Statins decrease expression of the proinflammatory neuropeptides calcitonin gene-related peptide and substance P in sensory neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 3, 2008, Pages 1172-1180

  Bucelli, Robert C ^a   Gonsiorek, Eugene A ^a   Kim, Woo Yang ^a   Bruun, Donald ^b   Rabin, Richard A ^a   Higgins, Dennis ^a   Lein, Pamela J ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ATORVASTATIN; BONE MORPHOGENETIC PROTEIN; CALCITONIN GENE RELATED PEPTIDE; CHOLESTEROL; COMPACTIN; GGTI 298; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVALONIC ACID; MEVINOLIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PRAVASTATIN; SIMVASTATIN; SMAD1 PROTEIN; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE FIBER GROWTH; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; NEURONS, AFFERENT; NEUROPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE P;

EID: 40849094518     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.132795     Document Type: Article

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