Statins induce differentiation and cell death in neurons and astroglia

GLIA

Volumn 55, Issue 1, 2007, Pages 1-12

  März, Pia ^a   Otten, Uwe ^a   Miserez, André R ^b,c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c Diagene Inc   (Switzerland)

Author keywords

Astrocyte; Brain; Cholesterol; Cytotoxicity; HMG CoA reductase inhibitor; Isoprenoids; Rat; Stellation; Sterol regulatory element binding protein

Indexed keywords

ATORVASTATIN; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; LOW DENSITY LIPOPROTEIN RECEPTOR; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; SIMVASTATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CEREBELLUM; CYTOTOXICITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; LIPOPHILICITY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CHOLESTEROL; COCULTURE TECHNIQUES; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; NEURONS; POLYISOPRENYL PHOSPHATES; PYRROLES; RATS; RATS, WISTAR; RECEPTORS, LDL; SIMVASTATIN; UP-REGULATION;

EID: 33751584846     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20422     Document Type: Article

References (56)

1. Abe K, Misawa M. 2003. Astrocyte stellation induced by Rho kinase inhibitors in culture. Brain Res Dev Brain Res 143:99-104.
2. Amarenco P, Tonkin AM. 2004. Statins for stroke prevention: Disappointment and hope. Circulation 109:III44-III49.
3. Bergstrom JD, Kurtz MM, Rew DJ, Amend AM, Karkas JD, Bostedor RG, Bansal VS, Dufresne C, VanMiddlesworth FL, Hensens OD, Liesch JM, Zink DL, Wilson KE, Onish J, Milligan JA, Bills G, Kaplan L, Nallin Omstead M, Jenkins RG, Huang L, Meinz MS, Quinn L, Burg RW, Kong YL, Mochales S, Mojena M, Martin I, Palaez F, Diez MT, Alberts AW. 1993. Zaragozic acids: A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Proc Natl Acad Sci USA 90:80-84.
4. Bösel J, Gandor F, Harms C, Synowitz M, Harms U, Djoufack PC, Megow D, Dirnagl U, Hortnagl H, Fink KB, Endres M. 2005. Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones. J Neurochem 92:1386-1398.
5. Briel M, Studer M, Glass TR, Bucher HC. 2004. Effects of statins on stroke prevention in patients with and without coronary heart disease: A meta-analysis of randomized controlled trials. Am J Med 117:596-606.
6. Brown MS, Goldstein JL. 1999. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96:11041-11048.
7. Brown MS, Goldstein JL. 2001. Molecular medicine. The cholesterol quartet. Science 292:1310-1312.
8. Chen CJ, Ou YC, Lin SY, Liao SL, Huang YS, Chiang AN. 2006. L-Glutamate aczivates RhoA GTPase leading to suppression of astrocyte stellation. Eur J Neurosci 23:1977-1987.
9. Chen J, Zhang ZG, Li Y, Wang Y, Wang L, Jiang H, Zhang C, Lu M, Katakowski M, Feldkamp CS, Chopp M. 2003. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol 53:743.
10. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. 1993. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261:921-923.
11. Cordle A, Koenigsknecht-Talboo J, Wilkinson B, Limpert A, Landreth G. 2005. Mechanisms of Statin-mediated inhibition of small G-protein function. J Biol Chem 280:34202-34209.
12. Dietschy JM, Turley SD. 2001. Cholesterol metabolism in the brain. Curr Opin Lipidol 12:105-112.
13. Eng LF, Ghirnikar RS, Lee YL. 2000. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 25:1439-1451.
14. Gaist D, Jeppesen U, Andersen M, Garcia Rodriguez LA, Hallas J, Sindrup SH. 2002. Statins and risk of polyneuropathy: A case-control study. Neurology 58:1333-1337.
15. Goya L, Feng PT, Aliabadi S, Timiras PS. 1996. Effect of growth factors on the in vitro growth and differentiation of early and late passage C6 glioma cells. Int J Dev Neurosci 14:409-417.
16. Hebert MA, O'Callaghan JP. 2000. Protein phosphorylation cascades associated with methamphetamine-induced glial activation. Ann NY Acad Sci 914:238-262.
17. Herz J, Bock HH. 2002. Lipoprotein receptors in the nervous system. Annu Rev Biochem 71:405-434.
18. Jeppesen U, Gaist D, Smith T, Sindrup SH. 1999. Statins and peripheral neuropathy. Eur J Clin Pharmacol 54:835-838.
19. Kahn BB, Myers MG Jr. 2006. mTOR tells the brain that the body is hungry. Nat Med 12:615-617.
20. Kostis JB, Rosen RC, Wilson AC. 1994. Central nervous system effects of HMG CoA reductase inhibitors: Lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia. J Clin Pharmacol 34:989-996.
21. Kotti TJ, Ramirez DM, Pfeiffer BE, Huber KM, Russell DW. 2006. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci USA 103:3869-3874. (Epub 2006 Feb 27).
22. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K. 2000. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6:1004-1010.
23. Kwak B, Mulhaupt F, Myit S, Mach F. 2000. Statins as a newly recognized type of immuno-modulator. Nat Med 6:1399-1402.
24. Lindberg C, Crisby M, Winblad B, Schultzberg M. 2005. Effects of statins on microglia. J Neurosci Res 82:10-19.
25. Lobner D. 2000. Comparison of the LDH, MTT assays for quantifying cell death: Validity for neuronal apoptosis? J Neurosci Methods 96:147-152.
26. März P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U. 1999. Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia 26:191-200.
27. März P, Herget T, Lang E, Otten U, Rose-John S. 1997. Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Eur J Neurosci 9:2765-2773.
28. Matthies H Jr, Schulz S, Hollt V, Krug M. 1997. Inhibition by compactin demonstrates a requirement of isoprenoid metabolism for long-term potentiation in rat hippocampal slices. Neuroscience 79:341-346.
29. Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A, Pfrieger FW. 2001. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294:1354-1357.
30. Menge T, Hartung HP, Stüve O. 2005. Statins - A cure for the brain? Nat Neurosci 6:325-331.
31. Meske V, Albert F, Richter D, Schwarze J, Ohm TG. 2003. Blockade of HMG-CoA reductase activity causes changes in microtubule-stabilizing protein τ via suppression of geranylgeranylpyrophosphate formation: Implications for Alzheimer's disease. J Neurochem 17:93-102.
32. Michikawa M, Yanagisawa K. 1999. Inhibition of cholesterol production but not of nonsterol isoprenoid products induces neuronal cell death. J Neurochem 72:2278-2285.
33. Miserez AR. 2001. Alzheimer dementia - A disorder of the lipoprotein metabolism? Schweiz Rundsch Med Prax 90:1297-1299.
34. Miserez AR, Muller PY, Barella L, Barella S, Staehelin HB, Leitersdorf E, Kark JD, Friedlander Y. 2002a. Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia. Atherosclerosis 164:15-26.
35. Miserez AR, Muller PY, Spaniol V. 2002b. Indinavir inhibits sterol-regulatory element-binding protein-1c-dependent lipoprotein lipase and fatty acid synthase gene activations. AIDS 16:1587-1594.
36. Muldoon MF, Manuck SB, Mendelsohn AB, Kaplan JR, Belle SH. 2001. Cholesterol reduction and non-illness mortality: Meta-analysis of randomised clinical trials. Brit Med J 322:11-15.
37. Ongini E, Impagnatiello F, Bonazzi A, Guzzetta M, Govoni M, Monopoli A, Del Soldato P, Ignarro LJ. 2004. Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proc Natl Acad Sci USA 101:8497-8502.
38. Patel TR, Corbett SA. 2004. Simvastatin suppresses LPS-induced Akt phosphorylation in the human monocyte cell line THP-1. J Surg Res 116:116-120.
39. Pavlov OV, Bobryshev YuV, Balabanov YuV, Ashwell K. 1995. An in vitro study of the effects of lovastatin on the human fetal brain cells. Neurotoxic Teratol 17:31-39.
40. Pedersen TR, Olsson AG, Faergeman O, Kjekshus J, Wedel H, Berg K, Wilhelmsen L, Haghfelt T, Thorgeirsson G, Pyorala K, Miettinen T, Christophersen B, Tobert JA, Musliner TA, Cook TJ. 1998. Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S). Circulation 97:1453-1460.
41. Puglielli L, Tanzi RE, Kovacs DM. 2003. Alzheimer's disease: The cholesterol connnection. Nat Neurosci 6:345-351.
42. Schulz JG, Bosel J, Stoeckel M, Megow D, Dirnagl U, Endres M. 2004. HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis. J Neurochem 89:24-32.
43. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J. 2003. ASCOT investigators. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial. Lancet 361:1149-1158.
44. Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. 1998. Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons. Proc Natl Acad Sci USA 95:6460-6464.
45. Song MR, Ghosh A. 2004. FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation. Nat Neurosci 7:229-235.
46. Tabernero A, Bolaños JP, Medina JM. 1993. Lipogenesis from lactate in rat neurons and astrocytes in primary culture. Biochem J 294:635-638.
47. Takai Y, Sasaki T, Matozaki T. 2001. Small GTP-binding proteins. Physiol Rev 81:153-208.
48. Takanaga H, Yoshitake T, Hara S, Yamasaki C, Kunimoto M. 2004. cAMP-induced astrocytic differentiation of C6 glioma cells is mediated by autocrine interleukin-6. J Biol Chem 279:15441-15447.
49. Tanaka K, Asanuma M, Ogawa N. 2004. Molecular basis of anti-apoptotic effect of immunophilin ligands on hydrogen peroxide-induced apoptosis in human glioma cells. Neurochem Res 29:1529-1536.
50. Tanaka T, Tatsuno I, Uchida D, Moroo I, Morio H, Nakamura, Noguchi Y, Yasuda T, Kitagawa M, Saito Y, Harai A. 2000. Geranylgeranylpyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydoxy-3-methylglutaryl-CoA reductase inhibition. J Neurosci 20:2852-2859.
51. Vaughan CJ, Delanty N. 1999. Neuroprotective properties of statins in cerebral ischemia and stroke. Stroke 30:1969-1973.
52. Vollmer T, Key L, Durkalski V, Tyor W, Corboy J, Markovic-Plese S, Preiningerova J, Rizzo M, Singh I. 2004. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 363:1607-1608.
53. Wagstaff LR, Mitton MW, Arvik BM, Doraiswamy PM. 2003. Statin-associated memory loss: Analysis of 60 case reports and review of the literature. Pharmacotherapy 23:871-880.
54. Xu L, Chock VY, Yang EY, Giffard RG. 2004. Susceptibility to apoptosis varies with time in culture for murine neurons and astrocytes: Changes in gene expression and activity. Neurol Res 26:632-643.
55. Zacco A, Togo J, Spence K, Ellis A, Lloyd D, Furlong S, Piser T. 2003. 3-Hydroxy-3-methylglutaryl Coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 23:11104-11111.
56. Zamrini E, McGwin G, Roseman JM. 2004. Association between statin use and Alzheimer's disease. Neuroepidemiology 23:94-98.