHMANN-MATTHESS M.L. (1987) Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide. J Natl Cancer Inst 78, 121.
-
(1987)
J Natl Cancer Inst
, vol.78
, pp. 121
-
-
Gifford, G.E.1
Lohmann-Matthess, M.L.2
-
41
-
-
0026777610
-
Selective induction of intracellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells
-
41. LOOK D.C., RAPP S.R., KELLER B.T. & HOLZMAN M.J. (1992) Selective induction of intracellular adhesion molecule-1 by interferon-gamma in human airway epithelial cells. Am J Physiol 263, L79.
-
(1992)
Am J Physiol
, vol.263
-
-
Look, D.C.1
Rapp, S.R.2
Keller, B.T.3
Holzman, M.J.4
-
42
-
-
0025182858
-
Interferon-gamma: Mechanism of action and therapeutic potential
-
42. BILLIAU A. & DIJKMANS R. (1990) Interferon-gamma: mechanism of action and therapeutic potential. Biochem Pharmacol 40, 1433.
-
(1990)
Biochem Pharmacol
, vol.40
, pp. 1433
-
-
Billiau, A.1
Dijkmans, R.2
-
43
-
-
0026739463
-
The interferon system: A bird's view of its biochemistry
-
43. SEN G.C. & LENGGEL P. (1992) The interferon system: a bird's view of its biochemistry. J Biol Chem 267, 5017.
-
(1992)
J Biol Chem
, vol.267
, pp. 5017
-
-
Sen, G.C.1
Lenggel, P.2
-
44
-
-
0025166115
-
Effects of IFN on human eosinophils in comparison with other cytokines: A novel class of eosinophil activators with delayed onset of action
-
44. VALERIUS T., REPP P., KALDEN J.R. & PLATZER E. (1990) Effects of IFN on human eosinophils in comparison with other cytokines: a novel class of eosinophil activators with delayed onset of action. J Immunol 145, 2950.
-
(1990)
J Immunol
, vol.145
, pp. 2950
-
-
Valerius, T.1
Repp, P.2
Kalden, J.R.3
Platzer, E.4
-
45
-
-
0031816128
-
Tumor necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea pig in vitro
-
45. PENNINGS H.J., KRAMER K., BAST A., BUURMAN W.A. & WOUTERS E.F. (1998) Tumor necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea pig in vitro. Eur Respir J 12, 45.
-
(1998)
Eur Respir J
, vol.12
, pp. 45
-
-
Pennings, H.J.1
Kramer, K.2
Bast, A.3
Buurman, W.A.4
Wouters, E.F.5
-
46
-
-
0028173026
-
Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity
-
46. DICOSMO B.F., GEBA G.P., PICARELLA D. et al. (1994) Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest 94, 2028.
-
(1994)
J Clin Invest
, vol.94
, pp. 2028
-
-
Dicosmo, B.F.1
Geba, G.P.2
Picarella, D.3
-
47
-
-
0026012259
-
Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
-
47. SALGAME P., ABRAMS J.S., CLAYBERGER C. et al. (1991) Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254, 279.
-
(1991)
Science
, vol.254
, pp. 279
-
-
Salgame, P.1
Abrams, J.S.2
Clayberger, C.3
-
48
-
-
0027169803
-
+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
-
+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178, 889.
-
(1993)
J Exp Med
, vol.178
, pp. 889
-
-
McMenamin, C.1
Holt, P.G.2
-
49
-
-
0027953086
-
Inhibition of IgE production and normalisation of airways responsiveness by sensitised CD8 T-cells in a mouse model of allergen-induced sensitisation
-
49. RENZ H., LACK G., SALOGA J. et al. (1994) Inhibition of IgE production and normalisation of airways responsiveness by sensitised CD8 T-cells in a mouse model of allergen-induced sensitisation. J Immunol 152, 351.
-
(1994)
J Immunol
, vol.152
, pp. 351
-
-
Renz, H.1
Lack, G.2
Saloga, J.3
|