Evidence-based survey of the elimination rates of ethanol from blood with applications in forensic casework

Forensic Science International

Volumn 200, Issue 1-3, 2010, Pages 1-20

  Jones, Alan Wayne ^a  

^a DEPARTMENT OF FORENSIC GENETICS AND FORENSIC TOXICOLOGY   (Sweden)

Author keywords

Alcohol; Blood; Drunk driving; Elimination rate; Ethanol; Forensic science; Kinetics; Legal medicine; Metabolism; Pharmacokinetics; Widmark factors

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; CYTOCHROME P450 2E1;

AEROBIC METABOLISM; ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOLISM; BLOOD SAMPLING; CRIME; DETOXIFICATION; DRIVER; ENZYME KINETICS; ENZYME SUBSTRATE; FORENSIC MEDICINE; FORENSIC SCIENCE; HUMAN; LAW SUIT; LEAN BODY WEIGHT; LIVER WEIGHT; MEDICAL LITERATURE; MICHAELIS MENTEN KINETICS; PRACTICE GUIDELINE; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; SEX DIFFERENCE; STANDARDIZATION; STOMACH;

EID: 77953914578     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2010.02.021     Document Type: Review

References (223)

1. Jones A.W. Forensic science aspects of ethanol metabolism. Forensic Science Progress 1991, Springer Verlag, Berlin, Germany. A. Mahley, R.L. Williams (Eds.).
2. Jones A.W. Biochemical and physiological research on the disposition and fate of ethanol in the body. Medicolegal Aspects of Alcohol 2008, 47-155. Lawyers & Judges Publishing Company, Tuscon. J.C. Garriott (Ed.).
3. Room R., Babor T., Rehm J. Alcohol and public health. Lancet 2005, 365:519-530.
4. Al-Lanqawi Y., Moreland T.A., McEwen J., Halliday F., Durnin C.J., Stevenson I.H. Ethanol kinetics: extent of error in back extrapolation procedures. Br. J. Clin. Pharmacol. 1992, 34:316-321.
5. Jackson P.R., Tucker G.T., Woods H.F. Backtracking booze with Bayes-the retrospective interpretation of blood alcohol data. Br. J. Clin. Pharmacol. 1991, 31:55-63.
6. Lewis M.J. Blood alcohol: the concentration-time curve and retrospective estimation of level. J. Forensic Sci. Soc. 1986, 26:95-113.
7. Montgomery M.R., Reasor M.J. Retrograde extrapolation of blood alcohol data: an applied approach. J. Toxicol. Environ. Health 1992, 36:281-292.
8. Hall J.A., Moore C.B. Drug facilitated sexual assault-a review. J. Forensic Leg. Med. 2008, 15:291-297.
9. Jones A.W., Kugelberg F.C., Holmgren A., Ahlner J. Occurrence of ethanol and other drugs in blood and urine specimens from female victims of alleged sexual assault. Forensic Sci. Int. 2008, 187:40-46.
10. Scott-Ham M., Burton F.C. A study of blood and urine alcohol concentrations in cases of alleged drug-facilitated sexual assault in the United Kingdom over a 3-year period. J. Clin. Forensic Med. 2006, 13:107-111.
11. Kalant H. Intoxication automatism: legal concept vs scientific evidence?. Contemp. Drug Prob. 1996, 23:631-648.
12. Andreasson R., Jones A.W. Erik M.P. Widmark: Swedish pioneer in forensic alcohol toxicology. Forensic Sci. Int. 1889-1945, 72(1995):1-14.
13. Widmark E.M.P. Die theoretischen Grundlagen und die praktische Verwendbarkeit der gerichtlich-medizinischen Alkoholbestimmung 1932, Urban & Schwarzenberg, Berlin, 140 pp.
14. Widmark E.M.P. Principles and Applications of Medicolegal Alcohol Determinations 1981, Biomedical Publications, Davis, 163 pp.
15. Jones A.W. Excretion of alcohol in urine and diuresis in healthy men in relation to their age, the dose administered and the time after drinking. Forensic Sci. Int. 1990, 45:217-224.
16. Jones A.W., Andersson L. Influence of age, gender, and blood-alcohol concentration on the disappearance rate of alcohol from blood in drinking drivers. J. Forensic Sci. 1996, 41:922-926.
17. Kalant H. Pharmacokinetics of ethanol: absorption, distribution, and elimination. The Pharmacology of Alcohol and Alcohol Dependence 1996, 15-58. Oxford University Press, New York. H. Beglieter, B. Kissin (Eds.).
18. Crabb D.W. Ethanol oxidizing enzymes: roles in alcohol metabolism and alcoholic liver disease. Prog. Liver Dis. 1995, 13:151-172.
19. Edenberg H.J. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Res. Health 2007, 30:5-13.
20. Gonzalez F.J. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat. Res. 2005, 569:101-110.
21. Gonzalez F.J. The 2006 Bernard B. Brodie Award Lecture. CYP2E1. Drug Metab. Dispos. 2007, 35:1-8.
22. Lieber C.S. Cytochrome P-4502E1: its physiological and pathological role. Physiol. Rev. 1997, 77:517-544.
23. Zakhari S. Overview: how is alcohol metabolized by the body?. Alcohol Res. Health 2006, 29:245-254.
24. Jones A.W., Holmgren A. Age and gender differences in blood-alcohol concentration in apprehended drivers in relation to the amounts of alcohol consumed. Forensic Sci. Int. 2009, 188:40-45.
25. Lieber C.S. The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role. Drug Metab. Rev. 2004, 36:511-529.
26. Agarwal D.P., Goedde H.W. Ethanol oxidation: ethnic variations in metabolism and response. Prog. Clin. Biol. Res. 1986, 214:99-112.
27. Agarwal D.P., Goedde H.W. Medicobiological and genetic studies on alcoholism. Role of metabolic variation and ethnicity on drinking habits, alcohol abuse and alcohol-related mortality. Clin. Investig. 1992, 70:465-477.
28. Crabb D.W., Dipple K.M., Thomasson H.R. Alcohol sensitivity, alcohol metabolism, risk of alcoholism, and the role of alcohol and aldehyde dehydrogenase genotypes. J. Lab. Clin. Med. 1993, 122:234-240.
29. Forsander O.A., Lindros K.O. Influence of ethanol on the acetyl-coenzyme A level of intact rat liver. Acta Chem. Scand. [A]. 1967, 21:2568.
30. Li T.K., Yin S.J., Crabb D.W., O'Connor S., Ramchandani V.A. Genetic and environmental influences on alcohol metabolism in humans. Alcohol. Clin. Exp. Res. 2001, 25:136-144.
31. Agarwal D.P. Genetic polymorphisms of alcohol metabolizing enzymes. Pathol. Biol. (Paris) 2001, 49:703-709.
32. Crabb D.W., Edenberg H.J. Gene regulation of alcohol metabolizing enzymes. Alcohol. Clin. Exp. Res. 1996, 20:113A-116A.
33. Jornvall H., Hoog J.O., Persson B., Pares X. Pharmacogenetics of the alcohol dehydrogenase system. Pharmacology 2000, 61:184-191.
34. Crabb D.W., Matsumoto M., Chang D., You M. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc. Nutr. Soc. 2004, 63:49-63.
35. Thomasson H.R., Beard J.D., Li T.K. ADH2 gene polymorphisms are determinants of alcohol pharmacokinetics. Alcohol. Clin. Exp. Res. 1995, 19:1494-1499.
36. Klotz U., Ammon E. Clinical and toxicological consequences of the inductive potential of ethanol. Eur. J. Clin. Pharmacol. 1998, 54:7-12.
37. Tsutsumi M., Lasker J.M., Takahashi T., Lieber C.S. In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis. Arch. Biochem. Biophys. 1993, 304:209-218.
38. Salmela K.S., Kessova I.G., Tsyrlov I.B., Lieber C.S. Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. Alcohol. Clin. Exp. Res. 1998, 22:2125-2132.
39. Keiding S., Christensen N.J., Damgaard S.E., Dejgard A., Iversen H.L., Jacobsen A., Johansen S., Lundquist F., Rubinstein E., Winkler K. Ethanol metabolism in heavy drinkers after massive and moderate alcohol intake. Biochem. Pharmacol. 1983, 32:3097-3102.
40. Norberg A., Jones A.W., Hahn R.G., Gabrielsson J.L. Role of variability in explaining ethanol pharmacokinetics: research and forensic applications. Clin. Pharmacokinet. 2003, 42:1-31.
41. Wilkinson P.K. Pharmacokinetics of ethanol: a review. Alcohol. Clin. Exp. Res. 1980, 4:6-21.
42. Holford N.H. Clinical pharmacokinetics of ethanol. Clin. Pharmacokinet. 1987, 13:273-292.
43. Rangno R.E., Kreeft J.H., Sitar D.S. Ethanol 'dose-dependent' elimination: Michaelis-Menten v classical kinetic analysis. Br. J. Clin. Pharmacol. 1981, 12:667-673.
44. m for elimination of alcohol in young male subjects following low doses of alcohol. Alcohol Alcohol 1989, 24:555-564.
45. Wagner J.G., Wilkinson P.K., Sedman A.J., Kay D.R., Weidler D.J. Elimination of alcohol from human blood. J. Pharm. Sci. 1976, 65:152-154.
46. Clinical Pharmacokinetics 2006, Pharmaceutical Press, London. S. Dhillon, A. Kostrzewski (Eds.).
47. Rowland M., Tozer T.N. Clinical Pharmacokinetics-Concepts and Applications 1995, Williams & Wilkins, Baltimore.
48. Helander A., Beck O. Ethyl sulfate: a metabolite of ethanol in humans and a potential biomarker of acute alcohol intake. J. Anal. Toxicol. 2005, 29:270-274.
49. Hoiseth G., Karinen R., Christophersen A.S., Olsen L., Normann P.T., Morland J. A study of ethyl glucuronide in post-mortem blood as a marker of ante-mortem ingestion of alcohol. Forensic Sci. Int. 2007, 165:41-45.
50. Wurst F.M., Kempter C., Metzger J., Seidl S., Alt A. Ethyl glucuronide: a marker of recent alcohol consumption with clinical and forensic implications. Alcohol 2000, 20:111-116.
51. Droenner P., Schmitt G., Aderjan R., Zimmer H. A kinetic model describing the pharmacokinetics of ethyl glucuronide in humans. Forensic Sci. Int. 2002, 126:24-29.
52. Hoiseth G., Bernard J.P., Karinen R., Johnsen L., Helander A., Christophersen A.S., Morland J. A pharmacokinetic study of ethyl glucuronide in blood and urine: applications to forensic toxicology. Forensic Sci. Int. 2007, 172:119-124.
53. Hoiseth G., Morini L., Polettini A., Christophersen A., Morland J. Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification. Forensic Sci. Int. 2009, 188:52-56.
54. Wurst F.M., Vogel R., Jachau K., Varga A., Alling C., Alt A., Skipper G.E. Ethyl glucuronide discloses recent covert alcohol use not detected by standard testing in forensic psychiatric inpatients. Alcohol. Clin. Exp. Res. 2003, 27:471-476.
55. Winek C.L., Murphy K.L. The rate and kinetic order of ethanol elimination. Forensic Sci. Int. 1984, 25:159-166.
56. Jones A.W. Inter- and intra-individual variations in the saliva/blood alcohol ratio during ethanol metabolism in man. Clin. Chem. 1979, 25:1394-1398.
57. Lundquist F. The urinary excretion of ethanol by man. Acta Pharmacol. Toxicol. (Copenh). 1961, 18:231-238.
58. Swift R. Direct measurement of alcohol and its metabolites. Addiction 2003, 98(Suppl. 2):73-80.
59. Winek C.L., Carfagna M. Comparison of plasma, serum, and whole blood ethanol concentrations. J. Anal. Toxicol. 1987, 11:267-268.
60. Jones A.W. Pharmacokinetics of ethanol in saliva: comparison with blood and breath alcohol profiles, subjective feelings of intoxication, and diminished performance. Clin. Chem. 1993, 39:1837-1844.
61. Cole-Harding S., Wilson J.R. Ethanol metabolism in men and women. J. Stud. Alcohol 1987, 48:380-387.
62. Thomasson H.R. Gender differences in alcohol metabolism. Physiological responses to ethanol. Recent Dev. Alcohol. 1995, 12:163-179.
63. Jones A.W. Variability of the blood:breath alcohol ratio in vivo. J. Stud. Alcohol 1978, 39:1931-1939.
64. Jones A.W., Andersson L. Variability of the blood/breath alcohol ratio in drinking drivers. J. Forensic Sci. 1996, 41:916-921.
65. Jones A.W. Interindividual variations in the disposition and metabolism of ethanol in healthy men. Alcohol 1984, 1:385-391.
66. Jones A.W., Hahn R.G., Stalberg H.P. Pharmacokinetics of ethanol in plasma and whole blood: estimation of total body water by the dilution principle. Eur. J. Clin. Pharmacol. 1992, 42:445-448.
67. Geigy Scientific Tables 1981, Ciba-Geigy, Basel. C. Lenter (Ed.).
68. Iffland R., West A., Bilzer N., Schuff A. Zur Zuverlässigkeit der Blutalkoholbestimmung. Das verkeilungsverhältnis des Wassers zwischen Serum und Vollblut. Rechtsmedizin 1999, 9:123-130.
69. Widmark E.M.P. Eine Mikromethode zur Bestimmung von äthylalkohol im Blut. Biochem. Z. 1922, 131:473-484.
70. Jones A.W. Body mass index and blood-alcohol calculations. J. Anal. Toxicol. 2007, 31:177-178.
71. Jones A.W., Jonsson K.A. Food-induced lowering of blood-ethanol profiles and increased rate of elimination immediately after a meal. J. Forensic Sci. 1994, 39:1084-1093.
72. Jones A.W., Jonsson K.A., Kechagias S. Effect of high-fat, high-protein, and high-carbohydrate meals on the pharmacokinetics of a small dose of ethanol. Br. J. Clin. Pharmacol. 1997, 44:521-526.
73. Baraona E., Gentry R.T., Lieber C.S. Bioavailability of alcohol: role of gastric metabolism and its interaction with other drugs. Dig. Dis. 1994, 12:351-367.
74. Levitt M.D. Review article: lack of clinical significance of the interaction between H2-receptor antagonists and ethanol. Aliment. Pharmacol. Ther. 1993, 7:131-138.
75. Lieber C.S., Gentry R.T., Baraona E. First pass metabolism of ethanol. Alcohol. Alcohol. Suppl. 1994, 2:163-169.
76. Levitt M.D. Antagonist: the case against first-pass metabolism of ethanol in the stomach. J. Lab. Clin. Med. 1994, 123:28-31. discussion 32-23.
77. Levitt M.D., Levitt D.G. The critical role of the rate of ethanol absorption in the interpretation of studies purporting to demonstrate gastric metabolism of ethanol. J. Pharmacol. Exp. Ther. 1994, 269:297-304.
78. Levitt M.D., Levitt D.G. Appropriate use and misuse of blood concentration measurements to quantitate first-pass metabolism. J. Lab. Clin. Med. 2000, 136:275-280.
79. Levitt M.D., Levitt D.G., Furne J., DeMaster E.G. Can the liver account for first-pass metabolism of ethanol in the rat?. Am. J. Physiol. 1994, 267:G452-457.
80. Widmark E.M.P. The influence of glycocoll on the absorption and metabolism of ethyl alcohol. Kungl Physiol Sällsk Lund Förhand 1941, 12:1-11.
81. Barnhill M.T., Herbert D., Wells D.J. Comparison of hospital laboratory serum alcohol levels obtained by an enzymatic method with whole blood levels forensically determined by gas chromatography. J. Anal. Toxicol. 2007, 31:23-30.
82. Charlebois R.C., Corbett M.R., Wigmore J.G. Comparison of ethanol concentrations in blood, serum, and blood cells for forensic application. J. Anal. Toxicol. 1996, 20:171-178.
83. Bonnichsen R.K., Theorell H. An enzymatic method for the microdetermination of ethanol. Scand. J. Clin. Lab. Invest. 1951, 3:58-62.
84. Jones A.W., Schuberth J. Computer-aided headspace gas chromatography applied to blood-alcohol analysis: importance of online process control. J. Forensic Sci. 1989, 34:1116-1127.
85. Emerson V. Alcohol analysis. Crime Scene to Court-The Essentials of Forensic Science 2004, 350-376. Royal Society of Chemistry, Cambridge. P.C. White (Ed.).
86. Jones A.W., Lindberg L., Olsson S.G. Magnitude and time-course of arterio-venous differences in blood-alcohol concentration in healthy men. Clin. Pharmacokinet. 2004, 43:1157-1166.
87. Sedman A.J., Wilkinson P.K., Wagner J.G. Concentrations of ethanol in two segments of the vascular system. J. Forensic Sci. 1976, 21:315-322.
88. Jones A.W. Limits of detection and quantitation of ethanol in specimens of whole blood from drinking drivers analyzed by headspace gas chromatography. J. Forensic Sci. 1991, 36:1277-1279.
89. Jones A.W. Are changes in blood-ethanol concentration during storage analytically significant? Importance of method imprecision. Clin. Chem. Lab. Med. 2007, 45:1299-1394.
90. Andreasson R., Jones A.W. The life and work of Erik M.P. Widmark. Am. J. Forensic Med. Pathol. 1996, 17:177-190.
91. Dettling A., Fischer F., Bohler S., Ulrichs F., Skopp G., Graw M., Haffner H.T. Ethanol elimination rates in men and women in consideration of the calculated liver weight. Alcohol 2007, 41:415-420.
92. Cheymol G. Effects of obesity on pharmacokinetics implications for drug therapy. Clin. Pharmacokinet. 2000, 39:215-231.
93. Yanovski S.Z., Yanovski J.A. Obesity. N. Engl. J. Med. 2002, 346:591-602.
94. Forrest A.R.W. The estimation of Widmark's factor. J. Forensic Sci. Soc. 1986, 26:249-252.
95. 2O and ethanol dilutions in total body water measurements in humans. Clin. Investig. 1994, 72:830-837.
96. Seidl S., Jensen U., Alt A. The calculation of blood ethanol concentrations in males and females. Int. J. Legal Med. 2000, 114:71-77.
97. Watson P.E., Watson I.D., Batt R.D. Prediction of blood alcohol concentrations in human subjects. Updating the Widmark Equation. J. Stud. Alcohol 1981, 42:547-556.
98. Sharma A., Artiss J.D., Zak B. Solids as a consideration in legal measurements: blood ethanol concentration as a model. Microchem. J. 1987, 36:28-41.
99. Osterlind S., Ahlen M., Wolff E. Investigations concerning the constants "β"and "r"according to Widmark especially in women. Acta Pathol. Microbiol. Scand. Suppl. 1944, 54:489-498.
100. Jokipii S.G. Experimental Studies on Blood Alcohol in Healthy Subjects and in Some Diseases 1951, University of Helsinki, Helsinki, 99 pp.
101. Wilkinson P.K., Reynolds G., Holmes O.D., Yang S., Wilkin L.O. Nonlinear pharmacokinetics of ethanol: the disproportionate AUC-dose relationship. Alcohol. Clin. Exp. Res. 1980, 4:384-390.
102. Wartburg Von J. Pharmacokinetics of alcohol. Human Metabolism of Alcohol 1989, vol. 1:9-22. CRC Press, Boca Raton.
103. Pond S.M., Tozer T.N. First-pass elimination. Basic concepts and clinical consequences. Clin. Pharmacokinet. 1984, 9:1-25.
104. Alha A. Blood alcohol and clinical inebriation in Finnish men. Ann. Acad. Sci. Fenn. A 1951, 26:1-136.
105. Bode J.C. The metabolism of alcohol: physiological and pathophysiological aspects. J. R. Coll. Physicians Lond. 1978, 12:122-135.
106. Lisander B., Lundvall O., Tomner J., Jones A.W. Enhanced rate of ethanol elimination from blood after intravenous administration of amino acids compared with equicaloric glucose. Alcohol Alcohol. 2006, 41:39-43.
107. Jones A.W. Ethanol metabolism in patients with liver cirrhosis. J. Clin. Forensic Med. 2000, 7:48-51.
108. Winkler K., Lundquist F., Tygstrup N. The hepatic metabolism of ethanol in patients with cirrhosis of the liver. Scand. J. Clin. Lab. Invest. 1969, 23:59-69.
109. Dilger K., Metzler J., Bode J.C., Klotz U. CYP2E1 activity in patients with alcoholic liver disease. J. Hepatol. 1997, 27:1009-1014.
110. Welling P.G., Lyons L.L., Elliott R., Amidon G.L. Pharmacokinetics of alcohol following single low doses to fasted and nonfasted subjects. J. Clin. Pharmacol. 1977, 17:199-206.
111. Hein P.M., Vock R. Alkoholtrinkversuche mit über 60 Jahre alten männlichen Personen. Blutalkohol 1989, 26:98-105.
112. Jones A.W., Jonsson K.A. Between-subject and within-subject variations in the pharmacokinetics of ethanol. Br. J. Clin. Pharmacol. 1994, 37:427-431.
113. Schonheyder F., Strange-Petersen O., Terkildsen K., Posborg-Petersen V. On the variation of the alcoholemie curve. Acta Med. Scand. 1942, 109:460-470.
114. Passananti G.T., Wolff C.A., Vesell E.S. Reproducibility of individual rates of ethanol metabolism in fasting subjects. Clin. Pharmacol. Ther. 1990, 47:389-396.
115. Yelland L.N., Burns J.P., Sims D.N., Salter A.B., White J.M. Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose. Forensic Sci. Int. 2008, 175:65-72.
116. Neuteboom W., Jones A.W. Disappearance rate of alcohol from the blood of drunk drivers calculated from two consecutive samples; what do the results really mean?. Forensic Sci. Int. 1990, 45:107-115.
117. Lund A. The rate of disappearance of blood alcohol in drunken drivers. Blutalkohol 1979, 16:395-398.
118. Jones A.W., Neri A. Evaluation of blood-alcohol profiles after consumption of alcohol together with a large meal. Can. Soc. Forensic Sci. J. 1991, 24:165-173.
119. Simic M., Tasic M. The relationship between alcohol elimination rate and increasing blood alcohol concentration-calculated from two consecutive blood specimens. Forensic Sci. Int. 2007, 172:28-32.
120. Jones A.W. Ultra-rapid rate of ethanol elimination from blood in drunken drivers with extremely high blood-alcohol concentrations. Int. J. Legal Med. 2008, 122:129-134.
121. Jones A.W., Sternebring B. Kinetics of ethanol and methanol in alcoholics during detoxification. Alcohol Alcohol. 1992, 27:641-647.
122. Hagedom E., Steigleder E. Statistische Untersuchungen, über die Beziehungen zwischen Trinkende und Resorption anhand von doppelten Blutentnahmen. Blutalkohol 1968, 5:468-481.
123. Hilgermann R., Schleyer F. Über die Beziehungen zwischen Untersuchungsergebnissen von Doppelblutentnahmen und der Analysenpräzision. Blutalkohol 1971, 8:33-61.
124. Schweitzer H. Statistische Untersuchungen zur Alkoholelimination an 1512 Doppelentnahmen. Blutalkohol 1968, 5:73-91.
125. Bogusz M., Pach J., Stasko W. Comparative studies on the rate of ethanol elimination in acute poisoning and in controlled conditions. J. Forensic Sci. 1977, 22:446-451.
126. Bonnichsen R., Dimberg R., Maehly A., Aqvist S. Die Alkoholverbrennung bei Alkoholikern und bei übringen Versuchspersonen. Blutalkohol 1968, 5:301-317.
127. Gershman H., Steeper J. Rate of clearance of ethanol from the blood of intoxicated patients in the emergency department. J. Emerg. Med. 1991, 9:307-311.
128. Haffner H.T., Besserer K., Stetter F., Mann K. Die Äthanol Eliminationsgeschwindigkeit bei Alkoholikern unter besonderer Berücksichtigung der Maximalwertvariante der forensischen BAK Rückrechung. Blutalkohol 1991, 28:46-54.
129. Dam G., Sorensen M., Munk O.L., Keiding S. Hepatic ethanol elimination kinetics in patients with cirrhosis. Scand. J. Gastroenterol. 2009, 44:867-871.
130. Jones A.W. Biomarkers of acute and chronic alcohol ingestion. Medicolegal Aspects of Alcohol 2008, vol. 4:157-203. Lawyers & Judges Publishing Company, Tuscon.
131. Beierle I., Meibohm B., Derendorf H. Gender differences in pharmacokinetics and pharmacodynamics. Int. J. Clin. Pharmacol. Ther. 1999, 37:529-547.
132. Meibohm B., Beierle I., Derendorf H. How important are gender differences in pharmacokinetics?. Clin. Pharmacokinet. 2002, 41:329-342.
133. Soldin O.P., Mattison D.R. Sex differences in pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 2009, 48:143-157.
134. Kashuba A.D., Nafziger A.N. Physiological changes during the menstrual cycle and their effects on the pharmacokinetics and pharmacodynamics of drugs. Clin. Pharmacokinet. 1998, 34:203-218.
135. Clasey J.L., Kanaley J.A., Wideman L., Heymsfield S.B., Teates C.D., Gutgesell M.E., Thorner M.O., Hartman M.L., Weltman A. Validity of methods of body composition assessment in young and older men and women. J. Appl. Physiol. 1999, 86:1728-1738.
136. Chumlea W.C., Guo S.S., Zeller C.M., Reo N.V., Baumgartner R.N., Garry P.J., Wang J., Pierson R.N., Heymsfield S.B., Siervogel R.M. Total body water reference values and prediction equations for adults. Kidney Int. 2001, 59:2250-2258.
137. Roche A.E., Heymsfield S.B., Lohman T.G. Human body composition. Human Kinetics 1996, Champaign, 366 pp.
138. Davies B.T., Bowen C.K. Total body water and peak alcohol concentration: a comparative study of young, middle-age, and older females. Alcohol. Clin. Exp. Res. 1999, 23:969-975.
139. Fransson M., Jones A.W., Andersson L. Laboratory evaluation of a new evidential breath-alcohol analyser designed for mobile testing; the Evidenzer. Med. Sci. Law 2005, 45:61-70.
140. Cowan J.M., Weathermon A., McCutcheon J.R., Oliver R.D. Determination of volume of distribution for ethanol in male and female subjects. J. Anal. Toxicol. 1996, 20:287-290.
141. Goist K.C., Sutker P.B. Acute alcohol intoxication and body composition in women and men. Pharmacol. Biochem. Behav. 1985, 22:811-814.
142. Mishra L., Sharma S., Potter J.J., Mezey E. More rapid elimination of alcohol in women as compared to their male siblings. Alcohol. Clin. Exp. Res. 1989, 13:752-754.
143. Li T.K., Beard J.D., Orr W.E., Kwo P.Y., Ramchandani V.A., Thomasson H.R. Variation in ethanol pharmacokinetics and perceived gender and ethnic differences in alcohol elimination. Alcohol. Clin. Exp. Res. 2000, 24:415-416.
144. Thomasson H. Alcohol elimination: faster in women?. Alcohol. Clin. Exp. Res. 2000, 24:419-420.
145. de la Grandmaison G.L., Clairand I., Durigon M. Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci. Int. 2001, 119:149-154.
146. Kwo P.Y., Ramchandani V.A., O'Connor S., Amann D., Carr L.G., Sandrasegaran K., Kopecky K.K., Li T.K. Gender differences in alcohol metabolism: relationship to liver volume and effect of adjusting for body mass. Gastroenterology 1998, 115:1552-1557.
147. Dettling A., Skopp G., Graw M., Haffner H.T. The influence of sex hormones on the elimination kinetics of ethanol. Forensic Sci. Int. 2008, 177:85-89.
148. Sutker P.B., Goist K.C., Allain A.N., Bugg F. Acute alcohol intoxication: sex comparisons on pharmacokinetic and mood measures. Alcohol. Clin. Exp. Res. 1987, 11:507-512.
149. Sutker P.B., Goist K.C., King A.R. Acute alcohol intoxication in women: relationship to dose and menstrual cycle phase. Alcohol. Clin. Exp. Res. 1987, 11:74-79.
150. Mumenthaler M.S., Taylor J.L., O'Hara R., Fisch H.U., Yesavage J.A. Effects of menstrual cycle and female sex steroids on ethanol pharmacokinetics. Alcohol. Clin. Exp. Res. 1999, 23:250-255.
151. Lammers S.M., Mainzer D.E., Breteler M.H. Do alcohol pharmacokinetics in women vary due to the menstrual cycle?. Addiction 1995, 90:23-30.
152. Correa C.L., Oga S. Effects of the menstrual cycle of white women on ethanol toxicokinetics. J. Stud. Alcohol 2004, 65:227-231.
153. Mezey E., Hamilton B., Potter J.J. Effect of testosterone administration on rates of ethanol elimination in hypogonadal patients. Alcohol 1989, 6:331-333.
154. Baraona E. Site and quantitative importance of alcohol first-pass metabolism. Alcohol. Clin. Exp. Res. 2000, 24:405-406.
155. Dohmen K., Baraona E., Ishibashi H., Pozzato G., Moretti M., Matsunaga C., Fujimoto K., Lieber C.S. Ethnic differences in gastric sigma-alcohol dehydrogenase activity and ethanol first-pass metabolism. Alcohol. Clin. Exp. Res. 1996, 20:1569-1576.
156. Frezza M., di Padova C., Pozzato G., Terpin M., Baraona E., Lieber C.S. High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism. N. Engl. J. Med. 1990, 322:95-99.
157. Ammon E., Schafer C., Hofmann U., Klotz U. Disposition and first-pass metabolism of ethanol in humans: is it gastric or hepatic and does it depend on gender?. Clin. Pharmacol. Ther. 1996, 59:503-513.
158. Toon S., Khan A.Z., Holt B.I., Mullins F.G., Langley S.J., Rowland M.M. Absence of effect of ranitidine on blood alcohol concentrations when taken morning, midday, or evening with or without food. Clin. Pharmacol. Ther. 1994, 55:385-391.
159. Baraona E., Abittan C.S., Dohmen K., Moretti M., Pozzato G., Chayes Z.W., Schaefer C., Lieber C.S. Gender differences in pharmacokinetics of alcohol. Alcohol. Clin. Exp. Res. 2001, 25:502-507.
160. Baraona E., Gentry R.T., Lieber C.S. Blood alcohol levels after prolonged use of histamine-2-receptor antagonists. Ann. Intern. Med. 1994, 121:73-74.
161. Fraser A.G., Rosalki S.B., Gamble G.D., Pounder R.E. Inter-individual and intra-individual variability of ethanol concentration-time profiles: comparison of ethanol ingestion before or after an evening meal. Br. J. Clin. Pharmacol. 1995, 40:387-392.
162. Jones A.W., Holmgren A., Kugelberg F.C. Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results. Ther. Drug Monit. 2007, 29:248-260.
163. Holmgren A., Holmgren P., Kugelberg F.C., Jones A.W., Ahlner J. Predominance of illicit drugs and poly-drug use among drug-impaired drivers in Sweden. Traffic Inj. Prev. 2007, 8:361-367.
164. Kechagias S., Jonsson K.A., Norlander B., Carlsson B., Jones A.W. Low-dose aspirin decreases blood alcohol concentrations by delaying gastric emptying. Eur. J. Clin. Pharmacol. 1997, 53:241-246.
165. Kechagias S., Jonsson K.A., Jones A.W. Impact of gastric emptying on the pharmacokinetics of ethanol as influenced by cisapride. Br. J. Clin. Pharmacol. 1999, 48:728-732.
166. Jones A.W. Alcohol and drug interactions. Handbook of Drug Interactions 2003, 395-462. Humana Press, Totowa, NJ. A. Mozayani, L. Raymon (Eds.).
167. Fraser A.G. Pharmacokinetic interactions between alcohol and other drugs. Clin. Pharmacokinet. 1997, 33:79-90.
168. Hobbes J., Boutagy J., Shenfield G.M. Interactions between ethanol and oral contraceptive steroids. Clin. Pharmacol. Ther. 1985, 38:371-380.
169. Jones M.K., Jones B.M. Ethanol metabolism in women taking oral contraceptives. Alcohol. Clin. Exp. Res. 1984, 8:24-28.
170. Papple W.R. The effect of oral contraceptive steroids (OCS) on the rate of post-absorptive phase decline of blood alcohol concentration in the adult woman. Can. Soc. Forensic Sci. J. 1981, 15:17-24.
171. Lieber C.S. Mechanisms of ethanol-drug-nutrition interactions. J. Toxicol. Clin. Toxicol. 1994, 32:631-681.
172. Lieber C.S., Abittan C.S. Pharmacology and metabolism of alcohol, including its metabolic effects and interactions with other drugs. Clin. Dermatol. 1999, 17:365-379.
173. Li T.K., Theorell H. Human liver alcohol dehydrogenase: inhibition by pyrazole and pyrazole analogs. Acta Chem. Scand. [A]. 1969, 23:892-902.
174. Brent J. Fomepizole for ethylene glycol and methanol poisoning. N. Engl. J. Med. 2009, 360:2216-2223.
175. Brent J., McMartin K., Phillips S., Aaron C., Kulig K. Fomepizole for the treatment of methanol poisoning. N. Engl. J. Med. 2001, 344:424-429.
176. Hovda K.E., Jacobsen D. Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. Hum. Exp. Toxicol. 2008, 27:539-546.
177. Mascord D., Smith J., Starmer G.A., Whitfield J.B. The effect of fructose on alcohol metabolism and on the [lactate]/[pyruvate] ratio in man. Alcohol Alcohol. 1991, 26:53-59.
178. Thieden H.I., Lundquist F. The influence of fructose and its metabolites on ethanol metabolism in vitro. Biochem. J. 1967, 102:177-180.
179. Crow K.E., Newland K.M., Batt R.D. The fructose effect. N. Z. Med. J. 1981, 93:232-234.
180. Crownover B.P., La Dine J., Bradford B., Glassman E., Forman D., Schneider H., Thurman R.G. Activation of ethanol metabolism in humans by fructose: importance of experimental design. J. Pharmacol. Exp. Ther. 1986, 236:574-579.
181. Schmidt V., Rescheleit T., Oehmichen M., Schneble H. Alter Ein in neuem Schlauch Der "promille-killer"party pills. Blutalkohol 1995, 32:241-253.
182. Schneble H. Ernüchterungsmittle-nüchtern betrachter. Blutalkohol 1988, 25:18-65.
183. Cohen R.D. Effect of fructose on blood-alcohol levels. Lancet 1972, 2:1086.
184. Brown S.S., Forrest J.A., Roscoe P. A controlled trial of fructose in the treatment of acute alcoholic intoxication. Lancet 1972, 2:898-899.
185. Dundee J.W. Effect of fructose on blood-alcohol levels. Lancet 1972, 2:1086.
186. Woods H.F., Alberti K.G. Dangers of intravenous fructose. Lancet 1972, 2:1354-1357.
187. Kaplan H.L., Forney R.B., Hughes F.W., Jain N.C. Chloral hydrate and alcohol metabolism in human subjects. J. Forensic Sci. 1967, 12:295-301.
188. Sellers E.M., Lang M., Koch-Weser J.K.H. Interaction of chloral hydrate and ethanol in man. 1. Metabolism. Clin. Pharmacol. Ther. 1972, 13:37-49.
189. Jones A.W. Back-estimation of blood alcohol concentration. Br. J. Clin. Pharmacol. 1993, 35:669-670.
190. Ganert P., Bowthorpe W. Evaluation of breath alcohol profiles following a period of social drinking. Can. Soc. Forensic Sci. J. 2000, 33:137-143.
191. Jones A.W., Andersson L. Comparison of ethanol concentrations in venous blood and end-expired breath during a controlled drinking study. Forensic Sci. Int. 2003, 132:18-25.
192. Lindberg L., Brauer S., Wollmer P., Goldberg L., Jones A.W., Olsson S.G. Breath alcohol concentration determined with a new analyzer using free exhalation predicts almost precisely the arterial blood alcohol concentration. Forensic Sci. Int. 2007, 168:200-207.
193. Dettling A., Böhler S., Fisher F., Ulrichs F., Skopp G., Von Meyer L., Strohbeck-Kühner P., Graw M., Haffner H.T. Grundlagen der Pharmakokinetik des Ethanols anhand von Atemalkoholkonzentrationen. Teil 11 Vergleich der mathematischen Approximation der AAK- und BAK-kurven in der Eliminationsphase. Blutalkohol 2006, 43:376-384.
194. Tam T.W., Yang C.T., Fung W.K., Mok V.K. Widmark factors for local Chinese in Hong Kong. A statistical determination on the effects of various physiological factors. Forensic Sci. Int. 2005, 151:23-29.
195. Tam T.W., Yang C.T., Fung W.K., Mok V.K. Alcohol metabolism of local Chinese in Hong Kong: a statistical determination on the effects of various physiological factors. Forensic Sci. Int. 2006, 156:95-101.
196. Taylor R.E., Raysor B.R., Kwagyan J., Ramchandani V.A., Kalu N., Powell-Davis M., Ferguson C.L., Carr L., Scott D.M. Alterations in ethyl alcohol pharmacokinetics during oral consumption of malt liquor beverages in African Americans. Alcohol. Clin. Exp. Res. 2008, 32:2074-2080.
197. Mizoi Y., Adachi J., Fukunaga T., Kogame M., Ueno Y., Nojo Y., Fujiwara S. Individual and ethnic differences in ethanol elimination. Alcohol Alcohol. Suppl. 1987, 1:389-394.
198. Perper J.A., Twerski A., Wienand J.W. Tolerance at high blood alcohol concentrations: a study of 110 cases and review of the literature. J. Forensic Sci. 1986, 31:212-221.
199. Urso T., Gavaler J.S., Van Thiel D.H. Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci. 1981, 28:1053-1056.
200. Sullivan J.B., Hauptman M., Bronstein A.C. Lack of observable intoxication in humans with high plasma alcohol concentrations. J. Forensic Sci. 1987, 32:1660-1665.
201. Penttila A., Tenhu M. Clinical examination as medicolegal proof of alcohol intoxication. Med. Sci. Law 1976, 16:95-103.
202. Kalant H., LeBlanc A.E., Gibbins R.J. Tolerance to, and dependence on, some non-opiate psychotropic drugs. Pharmacol. Rev. 1971, 23:135-191.
203. Zink P., Reinhardt G. Der Verlauf der Blutalkoholkurve bei großem Trinkmengen. Blutalkohol 1984, 21:422-442.
204. Jones A.W., Wigmore J.G., House C.J. The course of the blood-alcohol curve after consumption of large amounts of alcohol under realistic conditions. Can. Soc. Forensic Sci. J. 2006, 39:125-140.
205. Ferner R.E., Chambers J. Alcohol intake: measure for measure. BMJ 2001, 323:1439-1440.
206. Dettling A., Witte S., Skopp G., Graw M., Haffner H.T. A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics. Int. J. Legal Med. 2008, 123:381-385.
207. Klockhoff H., Naslund I., Jones A.W. Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery. Br. J. Clin. Pharmacol. 2002, 54:587-591.
208. Koski A., Ojanpera I., Vuori E. Alcohol and benzodiazepines in fatal poisonings. Alcohol. Clin. Exp. Res. 2002, 26:956-959.
209. Jones A.W., Holmgren P. Comparison of blood-ethanol concentration in deaths attributed to acute alcohol poisoning and chronic alcoholism. J. Forensic Sci. 2003, 48:874-879.
210. Jones A.W. Urine as a biological specimen for forensic analysis of alcohol and variability in the urine-to-blood relationship. Toxicol. Rev. 2006, 25:15-35.
211. Oneta C.M., Lieber C.S., Li J., Ruttimann S., Schmid B., Lattmann J., Rosman A.S., Seitz H.K. Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase. J. Hepatol. 2002, 36:47-52.
212. Milroy C.M. Medical experts and the criminal courts. BMJ 2003, 326:294-295.
213. Gornall J. Standing up for justice. BMJ 2007, 334:1139-1141.
214. Brahams D. Truth, bias, and the medical "expert"Lancet 1999, 353:1380.
215. Mason J.K Expert evidence in the adversarial system of criminal justice. Med. Sci. Law 1986, 26:8-12.
216. Culliton B.J. Scientific "experts"and the law. Nat. Med. 1997, 3:123.
217. Samuels A., Barrister J.P. The single joint expert. Med. Sci. Law 2003, 43:9-12.
218. Shepherd J.P. Presenting expert evidence in criminal proceedings. BMJ 1993, 307:817-818.
219. Kaufman H.H. The expert witness. Neither Frye nor Daubert solved the problem: what can be done?. Sci. Justice 2001, 41:7-20.
220. Haffner H.T., Batra A., Bilzer N., Dietz K., Gilg T., Graw M., Mann K., von Meyer L., Penners B.M., Soyka M. Statistische Annäherung an forensische Rückrechnungswerte für Alkoholiker. Blutalkohol 1992, 29:53-61.
221. Bilzer N., Penners B.M., Conrad A. Die Methanolkinetik bei chronischem Alkoholismus. Blutalkohol 1991, 28:377-392.
222. Dubowski K.M. Human pharmacokinetics of ethanol. 1. Peak blood concentrations and elimination in male and female subjects. Alcohol Tech. Rep. 1976, 5:55-63.
223. Gubala W., Zuba D. Gender differences in the pharmacokinetics of ethanol in saliva and blood after oral ingestion. Pol. J. Pharmacol. 2003, 55:639-644.