Gender differences in pharmacokinetics of alcohol

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 4, 2001, Pages 502-507

  Baraona, Enrique ^a   Abittan, Chaim S ^a   Dohmen, Kazufumi ^a   Moretti, Michelle ^b   Pozzato, Gabriele ^b   Chayes, Zev W ^a   Schaefer, Clara ^a   Lieber, Charles S ^a,c  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF TRIESTE   (Italy)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alcohol; Gastric Alcohol Dehydrogenase; Gastric Emptying; Gender; Pharmacokinetics

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE;

ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; FIRST PASS EFFECT; HUMAN; HUMAN EXPERIMENT; LIVER METABOLISM; MALE; NORMAL HUMAN; POSTPRANDIAL STATE; PRIORITY JOURNAL; SEX DIFFERENCE; STOMACH EMPTYING;

EID: 0035045273     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02242.x     Document Type: Article

References (36)

1. Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender?
2. Sex differences in the metabolism of ethanol and acetaldehyde in normal subjects
3. Morbidity in alcoholics: Evidence for accelerated development of physical disease in women
4. Bioavailability of alcohol: Role of gastric metabolism and its interaction with other drugs
5. Lack of alcohol dehydrogenase isoenzyme activities in the stomach of Japanese subjects
6. Ethnic differences in gastric σ-alcohol dehydrogenase activity and ethanol first-pass metabolism
7. Human pharmacokinetics of ethanol: I. Peak blood concentrations and elimination in male and female subjects
8. Estrogen-related acetaldehyde elevation in women during alcohol intoxication
9. Bedside diagnosis of alcohol intoxication with a pocket-size breath-alcohol device: Sampling from unconscious subjects and specificity for ethanol
10. High blood alcohol levels in women: The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism
11. 2-blockers on alcohol bioavailability
12. Acute alcohol intoxication and body composition in women and men
13. Significant increase of blood alcohol by cimetidine after repetitive drinking of small alcohol doses
14. Distribution of ethanol in the human gastrointestinal tract
15. Investigation of alcohol dehydrogenase isozymes of biopsy gastric mucosa in Japanese
16. Male and female intoxication levels for three alcohol doses or do women really get higher than men?
17. First pass metabolism of ethanol: A gastrointestinal barrier against the toxicity of ethanol
18. First-pass metabolism of ethanol: An important determinant of blood alcohol levels after alcohol consumption
19. No sex and age influence on the expression pattern and activities of human gastric alcohol and aldehyde dehydrogenases
20. The kinetics of alcohol elimination in man
21. Gender differences in medium-chain dicarboxylic aciduria in alcoholic men and women
22. Scintigraphic evaluation of gastric emptying
23. Ethanol elimination in males and females: Relationship to menstrual cycle and body composition
24. More rapid elimination of alcohol in women as compared to their male siblings
25. 3 phenotype and gastric region
26. Sex-related differences among 100 patients with alcoholic liver disease
27. Rapid diagnosis of Campylobacter pyloridis infection
28. First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying
29. Ethanol metabolism and aging: The role of "first-pass metabolism" and gastric alcohol dehydrogenase activity
30. Effect of concentration of ingested ethanol on blood alcohol levels
31. Human gastric alcohol dehydrogenase activity: Effects of age, sex and alcoholism
32. Effects of Helicobacter pylori infection and gastritis on gastric alcohol dehydrogenase activity
33. Ethanol, its metabolism and gonadal effects: Does sex make a difference?
34. Elimination of alcohol from human blood
35. Alcohol and aldehyde dehydrogenases in human esophagus: Comparison with the stomach enzyme activities
36. Human stomach alcohol and aldehyde dehydrogenases: Comparison of expression pattern and activities in alimentary tract