Differential metabolism of alprazolam by liver and brain cytochrome (P4503A) to pharmacologically active metabolite

Pharmacogenomics Journal

Volumn 2, Issue 4, 2002, Pages 243-258

  Pai, H V ^a,b   Upadhya, S C ^a,b   Chinta, S J ^a   Hegde, S N ^a   Ravindranath, V ^a,b  

^a NATIONAL INSTITUTE OF MENTAL HEALTH AND NEUROSCIENCES   (India)

^b NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

Alprazolam; Brain; Cytochrome P450; Drug metabolism; Monooxygenase; Psychoactive drugs

Indexed keywords

ALPRAZOLAM; ANXIOLYTIC AGENT; BRAIN ENZYME; CYTOCHROME P450 3A; CYTOCHROME P450 3A1; CYTOCHROME P450 3A4; CYTOCHROME P450 ISOENZYME; DRUG METABOLITE; HYDROXYL GROUP; LIVER ENZYME; XENOBIOTIC AGENT;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BRAIN MICROSOME; CONTROLLED STUDY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG TRANSFORMATION; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN TISSUE; HYDROPHILICITY; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHOOL CHILD;

ADULT; AGED; ALPRAZOLAM; ANIMALS; ANTI-ANXIETY AGENTS; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; BLOTTING, NORTHERN; BRAIN; CHILD; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LIVER; MALE; MICROSOMES, LIVER; MIDDLE AGED; ORGAN SPECIFICITY; RATS; RATS, WISTAR; SPECIES SPECIFICITY;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0036045940     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500115     Document Type: Article

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